amiodarone / Generic mfg. - LARVOL DELTA

Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery (clinicaltrials.gov) - P2 | N=0 | Withdrawn | Sponsor: Baystate Medical Center | N=60 ➔ 0 | Not yet recruiting ➔ Withdrawn

Enrollment change • Trial withdrawal • Atrial Fibrillation • Cardiovascular

Prevention of New Onset AF After TAVI (PAF-TAVI Trial) (clinicaltrials.gov) - P3 | N=121 | Completed | Sponsor: Ana Belen Rivas Paterna | Unknown status ➔ Completed

Trial completion • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure

Amiodarone-induced liver injury with bright liver sign: A case report. (PubMed, World J Radiol) - "Amiodarone deposition within the liver can result in hepatic injury accompanied by diffuse hepatic hyperattenuation on CT, mimicking other conditions associated with increased liver attenuation. MRI plays a crucial role in differential diagnosis. By combining this case with a review of the relevant literature, we summarize the characteristic imaging features of AILI to facilitate its diagnosis and management."

Journal • Atrial Fibrillation • Cardiovascular • Genetic Disorders • Hematological Disorders • Hepatology • Liver Failure

Cardiac Paroxysmal Orthodeoxia Syndrome: A comprehensive process of this challenging disease starting from the clinical suspicion till the therapeutic procedure. (PubMed, Curr Probl Cardiol) - "The diagnosis of POS has been challenging especially during the current pandemic. Our case emphasizes on the importance of a detailed history and physical exam, the role of multimodality imaging techniques to diagnose POS and the high success rate of percutaneous methods for PFO closure."

Journal • Review • Cardiovascular • Fibrosis • Immunology • Infectious Disease • Musculoskeletal Diseases • Novel Coronavirus Disease • Orthopedics • Pulmonary Disease • Pulmonary Embolism • Rare Diseases • Respiratory Diseases

Melanoma development and progression during polypharmacy and the additional intake of metformin and sitagliptin: links to nitroso photocarcinogenesis and oncopharmacogenesis (EADV 2026) - "Results We present 3 cases of patients with melanomas of the skin that developed and progressed in the context of intake of secondary/tertiary amino groups: (1) Patient 1's regimen during the years included bisoprolol (secondary), nebivolol (secondary), candesartan /hydrochlorothiazide (secondary), amlodipine (secondary), and clopidogrel (tertiary), and esomeprazole (tertiary) [Figure a,b]; (2) Patient 2's included amiodarone (tertiary), apixaban, furosemide (secondary), spironolacton, and pantoprazole (tertiary) [Figure c,d]; and (3) Patient's 3 regimen included sitagliptin (secondary)/metformin (secondary and tertiary), glimepiride (secondary), and gliclazide (tertiary) [Figure e,f]. The primary defects were closed with single interrupted sutures (f). Conclusions We comment on the possible relevance of endogenous Nitroso formation in the drugs mentioned above in relation to melanoma pathogenesis."

Biomarker • Genetic Disorders • Melanoma • Oncology • Solid Tumor

Bilateral Vortex Keratopathy in a Patient Receiving Long-Term Ribociclib Therapy. (PubMed, Eye Contact Lens) - "The patient had no history of tamoxifen, amiodarone, or chloroquine use, and there were no clinical features suggestive of Fabry disease. The patient remained asymptomatic, and systemic therapy was continued without modification. This case suggests that ribociclib-associated vortex keratopathy may be detected after prolonged exposure and remain clinically silent at presentation, highlighting the importance of careful clinical assessment to avoid unnecessary interruption of essential oncologic treatment."

Journal • Age-related Macular Degeneration • Breast Cancer • Cataract • Dry Age-related Macular Degeneration • Fabry Disease • Genetic Disorders • Macular Degeneration • Oncology • Ophthalmology • Retinal Disorders • Solid Tumor

Modified ACLS and Dual Sequential Defibrillation for Refractory Ventricular Tachycardia During VA-ECMO Support (ASA 2026) - "Because VA-ECMO maintained adequate systemic perfusion, chest compressions were withheld per modified ACLS protocols. Resuscitation consisted of six standard defibrillations, two rounds of dual sequential defibrillation with anterolateral and anteroposterior pad placement, Impella repositioning, and antiarrhythmic loading with amiodarone and lidocaine before achieving return to sinus rhythm."

Acute Coronary Syndrome • Cardiovascular • Ventricular Tachycardia

When VVI Fails: Pacemaker Undersensing Triggering R-on-T Ventricular Fibrillation After Mitral Valve Repair (ASA 2026) - "Pacemaker sensitivity was optimized, and amiodarone was initiated, with no recurrence. This case highlights a rare but preventable cause of malignant arrhythmia and underscores the importance of early postoperative pacemaker interrogation."

Cardiovascular

Refractory Ventricular Tachycardia Storm: When Should Stellate Ganglion Block Be Initiated? (ASA 2026) - "She subsequently developed recurrent VT/VF requiring multiple defibrillations despite amiodarone, lidocaine, and beta-blockade therapies. A diagnosis of Takotsubo cardiomyopathy versus channelopathy was presumed. A stellate ganglion block with continuous ropivacaine infusion was performed, resulting in stabilization and allowing for further management."

Cardiomyopathy • Cardiovascular • Gastroenterology • Pancreatitis • Ventricular Tachycardia

Anesthetic Management of Emergent Thyroidectomy for Refractory Ventricular Tachycardia due to Amiodarone-Induced Thyrotoxicosis (ASA 2026) - "We report a case of refractory ventricular tachycardia necessitating emergent thyroidectomy after failure of medical therapy, including methimazole, corticosteroids, plasmapheresis, and stellate ganglion blocks. Perioperative management emphasized invasive hemodynamic monitoring, attenuation of catecholamine surges, and multidisciplinary coordination. This case highlights the complexity of severe thyrotoxicosis with refractory arrhythmias and the need for definitive surgical intervention when medical therapy fails."

Cardiovascular • Hematological Disorders • Pulmonary Embolism • Thrombosis • Ventricular Tachycardia

From Contrast to Collapse: Thyroid Storm (ASA 2026) - "Thyroid storm, likely precipitated by chronic amiodarone and iodinated contrast, was treated with standard anti-thyroid therapy and therapeutic plasma exchange prior to thyroidectomy. This case discusses thyroid storm management and potential triggers in patients with multiple risk factors."

Cardiovascular • Ventricular Tachycardia

Management of Refractory Ventricular Tachyarrhythmias and Ventricular Storm in a Patient on Mechanical Circulatory Support (ASA 2026) - "After ROSC, Impella CP was placed for severe LV dysfunction (LVEF 10%) and VA-ECMO was started for persistent hypoperfusion with multiorgan failure.The ICU course was complicated by recurrent ventricular arrhythmias and ventricular storm despite antiarrhythmic therapy with amiodarone and mexiletine, minimization of vasoactive medications, ventricular overdrive pacing, and mechanical support optimization. On HOD#9, a right stellate ganglion block was placed without further episodes of ventricular arrhythmia.This case demonstrates the complexities of arrhythmia control in multisystem organ failure."

Clinical • Cardiovascular • Ventricular Tachycardia

Thyroidectomy in Refractory Amiodarone-Induced Thyrotoxicosis with CRT-D and Ventricular Tachycardia: A Perioperative Challenge (ASA 2026) - "Postoperatively, refractory vasoplegia, likely from chronic thyrotoxicosis and cardiomyopathy, required vasopressors and ICU care. This case underscores the need for anticipatory, multidisciplinary perioperative planning in complex thyroid surgery with significant cardiac comorbidity."

Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Immunology • Obesity • Sarcoidosis • Ventricular Tachycardia

Too Long to QT: A Case of Pneumoperitoneum-Induced Torsades de Pointes (ASA 2026) - "Reinsufflation at 10 mmHg triggered recurrent torsades, treated with additional magnesium, amiodarone (150 mg), and metoprolol (10 mg), and the procedure was aborted. Postoperative evaluation revealed marked baseline QT prolongation (QTc 522 ms) due to chronic citalopram use, compounded by hypomagnesemia following bowel preparation and preoperative metronidazole. This case highlights the synergistic interaction of QT-prolonging medications, perioperative hypomagnesemia, and pneumoperitoneum-induced physiologic stress in precipitating torsades de pointes."

Clinical • Melanoma • Solid Tumor

Utilization of Stellate Ganglion Block for Treatment of Refractory Ventricular Tachycardia Storm in the ICU (ASA 2026) - "We present the case of a 69-year-old male admitted to the ICU for management of cardiogenic shock s/p LVAD placement who had frequent runs of polymorphic sustained VT despite pharmacologic treatment with amiodarone and lidocaine infusions. Following placement of a left stellate ganglion catheter with intermittent Ropivacaine boluses, the patient had significantly fewer episodes of VT overnight than in prior days and was able to tolerate endoscopy for treatment of gastrointestinal bleeding without arrhythmic events or significant hemodynamic changes. This case highlights how a stellate ganglion block can be a useful temporizing measure to stabilize a malignant arrhythmia in a critically ill patient."

Cardiovascular • Gastroenterology • Ventricular Tachycardia

Ventricular Fibrillation During Normothermic Mitomycin-C HIPEC: First Reported Case and a Multimodal Monitoring Framework for Early Recognition (ASA 2026) - "Amiodarone bolus was administered & defibrillation 200 J delivered; ROSC at 4 minutes. Patient was extubated neurologically intact. Limited reports describe ventricular arrhythmias during HIPEC (predominantly supraventricular arrhythmias); this case represents a rare occurrence of Vfib, likely due to metabolic changes and electrolyte shifts with possible bicarbonate-induced intracellular K⁺ shift contributing."

Clinical • Cardiovascular

Reversing Course: Kcentra for Emergent CABG in a Patient on Apixaban with Refractory VT (ASA 2026) - "Post-catheterization, he developed refractory non-sustained ventricular tachycardia despite amiodarone and lidocaine infusions. Four-factor prothrombin complex concentrate (Kcentra) was administered for anticoagulation reversal. This case highlights the management of anticoagulation reversal in patients requiring emergent cardiac surgery while on direct oral anticoagulants."

Clinical • Atrial Fibrillation • Cardiovascular • Coronary Artery Disease • Ventricular Tachycardia

Peripartum Paroxysmal Atrial Fibrillation - A Rare Complication of Cesarean Delivery (ASA 2026) - "Cardioversion was achieved following an intraoperative amiodarone bolus and digoxin. Transthoracic echocardiogram was performed, and outpatient Holter monitor was recommended with cardiology follow-up. In this case, we will explore the pathophysiologic causes of peripartum atrial fibrillation and treatment."

Atrial Fibrillation • Cardiovascular • CNS Disorders • Depression • Hypotension • Pulmonary Disease

Short-Coupled Polymorphic Ventricular Tachycardia Presenting as Torsades de Pointes with Normal QTc during Septic Shock: a Critical Care Management Challenge (ASA 2026) - "Electrolyte correction, magnesium, and amiodarone provided transient stabilization of her TdP. This ECG entity arises from a PVC during repolarization, creating dispersion of refractoriness, resulting in TdP. Recognition is critical, as management targets ventricular ectopy and physiologic triggers rather than QT prolongation alone."

Cardiovascular • Critical care • Renal Disease • Septic Shock • Ventricular Tachycardia

Heart Don't Fail Me Now: Perioperative Cardiac Optimization of Patient with Amiodarone-Induced Thyrotoxicosis During Thyroidectomy (ASA 2026) - "A 62-year-old man with history of sustained ventricular tachycardia (on Amiodarone daily, ICD active), severe ischemic cardiomyopathy with multi-vessel stenosis (RCA 100%, distal LAD 90%), obstructive sleep apnea, prior cardioembolic stroke with residual right-sided deficits (on Eliquis) presented for acute on chronic heart failure exacerbation with EF of 20%. Echo was notable for left ventricular wall motion abnormalities. This case required careful titration of anesthetics to maintain hemodynamics and fluid status while maintaining a deep plane of anesthesia without paralysis with multi-disciplinary coordination."

Clinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Ischemic stroke • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder • Ventricular Tachycardia

Amiodarone-induced hyperthyroidism - the efficacy of different types of management (EANM 2026) - "AIH patients treated with 131I or total thyroidectomy were more severly hyperthyroid than AIH patients managed by follow-up or medical treatment only. Since the possibility of AIH recurrence with possible deterioration of the underlying heart condition remains a critical challenge once euthyroid state has been established, our finding that duration of hyperthyroidism was similar in both groups emphasizes the efficacy of our approach to the management of AIH."

Clinical • Atrial Fibrillation • Cardiovascular • Endocrine Disorders • Ventricular Tachycardia

ASSOCIATION BETWEEN PSORIASIS AND METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD): A CASE-CONTROL STUDY (UEGW 2026) - "Individuals with viral hepatitis, significant alcohol consumption, or use of hepatotoxic medications (e.g., amiodarone, high-dose methotrexate, corticosteroids) were excluded... Despite a trend toward lower metabolic risk factors, the prevalence of MASLD in patients with psoriasis was numerically higher than in non-psoriasis controls; however, this difference did not reach statistical significance. High BMI was identified as an independent risk factor for MASLD in patients with psoriasis, while significant or advanced fibrosis appeared to be uncommon in this population. An increased burden of hepatic steatosis may be observed in patients with psoriasis, possibly linked to shared metabolic and inflammatory mechanisms."

Clinical • Addiction (Opioid and Alcohol) • Dermatology • Dyslipidemia • Fibrosis • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Cirrhosis • Metabolic Disorders • Metabolic Dysfunction-Associated Steatotic Liver Disease • Psoriasis

AMIODARONE-INDUCED CIRRHOSIS (UEGW 2026) - "Diagnosis requires high clinical suspicion and integration of drug history, characteristic imaging (hepatic hyperdensity on CT), and histopathology showing pseudoalcoholic features. Early recognition is essential, as progression may be irreversible despite drug withdrawal."

Cardiovascular • CNS Disorders • Coronary Artery Disease • Fibrosis • Hematological Disorders • Hepatology • Immunology • Nephrology • Ophthalmology • Portal Hypertension • Renal Disease

Artificial Intelligence for Precision Antiarrhythmic Drug Therapy in Atrial Fibrillation: From Recurrence Prediction to Comparative Treatment Selection. (PubMed, Medicina (Kaunas)) - "Moreover, patient-specific AF digital twins have been used to simulate electrophysiological responses to amiodarone and identify patients with different subsequent rhythm outcomes...AI-supported antiarrhythmic therapy represents a promising transition from population-based prescribing toward individualized estimation of efficacy, toxicity, and monitoring requirements. Its clinical adoption will require multicenter external validation, causal treatment-effect modeling, prospective workflow evaluation, randomized impact trials, transparent uncertainty reporting, and continued clinician oversight."

Journal • Review • Atrial Fibrillation • Cardiovascular • Heart Failure • Nephrology

Comparative Effectiveness of Amiodarone Versus Lidocaine as Antiarrhythmic Therapy for Cardiac Arrest with Shockable Rhythms: A Systematic Review and Meta-Analysis. (PubMed, J Clin Med) - " No survival difference was observed between amiodarone and lidocaine arrest. Although lidocaine showed more favorable in-hospital outcomes, long-term survival was similar, suggesting agents may be selected based on availability and practice."

HEOR • Journal • Retrospective data • Review • Cardiovascular