azithromycin / Generic mfg. - LARVOL DELTA

Photocatalytic degradation of azithromycin and ceftriaxone using synthesized Ag/g-C3N4/Fe3O4 nanocomposites in aqueous solution. (PubMed, Sci Rep) - "The nanocomposite also exhibited enhanced visible light absorption due to its tailored bandgap and electron-hole separation efficiency. The findings confirm that the Ag/g-C3N4/Fe3O4 nanocomposite is a robust and efficient photocatalyst for antibiotic degradation, offering a sustainable and effective solution for wastewater treatment applications."

Journal

Clinical Characteristics of Pediatric Parapertussis: A Single-Center Case-Control Study. (PubMed, J Infect Chemother) - "Azithromycin was administered to 64.4% of patients...This study shows that parapertussis generally follows a mild clinical course but is often found with other pathogens. Given the lack of nationwide surveillance for parapertussis in Japan, more data are needed to assess the disease burden and develop management strategies."

Journal • Cough • Critical care • Infectious Disease • Pediatrics • Pertussis • Respiratory Diseases

Evaluating the Safety and Efficacy of Malaria Preventive Measures in Pregnant Women with a Focus on HIV Status: A Systematic Review and Network Meta-Analysis. (PubMed, J Clin Med) - " In HIV-positive pregnant women, Co-trimoxazole with dihydroartemisinin significantly reduced malaria incidence compared to Co-trimoxazole alone (RR = 0.45, 95% CI [0.30; 0.68]) and sulfadoxine-pyrimethamine (SP) (RR = 0.14, 95% CI [0.04; 0.48]). Co-trimoxazole with dihydroartemisinin and mefloquine are effective for HIV-infected pregnant women, while azithromycin-piperaquine and mefloquine work well for those without HIV. Customized prevention strategies considering HIV status are crucial for optimal protection."

Journal • Retrospective data • Review • Human Immunodeficiency Virus • Infectious Disease • Malaria

In Vitro Activity of Imipenem/Relebactam Alone and in Combination Against Cystic Fibrosis Isolates of Mycobacterium abscessus. (PubMed, Antibiotics (Basel)) - "These findings suggest that imipenem/relebactam may offer a significant advancement in the management of MABS infections in PwCF. The promising efficacy of multidrug regimens combining imipenem/relebactam with agents like cefoxitin, azithromycin, moxifloxacin, clofazimine, and rifabutin highlights potential therapeutic strategies."

Journal • Preclinical • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases

A Case of Granulomatous Interstitial Nephritis Associated with Mycobacterium chimaera Disseminated Infection. (PubMed, Microorganisms) - "The patient was started on antimicrobial therapy with azithromycin, moxifloxacin, rifampicin, and ethambutol while prednisone was tapered down, leading to an improvement in kidney function, blood count, and blood calcium level. Our case suggests that a Mycobacterium chimaera infection should be considered for patients with a history of cardiac surgery and granulomatous interstitial nephritis even in the absence of mycobacteria in a kidney biopsy."

Journal • Cardiovascular • Endocrine Disorders • Hematological Disorders • Immunology • Infectious Disease • Metabolic Disorders • Myositis • Nephrology • Renal Disease

Cohabitating in the City: A Case of Hemolytic Anemia in a Patient Coinfected With Babesiosis, Lyme Disease, and Mononucleosis. (PubMed, Cureus) - "Treatment with doxycycline and valganciclovir was started, as IgM antibodies were positive for Lyme disease and cytomegalovirus (CMV). Due to worsening symptoms and clinical deterioration, the treatment was broadened with azithromycin and atovaquone, after which the patient experienced significant clinical and paraclinical improvement. Further studies revealed active babesiosis and EBV infection, besides a negative CMV viral load, indicating a false-positive initial result. After finishing treatment for babesiosis and Lyme disease, the patient recovered completely and remains asymptomatic to this day. Diagnosing active babesiosis, Lyme, and EBV coinfection was challenging because of the absence of erythema migrans, lack of apparent tick exposure history, and concerns for cross-reactivity. To the best of our knowledge, this is one of the first cases of coinfection among these three pathogens reported in medical literature."

Journal • Anemia • Autoimmune Hemolytic Anemia • Cytomegalovirus Infection • Dermatology • Epstein-Barr Virus Infections • Fatigue • Hematological Disorders • Immunology • Infectious Disease • Inflammatory Arthritis • Lyme Disease • Musculoskeletal Pain • Pain • Rheumatology

First Report of Genetic Resistance to Azithromycin in Treponema pallidum from Blood Samples Among Men Who Have Sex with Men and People Living with HIV from Mexico. (PubMed, Microorganisms) - "We report the first data on the molecular prevalence of TPA and the first identification of genetic resistance to azithromycin (punctual mutation A2058G) in Mexico. Resistance testing for syphilis is not routinely performed in Mexico, but azithromycin continues to be prescribed despite syphilis being treatable with benzathine penicillin G. Therefore, the surveillance of cases of syphilis treatment failure, especially in vulnerable populations, which are the population group that maintains the active transmission of TPA, is recommended."

Journal • Human Immunodeficiency Virus • Infectious Disease

Presumed Bartonella-Associated Spondylodiscitis in a 3-Year-Old Child: A Case Report and Review of the Literature. (PubMed, Children (Basel)) - "Empirical antibiotic treatment with ampicillin/sulbactam showed no clinical response. Serologic testing revealed a positive Bartonella henselae IgM (IgG negative), leading to a change in antibiotic treatment to azithromycin and rifampicin for three weeks, resulting in rapid clinical improvement...A review of the literature identified 28 pediatric cases of Bartonella henselae spondylodiscitis, with significant variation in diagnostic and treatment approaches. This case underscores the importance of considering Bartonella in the differential diagnosis of pediatric vertebral osteomyelitis."

Journal • Back Pain • Infectious Disease • Inflammation • Musculoskeletal Pain • Pain • Pediatrics

Antimicrobial activity of lefamulin against pathogens most commonly causing community-acquired pneumonia: results from the China antimicrobial surveillance network in 2020-2022. (PubMed, Eur J Clin Microbiol Infect Dis) - "Lefamulin exhibited potent in vitro activity against prevalent and drug-resistant pathogens associated with CAP in China."

Journal • Infectious Disease • Influenza • Pneumococcal Infections • Pneumonia • Respiratory Diseases

Therapeutic drug monitoring for antimicrobial agents for people living with HIV (TAP). (PubMed, Wellcome Open Res) - "This prospective observational study will enroll adult PLWH receiving amoxicillin, azithromycin, ciprofloxacin, rifampicin, isoniazid, or ceftriaxone. We anticipate that the findings from this research will characterize pharmacokinetic and pharmacodynamics relationships to predict treatment response for optimal antimicrobial therapeutic and anti-tuberculosis dosing among people living with HIV (PLWH). The study is registered with Pan African Clinical Trials Registry, registration number PACTR202409710100607, registration date 07 August 2024, pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=31764."

Journal • Human Immunodeficiency Virus • Infectious Disease • Oncology • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Changes in Chronic Graft-versus-Host Disease Treatment over Time: A 15-Years Survey within Allogeneic Hematopoietic Stem Cell Transplant Centers in Germany, Austria, and Switzerland. (PubMed, Transplant Cell Ther) - "The survey documents the effect of evidence and approval on clinical care with single agent prednisone representing the standard of care in 1st-line treatment while rux combined with steroids defines the new standard for 2nd-line treatment of cGVHD. ECP is used in case of contraindication for rux and both agents are also used in progressive onset cGVHD. In contrast, treatment of BOS and sclerotic cGVHD beyond 2nd-line treatment remains heterogeneous with new agents being integrated in the treatment landscape."

Journal • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Transplantation

FEV1 Trajectory in a Multicenter Prospective Cohort of Patients With Bronchiolitis Obliterans Syndrome After Hematopoietic Cell Transplantation (ATS 2025) - P | "Current treatments include inhaled corticosteroids (ICS), azithromycin, montelukast, and long-acting beta-agonists ('FAM+LABA' regimen), ± additional systemic immunosuppression (IS)...Initial treatments including IS (e.g. steroids, ruxolitinib, belumosudil, etc.) were tracked... There is heterogeneity in BOS FEV1 trajectories. ppFEV1 at BOS diagnosis and use of systemic therapy did not significantly influence overall progression of BOS in our cohort. Additional work is needed to further elucidate factors that influence BOS phenotypes."

Clinical • Pulmonary Disease • Respiratory Diseases • Transplantation

Mycoplasma pneumoniae infection complicated by autoimmune haemolytic anaemia (AIHA) and focal seizures in a paediatric patient. (PubMed, BMJ Case Rep) - "The patient responded to treatment with intravenous azithromycin and ceftriaxone. This case highlights the importance of promptly recognising and treating more severe and less common manifestations of M. pneumoniae infection."

Journal • Anemia • Autoimmune Hemolytic Anemia • Cardiovascular • CNS Disorders • Cough • Epilepsy • Hematological Disorders • Immunology • Infectious Disease • Pediatrics • Pneumonia • Respiratory Diseases

Mycobacterium Avium Complex Biofilm in a Lung Cavity (ATS 2025) - "This was treated with chemotherapy, erlotinib and radiation therapy for brain metastasis...Sputum collected two months pre-operatively demonstrated many acid-fast bacilli (AFB) on smear, and rough and smooth variants of M. intracellulare subspecies chimaera, susceptible to clarithromycin and amikacin. We treated her with oral azithromycin, ethambutol, clofazimine, and omadacycline; inhaled amikacin and off-label ceftazidime-avibactam IV were added for additional coverage during the perioperative period...To our knowledge, this is the first report of MAC biofilm in a human. MAC biofilm within cavities may be a cause of disease that is refractory to medical therapy."

Cough • Fibrosis • Hematological Disorders • Hepatology • Immunology • Leukopenia • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Respiratory Diseases • Solid Tumor

Curcumin Reverses Antibiotic Resistance and Downregulates Shiga Toxin Expression in Enterohemorrhagic E. coli. (PubMed, Diseases) - "Our findings support the potential of CUR as a sensitizer or in combination therapy against EHEC."

Journal • Atypical Hemolytic Uremic Syndrome • Hematological Disorders • Infectious Disease • Nephrology

Addressing Contaminants of Emerging Concern in Aquaculture: A Vacuum Membrane Distillation Approach. (PubMed, Membranes (Basel)) - "The system demonstrated remarkable performance in removing several key antimicrobials, including sulfamethoxazole, ciprofloxacin, azithromycin, and clindamycin (500 μg·L-1), with rejection rates of 99.1%, 98%, 99.9%, and 99%, respectively, and an average flux of 7.08 L·m-2·h-1. The findings highlight the potential of VMD as an effective and sustainable technology for the removal of CECs and biocompounds, enhancing water safety and reducing environmental hazards. This study offers a promising solution for addressing water contamination on a broader scale."

Journal

Design of a Foam-Actuated Nano-Emulgel for Perioceutic Drug Delivery: Formulation, Characterization, and Antimicrobial Efficacy. (PubMed, Gels) - "Azithromycin, a conventional lipophilic drug for periodontal treatment, often causes systemic side effects when administered orally...This was supported by the shear-thinning, muco-adhesive, and drug-retentive properties of the xanthan gel base. The study also examined the influence of the oil phase with xanthan gum gel on foam texture, rheology, and stability, demonstrating a promising prototype for periodontitis treatment."

Journal • Dental Disorders • Periodontitis

Surgical Bundle to Reduce Infectious Morbidity after Cesarean Delivery in Individuals with Morbid Obesity. (PubMed, Am J Perinatol) - "A morbid obesity surgical bundle increased antibiotic use but did not reduce SSIs, hospital readmission, ED department visits, and wound complications."

Journal • Genetic Disorders • Infectious Disease • Obesity

Prevalence and epidemiology of Mycoplasma genitalium and the absence of macrolide resistance in M. genitalium among pregnant women attending antenatal care in Zambia. (PubMed, Front Public Health) - "These findings suggest that azithromycin remains an efficacious treatment option for MG in this population. Nevertheless, continuous surveillance and judicious macrolide use to maintain treatment efficacy are imperative. Further research and sustained monitoring of MG are essential to inform public health strategies and clinical guidelines in Zambia and similar settings worldwide."

Journal • Human Immunodeficiency Virus • Infectious Disease • Urology

Co-delivery of Azithromycin and nisin through liposomes for skin infection to reduce antimicrobial drug resistance. (PubMed, Int J Pharm) - "Antimicrobial activity and biofilm eradication against Staphylococcus aureus results showed that combined liposomal formulations were more effective than AZM-loaded formulations. In conclusion, this study presents co-delivery of AZM and nisin through liposome formulations as an effective treatment option for skin infection to reduce AMR."

Journal • Dermatology • Infectious Disease

Evaluating the Impact of an Antibiotic Prophylaxis Bundle on Surgical Site Infections Following Cesarean Delivery in Women with Obesity: A Retrospective Cohort Study (ACOG 2025) - "We analyzed 1,219 cesareans including 454 before implementation of the prophylaxis bundle and 765 afterward. The overall rate of SSI before the protocol was 6.2% compared to 6.4% after the protocol (P=.90). There was no significant difference in SSI rates before and after the protocol when compared across BMI class, preterm versus term gestation, and ruptured versus unruptured membranes."

Retrospective data • Genetic Disorders • Infectious Disease • Obesity

Differential Rates of Vulvovaginal Candidiasis Across Oral Antibiotic Use for Acne Treatment: A Large Database Retrospective Review Using TriNetX (ACOG 2025) - "INTRODUCTION: Oral tetracyclines and macrolides are commonly used for treating moderate-to-severe acne but can predispose patients to vulvovaginal candidiasis (VVC). The risk comparison after propensity matching revealed that azithromycin and doxycycline showed a significantly higher incidence of VVC compared to the control cohort with HR 2.349 (1.928, 2.862) and HR 1.239 (1.129, 1.359), respectively (P<.0001). Azithromycin also showed a significantly higher incidence of VVC than doxycycline, with HR 1.662 (1.396, 1.98; P<.0001). Erythromycin and minocycline did not show a significantly higher incidence than the control with HR 1.355 (0.814, 2.257) and HR 1.08 (0.908, 1.285), respectively."

Retrospective data • Review • Acne Vulgaris • Candidiasis • Human Immunodeficiency Virus • Infectious Disease • Vaginitis

Cutaneous manifestations of atypical mycobacterium chelonae: A case report (SID 2025) - "Initial treatment included prednisone 20 mg BID resulted in significant immunosuppression. Treatment for suspected Staphylococcus aureus sepsis included multiple courses of antibiotics for vancomycin, ceftriaxone, daptomycin, tigecycline, linezolid, imipenem and amikacin...Although the nodules began to respond to appropriate treatment with minocycline, azithromycin and tigecycline the patient's condition was compromised by CHF and he expired. The state of Hawaii as well as the field of dermatology are both experiencing physician shortages, which has led to poor dermatologic access in the region [1]. This demonstrates multiple cutaneous manifestations of systemic AFB infection."

Case report • Clinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Dermatology • Heart Failure • Infectious Disease • Septic Shock • Ventricular Tachycardia

Disseminated Mycobacterium Chelonae Mimicking Erythema Nodosum in a Patient With Gout (ATS 2025) - "We present the case of a 74-year-old male with past medical history of heart failure, atrial fibrillation, and gout who was recently placed on prednisone taper for gout flare and presented to the hospital for new subcutaneous nodules and polyarthralgia of the bilateral ankles, and left knee, and big toe...Full thickness skin biopsy was notable for acid-fast bacilli, with Karius testing showing M.chelonae and so the patient was transitioned to intravenous antibiotics (imipenem, azithromycin, and doxycycline) with improvement of his condition...Prior studies have found that M.chelonae usually occurs in the setting of corticosteroid therapy and is often disseminated. Furthermore, the case highlights that clinicians should realize that gout can also predispose patients to opportunistic infections due to innate immune dysregulation due to the effects of uric acid."

Clinical • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Dermatology • Gout • Heart Failure • Infectious Disease • Inflammatory Arthritis • Musculoskeletal Diseases • Musculoskeletal Pain • Pulmonary Disease • Renal Disease • Respiratory Diseases • Rheumatology • Sarcoidosis • Septic Shock • Tuberculosis

Pleural Mycobacterium Avium Complex (MAC) Empyema: A Rare Presentation of Disseminated Mac Infection in a Patient With Systemic Lupus Erythematosus/Dermatomyositis Overlap (ATS 2025) - "Treatment was adjusted to clarithromycin, ethambutol, and rifabutin...He is currently treated with rifabutin, ethambutol, azithromycin, and amikacin with close monitoring via pulmonology, rheumatology, and infectious disease... This case illustrates an atypical presentation of an uncommon infection, specifically the complexities of managing MAC empyema in immunocompromised patients with autoimmune disorders. While MAC infections are rare, their prevalence in immunocompromised patients is increasing, warranting high index of suspicious and aggressive treatment. Importantly, further research into optimal management is needed."

Clinical • Dermatomyositis • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Myositis • Respiratory Diseases • Systemic Lupus Erythematosus • Tuberculosis