acitretin / Generic mfg. - LARVOL DELTA

Incidental Discovery of Celiac Disease in a Patient with Mycosis Fungoides (ACG 2025) - "Her past medical history includes hypertension and ANA-positive inflammatory arthritis managed with losartan, hydroxychloroquine and low-dose prednisone, as well as surgical resection of an ovarian adenofibroma. Her mycosis fungoides had been treated with multiple modalities including UVB therapy (discontinued due to lack of response), bexarotene (discontinued due to hypertriglyceridemia), mogamulizumab (discontinued due to lack of response) and Acitretin with topical tretinoin cream...Inadequate response to oral vitamin A supplementation suggests ongoing malabsorption. This case highlights the importance of considering CD in patients with unexplained vitamin deficiencies, even in the absence of gastrointestinal complaints.Figure: Skin lesion characteristic of Mycosis fungoides"

Clinical • Cardiovascular • Celiac Disease • Cutaneous T-cell Lymphoma • Dermatology • Dyslipidemia • Hypertension • Hypertriglyceridemia • Immunology • Inflammatory Arthritis • Mycosis Fungoides • Oncology • Rheumatology • Solid Tumor • CFTR • ELANE

Recurrent skin tumour with mixed features of microcystic adnexal carcinoma, squamous cell carcinoma, and basal cell carcinoma in a renal transplant recipient; a very rare case report (ECP 2025) - "He underwent adjuvant radiotherapy with 45Gy in 10 fractions and was started on Acitretin... Few cases of MAC have ever been reported in transplant recipients. Post-transplant SCC can show divergent differentiation. Two confirmed cases of MAC in RTRs were locally aggressive requiring extensive surgical resection due to bone invasion."

Case report • Clinical • Basal Cell Carcinoma • Non-melanoma Skin Cancer • Oncology • Skin Cancer • Squamous Cell Carcinoma • Transplantation • CK19 • KRT19

Protective effects of melatonin and naringenin against acitretin induced hepatotoxicity via modulation of oxidative stress and inflammatory signaling. (PubMed, Sci Rep) - "Notably, combination therapy provided superior hepatoprotection compared to individual treatments, suggesting a synergistic effect. These findings propose melatonin and naringenin as promising adjuncts to enhance the safety profile of acitretin therapy in clinical practice."

Journal • Dermatology • Fibrosis • Hepatology • Immunology • Inflammation • Liver Failure • Psoriasis • CASP3 • CAT • HMGB1 • IL6 • MMP9 • TGFB1 • TNFA

An Adult-Onset Case of Porokeratotic Eccrine Ostial and Dermal Duct Nevus (PEODDN) in a Previously Healthy 28-Year-Old Indian Male: A Case Report. (PubMed, Cureus) - "Treatment options remain variable, and while no standard therapy offers complete resolution, our findings support the potential role of oral retinoids in improving lesion appearance and symptoms in adult-onset cases. Further evaluation of systemic retinoid therapy in PEODDN is warranted."

Journal • Dermatology • Oncology

Nail Lichen Planus in 81 Patients: A Retrospective Study of Clinical Characteristics, Histopathological Features, and Long-Term Treatment Outcomes. (PubMed, J Dermatol) - "Oral acitretin showed moderate efficacy in early disease, while topical corticosteroids, calcineurin inhibitors, and hydroxychloroquine were largely ineffective. This study presents the largest long-term cohort of biopsy-confirmed NLP to date and offers new insights into its clinical spectrum, diagnostic strategies, and real-world treatment outcomes. It highlights the utility and limitations of longitudinal biopsy, the potential predictive value of periungual inflammation, and the emerging role of JAK inhibitors as promising therapeutic agents in recalcitrant cases."

Journal • Retrospective data • Dermatology • Dermatopathology • Inflammation • Lichen Planus

Acitretin in the Management of Pediatric Generalized Pustular Psoriasis: A Clinical Case (EADV 2025) - No abstract available

Clinical • Dermatology • Immunology • Pediatrics • Psoriasis • Pustular Psoriasis

Widespread Granuloma Annulare in a 74-year-old Filipino Treated with Narrowband UVB Phototherapy and Acitretin (EADV 2025) - No abstract available

Rare Diseases

Multiple Verrucous Nodules and Masses in an Adolescent Boy With Porokeratoma: A Case Report and Literature Review. (PubMed, Pediatr Dermatol) - "After excision of larger nodules, the patient was treated for 3 months with oral acitretin and topical retinoic acid, after which some nodules and masses subsided. Limitations include the unavailability of HPV virology and molecular genetic profiling, which would have been helpful, if not essential."

Journal • CNS Disorders • Depression • Oncology • Psychiatry

Systemic treatment of immune checkpoint inhibitor-induced psoriasis: Inference-based guidance. (PubMed, J Eur Acad Dermatol Venereol) - "Although there is no direct evidence, we support the following saPs may be used to treat ICI-Ps without an appreciable loss of ICI effectiveness. Generally, it is not necessary to interrupt ICI therapy. When available, non-steroid saPs are preferred over systemic corticosteroids for the treatment of psoriasis."

Checkpoint inhibition • Journal • Dermatology • Immunology • Oncology • Psoriasis • Rheumatology • IL12A • IL23A • TYK2

Nivolumab-Induced Lichenoid Eruption: A Case Report. (PubMed, Cureus) - "We describe a case of nivolumab-induced lichenoid eruption in a patient with metastatic desmoplastic melanoma. Five months after treatment initiation, the patient developed pruritic violaceous papules and plaques, with histopathology revealing lichenoid interface dermatitis. This lichenoid reaction was managed with clobetasol ointment, low-dose oral prednisolone, intralesional corticosteroids, and acitretin, allowing the continuation of immunotherapy with nivolumab, which was completed after one year of treatment."

Journal • Dermatitis • Dermatology • Immunology • Lichen Planus • Melanoma • Oncology • Skin Cancer • Solid Tumor

Hidden targets in dermatology: In vitro and In silico inhibitory effects of common 23 dermatologic drugs on human carbonic anhydrase isoenzymes I and II. (PubMed, J Enzyme Inhib Med Chem) - "The most potent inhibitors were isotretinoin for hCA I (Ki= 5.75 µM) and valaciclovir for hCA II (Ki= 5.74 µM). Ketotifen (Ki= 6.98 µM), pantoprazole (Ki= 7.16 µM) and acyclovir (Ki= 7.31 µM) were also potent inhibitors for hCA I. Isotretinoin (Ki= 6.54 µM), brivudine (Ki= 7.44 µM) and fluconazole (Ki= 7.91 µM) were also potent inhibitors for hCA II. Terbinafine hydrochloride was a weak CA inhibitor for both of these isoenzymes (Ki= 20.58 µM for hCA I and 20.32 µM for hCA I)...Molecular docking studies have shown that acitretin and isotretinoin, in particular, will inhibit hCA I at lower concentrations and have higher docking scores. For hCA II, it was shown that Isotretinoin and Ketotifen would inhibit at lower concentrations and have higher placement scores."

Journal • Preclinical • Dermatology

Upadacitinib Versus Acitretin for the Resolution of Pustules in Palmoplantar Pustulosis During Acute Phase: A Single-Center, Open-Label Prospective Cohort Study. (PubMed, Am J Clin Dermatol) - P4 | "UPA demonstrated superior efficacy over ACI in rapidly clearing pustules and improving skin lesions and quality of life in acute PPP episodes. The findings suggest that JAK1 inhibition may be a promising therapeutic approach for PPP, warranting further investigation in larger trials."

Journal • Dermatology • Immunology • Inflammation • Psoriasis

Biologic and small molecule therapies for psoriasis in individuals with Down syndrome: Two cases and a systematic review. (PubMed, SAGE Open Med Case Rep) - "We report two DS patients with psoriasis demonstrating variable therapeutic responses: one controlled with acitretin and another requiring secukinumab after multiple treatment failures...Methotrexate was the most frequently failed therapy. Biologics targeting IL-17 and IL-23 pathways achieved the highest rates of complete resolution. These findings reflect Th1/Th17-driven inflammation in DS and highlight the need for individualized, pathway-specific management strategies."

Journal • Dermatology • Developmental Disorders • Genetic Disorders • Immunology • Inflammation • Psoriasis • IL17A • IL23A

Update on Erythrodermic Psoriasis: Proposal of a Management Algorithm by an Innovative Severity Evaluation Approach. (PubMed, Psoriasis (Auckl)) - "These treatments include conventional systemic drugs (such as acitretin, cyclosporin A, and methotrexate), biologics (including IL-17, IL-12/23, and TNF-α inhibitors), and small molecule drugs (such as apremilast and JAK inhibitors). Additionally, we incorporated new evidence on the use of acitretin, biologics, and JAK inhibitors for EP. We also introduced, for the first time, a practical management algorithm based on severity evaluation to guide the appropriate treatment of EP."

Journal • Review • Dermatology • Immunology • Psoriasis • IL12A • IL17A

Role of acitretin in regulating glucose and lipid homeostasis in an imiquimod-induced psoriasis model mouse. (PubMed, Zhong Nan Da Xue Xue Bao Yi Xue Ban) - "Acitretin helps maintain the balance between hepatic glycogenesis and gluconeogenesis, enhances insulin sensitivity, and improves pancreatic islet function, thereby promoting systemic and cellular glucose homeostasis."

Journal • Preclinical • Dermatology • Diabetes • Genetic Disorders • Immunology • Inflammation • Metabolic Disorders • Obesity • Psoriasis • AKT1 • PDX1 • PPARG • SIRT1 • SLC2A1 • SLC2A4

Identifying Key Genes and Approved Medications Associated with Major Depressive Disorder Using Network Analysis and Systems Biology. (PubMed, Iran J Psychiatry) - "These medications include Acitretin, Adalimumab, Alteplase, Cisplatin, Digoxin, Etanercept, Infliximab, Insulin, Omeprazole, Pentoxifylline, and Rabeprazole. This study provides a new vision of the pathogenesis and treatment of MDD. However, further experimental and clinical studies are necessary."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry • IL1B • IL6 • STAT1 • STAT3

Successful management of recalcitrant cutaneous warts with low-dose acitretin monotherapy in a patient with idiopathic CD4+ lymphocytopenia. (PubMed, Skin Health Dis) - "As HPV evades the Janus kinase/STAT pathway to promote keratinocyte proliferation, acitretin may work through reversal of this mechanism. This case demonstrates effectiveness of acitretin in treating recalcitrant viral warts, specifically in a patient with ICL."

Journal • Monotherapy • Dermatology • Hematological Disorders • Human Papillomavirus Infection • Infectious Disease • Oncology • CD4 • STAT1

Psoriasis. (PubMed, Nat Rev Dis Primers) - "In moderate-to-severe disease, oral systemic therapies, such as methotrexate, ciclosporin, acitretin, apremilast and deucravacitinib, provide a range of immunomodulatory effects. Early screening for psoriatic arthritis, proactive cardiovascular risk reduction and multidisciplinary care are crucial to optimizing long-term outcomes. Ongoing research continues to advance precision medicine approaches, with the goal of enhancing treatment durability and improving quality of life for individuals living with psoriasis."

Journal • Review • Cardiovascular • CNS Disorders • Dermatology • Immunology • Inflammation • Inflammatory Arthritis • Mental Retardation • Metabolic Disorders • Psoriasis • Psoriatic Arthritis • Psychiatry • Rheumatology • Seronegative Spondyloarthropathies • HLA-C • IL12A • IL12B • IL17A • IL17RA • IL23A • TYK2

Dramatic clearance of extensive psoriasis in a pediatric patient with upadacitinib (CDA 2025) - "Introduction : Psoriasis is a chronic inflammatory skin condition that commonly presents on the knees, elbows, trunk, and scalp, but can involve the palmoplantar surfaces. The patient presented with severe palmoplantar psoriasis at age 3, progressing to widespread disease by age 8, with genital involvement, painful fissures, and impaired mobility. He underwent extensive treatments, including methotrexate, acitretin, cyclosporine, ustekinumab, ixekizumab, apremilast, secukinumab, and deucravacitinib, alongside topical therapies including clobetasol, roflumilast, halobetasol and betamethasone diproprionate-based preparations. Despite moderate responses to some regimens, sustained control was not achieved, and treatment side effects, including elevated liver enzymes, dyslipidemia and gastrointestinal discomfort, further limited options."

Clinical • Atopic Dermatitis • Dermatitis • Dermatology • Dyslipidemia • Gastrointestinal Disorder • Immunology • Inflammatory Arthritis • Metabolic Disorders • Pain • Pediatrics • Psoriasis • Psoriatic Arthritis • Rheumatology • Seronegative Spondyloarthropathies

Treatment of Refractory PRP with Off-label Guselkumab and Abrocitinib: A Promising Combination Therapy (CDA 2025) - "She had failed NBUVB phototherapy, cyclosporine, topical steroids and keratolytics, prednisone, and was currently taking acitretin alternating dose 25mg/35mg daily...She started combination of methotrexate and acitretin which failed. Ustekinumab 90mg every twelve weeks was initiated off-label with alitretinoin 30mg daily; no change...Current treatments approved for both psoriasis and atopic dermatitis seem to provide benefit, and combination therapy may be more beneficial. More research is necessary to find an effective single agent or to identify ideal doses of combination therapies."

Combination therapy • Atopic Dermatitis • Dermatitis • Dermatology • Dermatopathology • Immunology • Pruritus • Psoriasis • IL23A

Balancing efficacy and hepatotoxicity: a comprehensive review of oral medications in psoriasis management. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "Oral systemic therapies, including methotrexate, cyclosporine, acitretin, and apremilast, remain integral to psoriasis management, particularly for patients with moderate-to-severe disease who cannot afford biologic therapy. A balanced approach that integrates clinical monitoring, lifestyle modifications, and emerging precision medicine techniques is essential for optimizing long-term treatment outcomes. Future research should focus on refining predictive models for drug-induced liver injury and developing targeted therapies with improved efficacy and safety profiles."

Journal • Review • Dermatology • Hepatology • Immunology • Inflammation • Liver Failure • Psoriasis • TYK2

Investigating the efficacy of calcipotriol-acitretin combination therapy versus monotherapy protocols in psoriasis and its effect on serum inflammatory factors: a systematic review and meta-analysis. (PubMed, Eur J Med Res) - "The calcipotriol-acitretin combination therapy could be a safe and effective therapeutic strategy in the treatment of psoriasis. However, the lack of PROSPERO registration and the high heterogeneity in this study limited the conclusion, and more high-quality RCTs were needed for further evaluation."

Journal • Monotherapy • Retrospective data • Review • Dermatitis • Dermatology • Immunology • Inflammation • Pain • Psoriasis • IL10 • IL17A • IL23A • IL4 • IL6 • TNFA

Treatment of Hailey-Hailey disease with the Janus kinase inhibitor abrocitinib: A case report. (PubMed, SAGE Open Med Case Rep) - "Despite multiple failed therapies, including methotrexate, dapsone, acitretin, and naltrexone, she showed rapid improvement within 2 weeks of abrocitinib (100 mg daily), a JAK1 inhibitor, with sustained control at 2 months follow-up. This case adds to growing evidence that JAK inhibitors, particularly abrocitinib, may serve as an effective targeted therapy for refractory Hailey-Hailey disease. Further clinical trials are needed to confirm its long-term efficacy and safety."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Genetic Disorders • Immunology • Inflammation • Pain • IL13 • IL4

Acupoint Injection Combined with BCG-PSN and Thymosin Enteric-Coated Tablets Improve China Han Psoriasis Vulgaris by Regulating T Cell Subsets. (PubMed, Psoriasis (Auckl)) - "Multivariable Cox regression analysis demonstrated that MII significantly reduced psoriasis relapse risk versus NB-UVB (58.7% reduction; HR = 0.413, 95% CI: 0.329-0.517, P < 0.001) and acitretin (65.3% reduction; HR = 0.347, 95% CI: 0.276-0.435, P<0.001). Acupoint injection combined with BCG-PSN, thymosin enteric-coated tablets and levamisole treat psoriasis and prevent relapse of psoriasis, via modulation of Treg/Th1/Th17."

Journal • Dermatology • Immunology • Inflammation • Psoriasis • IFNG • IL17A

A Case Report of Successful Treatment of Keratoderma Secondary to Severe Plantar Psoriasiform Dermatitis with Roflumilast Cream (CDA 2025) - "His medical history included dyslipidemia, alcohol use disorder, and non-alcoholic fatty liver disease, precluding the use of systemic treatments such as Methotrexate and Acitretin due to hepatotoxicity risk...Given the refractory nature of the condition and the patient’s contraindications to systemic therapy, the patient was enrolled for Dupilumab and while awaiting approval was prescribed Roflumilast 0.3% cream off-label for once-daily application...Its favorable safety profile, tolerability, and cost-effectiveness compared to biologics suggest its potential as a viable treatment option for PSD. Further studies are warranted to evaluate Roflumilast’s efficacy in inflammatory dermatoses and role in managing refractory cases."

Case report • Clinical • Addiction (Opioid and Alcohol) • Atopic Dermatitis • Dermatitis • Dermatology • Dyslipidemia • Hepatology • Immunology • Inflammation • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Psoriasis