aCD21 CAR / Autolus, University College London - LARVOL DELTA

Development of anti-CD21 Chimeric Antigen Receptor (CAR)-T Cells for T-Cell Acute Lymphoblastic Leukemia (T-ALL) - CAR engineering for a complex antigen. (ASGCT 2025) - "The dual αδ PI3K inhibitor copanlisib upregulated CD21 in T-ALL cell lines and PDX both in vitro and in vivo. Anti-CD21 Fab-CAR-T cells, targeting membrane-proximal epitopes, showed potent anti-CD21 activity. Pharmacological upregulation of CD21 can enhance efficacy in low antigen density. This novel approach avoids fratricide and T-cell aplasia, offering promise for treating T-ALL Disease Focus of Abstract:Leukemia"

IO biomarker • Acute Lymphocytic Leukemia • Hematological Malignancies • Leukemia • Oncology • T Acute Lymphoblastic Leukemia • T-cell Acute Lymphoblastic Lymphoma • CD21 • CD7

Preclinical development of anti-CD21 chimeric antigen receptor T cells to treat T cell acute lymphoblastic leukemia. (PubMed, Sci Transl Med) - "This study establishes CD21 as a viable CAR-T target and highlights advances in CAR design for bulky antigens, as well as the potential for pharmacological strategies to augment target expression. Anti-CD21 CAR-T cells represent a promising therapeutic option for improving outcomes for patients with T-ALL."

IO biomarker • Journal • Preclinical • Acute Lymphocytic Leukemia • Bone Marrow Transplantation • Hematological Malignancies • Leukemia • Oncology • T Acute Lymphoblastic Leukemia • T-cell Acute Lymphoblastic Lymphoma • Transplantation • CD21

Anti-CD21 Chimeric Antigen Receptor (CAR)-T Cells for T Cell Acute Lymphoblastic Leukaemia (T-ALL) (ASH 2021) - "Its expression is largely restricted to the malignant T cell compartment, overcoming issues with fratricide and on-target off-tumour effects seen in many T-ALL CAR-T strategies to date. Despite the complexity of the target, we have successfully generated an aCD21 CAR that is functional both in vitro and in vivo ."

IO biomarker • Acute Lymphocytic Leukemia • Hematological Malignancies • Leukemia • Oncology • T Acute Lymphoblastic Leukemia • CD19 • CD1a • CD21 • CD5 • CD7 • IFNG