Akeega (abiraterone/niraparib) / J&J - LARVOL DELTA

The deep brain stimulation response network in Parkinson's disease operates in the high beta band. (PubMed, Brain) - "We identified a DBS response network that resembles the previously defined MRI network and operates in the high beta band. Maximal connectivity to this network was associated with optimal DBS outcomes and was able to cross-predict clinical improvements across DBS surgeons and centres."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease

Results of rotational thromboelastometry confirm venous thromboembolic risk prediction in urologic patients. (PubMed, Arch Ital Urol Androl) - "Rotational thromboelastometry can provide a detailed evaluation of the hemostatic status in patients undergoing urologic surgery that can be used as an adjunct to the VTE risk assessment models and thus, help to offer prophylaxis on a rather personalized basis. Future studies should assess the utility of thromboelastometry in identifying patients at high risk for VTE after major urological procedures."

Journal • Bladder Cancer • Cardiovascular • Oncology • Renal Calculi • Solid Tumor • Urology • Venous Thromboembolism

Longitudinal Analysis of Intracochlear Electrocochleographic Amplitude Patterns in Cochlear Implant Recipients. (PubMed, Ear Hear) - "Our results suggest that nonapical peak patterns are not necessarily markers of insertion trauma and may instead reflect variability in cochlear integrity (e.g., dead regions). Peak location during insertion monitoring was not associated with postoperative HP, and both maximum amplitude and tonotopic peak location remained stable intraoperatively. In contrast, early postoperative reductions in ECochG amplitude were common and associated with HP, highlighting the need to investigate strategies to minimize early intracochlear reactions. Overall, the study demonstrates the value of ECochG for monitoring intracochlear processes over time."

Journal • Otorhinolaryngology

Ultrasonic-assisted micro-milling of cortical bone: An experimental study. (PubMed, Proc Inst Mech Eng H) - "This study examines the effects of feed rate, rotational speed, tool diameter, depth of cut, and vibration amplitude on cutting force and temperature in UAM of cortical bone...These models can help surgeons anticipate cutting conditions preoperatively, reducing surgical risks and preserving bone integrity. The findings support optimization of orthopedic machining processes, improving surgical outcomes and advancing bone-milling techniques."

Journal • Orthopedics

Enhancing Fetal Brain Imaging: ALPS-FMEG Technique Achieves Accurate Signal Extraction by Mitigating Movement Artifacts. (PubMed, Ann Biomed Eng) - "ALPS-FMEG improves fetal brain signal extraction by addressing movement artifacts. This method supports robust fetal brain analysis and may be adaptable to future fMEG systems, including optically pumped magnetometers, enhancing prenatal neurophysiology and clinical research, though manual steps currently limit scalability and could be addressed via automation for broader practical use."

Journal • CNS Disorders

High-velocity laser Doppler vibrometry measurements on an aluminum nitride bimorph wedge resonator. (PubMed, Commun Eng) - "These results highlight the feasibility of operating MEMS devices at much higher velocities, paving the way for next-generation inertial sensors with increased performance. The resonator operates at a higher-order mode near 1.81 MHz, with clear evidence of Duffing-type nonlinearities at large drive amplitudes, as confirmed in time-domain and frequency-domain measurements."

Journal • Musculoskeletal Diseases • Orthopedics

Somatosensory evoked potentials and high-frequency oscillations after transcranial static magnetic stimulation over the primary somatosensory cortex. (PubMed, Sci Rep) - "TSMS over the left S1 significantly reduced the amplitude of early HFOs 20 min after stimulation, whereas late HFOs remained unchanged...Early and late HFOs are thought to reflect the action potentials of thalamocortical fibers and the activity of GABAergic interneurons, respectively. These findings therefore suggest that tSMS over the S1 selectively attenuates thalamocortical input while exerting no effect on GABAergic interneuron activity."

Journal

GLP-1 receptor agonist suppresses fatty infiltration while improving range of motion and electromyographic function in a chronic rotator cuff tear rat model. (PubMed, J Shoulder Elbow Surg) - "Systemic liraglutide administration attenuated chronic muscle degeneration after RC tear by limiting FI, preserving muscle fiber morphology, maintaining joint mobility, and supporting neuromuscular function. These findings provide preclinical justification for therapeutic repositioning of GLP-1RAs in musculoskeletal disorders characterized by irreversible fatty degeneration."

Journal • Preclinical • Muscular Atrophy • Musculoskeletal Diseases

On exploring muscle aging of the biceps brachii in the middle-aged population using HD-sEMG signal analysis. (PubMed, Exp Gerontol) - "Muscle activation amplitude, spatial distribution, and signal complexity were analyzed...Taken together, these findings suggest that midlife, in women, may be characterized by subtle, task-dependent neuromuscular reorganization rather than a generalized decline. Early identification of such changes using HD-sEMG metrics may support timely interventions aimed at preserving neuromuscular function across the lifespan."

Journal

Recession-resection combined with vertical offset of horizontal rectus muscles for management of combined head turn and head tilt in idiopathic infantile nystagmus syndrome. (PubMed, BMJ Case Rep) - "Orthoptic evaluation revealed orthotropia with full ocular motility and a high-frequency, moderate-amplitude horizontal pendular nystagmus, which dampened in the preferred AHP. The remainder of ocular examination was unremarkable.Surgical correction was performed using Park's modification of the horizontal Kestenbaum procedure to shift both eyes to the left. To address the head tilt, extorsion of the left eye and intorsion of the right eye were achieved by vertically offsetting the horizontal rectus muscles.Postoperative evaluation showed complete resolution of the head turn, with a residual 5° left head tilt, which remained stable at 1-year follow-up.In conclusion, this surgical approach offers a simple and effective method for simultaneous correction of head tilt and turn in idiopathic infantile nystagmus syndrome, reducing the need for more complex muscle surgery."

Journal • Ophthalmology

Vestibular habituation is associated with distinct autonomic signatures and greater reduction in visually induced motion sickness: A randomized controlled trial. (PubMed, Hear Res) - "Skin conductance response amplitude (SCR) increased in the S-W group only. SKT decreased substantially (2-4 °C) in the S-D group but minimally (< 1 °C) in the S-W group (between-group P < 0.01, baseline-adjusted). In conclusion, the stepwise protocol was associated with greater VIMS symptom relief and a more favorable autonomic profile than the short-duration approach, suggesting it may serve as a potential non-pharmacological countermeasure for virtual reality or simulator settings."

Journal

Nonlinear dynamics of a non-stationary rotor-disk-bearing system with rub-impact and geometric nonlinearity under non-ideal excitation. (PubMed, Sci Rep) - "Results show that rub-impact significantly alters the system's vibrational response, particularly near critical speeds, leading to amplitude amplification, prolonged resonance, energy localization, and the emergence of the Sommerfeld effect. Parametric studies further evaluate the effects of damping, nonlinear bearing stiffness, and variations in applied torque on system behavior."

Journal

A high-performance training-free pipeline for robust random telegraph signal characterization via adaptive wavelet-based denoising and Bayesian digitization methods. (PubMed, Sci Rep) - "The simplest RTS arises from discrete stochastic switching events between two binary states, quantified by their transition amplitude and dwell times in each state...Qualitative validation on experimental RTS data when no ground truth is available illustrates practical usability and flexibility for real-time or large-scale analysis in real measurement settings. Together, the proposed framework establishes a scalable and reproducible foundation for autonomous RTS analysis and systematic benchmarking, with potential to support future extensions toward more complex and device-specific RTS studies."

Journal

Task modulation of visual category selectivity at physical and conceptual levels: An ERP study. (PubMed, Brain Cogn) - "This study tested whether task‑related ERP modulations during object categorization depend on low‑level category‑specific features-specifically the amplitude spectrum (AS)-or whether they arise independent of these features...The lack of sustained early effects raises questions about how sensory evidence is transformed across processing stages. Manipulating category relevance revealed task modulation beyond response-format effects, showing how top-down goals shape both early sensory and later category-level processing as reflected in distinct visual ERP components."

Journal

SPI/HG composite microgels with tunable structure and rheological properties for semi-solid foods. (PubMed, Int J Biol Macromol) - "Under large-amplitude oscillatory shear (LAOS), the microgel network transitioned from strain-hardening ("hard gel") at low strain to strain-softening ("soft gel") at large strain, accompanied by pronounced shear thinning. Such structural adaptability and shear deformability-evidenced by plastic flow under shear without loss of textural integrity-endow SPI/HG microgels (0.2% HG) with strong potential as fat replacers in semi-solid foods, including margarine and mayonnaise."

Journal

Usability of Augmented Reality Head Mounted Displays (AR HMD) for Reading Studies. (PubMed, Klin Monbl Augenheilkd) - "This study demonstrated the potential usability of an AR HMD device for reading experiments. Future uses of AR-HMD could leverage its advanced technical capabilities (eye and head tracking) for complex visual behavioral studies, realistic simulation of ophthalmic diseases, and objective assessment of driving capability in real-world scenarios."

Journal • Ophthalmology • Retinal Disorders

Brain functional basis of the association between positive expectation and acupuncture efficacy in knee osteoarthritis. (PubMed, Brain Imaging Behav) - "Neuroimaging, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and other clinical data were collected at baseline and after treatment (week 4). Correlation analyses between the brain imaging and clinical data were performed. Baseline expectations and improvements in WOMAC function were associated with fractional amplitude of low-frequency fluctuation (fALFF) changes in the posterior cingulate cortex (PCC)/precuneus and increased PCC/precuneus-medial prefrontal cortex (mPFC) connectivity in the AG, but not in the SG or WG. Both altered fALFF in the PCC/precuneus and enhanced PCC/precuneus-mPFC connectivity were neural correlates of the association between positive expectations and the therapeutic efficacy of acupuncture."

Journal • Immunology • Osteoarthritis • Pain • Rheumatology

Empowering operators: Ergonomic advances in cylindrical lawnmower design. (PubMed, Work) - "The measured noise and HAV amplitudes exceeded the permissible limits of international standards...HAV has been reduced from 23 ms-2 to below 10 ms-2, thereby increasing the safe exposure time by approximately 2.3 times with interventions. However, the operator's physiological, psychophysical, and postural parameters remained unchanged as operational requirements remained the same.ConclusionNoise and HAV reduction through interventions provided a safer working environment for the lawnmower operators."

Journal • Musculoskeletal Diseases

Electrocochleography with an extratympanic tympanic membrane electrode : Age-dependent reference values for vertigo diagnostics (PubMed, HNO) - "Extratympanic ECochG enables a minimally invasive and reliable diagnostic approach with age-stratified reference values. It represents a practical adjunct to imaging in Ménière's disease and allows a more differentiated assessment of pathological inner ear function."

Journal • Otorhinolaryngology • Vertigo

Injection of acoustic waves via volumetric sources on a control surface for computational aeroacoustics. (PubMed, J Acoust Soc Am) - "Numerical results show good agreement with analytical solutions in both phase and amplitude...The radiated acoustic field is compared with the one obtained using the Ffowcs Williams-Hawkings integral formulation. The two solutions are again found in good agreement for this more realistic configuration."

Journal

A Recyclable Polythioester With α-Gem-Dimethyl Substitution: Instantaneous Crystallization Triggered by Large and Rapid Stretching. (PubMed, Adv Mater) - "However, large-amplitude rapid stretching (strain ~600%, strain rate ≥ 10 s-1), where the Deborah number based on the Rouse time of entanglement strand exceeds 1, triggers its crystallization, accelerating the crystallization rate by > 200,000 fold and achieving ~40% crystallinity within 1 s. This approach yields highly oriented fibers with outstanding mechanical properties (Young's modulus of 0.80 GPa, tensile strength of 120 MPa, breaking strain of 70%), high transparency, and the potential as a waveguide...The slow quiescent crystallization shall arise from entropic barriers associated with conformational adjustments toward the helix. Our findings highlight sulfur substitution's profound impact on polymer properties and prove that significantly enhancing the crystallization process holds promise for making PTE a high-value-added recyclable material."

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Defining circadian health: Conceptual framework and development of a circadian health index. (PubMed, Sleep Med Rev) - "Classically, endogenous circadian rhythms are characterized according to three principal dimensions: circadian phase, amplitude and stability...Finally, we propose a novel tool aimed at assessing those circadian health dimensions as well as the computation of a composite index to quantify circadian health, along with a graphical representation to visualize it. While further validation is still needed, this proposal will help clinicians and researchers better decipher circadian rhythms and their impact on mental and physical health and may offer new opportunities for public health promotion in both general and clinical populations."

Journal • Review

Compensatory scaling of modulatory neural populations in response to motor challenges. (PubMed, Proc Natl Acad Sci U S A) - "Electromyographic and behavioral recordings revealed that, when compared to control mice, mice whose V0c interneuron cholinergic output was genetically inactivated failed to display speed-dependent modulation of the gastrocnemius muscle, and exhibited lower amplitude bursting in the gastrocnemius muscle during swimming...Last, we observed a progressive recruitment of these two populations in mice with amyotrophic lateral sclerosis, and the recruitment of serotonergic neurons is hastened in those mice whose V0c interneurons had their cholinergic output inactivated. These findings highlight that modulatory systems scale their activity to match motor demand across various circumstances."

Journal • Amyotrophic Lateral Sclerosis • CNS Disorders • FOS

Continental mantle earthquakes of the world. (PubMed, Science) - "Comparing the Sn and Lg seismic wave amplitude ratio (Sn/Lg) of an earthquake with that of nearby earthquakes distinguishes CMEs and, unlike previous methods, can be applied globally...CME occurrence is widespread globally yet patterned regionally, reflecting local lithospheric structure and tectonic history. Our results highlight the value of CMEs for understanding continents and global tectonics."

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Evaluation of preoperative cortical excitability patterns in patients undergoing glioblastoma resection in the motor area. (PubMed, Neurosurg Rev) - "Key excitability measures included resting motor threshold, motor-evoked potential (MEP) amplitudes, relative paired-pulse responses, and indices of intracortical inhibition and facilitation...Collectively, these findings support quantitative TMS-derived intracortical measures as physiologically informative biomarkers that extend beyond spatial motor mapping and hold promise for refining surgical risk stratification. Prospective studies linking these markers to postoperative motor outcomes are needed to establish their clinical utility."

Journal • Observational data • Retrospective data • Brain Cancer • Glioblastoma • Oncology • Solid Tumor