acitretin / Generic mfg. - LARVOL DELTA

Effect of acitretin on Mohs surgery complexity, repair, and postsurgical outcomes in solid organ transplant patients: A TriNetX analysis from 2002 to 2022 (SID 2025) - "Pre-operative acitretin is associated with increased complexity of Mohs surgery and greater postoperative complications for the treatment of cSCC in SOT patients. Higher rates of graft failure, dehiscence, and SSI likely stem from both the increased surgical complexity for acitretin patients as well as acitretin's inhibition of angiogenesis and collagen synthesis during the proliferative phase of wound healing."

Clinical • Late-breaking abstract • Surgery • Genetic Disorders • Infectious Disease • Non-melanoma Skin Cancer • Oncology • Skin Cancer • Solid Organ Transplantation • Squamous Cell Carcinoma • Squamous Cell Skin Cancer • Transplantation

XPC gene variation in an individual with generalized eruptive keratoacanthomas of grzybowski (SID 2025) - "Treatments included topical 5-fluorouracil, 5-fluorouracil + calcipotriene cream, imiquimod, triamcinolone cream, and clobetasol ointment; injected 5-fluorouracil and triamcinolone; and oral nicotinamide, acitretin, methotrexate, and cyclophosphamide. Similarly, GEKA has been linked to HPV 39 infection, and sporadic keratoacanthomas have shown positivity with multiple HPV subtypes, but this testing is not currently available at our institution. Further testing is indicated to determine the significance of these genetic findings and to explore the role of HPV in GEKA."

Clinical • Late-breaking abstract • Dermatology • Infectious Disease • Oncology • Squamous Cell Carcinoma • TGFBR1 • XPC

Resistance to biologics therapy in psoriasis is associated with obesity and markers of innate immunity (SID 2025) - "Patients with severe plaque type severe psoriasis (Psoriasis Area and Severity Index > 10 and body surface area > 10) despite conventional treatment with cyclosporine, methotrexate, acitretin, and phototherapy for longer than 3 months, and treatment with biologics for at least 24 months were included. Immunofluorescence analysis showed significantly enhanced protein expression of lipocalin 2, S100A8/A9, IL-36α, IL-36γ, IL-1RA, and TRAIL in the epidermis. Dysregulated innate immune responses in the epidermis and heightened neutrophil activity may be responsible for decreased sustainability of therapeutic responses to biologics."

Dermatology • Genetic Disorders • Immunology • Obesity • Psoriasis • CXCL8 • IL17A • IL1R1 • IL23A • LCN2 • S100A8 • S100A9 • TNFSF10

Pityriasis rubra pilaris with symmetric polyarthralgia and lymphadenopathy (SID 2025) - "Proposed treatments include immunomodulators, acitretin, methotrexate and isotretinoin...He also had an impressive response to sonidegib, with shrinking of the large BCC tumors on his back, which were subsequently excised via Mohs...Regarding treatment of the patient's joint pain, the patient was continued on ixekizumab and started on celecoxib as needed for pain. PRP-associated arthritis is a rare component of the primarily dermatologic disorder, and it is important for clinicians to be aware of this association to adequately address joint manifestations. When applicable, paraneoplastic PRP should be explored, and underlying neoplasms should be treated."

Genetic Disorders • Immunology • Inflammatory Arthritis • Musculoskeletal Diseases • Musculoskeletal Pain • Non-melanoma Skin Cancer • Pain • Rheumatology • Skin Cancer • Solid Tumor • IL17A

MAIN CLINICAL MANIFESTATIONS AND ANALYSIS DISORDERS OF ICHTHYOSIS DISEASE DURING CHILDHOOD (ESPGHAN 2025) - "66,3% of patients only received topic treatment and 33,7% of them were also given oral treatment (acitretin or subcutaneous biologics)...The main micronutrients disorder is deficiency of vitamin-D. Therefore, the early diagnosis and supplementation of deficiencies could be satisfactory in these patients."

Clinical • Alopecia • Atopic Dermatitis • Dermatology • Dry Eye Disease • Endocrine Disorders • Immunology • Keratitis • Ocular Inflammation • Ophthalmology • Otorhinolaryngology • Secondary Hyperparathyroidism • Vitiligo

Not Just an Itch: A Rare Dermatological Manifestation in Chronic Kidney Disease (ERA 2025) - "Her medical history includes long-standing hypertension treated with irbesartan, a surgically and endovascularly managed cerebral aneurysm in 2006, and a history of preeclampsia and HELLP syndrome during pregnancies (G5P5)...Current medications include esomeprazole, acetylsalicylic acid, sertraline, epoetin beta, folic acid, sevelamer, cinacalcet, cholecalciferol, calcitriol, and lactulose...The onset of the lesions coincided with the initiation of atorvastatin therapy, which was discontinued without clinical improvement...Treatment was started with acitretin 10 mg, allopurinol 100 mg, and emollients, resulting in initial improvement... This case underscores the importance of recognizing RPC as a rare but clinically significant skin disorder, particularly in patients with systemic illnesses like CKD. While uncommon, its association with systemic diseases highlights the need for a multidisciplinary approach. After excluding potential drug-induced causes, a skin biopsy..."

Autosomal Dominant Polycystic Kidney Disease • Cardiovascular • Chronic Kidney Disease • Dermatology • Diabetes • Diabetic Nephropathy • Genetic Disorders • Gynecology • Hypertension • Metabolic Disorders • Mood Disorders • Nephrology • Oncology • Polycystic Kidney Disease • Pruritus • Renal Disease • Vascular Neurology

Outcomes of Isolated Nail Psoriasis Treatment With Roflumilast 0.3% Cream: A Case Series of 7 Patients. (PubMed, J Cutan Med Surg) - "Topical roflumilast showed promising results to treat topically NP. In this case series topical roflumilast was effective, well-tolerated and not associated with AEs."

Journal • Dermatology • Immunology • Inflammatory Arthritis • Psoriasis • Psoriatic Arthritis • Rheumatology • Seronegative Spondyloarthropathies

Urbach-Wiethe syndrome: report of two clinical cases. (PubMed, Dermatol Reports) - "Treatment remains a major challenge since no standardized therapies exist, but oral acitretin appears to be effective in improving skin manifestations. We report two clinical cases of young women suffering from LP, presenting with dermatological, otorhinolaryngological, and neurological symptoms, currently referred to our Rare Cutaneous Syndrome Center at the Policlinico Umberto I in Rome (Italy)."

Journal • CNS Disorders • Cognitive Disorders • Dermatology • Developmental Disorders • Dysphonia • Dystonia • Epilepsy • Gastrointestinal Disorder • Infectious Disease • Movement Disorders • Otorhinolaryngology • Respiratory Diseases

Pediatric Pustular Psoriasis in Southern China: A 12-Year Retrospective Analysis of 41 Cases Focusing on Clinical Characteristics and Treatment Outcomes. (PubMed, Psoriasis (Auckl)) - "Patients who received acitretin alone were designated as the Acitretin group, while those who received acitretin combined with intravenous immunoglobulin, ciclosporin, or steroids (or any combination of these agents) were identified as the Combination group. Common comorbidities include nutritional disorders such as malnutrition and anemia. Combination treatment based on acitretin is recommended for children with PP and severe inflammation."

Journal • Retrospective data • Dermatology • Hematological Disorders • Immunology • Inflammation • Pediatrics • Psoriasis • Pustular Psoriasis • CRP

Clinicopathological and management outcome in 70 patients with pityriasis rubra pilaris: A retrospective analysis. (PubMed, Indian J Dermatol Venereol Leprol) - "Oral retinoids, especially acitretin, were the most preferred and effective treatment. Five patients showed improvement with methotrexate and two needed biological agents...Conclusion PRP is still a rare, difficult-to-manage disease. More studies are required to standardise and improve the diagnosis and treatment approaches for the disease."

Journal • Retrospective data • Dermatology • Dermatopathology • Rare Diseases

Cardiovascular safety of systemic psoriasis treatments: A prospective cohort study in the BIOBADADERM registry. (PubMed, J Eur Acad Dermatol Venereol) - "This real-world evidence study indicates a potential association between APR and IL-17 with a lower incidence of MACE, while CYC showed a higher incidence compared to MTX. These findings underscore the importance of considering cardiovascular outcomes when selecting systemic therapies for patients with psoriasis."

Journal • Cardiovascular • Dermatology • Immunology • Inflammation • Psoriasis • IL12A • IL17A • IL23A

Successful treatment of generalized pustular psoriasis with chronic hepatitis B using spesolimab: A case report. (PubMed, Medicine (Baltimore)) - "Our study shows that spesolimab could be employed as a safe and effective therapeutic option for patients with GPP and other underlying conditions."

Journal • Dermatology • Hepatitis B • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure • Psoriasis • Pustular Psoriasis

Poikiloderma With Neutropenia due to Novel USB1 Mutation. (PubMed, Pediatr Dermatol) - "We present a 17-year-old male with a novel USB1 gene mutation (c.368T>C [p.Leu123Pro]), who exhibited typical dermatological features, including poikiloderma, nail thickening, and calcinosis cutis, in addition to hypogonadism. This case highlights the broad clinical spectrum of PN and the need for comprehensive care and surveillance."

Journal • Dermatology • Endocrine Disorders • Hematological Disorders • Infectious Disease • Metabolic Disorders • Neutropenia • Oncology

Hypertrophic lupus erythematosus hypertrophic lichen planus overlap responding to acitretin and anifrolumab. (PubMed, JAAD Case Rep) - No abstract available

Journal • Cutaneous Lupus Erythematosus • Dermatology • Dermatopathology • Immunology • Inflammatory Arthritis • Lichen Planus • Lupus

Clinical Responses and Transcriptomic Analysis of Spesolimab in a Girl With Severe Dermatitis, Multiple Allergies and Metabolic Wasting Syndrome. (PubMed, Exp Dermatol) - "Previous studies have demonstrated that acitretin and systemic biologics targeting IL-17, IL-12/IL-23, and IL-4 are effective in treating SAM syndrome. This case highlights the therapeutic potential of targeting the IL-36 pathway in SAM syndrome and supports the use of skin RNA-seq for personalised selection of anti-inflammatory biologics in rare dermatological disorders. This report marks the first clinical application of Spesolimab in SAM syndrome, offering a novel therapeutic approach."

Journal • Allergy • Cachexia • Dermatitis • Dermatology • Genetic Disorders • Immunology • Infectious Disease • Psoriasis • Pustular Psoriasis • IL12A • IL17A • IL23A • IL4

Modulating the NLRP3 Inflammasome: Acitretin as a potential treatment for Sepsis-induced acute lung injury. (PubMed, Int Immunopharmacol) - "Acitretin demonstrated significant anti-inflammatory properties through the suppression of the NLRP3 inflammasome, suggesting its potential as a therapeutic strategy for sepsis and related complications."

Journal • Acute Lung Injury • Dermatology • Immunology • Infectious Disease • Inflammation • Psoriasis • Respiratory Diseases • Septic Shock • IL1B • NLRP3

Possible ruxolitinib-associated acquired epidermodysplasia verruciformis and skin cancers: a case report (EADO-WCM 2025) - "The patient had a history of nonmelanoma skin cancers (NMSCs) and viral warts, previously treated with cryotherapy, topical imiquimod, and surgeries...Acitretin initiation and HPV vaccination were under consideration but have not yet been implemented, as the patient initially received care outside the authors' institution...Its immunosuppressive effects may predispose patients to HPV-related conditions and skin malignancies. Advances in HPV typing and gene sequencing may further aid in identifying AEV lesions with a higher risk of progression to SCC."

Case report • Clinical • Basal Cell Carcinoma • Dermatology • Genetic Disorders • Non-melanoma Skin Cancer • Polycythemia Vera • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma • Squamous Cell Skin Cancer

Association of Obesity and Innate Immune Markers With Resistance to Biologic Therapy in Psoriasis. (PubMed, JAMA Dermatol) - "A cross-sectional study was carried out including patients aged 18 years or older who visited the Gachon University Gil Medical Center dermatology clinic between January 2012 and December 2022 with plaque-type severe psoriasis with a Psoriasis Area and Severity Index score greater than 10 and body surface area larger than 10 despite conventional treatment with cyclosporine, methotrexate, acitretin, and phototherapy for longer than 3 months, and treatment with biologics for at least 24 months. This cross-sectional study found that dysregulated innate immune responses in the epidermis and heightened neutrophil activity may be responsible for decreased sustainability of therapeutic responses to biologics. Given that current biologics mainly target dermal adaptive immune-related mediators, the development of novel therapeutic strategies to target the epidermal innate immune response, including neutrophils, is warranted."

Journal • Dermatology • Genetic Disorders • Immunology • Obesity • Oncology • Psoriasis • CXCL8 • IL17A • IL1R1 • IL23A • LCN2 • S100A8 • S100A9 • TNFA • TNFSF10

Epidemiological, Genetic, Clinical, and Treatment Differences of Generalized Pustular Psoriasis and Acrodermatitis Continua of Hallopeau Across Ethnicities: A Systematic Review. (PubMed, Am J Clin Dermatol) - "This systematic review underscores notable ethnic differences in genetic profiles, clinical features, and therapeutic responses in GPP and ACH. The diagnosis of GPP and ACH may differ across studies and the true impacts of ethnicities on these differences remain to be confirmed. Nonetheless, the results from this study enhance our understanding of the heterogeneous characteristics of GPP and ACH, highlighting the necessity of incorporating ethnic differences into the diagnosis, genetic testing, and management strategies for patients with GPP and ACH."

Journal • Review • Dermatitis • Dermatology • Immunology • Psoriasis • Pustular Psoriasis

Apolipoproteins in Psoriasis: The Effect of Acitretin Treatment and UVB Phototherapy. (PubMed, Metabolites) - "The results of this study confirm the presence of metabolic disturbances in psoriatic patients. The treatment with NB-UVB or acitretin did not cause any significant changes in the apolipoproteins profile. Thus, we found no detrimental impact of acitretin on the apolipoproteins profile, despite the observed rise in total cholesterol concentration after the treatment. Further research is needed to explore whether specific therapeutic approaches can modify these disturbances and potentially improve long-term cardiovascular outcomes in this population."

Journal • Cardiovascular • Dermatology • Immunology • Inflammation • Metabolic Disorders • Psoriasis • APOA1 • APOA2 • APOC1 • APOD • APOE • CLU • CRP

Analysis of the therapeutic effect of acitretin capsules combined with cooling blood and detoxifying formula on psoriasis hemorrhagic fever and its impact on the gut microbiota of patients. (PubMed, Medicine (Baltimore)) - "The EG also showed a significant increase in GM diversity after treatment (P < .05). Acitretin capsules combined with the CBDF is effective in treating psoriasis hemorrhagic fever and positively affects the GM, offering a potential new treatment approach."

Journal • Dermatology • Hematological Disorders • Immunology • Inflammation • Psoriasis • IL2 • IL6

Brodalumab for Darier Disease: A Case Series Highlighting IL-17 Inhibition as a Potential Treatment. (PubMed, Int J Dermatol) - No abstract available

Journal • IL17A

Comparative Analysis of Sociodemographic, Clinical Features, Laboratory Findings, and Treatment Protocols in Generalized and Localized Cutaneous Lichen Planus. (PubMed, Cureus) - "Narrowband ultraviolet B and acitretin were more effective in treating patients with GCLP (p<0.001 and p=0.001, respectively). When the relapse rates in both LP groups were compared, relapses were more frequent in the patients with GCLP (p=0.022).  The lesion localization, treatment needs, and relapse rates of patients with GCLP differ from those of patients with LCLP.  This article was previously presented as an e-poster at the 32nd National Turkish Dermatology Congress on November 24, 2024."

Journal • Dermatology • Dermatopathology • Dyslipidemia • Hepatitis B • Hepatology • Hypertriglyceridemia • Infectious Disease • Inflammation • Lichen Planus • Pruritus

Lessons learned from the COAST (Contemporary Outcomes After cutaneous SCC in Transplant recipients) study: management and outcomes following the first cutaneous squamous cell carcinoma in kidney transplant recipients (EADO-WCM 2025) - "Within 6 months of a first CSCC, 6% started systemic chemoprevention (acitretin/nicotinamide), 20% had topical chemoprevention (mainly 5-fluorouracil cream) and 5% destructive therapies...IR strategies were variable within and between study centres (Figure 1) and were more frequently undertaken in patients with HR-CSCC or in those on azathioprine (p=0.01)...These data highlight the urgent need for prospective studies to identify optimal management of KTR following a first CSCC. Here we propose a risk stratification approach which may be used to guide use of prevention strategies."

Clinical • Basal Cell Carcinoma • Dermatology • Non-melanoma Skin Cancer • Oncology • Squamous Cell Carcinoma • Squamous Cell Skin Cancer • Transplantation

Management of Mycosis Fungoides and Sézary Syndrome With Oral Systemic Therapies. (PubMed, J Cutan Med Surg) - "FDA-approved oral therapies include bexarotene and vorinostat, both of which are effective in patients who are recalcitrant to prior topical therapies. Off-label oral therapies include methotrexate, acitretin, and chlorambucil...Chlorambucil is mainly used to treat erythrodermic MF. Investigational oral therapies for MF include tenalisib, duvelisib, cerdulatinib, lenalidomide, bortezomib, and azacytidine, and direct comparison studies between these investigational agents and FDA-approved therapies should be undertaken to better understand their role in the management of MF and SS."

Journal • Review • Cutaneous T-cell Lymphoma • Dermatology • Hematological Malignancies • Lymphoma • Mycosis Fungoides • Oncology • Sezary Syndrome • T Cell Non-Hodgkin Lymphoma