amoxycillin/clavulanate / Generic mfg. - LARVOL DELTA

Beauty Centre Laser Resurfacing: When Rejuvenation Becomes Dermatological Harm (EADV 2026) - "She was treated with oral amoxicillin/clavulanic acid twice daily and topical mupirocin for three weeks. Dermatologists should proactively counsel patients about the risks of energy-based procedures, the importance of medically qualified operators, and the need to coordinate cosmetic interventions with ongoing treatment. This case also underscores the potential for permanent scarring, treatment interruption, and medicolegal consequences following inadequately supervised cosmetic procedures."

Aesthetic Medicine • Dermatology • Immunology • Infectious Disease • Pneumonia • Vitiligo

Giant Scalp Melanoma Misdiagnosed as Seborrheic Dermatitis: A Case of Diagnostic Delay and Fulminant Fatal Course (EADV 2026) - "Oral amoxicillin–clavulanic acid was initiated for erysipelas...Given rapidly progressive metastatic disease, combination immunotherapy with ipilimumab and nivolumab was initiated...Table 1. Reported cases of giant scalp melanomas"

Clinical • Dermatitis • Dermatology • Hepatology • Hypertension • Immunology • Liver Cancer • Liver Failure • Lung Cancer • Melanoma • Renal Disease • Respiratory Diseases • Seborrheic Dermatitis • Solid Tumor • SOX10

Tree trunk-like acneiform eruption induced by EGFR inhibitor treatment (EADV 2026) - "Case Presentation A 73-year-old male was treated with capecitabine and panitumumab for colorectal carcinoma with hepatic metastases when a progressive acneiform eruption developed shortly after the initiation of treatment...Medical history was significant for hepatitis B infection and other comorbidities, with concurrent medication including entecavir, metoprolol, rivaroxaban, diltiazem and irbesartan/hydrochlorothiazide. Although prophylactic treatment with doxycycline 100mg twice daily and topical corticosteroid cream had been previously prescribed, the patient was non-compliant, taking only two tablets per week. As a result, secondary Staphylococcus aureus superinfection was confirmed by skin culture and treatment was initiated with topical vaseline-salicylic acid 5%, urea 6%-clobetasol propionate, and oral amoxicillin-clavulanate 1 g twice daily...In other cases, non-compliance can also lead to postponing or interrupting treatment with EGFR inhibitors, worsening the..."

Colorectal Cancer • Dermatology • Hepatitis B • Hepatocellular Cancer • Hepatology • Infectious Disease • Solid Tumor

EPSTEIN–BARR VIRUS REACTIVATION IN A CHILD WITH GENERALIZED PUSTULAR PSORIASIS TREATED WITH SECUKINUMAB (EADV 2026) - "Initial treatment with acitretin and methotrexate was insufficient, leading to the introduction of secukinumab with rapid clinical improvement...Subsequently, the patient developed acute generalized exanthematous pustulosis induced by amoxicillin–clavulanic acid, confirmed by histopathology and pharmacovigilance assessment...This case highlights the necessity of careful monitoring and prior viral screening in children treated with secukinumab. It also demonstrates that biological therapy can be safely reintroduced after managing intercurrent complications, provided there is rigorous multidisciplinary follow-up."

Clinical • Dermatology • Dermatopathology • Endocrine Disorders • Epstein-Barr Virus Infections • Immunology • Inflammation • Plaque Psoriasis • Psoriasis • Pustular Psoriasis • Rare Diseases • IL17A

Adalimumab in Refractory Folliculitis Decalvans: Clinical Experience at Our Center (EADV 2026) - "All had previously received multiple treatments, including intralesional triamcinolone acetonide injections, oral prednisone, systemic antibiotics (doxycycline, clindamycin–rifampicin, amoxicillin/clavulanate, and ciprofloxacin), cyclosporine, and isotretinoin, with limited response...Conclusion In our experience, Adalimumab represents a well-tolerated therapeutic option associated with a moderate clinical response in patients with refractory folliculitis decalvans who have failed conventional treatments. In selected cases, treatment intensification or combination with local therapies may be required to optimize the clinical response"

Clinical • Alopecia • Dermatopathology • Immunology • Inflammation

A multi-stage assessment of a novel shampoo for seborrheic dermatitis: clinical safety and efficacy and skin microbiota analysis (EADV 2026) - "Antimicrobial activity of the shampoo (A) was evaluated according to EUCAST recommendations using the disc diffusion method, with fluconazole (25 µg) and amoxicillin/clavulanic acid (30 µg + 10 µg) as reference substances...It provided symptom relief, antimicrobial activity, and microbiome support while maintaining high tolerability. These findings indicate that it is a safe and effective option for skin cleansing in patients with SD-prone scalp."

Clinical • Dermatitis • Dermatology • Immunology • Ophthalmology • Pruritus • Psoriasis • Seborrheic Dermatitis

GRANULOMATOUS VULVITIS AS A DIAGNOSTIC CHALLENGE: A CASE REPORT (EADV 2026) - "Previous topical corticosteroid therapy was ineffective, while transient clinical improvement was observed after treatment with amoxicillin/clavulanate. Hydroxychloroquine 200 mg once daily was initiated, with dermatologic and ophthalmologic follow-up planned. Conclusion This case highlights the diagnostic complexity of Granulomatous vulvitis, particularly in the presence of non-uniform histopathological findings, and underscores the necessity of a targeted, multidisciplinary approach to exclude systemic granulomatous disorders before establishing an idiopathic diagnosis"

Case report • Clinical • Crohn's disease • Dermatology • Gastroenterology • Hematological Disorders • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Ophthalmology • Pruritus • Sarcoidosis

Erythema gyratum repens-like eruption in a patient with coexisting pemphigus foliaceus and psoriasis (EADV 2026) - "The patient was started on topical and systemic corticosteroid therapy, associated with intravenous amoxicillin-clavulanic acid and topical treatment containing neomycin, metronidazole, and hydrocortisone, resulting in rapid improvement and marked reduction of scaling within several days...Given the progressive evolution and recurrence of lesions despite corticosteroid therapy, cyclosporine treatment was initiated, resulting in progressive improvement of the cutaneous eruption. Conclusion This case highlights a rare erythema gyratum repens-like presentation associated with overlapping psoriasis and pemphigus foliaceus. Our report supports the concept that erythema gyratum repens-like eruptions may occur in the setting of autoimmune inflammatory dermatoses and should be considered in the differential diagnosis of rapidly evolving figurate erythematous lesions."

Clinical • Dermatology • Dermatopathology • Immunology • Lung Cancer • Pemphigus Vulgaris • Pruritus • Psoriasis • Solid Tumor • CRP

Efficacy of Minocycline in Refractory Hidradenitis Suppurativa: A Case Report (EADV 2026) - "She had previously received several therapeutic lines without significant improvement, including antibiotics (metronidazole, cephalosporins, amoxicillin–clavulanic acid, pristinamycin) and tetracyclines (doxycycline and lymecycline). Minocycline appears to be an effective therapeutic option in hidradenitis suppurativa, including cases resistant to other tetracyclines. This case highlights its potential benefit in refractory forms, with prolonged remission and significant improvement in quality of life After minocycline"

Case report • Clinical • Dermatology • Hidradenitis Suppurativa • Immunology

RECURRENT LOWER-LIMB ERYSIPELAS REVEALING UNDERLYING CHRONIC OSTEOMYELITIS: TWO CASE REPORTS. (EADV 2026) - "Empirical amoxicillin–clavulanic acid failed after 72 hours, with extension of the plaque, blistering and persistent invalidating pain...Conclusion Chronic osteomyelitis should be considered in any "erysipelas-like" leg that is recurrent, fails first-line antibiotics, or occurs on a limb with previous trauma, fracture, surgery or chronic ulceration. Bone imaging should be part of the initial work-up of every atypical or treatment-resistant red leg."

Case report • Clinical • Dermatology • Infectious Disease • Inflammation • Musculoskeletal Diseases • Orthopedics

Unexpected Diagnosis in a Non-Endemic Region: A Case of Facial Cutaneous Leishmaniasis in the Thrace Region of Türkiye (EADV 2026) - "It was learned that the patient had previously received amoxicillin-clavulanate, doxycycline, clindamycin, and topical antibiotics without benefit, and the lesion had progressively enlarged. This highlights the importance of individualised treatment decisions based on patient and lesion characteristics. In conclusion, this case emphasises that CL should be considered in clinically compatible lesions even in non-endemic regions such as Thrace, and successful outcomes can be achieved with appropriate, individualised treatment selection."

Clinical • Basal Cell Carcinoma • Dermatology • Hematological Malignancies • Infectious Disease • Lymphoma • Mood Disorders • Non-melanoma Skin Cancer • Respiratory Diseases • Tuberculosis

Pediatric facial sporotrichosis misdiagnosed as bacterial infection: delayed diagnosis and successful treatment with saturated solution of potassium iodide (EADV 2026) - "Prior to dermatological evaluation, he had been treated with multiple systemic antibiotics, including cephalexin, amoxicillin–clavulanate, and trimethoprim–sulfamethoxazole, in addition to surgical drainage, without clinical improvement...Although itraconazole is currently considered first-line therapy, SSKI remains an effective, accessible, and well-tolerated alternative, particularly in resource-limited settings...Early recognition prevents unnecessary treatments and ensures prompt, effective therapy with minimal sequelae. Complete resolution of the lesion after four months of SSKI treatment, with no residual scarring."

Clinical • Dermatopathology • Infectious Disease • Pediatrics

Rare primary cutaneous nocardiosis infection caused by Nocardia acidovorans in a patient receiving Zanubrutinib for B-cell lymphoma (EADV 2026) - "The patient previously received multiple courses of antibiotics including ceftriaxone and Amoxicillin/clavulanic acid over a six-month period with minimal improvement. Early biopsy and microbiologic examination are critical for establishing the diagnosis and guiding proper treatment. Healthcare providers should be aware of these atypical opportunistic infections, and their metamorphous presentations as immunomodulatory therapy becomes more common."

Clinical • Atrial Fibrillation • B Cell Lymphoma • Cardiovascular • Dermatitis • Hematological Malignancies • Hypertension • Immunology • Infectious Disease • Lymphoma • Metabolic Disorders • Mood Disorders • Nephrology • Non-Hodgkin’s Lymphoma • Obstructive Sleep Apnea • Osteoarthritis • Renal Disease • Respiratory Diseases • Sleep Disorder • Thrombocytopenia

Determinants of the Severity of Lyell Syndrome: Epidemiological and Clinical Profile, Role of the Implicated Molecule, and Time to Onset (EADV 2026) - "The most frequently implicated drugs were allopurinol (30%), lamotrigine (12.5%), NSAIDs (10%), paracetamol (10%), and amoxicillin–clavulanic acid (10%). The most severe forms occur more frequently when the time to onset is 7–28 days and after exposure to certain drug classes, particularly antibiotics and NSAIDs. Early identification of these factors remains essential to optimize prognostic assessment and patient management."

Clinical • Conjunctivitis • Keratitis • Ocular Infections • Ocular Inflammation • Ophthalmology • Steven-Johnson Syndrome

Acute Generalized Exanthematous Pustulosis Triggered by Amoxicillin-Clavulanate in a Patient With Severe Atopic Dermatitis Successfully Treated With Etanercept: A Case Report (EADV 2026) - "Cyclosporine and Augmentin were immediately discontinued...The patient was subsequently started on upadacitinib 30 mg daily for long-term AD control, achieving excellent clinical response within weeks. Conclusion This case highlights the diagnostic challenge of AGEP occurring in the setting of severe AD and supports the potential utility of etanercept as an effective therapeutic option in severe or rapidly progressive AGEP. Early recognition and prompt withdrawal of the offending agents remain essential to achieving favorable outcomes."

Case report • Clinical • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Facial Acute Localized Exanthematous Pustulosis in a Child (EADV 2026) - "His past medical history included bilateral ureteropyelic dilatation with vesicostomy and Still's disease, treated with baricitinib, canakinumab, and systemic corticosteroids...ALEP is mainly drug-induced in adults, particularly by antibiotics, whereas in children reported triggers are more diverse, including antibiotics (such as amoxicillin–clavulanic acid) as well as non-drug causes (insect bites, plant exposures…) being more represented. Early recognition is essential to promptly discontinue the suspected drug, guide allergy testings, and establish recommendations for future prescriptions. We report a new case of pediatric facial ALEP, with the aim of improving recognition and understanding of this rare form of drug-induced toxidermia."

Clinical • Immunology • Nephrology

Between grains and pain: Therapeutic challenges in six cases of mycetoma (EADV 2026) - "Results Six cases were included, comprising five actinomycetomas and one eumycetoma.Among actinomycetoma cases, three patients received Cotrimoxazole monotherapy (40 mg/kg/day), with favorable outcomes in two cases with almost complete clinical regression and no relapse after two years of follow up.In the third patient, treatment had to be discontinued due to a maculopapular drug eruption.An alternative therapeutic regimen was therefore initiated, consisting of an intensive phase with intramuscular Amikacin (15 mg/kg/day) administered for three weeks per month combined with Ciprofloxacin (500 mg twice daily) for three months...The remaining two patients, who presented with bone involvement, were treated with triple antibiotic therapy consisting of Cotrimoxazole (10 mg/kg/day), Amoxicillin–clavulanic acid (1 g three times daily) and Amikacin (15 mg/kg/day administered in cyclical regimens), resulting in progressive clinical improvement over a two years follow up period.In..."

Clinical • Infectious Disease • Pain

Morbilliform Exanthem: A Rare Etiology Not to Be Missed (EADV 2026) - "Case Presentation A 41-year-old woman with no significant past medical history presented to the emergency department with sepsis syndrome, occurring four weeks after initiation of cefixime for symptoms including fever, chills, headache, and pollakiuria, and five days after initiation of amoxicillin–clavulanic acid prescribed for suspected cholecystitis following the onset of abdominal pain associated with hepatic cytolysis. Clinical presentation of the rash Conclusion Although exceedingly rare, Q fever should be considered in the differential diagnosis of febrile morbilliform eruptions when no conventional etiology is identified, particularly in the presence of atypical clinical features and/or associated purpura. Recognition of this diagnosis allows prompt initiation of effective doxycycline therapy and may prevent unnecessary investigations for drug-induced reactions or autoimmune vasculitis."

Cardiovascular • Eosinophilia • Gastroenterology • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Inflammation • Pneumonia • Respiratory Diseases • Septic Shock • Systemic Inflammatory Response Syndrome • Vasculitis

When Two High-Risk Drugs Collide: Allopurinol-Induced DRESS Syndrome Exacerbated by Cotrimoxazole (EADV 2026) - "The progression was marked by a flu-like syndrome followed by tonsillitis and a urinary tract infection, which prompted the intake of several antibiotics, including amoxicillin-clavulanic acid, ciprofloxacin, cotrimoxazole (Bactrim), and pristinamycin . Allopurinol is a primary cause, and its presentation can be worsened by cotrimoxazole . Early recognition is essential for a favorable outcome ."

Cardiovascular • Cholestasis • Eosinophilia • Gout • Hepatology • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Nephrology • Otorhinolaryngology

When the Ephemeral Persists: Pediatric Urticarial Vasculitis – A Case Report (EADV 2026) - "Her history included a flu-like syndrome with abdominal pain and vomiting, treated with amoxicillin/clavulanic acid...Normocomplementemic disease usually has a favorable outcome, whereas hypocomplementemic forms are associated with a higher risk of chronic arthritis and renal involvement. This case underscores the generally excellent prognosis of uncomplicated pediatric UV when recognized early and managed appropriately."

Case report • Clinical • Dermatology • Immunology • Infectious Disease • Musculoskeletal Pain • Pediatrics • Renal Disease • Respiratory Diseases • Urticaria • Vasculitis

Black Hairy Tongue in a 9-Month-Old Infant Following Amoxicillin-Clavulanate Therapy: A Rare Pediatric Case Report. (EADV 2026) - "Recognition of this benign condition is important to avoid unnecessary diagnostic investigations and treatments. Conservative management with reassurance and gentle tongue brushing was sufficient for complete resolution."

Case report • Clinical • Endocrine Disorders • Infectious Disease • Pediatrics • Pneumonia • Rare Diseases • Respiratory Diseases

Efficacy of Intermittent, Cyclical Azithromycin in Pediatric Pityriasis Lichenoides: A Case Series (EADV 2026) - "Although macrolides, specifically erythromycin and to a lesser extent clarithromycin, are widely accepted therapies for children and adults, data regarding the use of azithromycin remain limited...Over the course of the disease, she did not respond to topical steroids and oral amoxicillin-clavulanate 45 mg/kg/day for 7 days...This approach reduces the cumulative dose, duration of drug exposure, and caregiver burden compared with daily dosing. Further data are required to establish the safety profile and optimal dosing regimen."

Clinical • Infectious Disease • Inflammation • Pediatrics

Missed opportunities for early diagnosis of hidradenitis suppurativa in emergency departments: a national survey of practice patterns (EADV 2026) - "Systemic antibiotics were prescribed by 72% of respondents, with amoxicillin-clavulanate being the first-line choice (75%)...Increased emphasis on early recognition of HS and the use of minimally invasive treatment, including intralesional corticosteroids, may help reduce diagnostic delay and disease-related morbidity. A timely transition from ED care to outpatient management should be organized, with referral to a dermatologist, particularly in patients with recurrent intertriginous abscesses."

Dermatology • Dermatopathology • Hidradenitis Suppurativa • Immunology • Inflammation

Breast Sarcoidosis as a Rare Case: Clinical Course and the Role of Dermatological Differential Diagnosis (EADV 2026) - "Symptoms partially improved after amoxicillin-clavulanic acid therapy; however, a subcutaneous nodule persisted...Although rare, sarcoidosis may present with breast involvement. Therefore, in cases where granulomatous inflammation is identified, sarcoidosis and other systemic granulomatous diseases should always be considered in the differential diagnosis."

Clinical • Cough • Immunology • Infectious Disease • Pulmonary Disease • Rare Diseases • Respiratory Diseases • Sarcoidosis • Tuberculosis

A mimicker of squamous cell carcinoma - a chronic scalp erosion case report with use of LC-OCT (EADV 2026) - "Empirical treatment with amoxicillin/clavulanic acid was initiated. After that, culture identified methicillin-sensitive Staphylococcus aureus (MSSA) and Escherichia coli; targeted trimethoprim-sulfamethoxazole was instituted per antibiogram.Follow-up, revealed substantial improvement with erosion size reduction and good treatment tolerance, confirmed videodermatoscopically by diminished ulceration and inflammatory features...Multimodal approaches integrating advanced imaging reduce misdiagnosis risk, potentially sparing unnecessary excisions while enabling precise infectious management. LC-OCT emerges as invaluable for non-invasive triage of ambiguous scalp lesions, supporting stepwise multidisciplinary evaluation in high-stakes sun-damaged sites to optimize outcomes and avoid overtreatment."

Case report • Clinical • Basal Cell Carcinoma • Genetic Disorders • Non-melanoma Skin Cancer • Oncology • Skin Cancer • Squamous Cell Carcinoma • Squamous Cell Skin Cancer