Advantan (methylprednisolone aceponate) / Bayer - LARVOL DELTA

Randomized clinical trial comparing removal followed by topical imiquimod versus removal followed by topical methylprednisolone in the treatment of keloids. (PubMed, Acta Cir Bras) - "Surgical removal plus application of topical imiquimod was shown as safe, and its efficacy was not statistically inferior for the treatment of keloids as compared to methylprednisolone. Due to the lack of efficacy in most therapeutic modalities, surgical removal plus topical imiquimod could be recommended as an additional first line therapy and especially for recurrent keloids. Studies with larger samples are necessary to evaluatre therapies for keloids."

Clinical • Journal • Dermatology • Fibrosis

EFFECT OF SYSTEMIC THERAPIES ON SKIN BACTERIOME IN PATIENTS WITH ATOPIC DERMATITIS: A PILOT PROSPECTIVE STUDY. (PubMed, J Invest Dermatol) - "Here, we aimed to investigate the effects of four different therapies on clinical outcomes and skin bacteriome in patients with atopic dermatitis, namely: Janus kinase inhibitors, dupilumab, cyclosporine A, and topical corticosteroids (intermittently used methylprednisolone aceponate). While overall bacteriome alpha diversity remained unchanged, the ratio of Staphylococcus to Corynebacterium and Cutibacterium decreased significantly after Janus kinase inhibitors as well as dupilumab treatment but remained stable with cyclosporine A and topical corticosteroids. These results indicate that addressing type 2 inflammation by targeted drugs alters the skin bacteriome towards a healthy balance, while traditional anti-inflammatory treatments have minimal impact on microbial composition."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation

Severe atopic dermatitis poorly controlled, or something else? (EAACI 2025) - "Chronic eczema of hands from 1 year of evolution with poor control with topical treatment with methylprednisolone aceponate and tachromilium. propolis (10% in vaseline) (++), with relevance present after being found in the list of ingredients of topical tacrólimus as white wax. Improvement in lesions after changing tacrólimus for pimecrolimus Results The forms of clinical presentation of AD are very variable, but usually includes eczema. ACD is a delayed hypersensitivity reaction to contact allergens."

Atopic Dermatitis • Dermatitis • Immunology

Analgesia in radical mastectomy. Before and after erector spinalis plane block (Euroanaesthesia 2025) - "Background and Goal of Study: In our hospital, analgesia for breast surgery has traditionally been performed using a combination of NSAIDs and morphine, obtaining acceptable results. Specifically, the erector spinae block (ESP) has meant a significant change in the way of approaching this type of surgery, improving the anesthetic and analgesic quality.Materials and We performed a retrospective analysis of 40 patients undergoing radical mastectomy.The common procedure for both groups was:- Premedication: Midazolam 2 mg, Ranitidine 50 mg, Dexamethasone 8 mg.- Induction and maintenance: sevoflurane + fentanyl + rocuronium.- Postoperative analgesia: Paracetamol 1 g alternating with Dexketoprofen.- Rescues with Tramadol 100 mg and Dolantine 50 mg.The difference between groups was that half of them received ESP at T4 level with 25 ml of 0.5% ropivacaine 20 minutes before the intervention.We evaluated: hemodynamic stability during surgery, the dose of fentanyl administered,..."

Anesthesia • Pain

GRAHAM-LITTLE-PICCARDI-LASSEUR SYNDROME IN A BULGARIAN PATIENT: CASE REPORT AND SHORT PATHOGENETIC UPDATE IN RELATION TO THE CONNECTION TO ANTIGEN/ MOLECULAR MIMICRY. (PubMed, Georgian Med News) - "Initial therapy included loratadine and topical clobetasol propionate. Due to the suspicion of possible drug-induced reaction, the antihypertensive therapy, which consisted of valsartan, bisoprolol, spironolactone, and chlorthalidone, was discontinued and replaced with moxonidine...Prescribed outpatient treatment included acitretin, bilastine, and topical prednisolone for the scalp. Improvement was observed in the lesions located on the trunk and upper and lower extremities following betamethasone/salicylic acid ointment was prescribed, and methylprednisolone aceponate cream...It is this fact that suggests that polymedication could also be considered as a trigger of lichen planus and its subforms such as GLPLS. The hypothesis surrounding alterations in tissue homeostasis as a potential trigger factor for autoimmunity is being discussed, with a specific focus on infectious and drug-induced forms of lichen planus, as well as Graham-Little-Lasseur syndrome."

Journal • Alopecia • Dermatology • Dermatopathology • Immunology • Infectious Disease • Lichen Planus • Urology

Drug-Induced Subacute Cutaneous Lupus Erythematosus Associated with Fenofibrate Lipid Lowering Agent. (PubMed, Skinmed) - "Her treatment for the past 4 years included metformin, saxagliptin, atorvastatin, vitamin B12, vitamin D, lansoprazole, and aspirin. Methylprednisolone aceponate ointment, pimecrolimus ointment 0.1%, and sunblock were prescribed. Her facial eruption was only minimally lessened, while the dermatitis worsened on the trunk, arms, and legs."

Journal • Cutaneous Lupus Erythematosus • Dermatitis • Dermatology • Diabetes • Dyslipidemia • Immunology • Inflammatory Arthritis • Lupus • Metabolic Disorders

Improvement of Fox-Fordyce disease with botulinum toxin type A (EADV 2024) - "Treatment with methylprednisolone aceponate 1mg/g ointment and clindamycin 1% gel yielded no improvement after 3 months. Due to concomitant hyperhidrosis, she received one session of intradermal injection of 75 U botulinum toxin type A (BTX-A, Botox®, Allergan, Inc) into each axilla...Other modalities with varying success rates include topical calcineurin inhibitors, tretinoin, clindamycin, oral contraceptives, laser therapy, surgical excision, and phototherapy... A 36-year-old pre-menopausal woman presented with a four-year history of multiple mildly itchy papules in both axillae. She had no significant medical history and denied previous laser hair removal or use of topical products/fragrances. Physical examination revealed multiple firm, non-tender, skin-colored follicular papules grouped in the bilateral axilla."

Aesthetic Medicine • Dermatology • Pruritus

Case report: reticular erythematous mucinosis spontaneously resolved after melanoma excision (EADV 2024) - "The patient was recommended to use topical steroids, avoiding Hydroxychloroquine because of planning for pregnancy. Patient used Methylprednisolone aceponate cream during 14 days with minor changes of the lesion color, then no treatment has been performed... Malignant tumours of the skin could be considered as one of REM underlying causes. Further clinical trials needed."

Case report • Clinical • Diabetes • Endocrine Disorders • Immunology • Inflammatory Arthritis • Lupus • Melanoma • Metabolic Disorders • Oncology • Pruritus • Solid Tumor • Systemic Lupus Erythematosus • Thyroid Gland Carcinoma

Functional and clinic evaluation in dermatomyositis (EADV 2024) - "The variation of biologic parameters and the functional tests aspect are very important for the prognostic of the disease."

Dermatomyositis • Fatigue • Immunology • Musculoskeletal Pain • Myositis • Pain • Rheumatoid Arthritis

Lupus erythematosus tumidus (EADV 2024) - "Description of patients Patient 1 Patient 2 Sex / Age Male / 30 yo Male / 53 yo Medical history of interest Hepatomegaly Hypertension, dyslipidemia, smoking Time from outbreak to diagnosis 6 months 2 years Geographical location Central Asia North-Western region of Russia Season N/A Spring-Summer Trigger factors Sun exposure, doxycycline (2 months) Sun exposure, alcohol, ACE inhibitor (3 years) Previous diagnoses Dermatitis, JLIS, Rosacea, cutaneous sarcoidosis Dermatitis, Urticaria, Rosacea Clinical manifestation 3 round shape urticarial-like erythematous-violaceous plaques (oedematous erythema) with clearly defined boundaries Multiple annular and semi annular urticarial-like erythematous- violaceus plaques (oedematous erythema) and succulent papules Localisation Face Face, neck, chest, back Itch No Yes Indirect immunofluorescence ANA < 160 dsDNA – 1,3 IU/ml ANA < 160 dsDNA 0,02 IU/ml Histology Focal perivascular and pronounced perifollicular lympocytic..."

Cardiovascular • Cutaneous Lupus Erythematosus • Dermatitis • Dermatology • Dermatopathology • Dyslipidemia • Hepatology • Hypertension • Immunology • Inflammatory Arthritis • Lupus • Metabolic Disorders • Rosacea • Sarcoidosis • Tobacco Cessation • Urticaria • Vasculitis

Chronic cutaneous lupus erythematosus in a patient with a history of Kikuchi–Fujimoto disease (EADV 2024) - "A diagnosis of CCLE was made and the patient received hydroxychloroquine 200 mg/d, methylprednisolone aceponate topically, with good tolerance and improvement within a month. I present this case to highlight the rare clinical entity of KFD in the Caucasian population, the need for a long-term follow-up, and the high risk of associated autoimmune diseases such as SLE. Our patient only developed symptoms of chronic lupus, approximately 7 years after the symptoms of KFD disappeared. Therefore, long-term follow-up of patients with this syndrome seems necessary."

Clinical • Cutaneous Lupus Erythematosus • Epstein-Barr Virus Infections • Fatigue • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Inflammatory Arthritis • Leukopenia • Lupus • Lymphoma • Non-Hodgkin’s Lymphoma • Oncology

Pilot study of a branded (marketed) formulation methylprednisolone aceponate called Advantan ointment applied to the skin in healthy male and female volunteers to determine the appropriate dose duration (ED50) for use in a pivotal in vivo bioequivalence study. (ANZCTR) - P4 | N=12 | Completed | Sponsor: Zenith Technology Corporation Limited | Not yet recruiting ➔ Completed

Trial completion • Atopic Dermatitis • Dermatology • Immunology • Psoriasis

Pilot study of a branded (marketed) formulation methylprednisolone aceponate called Advantan fatty ointment applied to the skin in healthy male and female volunteers to determine the appropriate dose duration (ED50) for use in a pivotal in vivo bioequivalence study. (ANZCTR) - P4 | N=12 | Completed | Sponsor: Zenith Technology Corporation Limited | Not yet recruiting ➔ Completed

Trial completion • Atopic Dermatitis • Dermatology • Immunology • Psoriasis

INTERESTING FACT: Delayed systemic allergic reactions to corticosteroids: Clinical symptoms y cross-reactivity (EAACI 2024) - "The ST were diagnostic in 37% of cases, two patients by PT with positive readings at D2 and D4 for the culprit drugs (hydrocortisone, budesonide, and methylprednisolone aceponate respectively), IDT were positive in only one patient with the culprit drug (dexamethasone)...The most commonly was intravenous hydrocortisone and oral methylprednisolone, both belonging to group 1...We considered necessary to prove CS from different groups to offer safe alternatives to the patients. None of them presented reactions to two or more groups of CS and although cross-reactivity exists between CS of the same group, all of our patients presented good tolerance."

Clinical • Allergy • Dermatitis • Immunology

Patch testing findings in children with suspected Allergy Contact Dermatitis at a tertiary Hospital (EAACI 2024) - "In some cases, additional batteries such as the standard series of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) was applied, as were the patient's own product and additional allergens (chlorhexidine, latex, methylprednisolone aceponate, prednicarbate) based on clinical suspicion...In 61.5% (8) of the cases, the sensitization was considered relevant. It is important to carry out an exhaustive clinical history, to orientate the test according to the clinical suspicion and to carry out a patch test for atopic dermatitis with a poor evolution or atypical location."

Clinical • Allergy • Atopic Dermatitis • Dermatitis • Immunology

Patch testing findings in children with suspected Allergy Contact Dermatitis at a tertiary Hospital (EAACI 2024) - "In some cases, additional batteries such as the standard series of the Spanish Contact Dermatitis and Skin Allergy Research Group (GEIDAC) was applied, as were the patient's own product and additional allergens (chlorhexidine, latex, methylprednisolone aceponate, prednicarbate) based on clinical suspicion...In 61.5% (8) of the cases, the sensitization was considered relevant. It is important to carry out an exhaustive clinical history, to orientate the test according to the clinical suspicion and to carry out a patch test for atopic dermatitis with a poor evolution or atypical location."

Clinical • Allergy • Atopic Dermatitis • Dermatitis • Immunology

Care and medical costs of urticaria in children in Germany : Drugs, medical and inpatient services (PubMed, Dermatologie (Heidelb)) - "The lack of guidelines for the standardization of treatment in children still leads to ambiguities and different treatment concepts among the specialist groups, which must be eliminated in order to enable more efficient therapies. The treatment of chronic urticaria in children and adolescents is mainly carried out by pediatricians, general practitioners and dermatologists. Systemic and topical medications as well as inpatient services are the most important cost factors."

HEOR • Journal • Dermatology • Dermatopathology • Immunology • Pediatrics • Urticaria

Cream versus ointment: Randomized single-blinded study on the adherence to treatment with topical methylprednisolone aceponate. (PubMed, Contact Dermatitis) - "No dependence of adherence on galenics of topical treatment of chronic hand eczema could be proved. Patients who use more emollient tend to be more adherent to the topical treatment."

Adherence • Journal • Atopic Dermatitis • Contact Dermatitis • Dermatology • Immunology • Pruritus

Treatment of Infrabony Defects by Open Flap Debridement with or without Diode Laser. (PubMed, Kathmandu Univ Med J (KUMJ)) - "Open flap debridement is the surgical procedure which provides access and visibility of the site, application of laser as an adjunct has various advantanges...Diode laser can be used safely as an adjunct. However, long-term, multicentric, histologic and microbial studies are required."

Journal • Dental Disorders • Periodontitis

Ulcers associated to the overuse of an antihemorroidal ointment containing ephedrine and benzocaine (EADV 2023) - "Patch tests were performed using the baseline series of the Grupo Español en Investigación de Dermatitis de Contacto y Alergia Cutánea, ulcer leg series, local anaesthetics series and steroid series, obtaining positive results for Benzocaine 5%, Hemoal Forte®, Methylprednisolone Aceponate and Budesonide...Discusion / Recently, several cases of perianal ulceration due to an antihemorroidal ointment (ANSO®) have been reported mimicking the previously described cases associated to topical steroids, systemic nicorandil and suppositories containing vasoconstrictive agents... We present the first case of cutaneous ulcers associated to Hemoal Forte®. A directed anamnesis is frequently the key in any diagnostic process. Moreover, among all the complementary tests to study chronic cutaneous ulcers, one must always consider patch tests as a fundamental diagnostic tool."

Anesthesia • Contact Dermatitis • Dermatitis • Dermatology • Diabetes • Gastroenterology • Gastrointestinal Disorder • Immunology • Metabolic Disorders • Pain • Type 2 Diabetes Mellitus • Urinary Incontinence

Corticosteroids: a complex case of friend and foe (BAD 2023) - "The first episode occurred in 2016 when the patient was treated for a chest infection with amoxicillin and 5-mg prednisolone...In August 2019, the patient had a dexamethasone injection to her back and subsequently developed a widespread erythematous pruritic rash...Allergic reactions to corticosteroids have been reported, with an estimated prevalence of 0.1–0.3%, with contact dermatitis to corticosteroids having a higher frequency (0.5–5%). Although not life-threatening, contact allergy to corticosteroids can have significant impacts on quality of life and on treatment.Table 1Corticosteroid series patch testing results Hapten/compound_x000D_ . %_x000D_ . 48 h_x000D_ . 96 h_x000D_ . Budesonide 0.01 +/– +++ Betamethasone-17-valerate 1  ++ Triamcinolone..."

Clinical • Allergy • Contact Dermatitis • Dermatitis • Dermatology • Immune Modulation • Immunology • Infectious Disease • Pain

Reduction in topical corticosteroids prescribed post immunomodulatory systemic treatment initiation in moderate- to- severe atopic dermatitis: a retrospective real- world chart analysis (EAACI 2023) - "Method Patients receiving systemic treatment (dupilumab, tralokinumab, baricitinib, upadacitinib or abrocitinib) for AD as standard care in the Department of Dermatology of the University Hospital Jena were reviewed...TCS prescribed prior and post-systemic treatment were mainly methylprednisolone aceponate 0,1% (45.7% prior vs. 76.8% post), mometasone furoate 0,1% (27.6% prior vs. 17.9% post) and betamethasone valerate 0,1% (22.9% prior vs. 1.9% post), all potent TCS (group III) according to WHO...Due to retrospective study design, data was available for analysis only for a limited number of cases and primarily for subjects treated with dupilumab. Further prospective studies should be conducted to assess TCS sparing effect of immunomodulatory systemic treatments for AD."

Immunomodulating • Real-world • Retrospective data • Atopic Dermatitis • Dermatitis • Immune Modulation • Immunology

"Do you have any evidence that for prostate 2 weeks of treatments has a oncological advantange?" (@merino_tomas)

Genomic Responses of Human Immune and Non-Immune Cells to Glucocorticoids (clinicaltrials.gov) - P1 | N=35 | Completed | Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) | Recruiting ➔ Completed | N=60 ➔ 35 | Trial completion date: Oct 2023 ➔ Nov 2022 | Trial primary completion date: Oct 2023 ➔ May 2022

Enrollment change • Trial completion • Trial completion date • Trial primary completion date

Genomic Responses of Human Immune and Non-Immune Cells to Glucocorticoids (clinicaltrials.gov) - P1 | N=60 | Recruiting | Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) | Trial completion date: Oct 2022 ➔ Oct 2023 | Trial primary completion date: Oct 2022 ➔ Oct 2023

Trial completion date • Trial primary completion date