acyclovir / Generic mfg. - LARVOL DELTA

Case Report: A Case Report: Chickenpox Acquired Through Surface Contamination: A Rare Clincal Observation. (PubMed, F1000Res) - "Acyclovir 800 mg orally, five times a day, was given for ten days to treat chickenpox infection because acyclovir inhibits varicella zoster virus replication...The patient showed marked improvement within a week and fully recovered without complications or post-herpetic sequelae. This case emphasizes the importance of strict infection control and hygiene protocols in preventing rare indirect transmission of the VZV, particularly in healthcare settings."

Journal • CNS Disorders • Dermatology • Herpes Zoster • Infectious Disease • Pain • Pruritus • Sleep Disorder • Varicella Zoster

Zoster sine herpete: An atypical presentation of herpes zoster without rash (ASRA-FALL 2025) - "Of note, they were recently diagnosed with pneumonitis concomitant with severe persistent asthma by a pulmonologist and were on week four of a prednisone taper and trimethoprim-sulfamethoxazole regimen...They were also prescribed lidocaine 5% ointment and advised to continue their chronic pain regimen consisting of tapentadol extended-release 50 mg two times daily to provide neuropathic and nociceptive pain control in addition to acetaminophen, celecoxib, 1% diclofenac gel, and cyclobenzaprine...Discussion ZSH is an important diagnosis to consider for immunocompromised patients presenting with acute, localized, dermatomal pain without skin changes or a clear, identifiable source. Similar to HZ, ZSH treatment includes antivirals like valacyclovir or acyclovir alongside analgesics.2,4,5 Prevention also plays an important role with the herpes zoster vaccine given as a two-dose series.1,4 While rare, prompt diagnosis and timely treatment of ZSH are crucial to avoid..."

Asthma • Fibromyalgia • Herpes Zoster • Immunology • Infectious Disease • Inflammation • Musculoskeletal Pain • Neuralgia • Pneumonia • Respiratory Diseases • Rheumatology • Varicella Zoster

Progressive Multifocal Leukoencephalopathy as the Initial Presentation of Undiagnosed HIV Infection: A Case Report. (PubMed, Cureus) - "Initially suspected to have encephalitis, the patient was empirically treated with ceftriaxone, acyclovir, and later vancomycin. Early ART initiation is crucial, though the prognosis remains poor in severe cases. This case emphasizes the importance of comprehensive neurological assessment and vigilance in individuals with HIV presenting with new-onset neurological symptoms."

Journal • CNS Disorders • Human Immunodeficiency Virus • Infectious Disease • Pain • Pulmonary Disease • Rare Diseases • Respiratory Diseases • Tuberculosis

Severe Lactic Acidosis Precipitated by Alcohol Use in a Patient on Metformin and Semaglutide (OBESITY WEEK 2025) - "An endoscopy revealed gastritis and esophagitis with herpes simplex virus, treated with a proton pump inhibitor and acyclovir. This case report spotlights the complex metabolic challenges of obesity management and the potential complications of medications and alcohol use which can be exacerbated when patients are in a catabolic state after significant weight loss. Metformin and GLP-1 agonists are commonly used medications in primary care that can contribute to lactic acidosis. Significant weight loss is a catabolic change that may increase predisposition to this complication."

Clinical • Diabetes • Gastrointestinal Disorder • Genetic Disorders • Herpes Simplex • Hypoglycemia • Metabolic Disorders • Obesity • Polycystic Ovary Syndrome • Respiratory Diseases

Herpes Simplex Virus Pneumonia in Immunocompetent Patients Undergoing Cardiac Surgery: Case Series. (PubMed, J Cardiothorac Vasc Anesth) - "HSV-1 infection emerged as a relevant finding among these cardiac surgery patients with respiratory deterioration. Further studies are warranted to clarify the impact of HSV-1 on patient outcomes and to optimize treatment strategies."

Journal • Acute Respiratory Distress Syndrome • Anesthesia • Cardiovascular • Critical care • Herpes Simplex • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases • CRP

Targeted renal cyto-protection by medicarpin against acyclovir-induced nephrotoxicity via regulating SIRT1/FOXO3a and endothelin axis: An experimental and computational analysis. (PubMed, Tissue Cell) - "Nevertheless, MED supplementation markedly alleviated aforementioned damages via modulating redox profile, key regulatory signaling pathways, apoptotic and inflammatory responses as well as histological impairments. Our in-silico experimentation proved that MED confers nephroprotection against ACR-induced nephrotoxicity."

IO biomarker • Journal • Inflammation • Renal Disease • BCL2 • CASP3 • CASP9 • CDKN1A • EDN1 • EDNRA • EDNRB • FOXO3 • IL1B • IL6 • KIM1 • SIRT1 • TNFA • TP53

An Aciclovir Intermediate Can Prevent Drug-induced Acute Kidney Injury. (PubMed, Eur J Pharm Sci) - "This enables us to force maintenance of supersaturation for the duration of the nephron retention time (the time it takes for renal filtrate to pass from the glomerulus through to the collecting duct) facilitating clinically desirable doses and derisking treatment associated adverse effects. We expect that our approach is not limited to this specific case and may be applied to a wide range of clinical contexts where transient, high supersaturations cause pathological crystal growth."

Journal • Acute Kidney Injury • Nephrology • Renal Disease

Menstrual-Associated Rash Likely Due to an Over-The-Counter Menstrual Pain Product (ACAAI 2025) - "Abstract Introduction Distinguishing autoimmune progesterone dermatitis (APD) from fixed drug eruption (FDE) due to over the counter (OTC) medications can be challenging in menstrual-associated rashes...She was advised to discontinue the menstrual pain combination drug, but continued using other drugs, including acetaminophen, ibuprofen, suppressive dose acyclovir for chronic genital herpes, and piperazine antihistamines for rhinitis with no concerns...Furthermore, chronic herpes simplex infection may contribute to immune dysregulation. Our patient decided on avoidance and declined further challenges."

Contact Dermatitis • Dermatitis • Dermatology • Herpes Simplex • Immunology • Infectious Disease • Inflammation • Pain

More Than Meets The Ig: Unveiling APDS2 In A Child With Hypogammaglobulinemia (ACAAI 2025) - "His course was further complicated by HSV lesions around the nares, prompting treatment with IV acyclovir...He was initially started on sirolimus, and although his IgG levels remained at the low end of normal despite appropriate IgRT dosing, this improved following initiation of leniolisib after FDA approval. Discussion This case underscores the value of genetic evaluation even in patients with presumed primary antibody deficiency, particularly when clinical findings evolve or suggest combined immunodeficiency. Identifying APDS2 has direct implications for care, including targeted therapies such as PI3Kδ inhibitors (leniolisib) and hematopoietic stem cell transplantation in select cases."

Clinical • Bone Marrow Transplantation • CNS Disorders • Epilepsy • Human Papillomavirus Infection • Immunology • Infectious Disease • Inflammation • Pneumonia • Primary Immunodeficiency • Respiratory Diseases • PIK3CD • PIK3R1

Acute Retinal Necrosis Caused by VZV and EBV Co-Infection in Patient with Hodgkin Lymphoma History (PubMed, Harefuah) - "Intravenous acyclovir and intravitreal foscarnet injections and systemic prednisone were started. ARN caused by co-infection with VZV and EBV can by treatment-resistant, especially in immunosuppressive patients. Patients can benefit from early detection and intervention and frequent follow-up."

Journal • Epstein-Barr Virus Infections • Genetic Disorders • Hematological Disorders • Hematological Malignancies • Herpes Zoster • Hodgkin Lymphoma • Infectious Disease • Lymphoma • Ocular Infections • Ocular Inflammation • Oncology • Ophthalmology • Pain • Retinal Disorders • Uveitis • Varicella Zoster • Vasculitis

Disseminated Herpes Simplex Virus in Pregnancy: A Systematic Review of Cases. (PubMed, J Obstet Gynaecol Res) - "A high index of suspicion is required for diagnosis due to non-specific clinical features. Mandatory reporting and inclusion of disseminated HSV in sepsis guidelines are recommended."

Journal • Review • Herpes Simplex • Infectious Disease • Psychiatry • Rare Diseases • Septic Shock

Focus CNS symptomatology (DGHO 2025) - "Prior to identification of a potentially causative pathogen, empiric or preemptive anti-infective treatment should be initiated (e.g., a 3rd generation cephalosporine plus high-dose ampicillin and acyclovir) to avoid treatment delay. If fungal CNS disease is suspected, for example, in a patient with aspergillosis of the lungs, antifungal treatment (e.g., voriconazole or isavuconazole) should also be given. Suspected or proven neurotoxoplasmosis might be treated with a combination of pyrimethamine and sulfadiazine...Frequently, a multidisciplinary approach including different experts (e.g., haematologists/oncologists, infectious diseases specialists, neurologists and neurosurgeons) might be useful. An increasing amount of data suggests that novel diagnostics, such as CSF next-generation sequencing (NGS), might be helpful to establish the correct diagnosis in some patients."

Bone Marrow Transplantation • CNS Disorders • Epstein-Barr Virus Infections • Infectious Disease • Respiratory Diseases

Challenges in diagnosing atypical infections including neoehrlichiosis in a lymphoma survivor following chimeric antigen receptor (CAR) T cell therapy (DGHO 2025) - "First-line treatment consisted of six cycles of R-CHOP, two cycles of R-MTX, and consolidative radiotherapy of the initial gluteal bulk...Only by bronchioalveolar lavage persisting Covid infection was diagnosed and paxlovid led to a rapid recovery...Mucosal HSV-1 reactivation was detected, but treatment with acyclovir did not lead to an improvement... This case highlights the challenges of immune impairment after CD19 CAR T cell therapy in heavily pretreated DLBCL patients. In fever of unknown origin, also rare infections have to be considered."

B Cell Lymphoma • Diffuse Large B Cell Lymphoma • Fatigue • Hematological Malignancies • Infectious Disease • Lymphoma • Non-Hodgkin’s Lymphoma • Pneumonia • Respiratory Diseases • T Cell Non-Hodgkin Lymphoma • CD8

Fludarabine metabolism by cytosolic 5'-nucleotidase III and its tissue-specific localization mapping using mass spectrometry imaging. (PubMed, Drug Metab Dispos) - "Recently, our laboratory reported the dephosphorylation action of these nucleotidases toward the metabolites of clinically used nucleoside analog drugs, including gemcitabine, emtricitabine, tenofovir, and acyclovir. Using in vitro incubations and enzyme kinetics, we demonstrate the involvement of NT5C3 in the dephosphorylation of an important antineoplastic agent, fludarabine. Furthermore, we employed mass spectrometry imaging to visualize peptides corresponding to NT5C3 and other major nucleotidases in the kidney cortex and colonic mucosa."

Journal • Chronic Lymphocytic Leukemia • Hematological Malignancies • Leukemia • Oncology • NT5C2

A Multicenter Study on Symptomatic Neonatal Herpes Simplex Virus Infection in Korea From 2008 to 2017. (PubMed, J Korean Med Sci) - "Although uncommon, neonatal HSV infection occurs in Korean babies with a high 30-day mortality of 12.5%. Increased awareness is warranted among Korean pediatricians for the early diagnosis and treatment of neonatal HSV infection."

Clinical • Journal • Retrospective data • CNS Disorders • Epilepsy • Herpes Simplex • Infectious Disease • Pediatrics

Daratumumab for immune-mediated thrombotic thrombocytopenic purpura (iTTP): Results from the international, multicenter darttp study (ASH 2025) - "Patients had received a median of 3 (IQR 2)previous IST, including rituximab (100%), bortezomib and mycophenolate (25% each), cyclosporine andcyclophosphamide (20% each), azathioprine (15%), vincristine (10%), obinutuzumab, ofatumumab, andsplenectomy (5% each). Seventeen patients received daratumumab in the remission phase (i.e., forADAMTS13 relapse or intolerance to other IST), while 3 during an acute episode (plasma-based therapyand caplacizumab ongoing in 3 and 2 patients, respectively)...Disease duration, previous IST used, daratumumab schedule, ordemographics did not correlate with response or its duration...A patient not receiving acyclovir had a grade 2 zoster skininfection 3 months after her last daratumumab infusion. in this study, daratumumab warranted rapid ADAMTS13 remission in 75% of iTTP patientsrefractory or intolerant to rituximab and other conventional IST... in this study, daratumumab warranted rapid ADAMTS13 remission in 75% of iTTP patientsrefractory..."

Clinical • Cardiovascular • Dermatology • Hematological Disorders • Herpes Zoster • Thrombocytopenic Purpura • CD20

Efficacy and safety of recombinant adjuvanted zoster vaccine in patients with monoclonal gammopathies: A prospective study (ASH 2025) - "Prophylactic valacyclovir is routinely administered toprevent varicella-zoster virus (VZV) infection...All cases presented with localized pain and rash without systemic symptoms, and weremanaged with oral acyclovir. No cases of disseminated or severe VZV infection were observed.ConclusionTwo doses of RZV seems to induce humoral responses in the vast majority of patients with monoclonalgammopathies, with minimal toxicity. A minority of patients on anti-myeloma treatment withbreakthrough VZV infections had adequate IgG antibody levels, no systemic symptoms, and weresuccessfully managed with oral antiviral therapy."

Clinical • Hematological Malignancies • Lymphoma • Multiple Myeloma • XPO1

Immune reconstitution and infectious complications following CAR-T cell therapy (ASH 2025) - "Anti infectious prophylaxis was given as follows: anti-filamentous antifungals duringneutropenic periods, acyclovir and anti-Pneumocystis jirovecii (PJP) until CD4+cell count >200 cells/µL...No HSV-1/2, fungal, or PJPinfections were observed.Regarding risk factors for infections, steroid therapy for >10 days (p=0,001), the administration of >1 doseof tocilizumab (p=0,041) and the occurrence of grade ≥2 cytokine release syndrome (CRS) (p=0,036), wereassociated with increased infectious burden (one grade ≥3 or more than 3 Grade ≥2 infections)... In this real-world series we confirm that CAR-T cell recipients have prolonged immunedysfunction and infection risk, well beyond the first year after therapy. Prolonged steroid use wasassociated with increased risk of severe and/or repeated infections. Further immune characterization inlarger patient cohorts is needed to further identify risk factors for infections in these patients."

CAR T-Cell Therapy • B Cell Lymphoma • CNS Disorders • Diffuse Large B Cell Lymphoma • Follicular Lymphoma • Hematological Disorders • Hematological Malignancies • Infectious Disease • Lymphoma • Mantle Cell Lymphoma • Non-Hodgkin’s Lymphoma • Pneumonia • Respiratory Diseases • CD4

Efficacy and safety of RCD pulse regimen for acquired Hemophilia A (ASH 2025) - "TheRCD pulse regimen is a combined immunosuppressive therapy (IST) consisting of: 500mgcyclophosphamide intravenously on days 1, 8, 15, and 22; 40mg dexamethasone, intravenously or orally,on days 1, 8, 15, and 22; and 100mg rituximab intravenously on days 1, 8, 15, and 22...All patients received infection prophylaxis with sulfamethoxazole and trimethoprim (480 mgonce daily) and acyclovir (400 mg once daily)...Two patientswith inhibitors > 100 BU and 2 patients with inhibitors < 20 BU did not achieve CR after prednisolonealone or combination therapy with the addition of cyclophosphamide prior to RCD.To date, 7 of the 8 (87.5%) patients have achieved CR after 1 or 2 courses of RCD (3 newly diagnosedpatients after 1 courses of RCD, 1 newly diagnosed patient and 3 relapsed patients after 2 courses ofRCD). One patient who relapsed after 313 weeks of treatment with prednisone and other drugs cannotbe treated strictly in accordance with the protocol of this study, and has..."

Clinical • Breast Cancer • Cataract • CNS Disorders • Coronary Artery Disease • Depression • Diabetes • Gastroenterology • Gastrointestinal Disorder • Glomerulonephritis • Heart Failure • Hemophilia • Hemophilia A • Hypertension • Immunology • Infectious Disease • Interstitial Lung Disease • Metabolic Disorders • Nephrology • Ophthalmology • Pneumonia • Psychiatry • Rare Diseases • Renal Disease • Respiratory Diseases • Rheumatology • Solid Tumor

A portable poison exon for small-molecule control of mammalian gene expression. (PubMed, Nat Methods) - "We also present Pac-Cyclone, a cassette that simplifies the generation of cell lines with acyclovir-controlled endogenous gene expression. Finally, we demonstrate the programmability of Cyclone, underscoring its potential for developing diverse genetic circuits controlled by various ligands."

Journal • CCDC86

Cerebrolysin treatment in a case of post-herpes simplex encephalitis with neuropsychiatric symptoms. (PubMed, J Med Life) - "The patient was treated with acyclovir and dexamethasone in the acute phase, followed by Cerebrolysin administration in the post-acute phase. This case highlights the potential therapeutic role of Cerebrolysin in managing post-encephalitic cognitive dysfunction, underscoring the need for further studies."

Journal • CNS Disorders • Cognitive Disorders • Epilepsy • Herpes Simplex • Infectious Disease • Psychiatry

Necrotizing Herpetic Retinopathy: A Case of Delayed Acute Retinal Necrosis Presentation in a Patient With Uncontrolled Diabetes Mellitus and Complications. (PubMed, Cureus) - "The patient was placed on standard ARN treatment with IV acyclovir three times a day, ophthalmic prednisolone drops two to four times a day, and a single dose of intravitreal ganciclovir injection. This case report discusses a patient presenting with classic symptoms of a unique retinal pathology, ARN, complicated by severe retinal detachment. The goal of this case report is to bring awareness of a rare disease to assist providers in making an efficient diagnosis to prevent vision loss."

Journal • Atherosclerosis • Cardiovascular • Cytomegalovirus Infection • Diabetes • Diabetic Retinopathy • Hematological Disorders • Herpes Simplex • Herpes Zoster • Human Immunodeficiency Virus • Infectious Disease • Metabolic Disorders • Nicotine Addiction • Ophthalmology • Pain • Rare Diseases • Retinal Disorders • Tobacco Addiction • Type 1 Diabetes Mellitus • Type 2 Diabetes Mellitus • Varicella Zoster

Anesthetic Considerations in Pediatric Corneal Neurotization: A Case Report. (PubMed, Cureus) - "Perioperative antiviral prophylaxis (oral acyclovir) was maintained, and ondansetron was administered for PONV prophylaxis. Pain was assessed using the FLACC (Face, Legs, Activity, Cry, Consolability) scale, which remained at a level of <3/10 throughout the first 24 hours. This report highlights the importance of tailored anesthetic strategies in pediatric neurotization procedures, balancing surgical requirements with age-specific physiological considerations."

Journal • Anesthesia • Dry Eye Disease • Keratitis • Mood Disorders • Ocular Inflammation • Ophthalmology • Pain • Pediatrics • Psychiatry • Transplantation

A Case of Pasteurella multocida Bacteremia in an Infant. (PubMed, Cureus) - "He was admitted and treated empirically with intravenous (IV) vancomycin, IV ceftriaxone, and IV acyclovir at meningitic dosing for possible sepsis and meningitis. Exposure to dogs and cats is the leading risk factor; however, a bite wound or injury is not necessary for infection. This case demonstrates the high degree of clinical suspicion required to identify early presentations of P. multocida bacteremia and the importance for parents to be informed about the risk of infection and limit contact with pets during the first few months of life to prevent infection."

Journal • CNS Disorders • Infectious Disease • Pain • Pediatrics • Septic Shock

Acyclovir Encephalopathy in HSV Encephalitis Elderly With Normal Renal Function. (PubMed, Case Rep Neurol Med) - "Herpes simplex virus (HSV) encephalitis is a disease treated with acyclovir (ACV). We conducted the literature review, and AKI is considered as a risk factor for ACV encephalopathy in elderly patient using ACV or valacyclovir. However, we could not identify a cause for AKI in our case apart from the use of ACV."

Journal • Acute Kidney Injury • CNS Disorders • Epilepsy • Fatigue • Herpes Simplex • Nephrology • Renal Disease