amlitelimab SC (KY1005 SC) / Sanofi - LARVOL DELTA

Surveillance of CTX-M group 1-producing Enterobacterales at the migratory Little Stint (Calidris minuta)-goat-aquatic interface in the Kenyan Rift Valley: a One Health approach. (PubMed, Front Microbiol) - "Applying a One Health framework, this study characterized CTX-M Group 1 gene variants alongside co-carried β-lactamase gene families (bla OXA1 - like, bla SHV, and bla TEM) in Enterobacterales across the migratory shorebirds Little Stints (Calidris minuta)-livestock-aquatic interface in the Kenyan Rift Valley...Rather than a mere passive corridor, the Kenyan Rift Valley serves as a dynamic ecological epicenter where global migratory flyways intersect with local anthropogenic drivers to modulate AMR. Despite the lack of sequencing data, this study provides vital baseline landscape data highlighting the need for sustained One Health-AMR surveillance and environmental stewardship."

Journal • Infectious Disease • Pneumonia

Sensitivity analysis of annual energy production and associated economic losses due to external wake effects on offshore wind clusters: A case study of the Shinan offshore wind cluster in southwest sea of Korea. (PubMed, PLoS One) - "These findings provide empirical evidence supporting the establishment of minimum inter-farm spacing guidelines to mitigate revenue loss and potential stakeholder conflicts within designated offshore wind cluster zones. The study offers actionable insights for policymakers and developers to promote sustainable offshore wind cluster design under Korea's evolving regulatory framework."

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Detecting the Failures Nobody Sees: Applying Pareto Analysis and Failure Mode and Effects Analysis to Equipment Reliability in a Healthcare Simulation Institute. (PubMed, Cureus) - "Methods We analyzed a 24-month log of reported equipment incidents (N = 22) from the simulation institute of an offshore medical school using Pareto analysis, Fishbone (Ishikawa) diagrams with Five Whys questioning, and FMEA...Detectability deserves a place alongside severity in simulation operations improvement work. We set out the incident classification scheme, the scoring anchors, and a five-step workflow so that other programs can run the same analysis against their data."

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Effect of amlitelimab, a non-depleting anti-OX40 ligand antibody, on vaccine antibody responses in adult participants with moderate-to-severe atopic dermatitis: Results from HYDRO Phase 2 trial (EADV 2026) - P2, P2/3 | "Eligible adults (≥18 years of age) were randomly assigned 1:1 to receive a subcutaneous amlitelimab 500 mg loading dose followed by 250 mg every-4-weeks (Q4W) or matching placebo. Conclusions Treatment with amlitelimab 250 mg Q4W did not affect T-cell–dependent or T-cell–independent vaccine responses in adults with moderate-to-severe atopic dermatitis vs placebo. Amlitelimab was generally well tolerated when administered concomitantly with the vaccines."

Clinical • P2 data • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Pertussis • Pneumococcal Infections • Respiratory Diseases • Tetanus • TNFSF4

Characterization of Psoriasis Epigenetic Differentially Methylated Regions and Overlapping Genes Expression (EADV 2026) - P4 | "The strongest signal involved MCRIP1, with CpG shore and shelf hypomethylation...These findings support blood-based DNAm profiling as a non-invasive strategy for identifying epigenetic markers and therapeutic targets in psoriasis. FDR: false discovery rate; p Overlapped Gene Promoter."

Dermatology • Immunology • Inflammation • Metabolic Disorders • Psoriasis

Scrubbing Off Scrub Typhus: A Cultural Exposé of Exposure in Japan (EADV 2026) - "During the Shoreisai Festival on Mount Haguro (Yamagata Prefecture), effigies of mites are burned on New Year's Eve in hopes of a bountiful harvest...Outdoor settings frequently involve prolonged contact with low-lying vegetation and soil, increasing the likelihood of mite exposure. Incorporating cultural context and travel history into dermatologic assessment may improve early recognition and expedite management."

Cognitive Disorders • Infectious Disease

IMG-007, a non-depleting OX40 antagonist: Optimizing Peak Loading Concentration and Exposure Range to Unlock the Full Potential of OX40-OX40L Pathway Targeting in Immune Mediated Diseases (EADV 2026) - "Rocatinlimab, an ADCC-enhanced anti-OX40 antibody designed to deplete pathogenic OX40+ T cells with a relatively short half-life, demonstrated modest efficacy in Phase 3 e.g. ROCKET-HORIZON trial using monthly dosing (EASI-75: ~33% vs ~14% placebo at Week 24) alongside a notable MoA associated adverse event profile (aphthous ulcers, pyrexia, chills)...In contrast, amlitelimab, a non–T-cell-depleting anti-OX40L antibody, demonstrated improved tolerability but also modest efficacy in Phase 3 e.g. COAST 2 trial (EASI-75 ~41% vs~17% placebo at Week 24) and the overall dose-response relationship has not been well established...Conclusions In summary, prior clinical outcomes in the OX40/OX40L class may reflect suboptimal exposure and other molecule-specific effects rather than target inadequacy. A strategy focused on maximizing peak loading concentration and exploring a wide exposure range—enabled by improved pharmacokinetics and safety—may unlock the full therapeutic..."

Atopic Dermatitis • Dermatitis • Immunology • TNFSF4

Efficacy of amlitelimab in improving head and neck atopic dermatitis in Phase 2 and 3 trials: Results from COAST-1, COAST-2, SHORE, and ATLANTIS (EADV 2026) - P2, P3 | "In pts with up to 52 weeks of amlitelimab treatment in ATLANTIS (N=560), 53.4% of pts achieved head and neck EASI-75. Conclusions Improvements in AD signs and severity in head, neck, and eyelid regions were observed with amlitelimab across multiple trials with Q4W and Q12W dosing regimens, demonstrating a clinically meaningful benefit to multiple anatomical sites, including challenging-to-treat regions."

Clinical • P2 data • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • TNFSF4

Amlitelimab reduces atopic dermatitis (AD)-associated biomarkers in participants with moderate-to-severe AD: Results from Phase 3 COAST-1, COAST-2, and SHORE trials (EADV 2026) - P3 | "† p≤0.05, † † p≤0.001 vs placebo. *p<0.05, **p≤0.001 vs baseline."

Biomarker • IO biomarker • P3 data • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • IL12A • IL13 • IL17A • IL22 • IL23A • TNFSF4

Efficacy of amlitelimab in improving atopic dermatitis in participants who have failed or are naïve to advanced systemic therapy: Post hoc analysis from pooled COAST-1, COAST-2, and SHORE Phase 3 trials (EADV 2026) - P3 | "Conclusions In these pooled post hoc analyses, amlitelimab demonstrated consistent and progressive efficacy over 24 weeks in both participants who had previously failed advanced systemic therapy or were naïve to advanced systemic therapy. These results suggest that targeting the OX40L/OX40 pathway with amlitelimab may benefit individuals with moderate-to-severe AD regardless of prior advanced systemic therapy failure."

Clinical • Metastases • P3 data • Retrospective data • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • TNFSF4

SAT 8.04: From Storm to Shore: Charting the Course in HS Care (EADV 2026) - "This session is sponsored by: Sanofi"

Hidradenitis Suppurativa

Long-term monitoring and remote sensing reveal waterbird colony collapses with rising lake levels and multiple stressors. (PubMed, Ecol Appl) - "We investigated climate-mediated lake level fluctuations in coastal wetland ecosystems undergoing shoreline development and species invasions in the Laurentian Great Lakes...While future hydrological projections are uncertain, we expect Black Tern colony populations to fluctuate in response to lake levels in the region. Our study exemplifies how multiple stressors can undermine wetland resilience to climate change and present a conservation challenge for vulnerable wetland taxa."

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Depositional Environment and Diagenetic History of Gas Hydrate-Bearing Sediments of the Alaska North Slope (HYDRATE 02 Geo Data Well). (PubMed, Energy Fuels) - "Overall, these sediments were deposited in a shoreface to nearshore marine environment during the Paleogene, modulated by changing depositional energy associated with sea level variation...The unit E basal shale overlying the D1 sand contains a 0.25 m thick pyrite-dominant sand, indicating local bottom water anoxic conditions. X-ray fluorescence scanning and discrete measurements provide additional supporting interpretation of the depositional and diagenetic processes that have occurred at this site and track the relative amount of drilling fluid contamination with barium abundance in the core samples."

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Seamless Mechanical Programming Through Hybrid Epoxy-Acrylate Printing for Soft-Rigid Robots. (PubMed, Adv Mater) - "We achieve both continuous hardness gradients spanning Shore-A 8 to Shore-D 80...This capability enables single-shot fabrication of soft-rigid robotic systems that undergo large, cyclic deformations, including functionally graded pneumatic bellows with integrated tubing interfaces and spatially programmable deformation modes, bioinspired soft robotic hands with embedded bone-like structures, and an augmented undulating walker that achieves more than a twofold increase in locomotion speed relative to an all-soft counterpart. These results establish a generalizable materials and manufacturing framework for mechanically graded polymer systems, enabling robust soft-rigid integration in robotics and beyond."

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Trophic transfer characteristics of mercury affected by food source in coral reef fish from the South China Sea. (PubMed, J Hazard Mater) - "Even in minimally disturbed offshore waters with low background Hg levels, intense Hg biomagnification may lead to substantial health risks. Basal food-source composition is associated with Hg biomagnification, providing a reference for sustainable fishery governance and seafood consumption recommendations."

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Microplastics in multi-stream discharges from offshore oil and gas platforms: Occurrence and ecological risk. (PubMed, Mar Pollut Bull) - "The microplastic features in discharges from platforms were highly consistent with those in sediments of the Bohai offshore oil and gas fields, suggesting that discharges from offshore oil and gas platforms may represent potential sources of microplastics in the surrounding sediments. This work provides the first comprehensive microplastic dataset of China's offshore platform discharges, supporting targeted marine pollution regulation and mitigation."

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Brugmansia poisoning - a case report highlighting a preventable port call hazard for seafarers and travelers. (PubMed, Int Marit Health) - "This case of severeBrugmansiapoisoning underscores a dual public health challenge. First, it is a clinically significant toxicological emergency requiring recognition and supportive management. Second, it exemplifies a preventable risk for maritime populations - both seafarers on shore leave and cruise tourists - who may experiment with locally available psychoactive plants. Enhanced awareness and targeted education in port communities and among travelers are crucial preventive measures in maritime health."

Journal • Anesthesia • Cardiovascular • CNS Disorders • Ophthalmology • Psychiatry • Substance Abuse • Suicidal Ideation

Effects of Body Size and Month of Collection on Total Mercury and Methylmercury Concentrations in Orb-weaver Spiders: Implications for the Use of Riparian Spiders as Sentinels. (PubMed, Environ Toxicol Chem) - "Orb-weaver spiders (Family Araneidae) build webs on shoreline vegetation and human-made structures and feed on methylmercury (MeHg)-contaminated emerging insects from aquatic ecosystems...However, δ15N values explained a relatively low proportion of the variance in total Hg concentration, suggesting that dietary shifts alone could not explain the increase in total Hg over the course of the study. The different effects of month of collection on concentrations of total Hg and MeHg and resultant decline in %MeHg with season has important implications for using orb-weaver spiders as sentinels of Hg contamination of aquatic systems and suggests that total Hg should not be used a proxy for MeHg without accounting for seasonal variation in %MeHg."

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Urban Tree Pathogens: The Impact of Neofusicoccum luteum on Araucaria heterophylla (Norfolk Island Pine). (PubMed, Environ Manage) - "Thirty-two (32) mature A. heterophylla trees of varying health growing on the foreshores of Gold Coast, Australia, were selected for isolation of fungi from foliage samples...These results suggest that N. luteum may contribute to A. heterophylla decline and reduced growth rate, but is unlikely to be the sole causal agent and is unable to kill a tree rapidly. Strategies for improving A. heterophylla health and management emerging from this study include the need for: (a) supplem.entary irrigation during prolonged drought to prevent the pathogen from entering through damaged bark; and (b) consistent tree health monitoring."

Journal • Infectious Disease

Count and mass identify different shoreline-litter priorities: Evidence from Vietnamese monitoring programmes. (PubMed, Mar Pollut Bull) - "Counts should be retained for product occurrence and prevention, whereas mass should be added when management concerns material handling, disposal, or fishing-gear recovery. Reporting both priority rankings and material-coverage curves would provide a more decision-relevant basis for coastal-litter management, while any count-to-mass conversion should undergo local prospective validation."

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Preliminary indications of water-quality-related trace-element signals in aquatic moss balls from a Patagonian lake. (PubMed, J Environ Qual) - "However, the whole-aggregate signal combines biological and particulate components and cannot yet be interpreted as a measure of water quality. Paired analyses of water, sediment, retained particles, shoreline material, and cleaned moss tissue are required before monitoring applications can be assessed."

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Multidrug-Resistant Bacteria in South Atlantic Cetaceans over a Decade of Surveillance. (PubMed, Microorganisms) - "Because carcass-based sampling inherently targets a diseased or senescent fraction, these high prevalences may overestimate the resistome burden of healthy free-ranging populations. The detection of human pathogens across coastal and offshore habitats indicates persistent deficiencies in terrestrial effluent management, reinforcing cetaceans as One Health sentinels."

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Frontier Advances in Wind-Driven Triboelectric Nanogenerators for Realistic Wind Environments: Scenario-Oriented Architecture Design, System Integration, and Critical Assessment. (PubMed, Micromachines (Basel)) - "This review examines wind-driven TENGs from the perspective of realistic wind-field constraints, focusing on three representative scenarios: urban micro-winds, offshore wind-wave environments, and low-altitude complex flows...Key challenges involving usable regulated energy, environmental reliability, lifetime prediction, array scaling, sustainability, and deployment economics are critically discussed. Finally, five grand challenges with actionable milestones are proposed to facilitate the transition of wind-driven TENGs from laboratory prototypes toward deployable distributed micro-energy systems."

Journal • Review

Mercury in Red Knots (Calidris canutus rufa): Inter-Annual and Geographic Variation in Blood Mercury and Associated Toxicological Risk Along the Atlantic Flyway. (PubMed, Toxics) - "Shorebird populations are declining sharply, and trace metal contaminants may compound the many migration-related threats they face by affecting feeding, migration, and reproductive success...Two cohorts had small samples, and site, season, and migratory stage are confounded in the design. Risk varies markedly among years, and a single sampling event is unlikely to characterize mercury exposure or its associated risk."

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Genome-Wide Identification and Bioinformatics Analysis of Thaumatin-like Proteins in Aegiceras corniculatum. (PubMed, Genes (Basel)) - "Heterologous expression and antibacterial tests showed that recombinant AcTLP19 had no direct antifungal activity against B. cinerea or Fusarium oxysporum under the tested conditions, leaving open the possibility that it contributes to mangrove defense through indirect mechanisms, or that its antifungal activity was not captured under the specific assay conditions. This study advances our knowledge of mangrove stress responses and may contribute to future conservation strategies."

Journal • Infectious Disease