Digene (magnesium hydroxide/aluminium hydroxide/simethicone/magnesium aluminium silicate) / Abbott - LARVOL DELTA

High-risk HPV prevalence in the Czech cervical cancer screening population: a comparison of clinician-collected and self-collected sampling. (PubMed, Eur J Public Health) - P=N/A | "In arm A, the digene® HC2 DNA Collection Device was used for both CS and CVS...Furthermore, the results confirm that self-sampling kits represent a suitable alternative to clinician-collected samples. Clinical trials registration  ClinicalTrials.gov Identifier (NCT04133610)."

Journal • Cervical Cancer • Oncology • Solid Tumor

CLINICAL PERFORMANCE OF THE NEUMODX HPV ASSAY IN STM MEDIUM IN CERVICAL CANCER SCREENING SETTINGS (IPVC 2024) - "We assessed the validity of the NeuMoDx for cervical cancer screening purposes, via comparison to a clinically validated comparator assay (digene Hybrid Capture 2; HC2) in cervical specimens collected in digene Specimen Transport Medium (STM). A clinical validation panel comprised of 919 residual STM samples obtained from women aged 21-64 years participating in the organized Slovenian screening program, of these 835 were from women undergoing their regular screening visit after a previous negative screen test while 84 were from women with underlying cervical intraepithelial neoplasia grade 2 or worse (CIN2+) lesions. The clinical sensitivities were 95.2% (80/84; 95%CI 88.0-98.2) and 94.0% (79/84; 95%CI 86.5-97.5) for the NeuMoDx and HC2 assay, respectively, while clinical specificities were 88.9% (742/835; 95%CI 86.8-90.6) and 89.3% (746/835; 95%CI 87.3-91.1) for NeuMoDx and HC2, respectively. The NeuMoDx HPV Assay demonstrated good performance in cervical samples..."

Clinical • Cervical Cancer • Gynecology • Oncology • Solid Tumor

SPRINT-HPV: HR-HPV DETECTION FROM CERVICAL SAMPLES IN POINT OF CARE (IPVC 2024) - "We developed a POC system that detects HPV types 16, 18, and nine other HR-HPV types. Cervical brush samples were collected at AIIMS in New Delhi, India, and stored using a Digene specimen transport medium (STM)... We developed and performed pilot testing of a portable isothermal POC system for HPV detection from cervical samples in low-resource settings. Further validation of the system is needed to establish analytic performance, especially for non-HPV16/18 genotypes. This fully integrated sample-to-answer platform offers a rapid, cost-effective solution for HR-HPV screening in LMICs."

Cervical Cancer • Oncology • Solid Tumor

Papilloma virus humain typing at the pathology department of the Oran University Hospital Centre (ECP 2024) - " At the level of the cytopathology department of the Centre University Hospital of Oran, we analysed 65 samples cervical with the digene hc2 hpv dna test and this in conjunction with a cervical smear in order to identify women with high risk of developing cervical cancer. Cervical cancer screening can certainly be improved in our country in replacing the practice of smear alone with combination with hpv testing at a faster rate safely spaced and to determine the need for colposcopy or other monitoring procedures."

Clinical • Cervical Cancer • Infectious Disease • Oncology • Solid Tumor

Turn-on detection of Al3+ ions using quinoline-based tripodal probe: mechanistic investigation and live cell imaging applications. (PubMed, Anal Methods) - "Furthermore, to evaluate the applied potential of probe TQSB, its sensing ability was studied in real samples such as soil samples and Al3+-containing Digene gastric tablets as well as on low-cost filter paper strips. Fluorescence microscopy imaging experiments further revealed that TQSB can be used as an effective probe to detect intracellular Al3+ in live cells with no cytotoxicity."

Journal

The Correlation Between interleukin-6 and The Progression of Chronic Hepatitis B (APASL 2024) - "The first group of sera were subjected to a hybrid capture, tube-based signal amplification using HBV Digene Hybrid-Capture I, Digene Corporation, USA... IL-6 is a vital mediator of inflammation and the acute phase response of the liver. Our studies proved that serum IL-6 levels were positively correlated with HBV disease severity and chronicity. Thus, IL-6 may be a useful indicator of disease activity and therapeutic efficacy in patients suffering from hepatitis B."

Fibrosis • Gastrointestinal Cancer • Hepatitis B • Hepatitis C • Hepatocellular Cancer • Hepatology • Infectious Disease • Inflammation • Liver Cirrhosis • Liver Failure • Oncology • Solid Tumor • IL6

Oral Human Papillomavirus Infection among Smokeless Tobacco-using Tribal Women in Mysuru, India. (PubMed, Indian J Community Med) - "Following informed consent, demographic data and oral samples were collected and processed using a digene HC2 High-Risk HPV DNA test (Qiagen, USA)...Oral HPV infection was low in this sample and this is consistent with the literature from other low and middle-income countries. SLT use is high in this group so interventions to reduce tobacco use are warranted."

Journal • Head and Neck Cancer • Human Papillomavirus Infection • Infectious Disease • Oncology • Oral Cancer • Solid Tumor

Cervical Fluids Are a Source of Protein Biomarkers for Early, Non-Invasive Endometrial Cancer Diagnosis. (PubMed, Cancers (Basel)) - "This study opens an avenue for developing non-invasive protein-based EC diagnostic tests, which will improve the standard of care for gynecological patients."

Biomarker • Journal • Endometrial Cancer • Gynecology • Oncology • Solid Tumor • Uterine Cancer • Women's Health • CTNNB1 • PPIA • SERPINH1 • TAGLN

Prevalence of Human Papillomavirus (HPV) Genotypes in Cervicovaginal Secretions of Human Immunodeficiency Virus (HIV) Positive Indian Women and Correlation With Clinico-Virological Parameters. (PubMed, Front Reprod Health) - "Cervicovaginal secretion samples were collected in the Digene specimen transport medium (STM) (Qiagen Gaithersburg Inc., MD, USA)...Studies are required to determine the predictive role of HR HPV genotypes, in significant copy numbers especially in HIV seropositive women. It would be clinically relevant if the HPV VLs, cervical cytology, and CD4 counts are considered into cervical cancer screening programs for triage and follow-up of these women."

Journal • Cervical Cancer • Human Immunodeficiency Virus • Immunology • Infectious Disease • Oncology • Solid Tumor • CD4

Histopathological profile of cervical punch biopsies and risk factors associated with high-grade cervical precancerous lesions and cancer in northwest Ethiopia. (PubMed, PLoS One) - "The findings of this study revealed that cervical cancer continues to be an important women's health challenge in northwest Ethiopia. Postmenopausal women, who had no screening history within a five-year period and those women who tested positive for HR-HPV need special attention. It is important to increase the awareness of women about cervical cancer and actions for early detection of precancerous lesions should be expanded."

Journal • Cervical Cancer • Gynecology • Human Immunodeficiency Virus • Infectious Disease • Oncology • Solid Tumor • Women's Health

Clinical performance of the Roche Cobas 4800 HPV test for primary cervical cancer screening in a Chinese population. (PubMed, PLoS One) - "The performance of Roche Cobas 4800 HPV test was validated and compared with Digene Hybrid Capture 2 (HC2) high-risk HPV DNA test for primary screening in a large Chinese screening cohort...The Cobas test demonstrated significantly higher specificity in identifying CIN2+/CIN3+ cases than HC2 test (66.46% vs 43.67% and 65.42% vs 42.86%, p<0.001), with comparable sensitivity in clinical evaluation. Increased specificity of Cobas test would accent women having the highest risk of developing CIN2+, with the potential to reduce unnecessary colposcopy referral in a screening population."

Journal • Cervical Cancer • Infectious Disease • Oncology • Solid Tumor

"Say no to Digene Because they hired @taapsee, a well known AntiHindu as brand ambassador @AbbottNews" (@ValueBPol)

"@AbbottNews did I just get a spurious bottle of Digene from @ApolloPharmacy ? Plastic, unsealed cap, license number 281. Bad printing on label. What's a spurious medicine identifier? #medtwitter" (@BlackMagicWooma)

"@AbbottNews Hi Digene Maker, Please Launch a Digene sachet for single use only, use for Marriage function, Party's function, travelling purpose etc.. Very huge demand for single use digestive syrup. Thanks" (@azeemkh27813594)

Efficiency of the hybrid capture 2 HPV DNA test compared to cytology testing in cervical cancer screening (ESGO 2021) - "Introduction/Background* The aim of this study was to determine the efficiency of the Hybrid Capture 2 (HC2; Digene, Qiagen, Hilden Germany) human papillomavirus (HPV) assay for the detection of cervical neoplasia compared to conventional cytology testing...Conclusion* Implementing a HC2 based cervical cancer screening algorithm could potentially reduce the number of colposcopy/biopsy referrals by over 50% without a substantial impact on the CIN2+ detection rate and no impact on the CIN3+ detection rate. This in turn decreases the associated costs of screening, decreases the number of unnecessary diagnostic procedures and, could increases patient comfort, satisfaction and adherence to the screening program"

Cervical Cancer • Gynecology • Obstetrics • Oncology • Solid Tumor

Long-term cervical precancer outcomes after a negative DNA- or RNA-based human papillomavirus result. (PubMed, Am J Obstet Gynecol) - "Among participants who were HPV negative at baseline, the long-term risk of CIN2+/CIN3+ did not significantly differ regardless of whether DNA- or RNA-based human papillomavirus testing assays were used. Screening program decision-makers can be confident that for women who test negative for HPV, DNA- and RNA-based assays have similar CIN2+ outcomes over many years."

Journal • Cervical Cancer • Gynecology • Oncology • Solid Tumor

Characterization of high risk human papilloma virus genotypes associated with oropharyngeal cancers in a Nigerian population. (PubMed, Pan Afr Med J) - "A portion of the specimen from which the DNA was extracted was placed in Digene HC2 DNA collection device while the 2 portion for histopathological analysis was fixed using 10% Neutral Buffered Formalin (NBF) and embedded in paraffin blocks...This finding provides a strong evidence for the use of the 9-valent prophylactic vaccine for the prevention of oropharyngeal cancer in Nigeria. Public awareness and HPV prevention strategies should reduce significantly the incidence of oropharyngeal carcinomas in our environment."

Clinical • Journal • Anesthesia • Head and Neck Cancer • Human Immunodeficiency Virus • Infectious Disease • Oncology • Oropharyngeal Cancer • Solid Tumor • Squamous Cell Carcinoma

"Still @AbbottNews won't pay you for promoting digene 🤣🤣🤣" (@GeeteshMashelk8)

The impact of socioeconomic status on HPV infection among young Brazilians in a nationwide multicenter study. (PubMed, Prev Med Rep) - "Cervical samples were obtained using a Digene® HC2 DNA Collection, and penile/scrotum samples were obtained using a wet Dacron swab...After adjustments, the presence of HPV in individuals with a brown skin color belonging to classes A-B was 57.00% higher [prevalence ratio 1.57 (95%: 1.23, 2.01)] than that in whites and had no impact on the other social classes. In conclusion, HPV infection affects all socioeconomic classes in Brazil, evidencing the importance of offering the HPV vaccine to the entire population."

Clinical • Journal • Infectious Disease • Oncology

Human Papillomavirus (HPV) Prevalence, Temporal Dynamics and Association with Abnormal Cervical Cytology Findings in Women from Croatia: Is there a Compounding Effect of Low-Risk/High-Risk HPV Co-Infection? (PubMed, Clin Lab) - "The overall HPV prevalence in female outpatients was high, underscored with rising co-positivity rates. Such co-infection with both low-risk and high-risk HPV (predominantly seen in women younger than 30) can exhibit a compounding effect in the occurrence of cytological abnormalities and low grade squamous intra-epithelial lesions (LSIL), which has to be considered in future diagnostic and screening algorithms."

Clinical • Journal • Cervical Cancer • Gynecology • Immunology • Infectious Disease • Oncology • Solid Tumor

Acceptability of self- collection for human papillomavirus detection in the Eastern Cape, South Africa. (PubMed, PLoS One) - "Cervical clinician-collected (FTA cards and Digene transport medium) and vaginal self-collected specimens were tested for HR-HPV using the hpVIR assay (FTA cards) and Hybrid Capture-2 (Digene transport medium)...The study found good agreement between clinician-collected and self-collected genital specimens. Self-collection can have a positive impact on a cervical screening program in South Africa by increasing coverage of women in rural areas, in particular those unable to visit the clinics and women attending clinics where cytology-based programs are not functioning effectively."

Journal • Cervical Cancer • Oncology • Solid Tumor

"Dear @AbbottNews India, does @taapsee holds a biomedical degree to qualify herself to endorse #Digene? Why not any Gastroenterologist to endorse an Antacid rather an actress? Plz contribute to the greater cause 🙏🏻 #ArnabGoswami #BollywoodScaredofArnab #JusticeForArnab #Bollywood" (@sunnydg23)

Gastroenterology

Performance analysis of high-throughput HPV testing on three automated workflows. (PubMed, APMIS) - "During a 3 months period, four technicians were involved in processing 5000 specimens per month on three automated platforms, (1) Qiagen Digene® HC2 HPV DNA test (HC2, signal amplification); (2) Roche Cobas® HPV test (DNA amplification), and (3) Hologic Aptima® HPV test (RNA amplification)...Although all HPV tests used in this comparison meet the international test guidelines, the performance (workflow) characteristics of the assays vary widely. A specific choice of a lab for high throughput testing can be different based on the labs demands, but also hands-on-time, time-to-results / # samples, maintenance, pre-run, run and post-run parameters, consumables, technical support and number of errors are important operational factors for the selection of a fully automated workflow for hrHPV testing."

Journal • Oncology

[VIRTUAL] EVALUATION OF THE USE OF RESIDUAL CLINICAL SPECIMENS FOR SURVEILLANCE OF ANAL HUMAN PAPILLOMAVIRUS (HPV) IN MALES (IPVC-I 2020) - "Methods Participants in the HPV research protocol self-collected an anal swab in digene Specimen Transport Medium (STM)...Conclusions Specimens remaining after Aptima GC/CT testing are suitable for surveillance of anal HPV. Use of anonymized residual clinical specimens to monitor HPV prevalence can reduce specimen collection burden for patients and clinic staff."

Clinical • Infectious Disease • Oncology

[VIRTUAL] HPV TESTING AMONG WOMEN IN SOUTHERN INDIA: SELF-COLLECTED VERSUS PHYSICIAN COLLECTED SWABS (IPVC-I 2020) - "The digene Hybrid Capture 2 HPV DNA Test was used to test for HPV...Conclusions Our findings indicate that there is substantial agreement between self-collected and physician collected swabs used for HPV testing. Self-collected swabs are a viable method to improve cervical cancer screening initiatives in Southern India."

Clinical • Cervical Cancer • Gynecologic Cancers • Oncology • Solid Tumor