AR153 / Y-Biologics - LARVOL DELTA

Pathological characteristics and genetic analysis of a stillborn harboring compound heterozygous nonsense variants of TH gene (PubMed, Zhonghua Yi Xue Yi Chuan Xue Za Zhi) - "Biallelic null variants of the TH gene may cause heart failure by affecting the development of cardiovascular system, which in turn may lead to intrauterine death. This study has provided new clues for the molecular diagnosis of stillbirth and recurrent pregnancy loss."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • ARG1

A next generation ADC: AR153, pH-dependent anti-B7H3 MMAE (AACR 2025) - "Additionally, in a B7-H3-expressing CDX model, ADCs demonstrated similar anti-cancer efficacy. Notably, pH-B7-H3 Ab exhibited superior penetration into tumor tissues compared to Non-pH-B7-H3 Ab, highlighting its potential to improve therapeutic outcomes by selectively targeting tumor cells while minimizing harm to normal tissues."

Oncology • Solid Tumor • CD276

Safety evaluation of the food enzym endo-1,4-β-xylanase from the genetically modified Bacillus subtilis strain AR-153. (PubMed, EFSA J) - "The Panel considered that the risk of allergic reactions upon dietary exposure cannot be excluded, but the likelihood is low. Based on the data provided, the Panel concluded that this food enzyme does not give rise to safety concerns, under the intended conditions of use."

Journal • Allergy

Ybiologics Announces New Drug Pipeline 'AR153' at 'WorldADC' [Google translation] (Medipana) - "Antibody drug development platform company YBiologics...announced on the 1st that it will be participating in the '15th World ADC' held in San Diego, USA from November 4th to 7th...and presenting 'AR153', an antibody drug conjugate (ADC) pipeline developed based on the company's innovative antibody discovery platform...The core of this presentation is a pH-dependent antibody that effectively works in the characteristic weakly acidic environment of the tumor microenvironment (TME). In general, the tumor microenvironment is weakly acidic with a low pH, unlike normal tissues, and this plays an important role in the growth and metastasis of cancer cells....This study targeted B7-H3, which is known to be overexpressed in various solid cancers. B7-H3 is a protein with a high expression rate in various solid cancers such as breast cancer, lung cancer, and prostate cancer, and is known to be involved in the growth and metastasis of cancer cells..."

New molecule • Preclinical • Breast Cancer • Genito-urinary Cancer • Lung Cancer • Oncology • Prostate Cancer • Solid Tumor