Asclera (polidocanol) / Merz Pharma - LARVOL DELTA

Comparative Study Of Foam Versus Liquid Sclerotherapy Standalone Or Combined With Diode LASER In Treatment Of Lower Limb Telangiectasias And Reticular Veins (EADV 2026) - "If VVs are untreated, it may cause serious complications e.g edema,thrombophlebitis,external hemorrhage,lipodermatosclerosis,dermatitis,pigmentation, induration, and ulceration(Kumar et al., 2020).Different sclerosing solutions are used to treat VVs, like polidocanol(POL), sodium tetradecyl sulphate, hypertonic saline and corrosive sclerosants(Patel et al., 2021)...Injection sclerotherapy followed by diode laser showed higher cosmetic improvement and patient satisfaction. Fig.2: Comparison between study groups as regarding patient's satisfaction."

Dermatitis • Hematological Disorders • Immunology • Varicose Veins

88% Phenol Diluted in Distilled Water: A Minimally Invasive Emerging Treatment for Digital Mucous Cysts. A Case Series (EADV 2026) - "Compared with the currently available evidence on polidocanol for digital mucous cysts, which reports cure rates of approximately 70–80% depending on the series and recurrence rates remain variable, intralesional phenol achieved complete resolution in 93.3% of cases in our initial experience. These preliminary results are encouraging and suggest that phenol may represent a promising minimally invasive alternative for the treatment of digital mucous cysts. Further studies including larger patient cohorts and longer follow-up are needed to confirm these findings."

Clinical • Infectious Disease

Impact of previous skin hydration on postsclerotherapy hyperpigmentation: a prospective, randomized, comparative study (SKINCARE Study). (PubMed, Int Angiol) - "In this randomized, double-arm, prospective, pilot study, the use of moisturizer 30 days before polidocanol 0.5% sclerotherapy did not reduce PSH."

Clinical • Journal

Ferret Glandular Myoepithelial Cells Are Multipotent Airway Progenitors with a Secretory Lineage Bias. (PubMed, Am J Respir Cell Mol Biol) - "Ferret GMECs are multipotent progenitors and contribute to gland development and airway repair. However, their descendants demonstrate bias toward the specification of secretory cells and CFTRLow ionocytes. This suggests that GMEC-driven repair may result in structurally restored yet functionally compromised epithelia, potentially contributing to mucus retention in muco-obstructive airway diseases."

Journal • Chronic Obstructive Pulmonary Disease • Cystic Fibrosis • Genetic Disorders • Immunology • Pulmonary Disease • Respiratory Diseases • ACTA2 • CFTR

CHALLENGES IN THE MANAGEMENT OF LEFT-SIDED PORTAL HYPERTENSION: A CASE OF RECURRENT ECTOPIC VARICEAL BLEEDING (UEGW 2026) - "It typically leads to isolated gastric or ectopic varices, presenting with recurrent gastrointestinal bleeding, with preserved liver function and patent portal vein.A 48-year-old woman with metastatic ileal neuroendocrine tumor underwent palliative gastrojejunostomy for bowel obstruction in 2021 and received chemotherapy followed by octreotide LAR. Since 2022, she had recurrent gastrointestinal bleeding from the peri-anastomotic region, initially attributed to ulcers or vessels, managed with multiple endoscopic hemostatic techniques (clips, adrenaline, polidocanol and thermal coagulation), including over-the-scope clip placement...Follow-up imaging showed portal vein repermeabilization but complete stent occlusion, despite anticoagulation and carvedilol...In 2026, recurrent bleeding from an ectopic anastomotic varix was successfully treated with cyanoacrylate injection.This case highlights a rare cause of LSPH due to extrinsic splenoportal compression, leading to..."

Clinical • Cardiovascular • Hematological Disorders • Hepatology • Neuroendocrine Tumor • Portal Hypertension • Solid Tumor • Thrombosis • Varicose Veins

EUS-Guided Cyanoacrylate Injection With Balloon-Compression Sclerotherapy Versus Band Ligation for Gastroesophageal Varices: A Randomized Trial. (PubMed, J Gastroenterol Hepatol) - P=N/A | "EUS-CYA combined with bc-EIS significantly improves esophageal variceal eradication and reduces treatment sessions compared with EUS-CYA + EVL, with comparable safety."

Journal • Cardiovascular • Gastroenterology • Gastrointestinal Disorder • Hypertension • Liver Cirrhosis • Portal Hypertension

Polidocanol Sclerotherapy for the Treatment of Symptomatic Hydroceles: Establishment of a Minimally Invasive Treatment Concept at a German Center (PubMed, Aktuelle Urol) - "The success rate was 71.9% after a single treatment and 87.5% after a maximum of 2 treatments. Surgery remains the gold standard, while sclerotherapy represents an effective minimally invasive alternative."

Journal • Anesthesia • Pain

Aspiration-Assisted Catheter-Directed Foam Sclerotherapy Using the Sclerosafe Device for Anterior Saphenous Vein Insufficiency: A Retrospective Study. (PubMed, Healthcare (Basel)) - "All procedures were performed in an outpatient setting under local anaesthesia (2 mL of 1% lignocaine at the puncture site) without tumescent infiltration...Polidocanol 2% foam (5 mL per session, Tessari technique) was administered and a standardised compression regimen was applied...In the absence of a control group and clinical outcome measures, the technique cannot be presented as an established alternative to thermal or non-thermal ablation, but it may be a technically attractive option in patients with clinical CEAP class C2-C4 disease. Prospective comparative studies are warranted to confirm these findings."

Journal • Retrospective data • Anesthesia • Cardiovascular • Hematological Disorders • Pain • Pulmonary Embolism • Respiratory Diseases • Varicose Veins

Letter to the Editor: Methodological Clarification on Polidocanol Dosing and Preparation for Axillary Osmidrosis Sclerotherapy. (PubMed, Dermatol Surg) - No abstract available

Journal

Airway glandular myoepithelial cells mediate airway regeneration and exhibit distinct CFTR functional profiles in a ferret model of cystic fibrosis (NACFC 2026) - "Tamoxifen was administered during postnatal gland development, during CF disease progression, or prior to polidocanol-induced airway epithelial injury in adult ferrets. Together, these findings demonstrate that ferret GMECs are multipotent progenitors involved in SMG development, airway repair, and pathological gland remodeling. They also establish GMECs as a clinically relevant cell population and potential therapeutic target in CF and other obstructive airway diseases that involve glandular remodeling. Importantly, these findings suggest that remodeling processes can directly influence airway CFTR function by mobilizing stem cell compartments with intrinsic biases toward specific cellular specification programs, thereby reshaping the CFTR-dependent functional properties of the regenerated airway epithelium."

Preclinical • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases • ACTA2 • CFTR • MUC5B

KRT7-lineage airway glandular ductal stem cells drive regeneration and CFTR function (NACFC 2026) - "A KRT7-CreERT2::ROSA26mTmG transgenic ferret model was generated to enable in vivo lineage tracing of KRT7-positive cells following tamoxifen induction. Airway epithelial injury was induced by intratracheal polidocanol administration to assess regenerative potential... This study identifies a subpopulation of ductal epithelial cells in adult ferret SMGs that highly express KRT7 and likely represent GDSCs actively involved in airway epithelial regeneration. These cells can generate CFTR-functional epithelium, highlighting their potential as a cellular source and therapeutic target for regenerative and gene-based strategies aimed at restoring epithelial function in cystic fibrosis and other mucus-obstructive airway diseases."

Chronic Obstructive Pulmonary Disease • Cystic Fibrosis • Genetic Disorders • Immunology • Respiratory Diseases • KRT19 • KRT7

CXCR1 surface expression promotes human airway epithelial cell engraftment (NACFC 2026) - "Engraftment assays were performed on well-differentiated HBEC ALI cultures transiently injured with 0.125% polidocanol (PDOC)... Although CXCR1 WT and CXCR1 DEL proteins were comparably expressed, only the WT receptor underwent full maturation to reach the cell surface. Enhanced engraftment by CXCR1 WT-expressing HBECs may be driven by inflammatory cues, such as IL8, released upon epithelial injury. These results support the feasibility of using engineered "smart cells " to enhance epithelial engraftment for CFTR variant-agnostic cell therapy in CF."

Cystic Fibrosis • Genetic Disorders • Immunology • Respiratory Diseases • CXCL8 • CXCR1

In vivo autologous basal cell transplantation reconstitutes airway epithelium in a ferret model (NACFC 2026) - "GFP+ FBECs were reintroduced into donor ferrets via bronchoscopic instillation 5 hours after airway injury with 2% polidocanol... We established proof-of-concept for successful conduct of autologous in vivo FBEC transplantation in a ferret model, achieving durable engraftment, multilineage epithelial differentiation, and sustained CFTR mediated ion transport and mucociliary function in engrafted areas. These findings support the feasibility of basal cell–based regenerative therapies for CF and provide a foundation for future studies using genetically corrected CF ferret airway cells."

Preclinical • Cystic Fibrosis • Genetic Disorders • Immunology • Respiratory Diseases • Transplantation • KRT5 • MUC5AC

Comparative Study between Isolated Iliac Vein Stenting vs. Concomitant Iliac Vein Stenting with Pelvic Vein Embolization in Patients with Pelvic Venous Insufficiency Secondary to Nonthrombotic Iliac Vein Lesions. (PubMed, Ann Vasc Surg) - "In women with PVI due to nonthrombotic iliac lesions, adding PVE to iliac stenting improved short-term symptom and hemodynamic outcomes, at the cost of longer procedure time."

Journal • Cardiovascular

Laser Cryosclerotherapy versus Conventional Sclerotherapy for Reticular Veins and Telangiectasias: A Randomized Controlled Trial. (PubMed, J Vasc Surg Venous Lymphat Disord) - "Laser Cryosclerotherapy protocol was superior to CS in all GAIS outcomes, with moderate-to-large effect sizes and consistent inter-rater agreement. Aesthetic response is progressive, consolidating between Day 30 and Day 90, with the largest effect size in the late period. Augmented reality amplified the magnitude of detected effects and improved inter-rater agreement, reinforcing its role as a standardizing tool in aesthetic phlebology RCTs. These statistical findings should be weighed against the greater cost and complexity of LCS relative to conventional sclerotherapy in a purely cosmetic CEAP C1 population (see Discussion)."

Clinical • Journal • Varicose Veins

Effect of Mesh on Foam Stability in Foam Preparation for Sclerotherapy. (PubMed, Dermatol Surg) - "Integrating a mesh into the double syringe system enhances foam stability. Smaller pore sizes produce finer, more stable foam, suggesting 40 to 160 mesh as the optimal clinical range."

Journal

Comparative efficacy and safety of sclerosing agents in oral and maxillofacial venous malformations: a systematic review and meta-analysis. (PubMed, Oral Surg Oral Med Oral Pathol Oral Radiol) - "Current comparative evidence is limited and heterogeneous, precluding recommendation of any single sclerosant as superior. Treatment should be individualized, and well-designed randomized controlled trials are needed to establish comparative efficacy and safety."

Journal • Retrospective data • Review

Combined treatment with Nd:YAG laser and polidocanol foam sclerotherapy in venous malformation of the hand: case report. (PubMed, J Vasc Bras) - "The combination of photocoagulation and sclerotherapy proved safe and effective in a superficial and localized lesion. This case underscores the relevance of combined therapy as a minimally invasive alternative for venous malformations of the hand, highlighting the importance of individualized treatment according to lesion location, depth, and extent."

Journal • Rare Diseases

Efficacy and safety of bronchoscopic submucosal polidocanol injection for bronchopleural fistula (PubMed, Zhonghua Jie He He Hu Xi Za Zhi) - "Post-procedural complications included fever in 3 patients (10.3%), mild hemoptysis in 4 (13.8%), and worsening pneumothorax in 1 (3.4%); no procedure-related infections or deaths occurred. These findings suggest that bronchoscopic submucosal polidocanol injection is an effective and safe treatment for postoperative bronchopleural fistulas ≤5 mm in diameter."

Journal • Retrospective data • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Clinical study on the relief of localized pruritus with 3% polidocanol emulsion (ChiCTR) - P=N/A | N=120 | Completed | Sponsor: Peking Union Medical College Hospital; Peking Union Medical College Hospital

New trial • Dermatology • Pruritus

Polidocanol Sclerotherapy Plus Adjuvant Autogenous Bone Marrow Injection for Management of Aneurysmal Bone Cyst: A Prospective Study. (PubMed, Indian J Orthop) - "Reported complications included recurrence (5.0%), ecchymosis (10.0%), and nausea and vomiting (5.0%). Use of polidocanol sclerotherapy followed by adjuvant autogenous bone marrow injection for management of ABCs is highly effective with adequate safety profile."

Journal • Cardiovascular • Orthopedics • Pain

Intralesional therapy for digital myxoid cysts: an updated scoping review. (PubMed, Ital J Dermatol Venerol) - "Intralesional sclerosing therapies exhibit high efficacy and durability, with comparable safety profiles compared to surgery and cure rates approaching those of surgical management. Standardized protocols, longer follow-up, and comparative studies are needed to refine patient selection and optimize outcomes. These results support the incorporation of sclerosant therapies into shared decision-making algorithms for DMC management. Significant heterogeneity in study methods and outcome definitions, as well as short and variable follow-up periods, limit definitive conclusions."

Journal • Infectious Disease • Inflammation • Pain

Watchful waiting versus methylprednisolone or polidocanol injections as treatment of simple bone cysts. (PubMed, Bone Jt Open) - "For treatment of SBCs, watchful waiting showed high chances of necessitating subsequent treatment, leading to lower CI-Healing and prolonged exposure to risk of failure. If treatment is required, polidocanol is a superior injectable compared with methylprednisolone, in terms of both healing and failure prevention."

Journal • Musculoskeletal Diseases • Oncology • Pediatrics

Predictive value of ultrasonographic parameters in the treatment of oral vascular anomalies. (PubMed, Oral Surg Oral Med Oral Pathol Oral Radiol) - "Individuals were submitted to sclerotherapy with 3% polidocanol under ultrasound guidance...Sclerotherapy guided by ultrasound is a safe and effective treatment for oral vascular anomalies. Ultrasonographic parameters, particularly baseline vascular flow, offer prognostic value for treatment response, whereas echogenicity is less informative."

Journal

Comment on "Modified ultrasound-guided polidocanol sclerotherapy is an effective treatment for thyroid cystic-solid nodules: A single-center retrospective study". (PubMed, Am J Otolaryngol) - No abstract available

Journal • Retrospective data