acyclovir / Generic mfg. - LARVOL DELTA

Interventions for treatment of herpes labialis (cold sores on the lips). (PubMed, Cochrane Database Syst Rev) - "Compared with placebo, topical nucleoside antivirals (aciclovir and penciclovir) probably reduce cold sore healing time by about one day. A study that compared topical penciclovir with topical aciclovir found that they may have similar effects on healing time. For oral nucleoside antivirals, we found that oral aciclovir compared with placebo may have little or no effect on healing time, while oral valaciclovir reduces healing time by about one day. The clinical importance of all reported reductions in healing time is uncertain, as no minimally important difference has been defined for this outcome in herpes labialis. Severe adverse events were rare, and mild or moderate adverse events were uncommon. Adverse events were generally balanced between treatments. From an equity standpoint, most studies focused on adults, predominantly women, with limited East Asian and paediatric representation. Future research should address these gaps by including under-represented groups..."

Clinical • Journal • Review • Herpes Simplex • Infectious Disease • Pain • Pediatrics

Diagnostic Uncertainty in Rapidly Progressive Brainstem Lesions: A Radiological Diagnosis of Probable CNS Relapse of Diffuse Large B-cell Lymphoma. (PubMed, Cureus) - "We present the case of a 78-year-old woman with a history of diffuse large B-cell lymphoma (DLBCL), previously treated as per the REMoDL-B (Randomised Evaluation of Molecular-Guided Therapy for Diffuse Large B-cell Lymphoma With Bortezomib) protocol with rituximab, bortezomib, cyclophosphamide, doxorubicin, vincristine, and prednisolone, alongside intrathecal methotrexate for CNS prophylaxis, who presented 10 years after achieving systemic remission with a 15-day history of hyperactivity, choreiform movements, pressured speech, and incontinence...Repeat MR imaging of the head was performed after the patient deteriorated clinically despite empirical treatment for infective encephalitis with intravenous ceftriaxone and aciclovir...Given an Eastern Cooperative Oncology Group (ECOG) performance status of 4, the patient was not a candidate for treatment and was discharged on a palliative pathway. This case highlights three key learning points: CNS relapse of DLBCL should..."

Journal • B Cell Lymphoma • Bipolar Disorder • CNS Disorders • CNS Lymphoma • Diffuse Large B Cell Lymphoma • Hematological Malignancies • Immunology • Lymphoma • Mood Disorders • Movement Disorders • Non-Hodgkin’s Lymphoma • Oncology

Severe Neuro-Ophthalmic Varicella-Zoster Virus Infection During Upadacitinib-Associated JAK-1 Inhibition (EADV 2026) - "Case Presentation An 81-year-old woman with rheumatoid arthritis previously treated with methotrexate and hydroxychloroquine was escalated to upadacitinib (15 mg/day) in February 2024...She was discharged with topical chloramphenicol and ganciclovir...A three-week course of intravenous acyclovir was completed with flucloxacillin administered for secondary bacterial superinfection...In essence, this case highlights the importance of structured vaccination review prior to initiating targeted immunomodulatory therapy. Early medication reconciliation and recognition of JAK-1 inhibition are also essential at first presentation with herpes zoster to enable timely risk stratification."

Atopic Dermatitis • CNS Disorders • Dermatitis • Fibrosis • Herpes Zoster • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Neuralgia • Ocular Inflammation • Ophthalmology • Pneumonia • Psoriatic Arthritis • Respiratory Diseases • Rheumatoid Arthritis • Seronegative Spondyloarthropathies • Varicella Zoster • JAK1

EFFICACY OF INTRALESIONAL ACYCLOVIR VERSUS CRYOTHERAPY FOR TREATMENT OF PLANTAR WARTS (EADV 2026) - "83% achieved complete response, 10% lost to follow-up and 7% refused treatment in Group A whereas 48% achieved complete and partial responses respectively and 4% had no response in Group B (p<0.001). Conclusions Acyclovir is an effective treatment modality of cutaneous warts with better results in males presenting with single plantar wart."

Clinical • Dermatology

Wolf's Isotopic Phenomenon Presenting as Psoriasiform Dermatitis after Herpes Zoster Leading to Prolonged Misdiagnosis and Repeated Antiviral Therapy (EADV 2026) - "Initial episodes were clinically interpreted as herpes zoster and treated repeatedly with oral acyclovir therapy over several months...Conclusion WIP should be considered in persistent or recurrent unilateral dermatoses following herpes zoster, especially when unresponsive to antiviral therapy, as early recognition prevents diagnostic delay and inappropriate treatment. Clinicopathological correlation remains crucial, as histological findings may be subtle and non-specific."

Atopic Dermatitis • Bullous Pemphigoid • Dermatitis • Dermatology • Dermatopathology • Fibrosis • Herpes Zoster • Immunology • Inflammatory Arthritis • Lupus • Varicella Zoster

A Case of Gianotti-Crosti Syndrome Secondary to Mpox (EADV 2026) - "An sexually transmitted infection screen performed the previous day was negative, although he was empirically started on aciclovir for presumed herpes infection...This case highlights that the first presentation of mpox may be atypical. With the recent increase in cases, it is important to be familiar with how mpox may present as it requires a high degree of clinical suspicion to avoid diagnostic delay."

Clinical • Asthma • Dermatitis • Hematological Malignancies • Hodgkin Lymphoma • Human Immunodeficiency Virus • Immunology • Infectious Disease • Lymphoma • Respiratory Diseases

Mechanical Koebner phenomenon in erythema multiforme: a documented case (EADV 2026) - "The therapeutic protocol included: Antiviral Therapy: Oral Aciclovir (2 g/day for 10 days) to treat the HSV trigger . Systemic Anti-inflammatory: Oral Prednisone (0.5 mg/kg/day for 5 days)...Recognizing trauma as a cofactor in EM localization is vital for clinicians. This documented rare finding contributes to the understanding of the complex mucocutaneous inflammatory mechanisms of EMM and confirms that isomorphic responses can occur even in acute hypersensitivity reactions."

Clinical • Conjunctivitis • Dermatology • Dermatopathology • Herpes Simplex • Immunology • Infectious Disease • Lichen Planus • Ocular Infections • Ocular Inflammation • Ophthalmology • Psoriasis • Vitiligo

When Serology Fails, the Lens Prevails: Bridging the Window Period in Mixed Genital Ulcer Disease (EADV 2026) - "Based on clinical-dermoscopic correlation, the patient was treated with a single intramuscular dose of 2.4 MU Benzathine-Penicillin-G and oral Acyclovir... This report highlights the limitations of the "Syndromic Approach" in mixed GUD infections. By providing objective morphological evidence during the serological window period, dermoscopy serves as a critical tool for early intervention, ensuring the immediate break in the chain of transmission for syphilis in high-risk populations."

Infectious Disease

When chronic ulcers are not graft-versus-host disease: HSV infection diagnosed by direct immunofluorescence in a pediatric transplant recipient (EADV 2026) - "Treatment included high-dose corticosteroids, etanercept, and mesenchymal stem cell infusions, along with management of secondary infections. Approximately eleven months after HSCT, while on prednisolone, sirolimus, and tacrolimus, and undergoing ultraviolet A and B phototherapy for chronic GVHD, the patient developed new painful ulcers over previously affected, desquamated, xerotic skin with post-inflammatory hyperpigmentation...The patient was hospitalized and started on intravenous antibiotic therapy with ciprofloxacin and clindamycin...Treatment with acyclovir was initiated, resulting in marked clinical improvement and complete resolution of the ulcerative lesions...Direct immunofluorescence proved to be a rapid and valuable diagnostic tool in this setting, allowing prompt diagnosis despite its known limitations in sensitivity compared with molecular methods. Early recognition and prompt antiviral therapy are essential to reduce morbidity and improve clinical outcomes."

Clinical • Acute Lymphocytic Leukemia • Bone Marrow Transplantation • Chronic Graft versus Host Disease • Graft versus Host Disease • Hematological Malignancies • Herpes Simplex • Immunology • Infectious Disease • Leukemia • Pediatrics • Transplantation

Dermato-Neuro Syndrome in Scleromyxedema triggered by Influenza A Infection: A Case Report Highlighting the Efficacy of Urgent Intravenous Immunoglobulin Therapy (EADV 2026) - "Previously, the patient did not respond to conventional immunosuppressants, dupilumab, bortezomib, phototherapy and isotretinoin...Empiric antibiotics for meningo-encephalitis were initiated immediately, along with aciclovir...The patient was intubated on day 2 of admission, and received empirical IVIg therapy (2g/kg) over five days and IV methylprednisolone (1g/day) for 3 days...The patient was discharged on day 13 with levetiracetam and phenytoin after achieving stable neurologic function...Additionally, the risks of DNS may be elevated in patients who prolong their IVIg infusion intervals. Early empirical initiation of IVIg therapy may be critical to improving neurological outcomes, and any undue delay may result in inadvertent patient mortality."

Case report • Clinical • CNS Disorders • Epilepsy • Infectious Disease • Influenza • Monoclonal Gammopathy • Respiratory Diseases

Erythema Multiforme: Clinical Characteristics, Epidemiology, Treatment, and Etiological Factors (EADV 2026) - "From a therapeutic perspective, 66% of patients received acyclovir and 34% antibiotics...Conclusion EM is an immune-mediated dermatosis most commonly associated with herpes simplex virus infection or medications. Management depends on disease severity and recurrence, with mild forms requiring symptomatic treatment, whereas recurrent forms may require antiviral prophylaxis."

Clinical • Dermatology • Herpes Simplex • Infectious Disease • Pneumonia • Respiratory Diseases

Varicella Gangrenosa in an Immunocompetent Child: A Rare Complication of Varicella (EADV 2026) - "Despite symptomatic treatment, including ibuprofen, lesions became painful over 48–72 hours, coalesced, ruptured, and formed purulent ulcers...He received IV antibiotics (vancomycin 10 mg/kg/dose, QID for 14 days) and IV acyclovir (20 mg/kg every 8 hours for 7 days)...Management requires early diagnosis, broad-spectrum antibiotics with streptococcal coverage, antivirals, supportive care, and prompt surgical debridement when necrotizing infection is suspected. This case highlights the need to suspect varicella gangrenosa in painful, rapidly ulcerating or necrotic varicella lesions, even in immunocompetent children, and to start prompt intravenous antiviral therapy"

Clinical • CNS Disorders • Hematological Disorders • Herpes Zoster • Pneumonia • Respiratory Diseases • Septic Shock • Thrombocytosis • Varicella Zoster

Catastrophic Autoinoculation of Orf Virus after Surgical Intervention: High-Volume, Low-Concentration Intralesional Cidofovir as a Life-Saving Salvage Therapy (EADV 2026) - "Case Presentation A 67-year-old female patient with a history of CLL (actively treated with Venetoclax and IVIG) presented in June 2025 with a recalcitrant papular Orf lesion on her 5th digit subsequent to livestock contact...The patient was initially managed with systemic intravenous acyclovir and topical imiquimod (5%), but the lesions showed no clinical response and continued to expand, causing significant morbidity...This case serves as a potent reminder that aggressive surgery should be avoided in the setting of active viral replication in IC patients. High-volume IL cidofovir should be considered an essential, definitive salvage option for recalcitrant Orf to prevent extensive surgical morbidity and achieve limb-sparing outcomes."

Chronic Lymphocytic Leukemia • Hematological Malignancies • Infectious Disease • Leukemia • Pyoderma Gangrenosum

Clinical Psychological Discordance in Von Zumbusch Generalized Pustular Psoriasis: Implication of an Alexithymic Profile (EADV 2026) - "The patient was treated with Cefotaxime and Acyclovir for 10 days. Than Methotrexate was initiated at 15 mg weekly via injection, leading to progressive clinical with appropriate psychological support...Our observation thus highlights the importance of a comprehensive approach combining dermatological, biological, and psychological assessment, particularly in severe forms of generalized pustular psoriasis. Screening for an alexithymic profile could represent a relevant factor in the overall evaluation of the patient and in optimizing therapeutic management."

Clinical • Discordant • Cardiovascular • CNS Disorders • Depression • Dermatology • Heart Failure • Hematological Disorders • Immunology • Inflammation • Plaque Psoriasis • Psoriasis • Pustular Psoriasis • Thrombocytosis

Herpes Zoster Ophthalmicus Post-Botox Injection: A Case Report (EADV 2026) - "Despite azithromycin and ibuprofen, the symptoms persisted. Conclusion This case highlights a rare occurrence of herpes zoster ophthalmicus following Botulinum toxin type A (BoNT-A) injection. Timely diagnosis and appropriate antiviral therapy such as acyclovir are essential in managing this condition effectively."

Case report • Clinical • Herpes Zoster • Ophthalmology • Varicella Zoster

Beyond the expected rash: Two exceptional cutaneous toxicities caused by pembrolizumab. (EADV 2026) - "The condition was initially interpreted as herpes zoster, and treatment with acyclovir and pregabalin was initiated...Acyclovir and pembrolizumab were discontinued, while topical 2% mupirocin cream was maintained, resulting in complete remission of the skin lesions...The involvement of the dermatologist is crucial in the differential diagnosis of skin lesions, allowing for distinction between immune-mediated cutaneous reactions, infections, skin cancer, and paraneoplastic syndromes, among others. This contributes to more accurate clinical decisions regarding the continuation or modification of pembrolizumab treatment, thereby ensuring better safety and quality of life for patients.These two cases emphasize the need for collaborative protocols and continuous training to address the challenges posed by cutaneous adverse effects in the context of emerging immunotherapeutic treatments."

Dyslipidemia • Genetic Disorders • Herpes Simplex • Herpes Zoster • Hypertension • Immunology • Infectious Disease • Kidney Cancer • Melanoma • Metabolic Disorders • Neuralgia • Pruritus • Skin Cancer • Solid Tumor • Varicella Zoster • Vitiligo

Acute methotrexate-induced cutaneous ulceration in generalized pustular psoriasis: A case report and review of the literature (EADV 2026) - "She previously responded to corticosteroids and cyclosporine, achieving remission with MTX 10 mg weekly postpartum...In 2024, she received IV hydrocortisone in the emergency setting, which worsened her condition...MTX was discontinued, and she received IV leucovorin, albumin, and supportive care. MRSA infection was treated with vancomycin...She improved with acyclovir and was discharged after 9 days...Regular monitoring of liver function and blood counts is essential. Targeted therapy with spesolimab offers a rapid and effective alternative in refractory cases and may redefine GPP management."

Case report • Clinical • Review • Dermatology • Herpes Simplex • Immunology • Infectious Disease • Plaque Psoriasis • Psoriasis • Pustular Psoriasis

Chronic recurrent urticaria in patient with recurrent herpes labialis: complete remission after administration with Aciclovir and Antihistamines (EADV 2026) - "She was treated for generalized urticaria with beginning systemic involvement under the form of angioedema and bronchospasm with Prednisolone and Methylprednisolone (according to the scheme, with a temporary effect) and Montelucast 10 mg, Levocetirizine dihydrochloride 5 mg, Loratadine 10 mg, betamethasone/clotrimazole/gentamicin cream...Due to the chronic chlamydial infection, it was decided to discontinue systemic therapy with Aciclovir for 21 days and proceed with Doxycycline 100 mg twice a day...The condition was successfully managed again with the administration of Aciclovir. A diagnosis of chronic recurrent urticaria in a patient with recurrent herpes labialis was made."

Clinical • Cardiovascular • Dermatology • Herpes Simplex • Immunology • Infectious Disease • Pruritus • Urticaria

A case of generalised dermal hypersensitivity reaction secondary to Epcoritamab (EADV 2026) - "She received 6 cycles of Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisolone (R-CHOP) chemoimmunotherapy and 2 cycles of high dose Methotrexate for CNS prophylaxis...She further received 2 cycles of Rituximab, Gemcitabine, Dexamethasone and Cisplatin (RGDP) before being commenced on third line treatment with Epcoritamab injections. Her other regular medications include fexofenadine and as required paracetamol. She takes prophylactic cotrimoxazole and aciclovir but these were started years ago with the initial chemoimmunotherapy treatments for DLBCL...A weaning course of oral prednisolone at 0.5mg/kg/day dose was commenced alongside betamethasone valerate 0.1% ointment and hydrocortisone 1% ointment for her periorbital rash...Little data is available if cutaneous toxicity secondary to Epcoritamab is dose dependent or if its elimination half-life may help predict best treatment regime with the least cutaneous toxicity. This case report increases..."

Clinical • Atopic Dermatitis • B Cell Lymphoma • Cutaneous Lupus Erythematosus • Diffuse Large B Cell Lymphoma • Follicular Lymphoma • Hematological Malignancies • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Lymphoma • Musculoskeletal Diseases • Musculoskeletal Pain • Neutropenia • Non-Hodgkin’s Lymphoma • Pneumonia • Respiratory Diseases • CD20

Rosacea Fulminans and Menopausal Hypoestrogenism: A Diagnostic Odyssey (EADV 2026) - "She had previously received oral antibiotics and acyclovir from multiple dermatologists without improvement...Empirical treatment was initiated on the day of the first consultation, before biopsy results became available, with prednisone 40 mg/day for 5 days followed by tapering, combined with doxycycline 200 mg/day, resulting in marked improvement after one week...The presence of granulomas with Langhans giant cells, a rare finding in RF, underscores the importance of excluding cutaneous tuberculosis, particularly in endemic regions. Combined systemic corticosteroids and isotretinoin resulted in complete remission."

Acne Vulgaris • Cardiovascular • Dermatology • Diabetes • Dyslipidemia • Hepatitis B • Hepatology • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Lupus • Metabolic Disorders • Respiratory Diseases • Rosacea • Tuberculosis • Type 2 Diabetes Mellitus • Women's Health

Erythroderma Beyond the Obvious: A Case Series Highlighting Diagnostic and Therapeutic Challenges in Three Refractory Cases (EADV 2026) - "Initial clinicopathological impression favored erythrodermic psoriasis, and the patient received multiple therapies including cyclosporine, methotrexate, infliximab, secukinumab and NB-UVB with inadequate response...Marked clinical improvement was achieved with ustekinumab...Minimal improvement occurred with cyclosporine, following which acitretin was initiated...Initial diagnosis of erythroderma secondary to atopic dermatitis with eczema herpeticum was considered, and treatment with acyclovir, antibiotics and systemic corticosteroids was initiated...Before further evaluation including lymph node FNAC could be completed, the patient developed sudden cardiovascular collapse and succumbed despite resuscitative efforts, with possible eosinophilic cardiac involvement suspected, although definitive confirmation could not be obtained. Conclusion These cases collectively highlight an unclassifiable erythroderma variant at the psoriasis–PRP interface, the potential role of..."

Clinical • Atopic Dermatitis • Cardiovascular • Cutaneous T-cell Lymphoma • Dermatitis • Dermatopathology • Eosinophilia • Hematological Malignancies • Hepatology • Hypereosinophilic Syndrome • Immunology • Infectious Disease • Lymphoma • Mycosis Fungoides • Pruritus • Psoriasis • Respiratory Diseases • Sezary Syndrome • Tuberculosis

When facial cellulitis doesn't respond: Fulminant odontogenic Mucormycosis in a Diabetic patient (EADV 2026) - "Case Presentation A 52-year-old male with poorly controlled type 2 diabetes presented with right facial edema, hyperemia, and oppressive palatal pain following recent upper molar extraction treated with outpatient levofloxacin...Empirical vancomycin and clindamycin were initiated...Despite tigecycline and acyclovir, the patient developed septic shock...Successful management requires immediate multidisciplinary coordination (internal medicine, dermatology, infectious diseases, maxillofacial surgery, otolaryngology, ophthalmology) with urgent initiation of liposomal amphotericin B, early biopsy for histopathological confirmation, aggressive surgical debridement, and correction of hyperglycemia and acidosis. In diabetic patients with blood glucose >360 mg/dL, fever, and ophthalmological findings after dental procedures, mucormycosis should be considered until proven otherwise."

Clinical • Cardiovascular • Dermatology • Diabetes • Hematological Disorders • Infectious Disease • Metabolic Disorders • Ophthalmology • Otorhinolaryngology • Septic Shock • Thrombosis • Type 2 Diabetes Mellitus

Herpes Simplex Virus Infection Following Hijama (Cupping Therapy) (EADV 2026) - "The patient was treated with oral acyclovir, leading to rapid clinical improvement and progressive resolution of the lesions. Conclusion This case highlights a rare infectious complication of Hijama and underlines the importance of strict aseptic measures during traditional therapeutic procedures. HSV infection should be considered in patients presenting with vesicular eruptions after cupping therapy, as early recognition allows prompt antiviral treatment and favorable outcomes."

Herpes Simplex • Infectious Disease • Mood Disorders • Musculoskeletal Diseases • Musculoskeletal Pain

Cutaneous Manifestations of DOCK8 Deficiency: Clinic-Immunological Correlation in Two Cases (EADV 2026) - "Treated with ciprofloxacin, itraconazole, topical corticosteroids, local care → marked improvement.Her 7-year-old paternal cousin had severe atopic dermatitis, treated miliary TB, one-year ulcerative-vegetating lesions in inguinal folds, intergluteal region, scrotum, neck, scalp, periorificial areas, flat warts, and herpetic keratitis...Treated with ciprofloxacin, acyclovir, local care → rapid improvement...Pulmonary atelectasis in the girl shows severe respiratory complicationsDOCK8-HIES shows diverse, severe cutaneous involvement. Early recognition and management are critical; hematopoietic stem cell transplantation is the only curative therap"

Clinical • Atopic Dermatitis • Bone Marrow Transplantation • Candidiasis • Dermatitis • Eosinophilia • Immunology • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Pneumonia • Primary Immunodeficiency • Respiratory Diseases • Skin Cancer • CD4 • CD8 • DOCK8 • STAT3

Postherpetic Abdominal Pseudohernia: Report of Two Cases (EADV 2026) - "He was treated with oral valacyclovir 1,000 mg three times daily for 7 days...She was treated with intravenous acyclovir for one week...Because of postherpetic neuralgia, pregabalin was started and later increased to 150 mg twice daily...Recognition of this entity is important to avoid misdiagnosis and unnecessary surgical referral. These two cases highlight the variable timing and clinical course of this rare motor complication."

Clinical • Cardiovascular • Constipation • Diabetes • Endocrine Disorders • Gastroenterology • Gastrointestinal Disorder • Herpes Zoster • Hypertension • Infectious Disease • Metabolic Disorders • Neuralgia • Varicella Zoster