allogeneic anti-CD83 CAR-T / CRISPR Therap - LARVOL DELTA

CRISPR/Cas9 gene-edited, allogeneic anti-CD83 CAR-T cells demonstrate potent activity in GvHD and AML tumor models (SITC 2022) - "In a xenogeneic GvHD model, a single dose of 1e6 CAR+ R/T/83 KO cells prevented GvHD while CD83 KO cells delayed GvHD onset. Conclusions Collectively, these data support the clinical evaluation of gene-edited, potency-enhanced, allogeneic anti-CD83 CAR-T cells in relapsed/refractory AML patients."

CAR T-Cell Therapy • IO biomarker • Preclinical • Acute Myelogenous Leukemia • Oncology • B2M • CTLA4 • TGFBR2

CRISPR Therapeutics Presents Data at the Society for Immunotherapy of Cancer (SITC) 37th Annual Meeting (GlobeNewswire) - "Additionally, together with collaborators at the Moffitt Cancer Center, the Company presented preclinical data in a poster presentation demonstrating the potential of potency-enhanced anti-CD83 CAR-T cells in preventing relapse in acute myeloid leukemia (AML)....While anti-CD83 CAR-T cells show encouraging activity alone, that activity can be improved through a variety of means, including knock out of CD83 to prevent CAR-mediated fratricide, knock out of B2M to reduce allogeneic rejection, and combination with belatacept. CRISPR/Cas9-mediated disruption of Regnase-1 and TGFBR2 expression further improves potency and survival in AML models in vivo."

Preclinical • Acute Myelogenous Leukemia • Graft versus Host Disease • Hematological Malignancies • Immunology • Leukemia • Oncology

CRISPR Therapeutics to Present at the Society for Immunotherapy of Cancer (SITC) 37th Annual Meeting (GlobeNewswire) - "CRISPR Therapeutics...announced an oral presentation and a poster presentation at the Society for Immunotherapy of Cancer (SITC) 37th Annual Meeting, taking place in Boston, MA or virtually from November 8 to 12, 2022."

P1 data • Preclinical • Acute Myelogenous Leukemia • Genito-urinary Cancer • Hematological Malignancies • Kidney Cancer • Leukemia • Oncology • Renal Cell Carcinoma • Solid Tumor • Urothelial Cancer