amiodarone / Generic mfg. - LARVOL DELTA

Amiodarone promoted autophagy and enhanced tissue repair, outperforming albendazole in treating the muscular phase of experimental trichinellosis spiralis. (PubMed, J Mol Histol) - "Our results revealed, for the first time, the exceptional potential of AMD as an autophagy modulator and regenerative supporter in treating trichinellosis. Thus, further investigations for the role of autophagy inducers as therapeutic options against other parasitic infections are recommended."

Journal • Infectious Disease • Inflammation • MAP1LC3B

Long-Term Outcomes and Post-Ablation Medication De-Escalation After Catheter Ablation for Premature Ventricular Complexes: A Nationwide Cohort Study. (PubMed, Int J Gen Med) - "Medication analysis confirmed dose de-escalation, particularly for mexiletine, propafenone, and amiodarone. Radiofrequency catheter ablation was associated with meaningful reductions in antiarrhythmic medication use, underscoring its potential therapeutic and economic benefits. These findings support radiofrequency catheter ablation as a component of long-term management strategies, while future prospective studies are needed to refine candidate selection and timing of intervention."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Prevalence, Spectrum, and Determinants of Cardiac Arrhythmias in the Postoperative Period Following Coronary Artery Bypass Grafting (CABG): A Prospective Observational Study. (PubMed, Cureus) - "Postoperative arrhythmias, particularly atrial fibrillation, are common after CABG and significantly worsen short-term outcomes. Longer cardiopulmonary bypass duration, higher BMI, and older age independently increase risk. Given the unique cardiovascular profile of South Asian populations, focused postoperative monitoring and preventive strategies are essential to reduce arrhythmia-related complications."

Journal • Observational data • Atrial Fibrillation • Cardiovascular

Real-World Impact of Amiodarone on Apixaban Population Pharmacokinetics in Hospitalized Patients. (PubMed, Clin Transl Sci) - "Overall differences in apixaban exposures do not appear to be clinically significant across both dosing regimens, but amiodarone coadministration was found to decrease apixaban clearance by 33% (ranging from 12% to 48%). The results support the current practice of no empiric dose adjustment for apixaban when concurrently administered with amiodarone."

Journal • PK/PD data • Real-world evidence • Atrial Fibrillation • Cardiovascular

Sex differences in out-of-hospital cardiac arrest across age groups. (PubMed, Heart) - "Sex differences in OHCA characteristics and outcomes were observed across all age groups and became more pronounced with increasing age, consistently indicating a better prognosis for males."

Journal • Cardiovascular • Pediatrics

Successful Reversion of Refractory Supraventricular Tachycardia With Neostigmine During Emergent Endoscopic Retrograde Cholangiopancreatography: A Case Report. (PubMed, A A Pract) - "We describe a 69-year-old man in septic shock undergoing an emergent endoscopic retrograde cholangiopancreatography (ERCP) whose narrow-complex supraventricular tachycardia (SVT, 180-200 bpm) persisted despite synchronized cardioversion, vagal maneuvers, adenosine, esmolol, and amiodarone. Noting transient reversion during maneuvers provoking vagal stimulation, when SVT reoccurred we titrated intravenous neostigmine in 0.5 to 1.0 mg increments (3.5 mg total), achieving a stable sinus rhythm at 80 bpm without adverse effects. This case illustrates neostigmine's value as an off-label vagomimetic rescue when guideline-directed therapies fail, and vagal stimulation appears beneficial. ."

Journal • Cardiovascular • Septic Shock • Ventricular Tachycardia

Initial Double Sequential External Defibrillation for Refractory Ventricular Fibrillation in Cardiac Sarcoidosis. (PubMed, JACC Case Rep) - "DSED can be safely and effectively used as initial therapy in patients with refractory VF."

Journal • Cardiovascular • Immunology • Sarcoidosis

A Rare Case of Overlapping Severe Cutaneous Adverse Reactions (ACAAI 2025) - "Although other new medications included midodrine and amiodarone, these were stopped prior to admission. Vancomycin is an uncommon culprit for both AGEP and DRESS. Detailed history and broad differential are crucial for evaluation of drug eruptions to guide appropriate management and follow up."

Clinical • Eosinophilia • Immunology

Real-life Organochlorine Mixture-Induced Lipid Dysregulation and Oxidative Stress in Leydig TM3 Cells: Mechanistic Insights into Male Reprotoxicity. (PubMed, Toxicology) - "Instead, the lipidomic signature closely resembled that of the lipotoxic drug amiodarone, rather than a non-cytotoxic fatty acid mixture. Our findings underscore the central role of lipid metabolism in testicular function and demonstrate that OC-MIX exerts reproductive toxicity via complex, non-classical endocrine mechanisms. This study highlights the value of integrating lipidomics with mechanistic in vitro models to assess the reproductive toxicity of environmental chemical mixtures."

Journal • Metabolic Disorders

Usability of CHA2DS2VASC score in predicting the effectiveness and safety of pharmacological cardioversion - data from the multicenter cardioversion with intravenous ANTazoline study. (PubMed, Front Cardiovasc Med) - "Antazoline was used in 59% of patients, amiodarone in 53%, and propafenone in 19%. In this retrospective sub-analysis of the CANT II registry, success of pharmacological cardioversion of AF is not associated with number of comorbidities as assessed by the CHA2DS2VASc score. PCV remains a feasible and generally safe option in emergency and cardiology department practice."

Journal • Atrial Fibrillation • Cardiovascular • Hypotension

Risk of serious bleeding with concomitant use of apixaban or rivaroxaban with amiodarone compared to flecainide or sotalol in patients with atrial fibrillation (ASH 2025) - "Covariates were well balanced post-matching (standardized differences <0.1).After matching, 253 patients in the amiodarone group experienced serious bleeding (25.8 events per1,000 person-years) compared to 175 in the comparator group (16.4 events per 1,000 person-years) (HR,1.53; 95% CI, 1.26 to 1.86).CONCLUSIONIn this comparative safety study, among patients with AF treated with apixaban or rivaroxaban,concomitant use of amiodarone was associated with a higher risk of serious bleeding compared to use offlecainide or sotalol. These findings highlight the importance of considering drug-drug interactions whenmanaging anticoagulated patients with AF to promote safe prescribing and minimize the risk of seriousbleeding complications."

Clinical • Asthma • Chronic Kidney Disease • Immunology • CYP3A4 • PER1

Characteristics and Outcomes of Mavacamten Use in 2440 Patients With Obstructive Hypertrophic Cardiomyopathy. (PubMed, J Am Heart Assoc) - "Over an 8-month median follow-up on mavacamten in patients with obstructive hypertrophic cardiomyopathy, new AF/AFL and HF occurred in 5% and 4%, respectively. Further work is needed to better understand the expected incidence of AF/AFL, HF, and other long-term outcomes of mavacamten treatment in obstructive hypertrophic cardiomyopathy."

Journal • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Genetic Disorders • Heart Failure • Hypertrophic Cardiomyopathy • Obesity • Obstructive Hypertrophic Cardiomyopathy • Ventricular Tachycardia

A Fat Chance: Paradoxical Embolic Stroke from Lipomatous Hypertrophy of the Interatrial Septum (AHA 2025) - "The patient was discharged on metoprolol, diltiazem, and amiodarone in stable condition. This case highlights a rare cause of embolic stroke—LHIS—as both a source of paradoxical embolism and a trigger for atrial fibrillation. This case highlights a rare cause of embolic stroke—LHIS—as both a source of paradoxical embolism and a trigger for atrial fibrillation. Accurate diagnosis requires histopathological confirmation, as imaging may misidentify LHIS as a myxoma. Clinicians should consider LHIS in cryptogenic stroke, especially in the presence of a PFO and interatrial masses."

Alzheimer's Disease • Atrial Fibrillation • Cardiovascular • CNS Disorders • Dementia • Diabetes • Hypertension • Ischemic stroke • Metabolic Disorders

Cardiogenic Shock due to Flecainide Toxicity: No substitute for time. (AHA 2025) - "Treatment of flecainide toxicity included sodium bicarbonate boluses, anti-tachycardia pacing, synchronized cardioversion, and amiodarone infusion...Cardiogenic shock was managed with bumetanide infusion and placement of an intra-aortic balloon pump...The patient did not tolerate milrinone due to hypotension and tachycardia...None of the antiarrhythmic strategies were immediately successful at restoring sinus rhythm. Ultimately, the most successful strategy was tincture of time to allow for flecainide clearance and the patient recovered."

Acute Kidney Injury • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypotension • Nephrology • Pulmonary Disease • Renal Disease

Flecainide Reduces Exercise-Induced Arrhythmic Burden in PKP2-Related Arrhythmogenic Cardiomyopathy (AHA 2025) - "Eight patients (mean age 31 ± 13 years, 50% male) underwent both on and off flecainide for a total of 29 ESTs [on beta-blockers (80%), flecainide (52%), amiodarone (3%), or sotalol (3%)]. Flecainide significantly reduces the EST arrhythmic burden in patients with PKP2-ACM, particularly in the recovery phase. Future studies are needed to determine if the EST can be used to guide flecainide dosing and efficacy in PKP2-ACM akin to current strategies employed for catecholaminergic polymorphic ventricular tachycardia."

Cardiomyopathy • Cardiovascular • Ventricular Tachycardia

The Hypertrophic Heart That Told Two Stories: A Case of Coexisting Hypertrophic Cardiomyopathy and Fabry Disease (AHA 2025) - "Telemetry captured one episode of SVT lasting approximately 24–30 seconds and multiple episodes of NSVT.The patient was started on IV amiodarone, which resolved the SVT and NSVT, though she remained in Afib with RVR. Anticoagulation with IV heparin was initiated...She was referred for endomyocardial biopsy and further evaluation for potential gene-targeted therapy.Discussion This case illustrates the rare coexistence of sarcomeric HCM and Fabry disease in a single patient. It underscores the importance of comprehensive evaluation, including genetic testing, in patients with hypertrophic cardiomyopathy - especially when imaging or family history raises suspicion for an infiltrative or metabolic etiology."

Clinical • Cardiomyopathy • Cardiovascular • Fabry Disease • Genetic Disorders • Hypertrophic Cardiomyopathy • Lysosomal Storage Diseases • Metabolic Disorders • Pulmonary Disease • Rare Diseases

Safety of Dofetilide Initiation Following a Shortened Amiodarone Washout Period (AHA 2025) - "In this cohort, dofetilide initiation less than 90 days after amiodarone discontinuation was not associated with increased torsades de pointes risk. These data challenge and support reconsideration of the blanket 3-month washout and suggest that a monitored, expedited rhythm-control transition is feasible and safe."

Clinical • Atrial Fibrillation • Cardiovascular

Comparative 1-Year Outcomes of Dofetilide Versus Amiodarone for Atrial Fibrillation in Hypertrophic Cardiomyopathy: A Propensity-Matched Study. (AHA 2025) - "In this large, real-world, propensity-matched analysis of HCM patients with AF, dofetilide was associated with markedly improved one-year survival and reduced major adverse cardiovascular events compared to amiodarone, despite higher AF recurrence rates. These findings challenge conventional amiodarone preference in structural heart disease and support prospective randomized trials to optimize antiarrhythmic strategies in this high-risk population."

Atrial Fibrillation • Cardiomyopathy • Cardiovascular • CNS Disorders • Heart Failure • Hypertrophic Cardiomyopathy • Ischemic stroke • Myocardial Infarction • Nephrology • Renal Disease • Ventricular Tachycardia

Sustained Ventricular Tachycardia secondary to Metastatic Sarcoma complicated by Propranolol-Induced Right Ventricular Heart Failure (AHA 2025) - "Dobutamine was discontinued and the patient was transferred out of the cardiac intensive care unit on oral amiodarone and mexiletine.DiscussionIn our case, metastatic sarcoma involving the right ventricle triggered sustained ventricular tachycardia. Amiodarone, lidocaine, and procainamide were used with improvement in ventricular rate. Propranolol was added due to its superior efficacy compared to other beta-blockers in pharmacologic cardioversion of VT storm.1 Although it successfully terminated sustained ventricular tachycardia, propranolol precipitated right ventricular failure in the context of sarcoma-induced right ventricular dysfunction, necessitating hemodynamic support with inotrope therapy."

Metastases • Cardiovascular • Congestive Heart Failure • Heart Failure • Metabolic Disorders • Pulmonary Disease • Sarcoma • Solid Tumor • Squamous Cell Carcinoma • Ventricular Tachycardia

Intravenous sotalol in pediatric cardiac intensive care patients compared to other antiarrhythmics: insights from a multicenter database (AHA 2025) - "Intravenous sotalol use in pediatric intensive care patients was associated with lower inpatient mortality and comparable length of stay compared to amiodarone and procainamide after regression analyses. These results support that intravenous sotalol is a safe alternative for pediatric arrhythmia management, meriting further prospective studies."

Clinical • Cardiovascular • Critical care • Heart Failure • Pediatrics • Ventricular Tachycardia

Impact of Advanced Cardiac Life Support Medications on Discharge Neurologic Function for Survivors of Cardiac Arrest With ECPR (AHA 2025) - "To minimize inherent bias in the receipt of ACLS drugs, we used inverse probability treatment weights balancing on age, total CPR time, initial rhythm, and pre-cannulation neurologic comorbidity.Results - As seen in Figure 1, antiarrhythmics were more likely to have a better neurological outcome (amiodarone p < 0.05 for CPC 1 and 2 cutoffs, lidocaine p < 0.001 for CPC 1-3 cutoffs). Consequently, the role of medications whose purpose is to achieve ROSC is unclear in patients being cannulated for ECPR. Our data support that increasing doses of epinephrine and non-antiarrhythmic ACLS medications both worsen the probability of neurologically-intact survival for patients who undergo ECPR."

Metastases • Cardiovascular • CNS Disorders

Iatrogenic aortocoronary dissection treated with bail-out stenting and requiring triple therapy: A case report (AHA 2025) - "Follow up CT chest showed a stable dissection flap, IV cangrelor was switched to aspirin and clopidogrel, and home apixaban was resumed. Hospital course was uneventful except for an episode of atrial fibrillation with rapid ventricular response, treated accordingly with beta blocker and amiodarone...She also was treated aggressively with high dose beta-blocker, as tolerated, to keep her heart rate below 60. Along with holding aspirin, these strategies resulted in hematoma resolution."

Case report • Clinical • Atrial Fibrillation • Cardiovascular

Resuscitative Balloon Occlusion of the Aorta with Head Up Cardiopulmonary Resuscitation VersusConventional Cardiopulmonary Resuscitation in a Porcine Model of Prolonged Cardiac Arrest (AHA 2025) - "After 26 minutes, epinephrine and amiodarone were given and defibrillation performed a minute later. In this ongoing study, HUP-CPR resulted in superior hemodynamics versus C-CPR beforeREBOA inflation. After 18 minutes of CPR, MAP and CerPP were significantly higher after REBOA inflation in the HUP-CPR group. By contrast, no significant hemodynamic changes were observed in the C-CPR group after REBOA inflation."

Preclinical • Anesthesia • Cardiovascular

Catheter Ablation Versus Antiarrhythmic Drug Therapy for Ventricular Tachycardia in Structural Heart Disease: A Meta-Analysis of Randomized Controlled Trials (AHA 2025) - "Antiarrhythmic drugs used were amiodarone, sotalol, mexiletine, and procainamide, with earlier studies using a wide array of therapies and later often using only amiodarone and sotalol. Catheter ablation significantly reduces the risk of VT recurrence, VT storm, and hospitalizations compared to AAD therapy in patients with structural heart disease. Although no mortality benefit was observed, these findings support catheter ablation as a potentially superior initial strategy for VT management in this population. More high-quality studies are warranted to clarify the long-term safety and effectiveness of this procedure."

Retrospective data • Cardiovascular • Heart Failure • Ventricular Tachycardia

The Wrong Hoofbeats: Chagas Cardiomyopathy Presenting as Ventricular Tachycardia with Misleading Lyme Serology (AHA 2025) - "He was started on guideline-directed medical therapy for cardiomyopathy and anticoagulation for LV thrombus. Amiodarone was initiated for VT, and an automatic implantable cardioverter defibrillator was placed for secondary prevention."

Cardiomyopathy • Cardiovascular • Dermatology • Immunology • Lyme Disease • Sarcoidosis • Thrombosis • Ventricular Tachycardia