amoxycillin/clavulanate / Generic mfg. - LARVOL DELTA

Molecular characterization of carbapenem resistance mechanisms and phenotypic correlations in clinical Klebsiella pneumoniae isolates from Ningbo, China. (PubMed, Front Microbiol) - "The tested agents included: (1) basic antimicrobials (tigecycline, polymyxin B, ceftazidime-avibactam); and (2) combination therapy candidates (ertapenem, imipenem, levofloxacin, piperacillin-tazobactam, ceftriaxone, cefepime, trimethoprim-sulfamethoxazole, fosfomycin, amikacin, aztreonam, chloramphenicol, amoxicillin-clavulanate, ceftazidime)...The 150 strains of CRKP exhibit high resistance rates to various conventional drugs; The sensitivity rates to tigecycline, polymyxin B, and ceftazidime-avibactam were 98.7, 98.0, and 68%, respectively; Conversely, the sensitivity rates to fosfomycin, amikacin, and chloramphenicol were 72.0, 40.0, and 16.7%, respectively; The main proportions of carbapemen genes producing in CRKP are as follows: KPC-2 (61.3%), NDM-5 (14.7%), IMP-4 (8.0%), OXA-232 (6.0%), and OXA-181 (1.3%); The main proportions of β-lactamase resistance genes are as follows: CTX-M-1 (13.33%), CTX-M-3 (25.33%), CTX-M-9 (17.33%), CTX-M-14 (34.67%), SHV-1 (26.66%),..."

Journal • Infectious Disease • Pneumonia

Management of Mastitis in the Hospital Setting: An International Audit Study. (PubMed, J Hum Lact) - "The management of mastitis/breast abscess varied considerably between countries. International evidence-based guidelines for the management of lactational mastitis are urgently needed."

Journal • Inflammation • Pain

The effect of the administration form of antibiotic therapy on the gut microbiome in patients with infected diabetic foot ulcers - DFIATIM trial. (PubMed, BMC Microbiol) - P4 | "The present study reported alterations in gut microbiota composition and functionality and provided the bacterial markers as well as potential metabolic signatures associated with each administration mode in patients with iDFUs, which may be used as a reference set for future studies of the effect of antibiotics administration on the gut microbiome of patients with iDFUs. This study shed light on the importance of understanding the effect of antibiotic administration form on gut microbiome in patients with iDFUs."

Journal • Diabetes • Gastrointestinal Disorder • Infectious Disease • Metabolic Disorders

Molecular Characterization, Antibiotic Resistance, and Biofilm Formation of Escherichia coli Isolated from Commercial Broilers from Four Chinese Provinces. (PubMed, Microorganisms) - "Most of the E. coli strains were resistant to enrofloxacin (56%), followed by cefepime (54%), amoxicillin/clavulanate (52%), streptomycin (50%), ampicillin (48%), clindamycin (47%), kanamycin (41%), polymyxin B (37%), tetracycline (35%), sulfamethoxazole/trimethoprim (33%), ceftazidime (31%), meropenem (4.7%), and florfenicol (2.9%). Similarly, 24.2% of the E. coli strains were avian pathogenic E. coli strains due to the presence of five or more virulence genes, specifically tsh, ompA, fimC, iss, fyuA, and astA, in a single strain by multiplex PCR. The present study recommends continuous surveillance and effective control measures to reduce the burden of avian pathogenic E. coli-related infections in poultry."

Journal • Infectious Disease

Impact of increasing the frequency of meetings in which the Antimicrobial Stewardship Programme team conducted prospective audit and feedback on antimicrobial consumption (PubMed, Rev Esp Quimioter) - "The increase in the frequency of meetings seems to be related to better use of antimicrobials in our center."

Journal • Infectious Disease

Antimicrobial Susceptibility Profiles of Staphylococcus aureus Isolates from Domestic Pigeons in Hungary in 2022. (PubMed, Antibiotics (Basel)) - "Very high resistance rates were observed for doxycycline (97.3%), enrofloxacin (87.7%), and amoxicillin (84.9%). By contrast, low resistance rates were detected for vancomycin (5.5%) and imipenem (8.2%). Decision tree modeling identified tiamulin, enrofloxacin, and amoxicillin-clavulanate resistance as the most significant predictors of MDR status...Continued monitoring, the genetic characterization of resistant strains, and the development of effective control strategies are urgently needed. This study provides a foundation for future research aimed at understanding the biological, ecological, and epidemiological roles of pigeon-associated MDR strains."

Journal

Current Practices in Antibiotic Prophylaxis for Transoral Endoscopic Thyroid and Parathyroid Surgery: A Comparative Study. (PubMed, Medicina (Kaunas)) - "Patients were divided into two groups: 82 received eABX (intravenous cefazolin preoperatively plus 7 days of oral amoxicillin/clavulanate), and 80 received pABX alone (intravenous cefazolin). However, eABX may be prudent during the learning curve due to longer operative times and higher complication risks. Future prospective, randomized trials are needed to standardize prophylaxis regimens."

Clinical • Journal • Retrospective data • Dermatology • Infectious Disease • CRP

The Risk Factors Associated with the Carriage to Critical Antimicrobial-Resistant Escherichia coli in Healthy Household Dogs: A One Health Perspective. (PubMed, Animals (Basel)) - "This study investigated risk factors associated with E. coli resistance to amoxicillin-clavulanic acid, ceftazidime, and enrofloxacin in 263 healthy dogs from urban and rural veterinary clinics in Chile. Notably, occasional contact with free-roaming animals also exhibited a protective effect (OR = 0.32, p = 0.011). These results underscore the need for AMR surveillance in companion animals, improved antimicrobial stewardship, and the adoption of a One Health approach to effectively address AMR across species."

Journal

Challenges in the Treatment of Urinary Tract Infections: Antibiotic Resistance Profiles of Escherichia coli Strains Isolated from Young and Elderly Patients in a Southeastern Romanian Hospital. (PubMed, Biomedicines) - " A significant increase in fluoroquinolone resistance was observed, especially for ciprofloxacin (p = 0.02), alongside rising ceftriaxone resistance (p = 0.004), suggesting the spread of ESBL-producing strains. Resistance to trimethoprim/sulfamethoxazole, ampicillin, and amoxicillin/clavulanic acid remained high, limiting their empirical use...Carbapenems remain effective for severe infections, while nitrofurantoin and fosfomycin are reliable first-line options for uncomplicated UTIs. Continuous AMR surveillance is essential to optimize treatment and curb multidrug-resistant strains."

Journal • Infectious Disease • Nephrology • Novel Coronavirus Disease

First Report of CTX-M-32 and CTX-M-101 in Proteus mirabilis from Zagreb, Croatia. (PubMed, Antibiotics (Basel)) - "The study demonstrated the presence of CTX-M ESBL and CMY-16 p-AmpC among hospital and community-acquired isolates. AmpC-producing isolates showed uniform resistance patterns, whereas ESBL-positive strains had variable degrees of susceptibility/resistance to non-β-lactam antibiotics, resulting in more diverse susceptibility patterns. The study found an accumulation of various resistance determinants among hospital and outpatient isolates, mandating improvement in detecting β-lactamases during routine laboratory work."

Journal • Infectious Disease

Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach. (PubMed, Antibiotics (Basel)) - " The isolates exhibited varying resistance to critical antibiotics used in both human and animal health, including ampicillin (31/31, 100%), tetracycline (31/31, 100%), amoxicillin-clavulanate (29/31, 94%), chloramphenicol (25/31, 81%), and sulfamethoxazole-trimethoprim (10/31, 33%). The genetic complexity observed across the pork production continuum threatens food safety and may impact human health. These findings underscore the need for enhanced AMR monitoring in livestock systems and support the integration of AMR surveillance into food safety policy frameworks."

Journal

Determination of Minimum Inhibitory Concentrations of Selected Antibiotics Against Trueperella pyogenes Originated from Bovine Clinical Endometritis. (PubMed, Pathogens) - "Regarding the prevalence of any bacteria, Farm B also had significantly more bacteria (p 32 μg/mL). In summary, T. pyogenes with high MIC90 against oxytetracycline, gentamicin, and sulfamethoxazole/trimethoprim were found, which calls attention to the prudent use of antibiotics."

Journal • Endometriosis

Prevalence of phenotypic drug resistance profiles and multi-drug-resistant Pseudomonas and Acinetobacter species recovered from clinical specimens in Ethiopia: a systematic review and meta-analysis. (PubMed, BMC Infect Dis) - "The pooled prevalence of Pseudomonas and Acinetobacter species and their antibiotic resistance were alarmingly high in clinical samples in Ethiopia. These findings highlight the crucial need for more antimicrobial surveillance, stronger stewardship programs, and targeted research to combat the growing threat of resistance. Strategic public health policies are required to decrease these pathogens."

Journal • Retrospective data • Review • Infectious Disease

Antibiotic for Community-Acquired Pneumonia in Hospitalized Adults: A Systematic Review and Bayesian Network Meta-Analysis. (PubMed, Respir Med) - "This study provided an overview of the optimal antibiotics in management of adult patients with CAP, based on treatment effectiveness and safety profiles."

Journal • Retrospective data • Infectious Disease • Pneumonia • Respiratory Diseases

Detection of rare β-lactamase bla SCO-1 from a Klebsiella pneumoniae high-risk clone in Peru. (PubMed, JAC Antimicrob Resist) - "Susceptibility to amoxicillin/clavulanic acid, amoxicillin/sulbactam, piperacillin/tazobactam, aztreonam, ceftriaxone, cefotaxime, ceftazidime, ceftazidime/avibactam, cefepime, imipenem, meropenem, ciprofloxacin, trimethoprim/sulfamethoxazole, gentamicin, amikacin and tigecycline was determined using the Kirby-Bauer disc diffusion method...Illumina WGS showed the presence of bla SCO-1 and bla OXA-1, bla SHV-28, bla TEM-1, bla CTX-M-15, as well as genes associated with resistance to quinolones, fosfomycin, aminoglycosides, sulphonamides, trimethoprim and phenicols...Phylogenetic relationships were established by comparisons with 19 K. pneumoniae genomes carrying bla SCO-1 from other countries in the Americas, revealing at least three different clades. This study highlights the importance of genomic surveillance of uncommon antimicrobial resistance genes such as bla SCO-1, which might contribute to further antimicrobial resistance levels in this country."

Journal • Infectious Disease • Pneumonia

Nano-engineered Antibiotic Formulation That Targets Chronic MRSA Infection. (PubMed, Appl Biochem Biotechnol) - "MRSA isolates exhibited complete resistance to ampicillin, ciprofloxacin, amoxicillin, and amoxicillin-clavulanic acid on Mueller-Hinton agar plates...Encapsulation of ciprofloxacin, amikacin, cloxacillin, and vancomycin within vesicles demonstrated improved antimicrobial efficacy against Escherichia coli, Staphylococcus aureus, Acinetobacter baumannii, Klebsiella pneumoniae, and MRSA...The results of this study suggest that liposomal antibiotics hold significant potential for treating severe infections both systemically and topically. They may enhance therapeutic effectiveness while minimizing adverse effects, offering a promising approach to combating antibiotic-resistant bacterial infections."

Journal • Infectious Disease • Pneumonia

Intraoperative Discovery of Nephrobronchial Fistula (ATS 2025) - "Case Descriptoin: A 52 year old woman who had completed a course of ciprofloxacin for cystitis two weeks prior presented to the hospital for three days of left flank pain, nausea, and dizziness...She remained on a prolonged course of amoxicillin-clavulanate after surgical intervention and was discharged home without further pulmonary complication...In these patients, there is risk for fistula formation to pararenal structures, including the lung. Early recognition of bronchial fistulization can prevent pulmonary complications and ensure the patient has involvement by appropriate care teams."

Infectious Disease • Inflammation • Nephrology • Pain • Renal Calculi • Urology

Q Fever Pneumonia: Cross-reactivity and Diagnostic Complexity (ATS 2025) - "He had received two outpatient courses of antibiotics (amoxicillin and amoxicillin/clavulanate) and a short prednisone course without improvement...Empiric treatment was initiated with piperacillin-tazobactam and vancomycin, with the later addition of doxycycline for atypical coverage...Given severity of pneumonia and systemic involvement, he was started on planned 12-18 months of doxycycline and hydroxychloroquine...Additionally, cross-reactivity among autoimmune and infectious markers can result in false positives, further complicating the diagnostic process. A detailed exposure history and serologic testing are essential for timely diagnosis and treatment."

Cardiovascular • Cough • Crohn's disease • Dermatology • Fatigue • Gastroenterology • Hematological Disorders • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Liver Failure • Musculoskeletal Pain • Nephrology • Nicotine Addiction • Pain • Pneumonia • Renal Disease • Respiratory Diseases • Vasculitis

No Cap! Recurrent Pneumonia in a Young Immunocompetent Adult (ATS 2025) - "The patient transitioned to amoxicillin-clavulanic acid and completed 6 weeks of total antibiotic therapy...The diagnosis and treatment of FΒA is dependent upon visualization of the foreign body with brοոϲhοѕϲοpy. In this case, the patient's history of recurrent pneumonia and subtle CT findings highlight the necessity of maintaining a high index of suspicion for FBA, even when initial patient history does not suggest it."

Clinical • Addiction (Opioid and Alcohol) • CNS Disorders • Cough • Infectious Disease • Pain • Pneumonia • Respiratory Diseases

Abdominal Pain in an Immunocompromised Lung Transplant Recipient Leading to Pneumaturia (ATS 2025) - "His immunosuppressive regimen consisted of mycophenolic acid, prednisone, and tacrolimus, along with prophylactic acyclovir/letermovir, bactrim, and itraconazole...He was empirically treated with piperacillin and tazobactam, which was transitioned to amoxicillin/clavulanate on discharge...Broad spectrum antibiotics alone are often insufficient. Our patient recognized pneumaturia quickly, leading to a timely intervention with a good outcome."

Clinical • Gastrointestinal Disorder • Hematological Disorders • Idiopathic Pulmonary Fibrosis • Immunology • Infectious Disease • Leukopenia • Pain • Pulmonary Disease • Respiratory Diseases • Septic Shock • Transplantation • Urology

A Case of Unilateral Pulmonary Edema (ATS 2025) - "Intravenous clavulanate/amoxicillin and oral clarithromycin were commenced to treat a possible pneumonia. (C) TOE demonstrating severe MR jet. (D) Post-operative CXR demonstrating prosthetic mitral valve and resolved right-sided opacity."

Clinical • Cardiovascular • Cough • Infectious Disease • Pneumonia • Pulmonary Disease • Pulmonary Embolism • Respiratory Diseases • CRP

Walking Into the Diagnosis: Severe Mycoplasma Pneumonia Complicating Newly Diagnosed Chronic Lymphocytic Leukemia (CLL) (ATS 2025) - "He was diagnosed with community-acquired pneumonia (CAP), was admitted to the hospital, and received ceftriaxone and azithromycin. He was discharged 2 days later with a prescription for amoxicillin/clavulanic acid to complete an outpatient course...He was started on linezolid, piperacillin-tazobactam, and azithromycin...The patient was also started on steroids and rituximab... This case exemplifies a multifactorial presentation involving CLL with secondary infection and autoimmune complications. This highlights the importance of a thorough workup in cases of unresolving pneumonia and persistent leukocytosis to identify underlying hematologic conditions and atypical pathogens."

Anemia • Autoimmune Hemolytic Anemia • Chronic Lymphocytic Leukemia • Complement-mediated Rare Disorders • Cough • Genito-urinary Cancer • Hematological Disorders • Hematological Malignancies • Immunology • Infectious Disease • Influenza • Leukemia • Novel Coronavirus Disease • Oncology • Pneumonia • Renal Cell Carcinoma • Respiratory Diseases • Respiratory Syncytial Virus Infections • Solid Tumor

Dude, Where's My Dentures? Aspiration of Partial Dentures Leading to Post-obstructive Pneumonia (ATS 2025) - "He was discharged home with a seven-day course of amoxicillin-clavulanate for his post-obstructive pneumonia...While attempting to use a bronchial blocker to pull the dentures into the tube, we noted that the dentures were wedged at the end of the ET tube with insignificant changes to peak pressures or gas exchange. We were able to remove the dentures easily."

Infectious Disease • Pain • Pneumonia

What Is in That Airway (ATS 2025) - "Chest X-ray revealed right lower lobe pneumonia for which he received Amoxicillin-Clavulanate for 10 days and azithromycin for 5 days...The patient was discharged on Levofloxacin with pulmonary clinic follow-up...Broncholiths are generally found by imaging and confirmed with bronchoscopy. Asymptomatic patients can be observed while symptomatic patients will usually undergo bronchoscopic or surgical removal."

Back Pain • Cardiovascular • Cough • Diabetes • Hypertension • Immunology • Infectious Disease • Metabolic Disorders • Musculoskeletal Pain • Oncology • Pain • Pneumonia • Respiratory Diseases • Tuberculosis • Type 2 Diabetes Mellitus

Uncommon Presentation of Pulmonary Echinococcosis With a Bacterial Superinfection in a Non-endemic Region (ATS 2025) - "The patient was discharged on a course of amoxicillin-clavulanic acid with close follow-up. Upon follow-up, echinococcal serology was positive, eosinophilia had resolved, and albendazole therapy was initiated for suspected echinococcal cyst...Peripheral eosinophilia can be a helpful diagnostic tool when evaluating for cyst spillage, as it is not typically expected in uncomplicated cysts nor pyogenic abscesses. This case highlights the importance of considering rare parasitic infections, even in non-endemic regions, as increased immigration can lead to increased prevalence of tropical diseases, even when initial diagnoses seem straightforward."

Cough • Eosinophilia • Hepatology • Infectious Disease • Oncology • Pain • Rare Diseases • Respiratory Diseases • Tuberculosis