ARO-DUX4 / Arrowhead, Sarepta Therap - LARVOL DELTA

Study of ARO-DUX4 in Adult Patients With Facioscapulohumeral Muscular Dystrophy Type 1 (clinicaltrials.gov) - P1/2 | N=60 | Recruiting | Sponsor: Arrowhead Pharmaceuticals | Phase classification: P1 ➔ P1/2

Phase classification • Muscular Dystrophy

Arrowhead Pharmaceuticals Announces Closing of Global License and Collaboration Agreement with Sarepta Therapeutics (Businesswire) - "Arrowhead Pharmaceuticals, Inc...today announced that the global licensing and collaboration agreement with Sarepta Therapeutics (NASDAQ: SRPT) announced on November 26, 2024, has now closed. Closing of the transaction was subject to the expiration or termination of the waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 and other customary conditions...Upon closing, Arrowhead receives a $500 million upfront payment and $325 million through the purchase by Sarepta of Arrowhead common stock priced at $27.25 per share. Arrowhead will also receive $250 million to be paid in annual installments of $50 million over 5 years...ARO-HTT for patients Huntington’s disease expected to be CTA-ready in 2025; ARO-ATXN1 for patients with spinocerebellar ataxia 1 (SCA1) expected to be CTA-ready in 2026; ARO-ATXN3 for patients with spinocerebellar ataxia 3 (SCA3) expected to be CTA-ready in 2026."

IND • Licensing / partnership • Ataxia • Huntington's Disease • Idiopathic Pulmonary Fibrosis • Muscular Dystrophy • Myotonic Dystrophy

Study of ARO-DUX4 in Adult Patients With Facioscapulohumeral Muscular Dystrophy Type 1 (clinicaltrials.gov) - P1 | N=60 | Recruiting | Sponsor: Arrowhead Pharmaceuticals | Trial completion date: Jun 2025 ➔ Sep 2025

Trial completion date • Muscular Dystrophy

Study of ARO-DUX4 in Adult Patients With Facioscapulohumeral Muscular Dystrophy Type 1 (clinicaltrials.gov) - P1 | N=52 | Recruiting | Sponsor: Arrowhead Pharmaceuticals | Not yet recruiting ➔ Recruiting

Enrollment open • Muscular Dystrophy

Study of ARO-DUX4 in Adult Patients With Facioscapulohumeral Muscular Dystrophy Type 1 (clinicaltrials.gov) - P1 | N=52 | Not yet recruiting | Sponsor: Arrowhead Pharmaceuticals

Trial completion date • Trial initiation date • Trial primary completion date • Muscular Dystrophy