amoxycillin/clavulanate / Generic mfg. - LARVOL DELTA

Changes in fecal microbiota after therapeutic exposure to amoxicillin-clavulanic acid in veal calves receiving multiple antibiotics. (PubMed, Microbiol Spectr) - "Studying the impact of antibiotic therapies on the gut microbiota has One Health relevance. Thus, we aimed to (i) analyze the impact of AMC treatment on the selection of resistant bacteria in the calf gut and its composition and (ii) analyze the dissemination resistance in farms in order to advise on potential strategies to counteract further spread of these microorganisms."

Journal • Gene Therapies • Infectious Disease

A Rare Cause of Umbilical Discharge in a Healthy Adult: A Case Report of Patent Urachal Sinus in Primary Care. (PubMed, J Med Cases) - "He was commenced on intravenous amoxicillin-clavulanic acid and underwent an incision and drainage for the infected umbilical urachal sinus...This case highlights the importance of maintaining a broad differential diagnosis, including rare congenital conditions such as a patent urachal sinus, when assessing adults presenting with umbilical discharge. It also illustrates the critical role of primary care providers in recognizing uncommon conditions, as timely recognition and diagnosis are essential for the effective management of this rare but potentially serious condition."

Journal • Dermatitis • Dermatology • Diabetes • Genetic Disorders • Immunology • Infectious Disease • Metabolic Disorders • Obesity • Pain

Phenotypic and Genotypic Profiling of Fosfomycin Susceptibility in Urinary Pathogens Isolated from Pregnant Women in North India. (PubMed, Indian J Med Microbiol) - "Fosfomycin remains effective against uropathogens in pregnant women, with no plasmid-mediated resistance found in this North Indian cohort. Its single-dose administration provides a compliance benefit, particularly in low-resource prenatal care settings. Continued regional surveillance and antimicrobial management are required to maintain its effectiveness and guide empirical treatment throughout pregnancy."

Journal • Infectious Disease • Nephrology • Pneumonia

How lived experience can be used to find the causes of errors in pediatric oral liquid dosage forms. (PubMed, Arch Pediatr) - "This study contributed to the understanding of how the occurrence of errors is multifactorial: there are not only visible errors, but also numerous misunderstandings that may or may not lead to errors. Lived experience proved invaluable in elucidating the cognitive and behavioral factors contributing to these errors and Reason's taxonomy of errors emerged as useful and applicable in the context of medication administration."

Journal • Pediatrics

Prevalence, bacterial etiology, and antimicrobial susceptibility patterns of urinary tract infections among pregnant women in rural West Amhara, Ethiopia. (PubMed, Sci Rep) - "Among all isolates, resistance was high for ampicillin (66.7%) and amoxicillin-clavulanic acid (40.0%). The majority of isolates (76.2%) were susceptible to nitrofurantoin, cotrimoxazole, and cefpodoxime...In conclusion, in rural communities in Amhara, there is high resistance to first-line antibiotics used to treat UTI in pregnancy and a need for accurate, low-cost UTI diagnostic methods. Increasing access to effective treatment of UTI in low- and middle-income countries is needed to improve maternal and pregnancy outcomes."

Journal • Infectious Disease • Nephrology • Pneumonia

Saccharomyces boulardii CNCM I-745 mitigates antibiotic-induced gut microbiome functional alterations independently of the host. (PubMed, Gut Microbes) - "Using both static (MiPro) and dynamic (SHIME®) in vitro gut microbiota models, we assessed the effects of Sb supplementation under antibiotic treatment with amoxicillin/clavulanic acid (AMC) or vancomycin (Van). Collectively, these results support a beneficial role for S. boulardii CNCM I-745 in preserving directly gut microbiome function and supporting host immune homeostasis during antibiotic treatment, particularly under AMC exposure. Our findings advance the understanding of probiotic-antibiotic-gut microbiome interactions, thereby guiding future optimization of microbiome-targeted adjuvant therapies."

Journal

Limitations Of Genetic Testing In A Patient With Autosomal Recessive Chronic Granulomatous Disease (ACAAI 2025) - "She was empirically treated with amoxicillin/clavulanate but developed rapid progression of symptoms including recurrent fevers and worsening dyspnea...She was initiated on TMP/SMX, levofloxacin, itraconazole, and daily prednisone with symptomatic improvement...Neutrophil cytosol factor 1 (p47phox) is a protein encoded by the NCF1 gene and a crucial component of the NADPH oxidase complex. This gene is difficult to sequence and is often missed on large genetic panel testing."

Clinical • IO biomarker • Anemia • Atopic Dermatitis • Dermatology • Fatigue • Hematological Disorders • Immunology • Infectious Disease • Primary Immunodeficiency • Pulmonary Disease • Thrombocytosis • CYBB • IFNG • STING • ZAP70

Wrong DRESS Exposes Hidden Guest (ACAAI 2025) - "Case Description A 56-year-old man with CLL on acalabrutinib presented with presumed community-acquired pneumonia and was started on azithromycin and amoxicillin-clavulanate...High-dose prednisone was initiated for suspected DRESS, resulting in rapid rash resolution and normalization of liver enzymes...Fluconazole was initiated, leading to marked respiratory improvement...Atypical features – early rash, lack of eosinophilia, and rapid steroid response – prompted further investigation. Bronchoscopy and targeted skin biopsy enabled accurate diagnosis and effective antifungal treatment."

Chronic Cough • Chronic Lymphocytic Leukemia • Cough • Dermatitis • Dermatology • Eosinophilia • Hematological Malignancies • Immunology • Infectious Disease • Leukemia • Pneumonia • Respiratory Diseases

Pembrolizumab-Induced Cytokine Release Syndrome in Non-Small Cell Lung Cancer (ACAAI 2025) - "Initially, the rash was attributed to amoxicillin-clavulanate since the patient had recently started a course for sinusitis and was sensitized to penicillin...His rash and fever responded to tocilizumab, consistent with CRS to his ICI therapy...4 A longer time to onset is associated with more severe symptoms and higher levels of IL-6, both of which were present in this case. Shared decision making should be employed regarding whether to continue pembrolizumab since continued infusions may cause additional harm."

Cytokine release syndrome • Hematological Malignancies • Immunology • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Otorhinolaryngology • Pulmonary Disease • Respiratory Diseases • Sinusitis • Solid Tumor • Systemic Inflammatory Response Syndrome • IL6

Prescribing Patterns in Pediatric Cellulitis: A Multi-State Analysis Stratified by Penicillin Allergy Status (ACAAI 2025) - "Results Among 1,051,086 pediatric cellulitis patients, cephalexin was the most prescribed antibiotic (n=398,547; 37.92%), followed by mupirocin and amoxicillin/clavulanate. Of 28,871 patients with documented penicillin allergy, cephalexin (n=8,682; 30.07%) remained most prescribed, followed by TMP-SMX, clindamycin, and cefdinir...Conclusions Despite allergy labels, lower-cost β-lactams like cephalexin were still frequently prescribed, resulting in slightly lower average drug costs in the penicillin-allergic group. These findings support the need for improved allergy documentation, de-labeling strategies, and adherence to evidence-based guidelines to optimize both care quality and cost-effectiveness."

Clinical • Allergy • Dermatology • Immunology • Infectious Disease • Pediatrics

Prevalence, Antimicrobial Resistance Pattern of Shigella Spp. and Assessed Their Pathogenic Potential Using the Caenorhabditis elegans Infection Model Associated with Acute Diarrheal Patients in Tangail, Bangladesh. (PubMed, Foodborne Pathog Dis) - "Shigella dysenteriae was resistant to amoxicillin-clavulanic acid, erythromycin, gentamicin, and nalidixic acid, while Shigella boydii showed resistance to ampicillin, amoxicillin-clavulanic acid, and nalidixic acid. However, no resistance was observed to azithromycin, tetracycline, levofloxacin, or ciprofloxacin...This study highlights the importance of regular surveillance of Shigella prevalence and AMR patterns in Bangladesh. Furthermore, exploring genomic epidemiology and alternative treatments for Shigella infections is crucial in combating its spread and resistance in Bangladesh."

Journal • Infectious Disease

Sulopenem etzadroxil/probenecid (Orlynvah) for uncomplicated UTIs. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • Infectious Disease • Nephrology

Myocarditis in a Dog Positive for Brucella canis. (PubMed, J Am Anim Hosp Assoc) - "The dog was hospitalized for 6 days on IV fluid therapy and treated with ampicillin/sulbactam and enrofloxacin. She was discharged on amoxicillin-clavulanic acid and maropitant citrate...It was revealed that two of her littermates had tested positive for Brucella canis, so antimicrobial therapy was switched to enrofloxacin and doxycycline...However, myocarditis is a rare clinical manifestation of brucellosis in humans. Depending on patient history, clinical signs, and diagnostic findings, brucellosis is a zoonotic disease that may be a differential diagnosis in dogs with suspected myocarditis."

Journal • Cardiovascular • Infectious Disease • Inflammation • TNNI3

A Simulated Client Study on Non-Prescription Antibiotic Sales and Counselling Practices in Iraqi Nurse-Led Clinics: Implications for Antimicrobial Resistance. (PubMed, Infect Drug Resist) - "These are amoxicillin and erythromycin...Amoxicillin/clavulanic acid accounted for 34.0% (48/141) of the antibiotics supplied...Widespread inappropriate and, in many cases, illegal antibiotic dispensing was observed in Iraqi nurse-led clinics, with limited patient assessment. These findings underscore the urgent need for enhanced antimicrobial stewardship, provider education, and regulatory enforcement to address AMR in Iraq."

Journal • Allergy • Immunology • Infectious Disease • Respiratory Diseases

Pathogenic potential of amoxicillin-clavulanic acid resistant Klebsiella pneumoniae isolated from aquatic environment: a study of multidrug resistance and virulence. (PubMed, BMC Infect Dis) - "Occurrence of hypervirulent, AMC resistant and MDR Klebsiella pneumoniae in aquatic environment is a concern and further studies are required to explore their potential threat in dissemination of resistance and clinical implications."

Journal • Gene Therapies • Infectious Disease • Pneumonia

Antimicrobial resistance of Enterobacterales in Central Africa: a systematic review and meta-analysis. (PubMed, Commun Med (Lond)) - "The high prevalence of AMR in Central Africa underscores the urgent need to strengthen antimicrobial susceptibility testing capacities, restrict empirical use of key antibiotics, and ensure equitable access to effective antimicrobials. Without coordinated investments for microbiology capacities scale-up, prescription regulation, strategies for water, sanitation and hygiene, and infection prevention and control, patient outcomes and regional AMR containment will be jeopardized."

Journal • Retrospective data • Infectious Disease

Differences in prescription for impetigo and cellulitis across years in three European countries. (PubMed, J Antimicrob Chemother) - "Prescribing patterns are very heterogeneous across European countries and publication of guidelines did not affect prescribing habits."

Journal • Dermatology • Dermatopathology • Infectious Disease

Redefining uUTI therapy: Orlynvah as a promising oral alternative (sulopenem etzadroxil and probenecid). (PubMed, Ann Med Surg (Lond)) - "The efficacy of Orlynvah was established through two large multicenter trials, which demonstrated superior outcomes compared to amoxicillin-clavulanate and improved efficacy over ciprofloxacin in cases involving resistant pathogens. The drug was generally well-tolerated, with few serious adverse events reported. Orlynvah offers a promising oral alternative in the era of rising antimicrobial resistance and represents a significant advancement in the management of uUTIs."

Journal • Infectious Disease • Nephrology

Symmetrical Drug-Related Intertriginous and Flexural Exanthema (SDRIFE) Unfolded: Diagnostic Pitfalls and Psoriatic Confounders Among Flexural Dermatoses. (PubMed, Cureus) - "We present a 53-year-old female with biopsy-proven inverse psoriasis who experienced a broad symmetrical erythematous rash in flexural areas after receiving amoxicillin-clavulanate treatment...Interestingly, previous flexural psoriasis might have contributed as a risk factor via barrier impairment or recall phenomenon. This case emphasizes the importance of increased clinical awareness and histological assessment in flexural lesions, particularly in individuals with pre-existing dermatoses."

Journal • Candidiasis • Dermatology • Immunology • Psoriasis

Antimicrobial use monitoring in neonatal population using a Defined Daily Doses method. (PubMed, Neonatology) - "DDDn proved to be a feasible tool for monitoring antimicrobial consumption in neonatal populations, offering a standardized metric that could improve ASPs and optimize antibiotic usage. More research is needed to validate DDDn across different antimicrobials and clinical settings."

Journal

Parvovirus B19 Infection Presenting as Acute Tubulointerstitial Nephritis in an Immunocompetent Patient: A Case Report. (PubMed, Cureus) - "Three months earlier, she had presented with a pruritic rash and abdominal pain treated with amoxicillin-clavulanate, followed by recurrence of symptoms and deterioration...Although rare, PVB19 infection can present as acute interstitial nephritis even in immunocompetent adults. Recognition of this atypical presentation is crucial to avoid unnecessary immunosuppression and to anticipate spontaneous recovery."

Journal • Acute Kidney Injury • Gastrointestinal Disorder • Hematological Disorders • Immunology • Infectious Disease • Nephrology • Pain • Renal Disease • Thrombocytosis

The Use of Gastrointestinal Reflux and Pro-Motility Medications in Hospitalized Infants with Congenital Heart Disease using the Pediatric Acute Care Cardiology Collaborative Registry (AHA 2025) - "Groups were compared based on the use of the following medications at discharge: histamine H2 antagonists, proton pump inhibitors, antacids, metoclopramide, erythromycin ethylsuccinate, or amoxicillin/clavulanic acid. Patients with SV CHD, those on elemental formula, tube assisted feeding and those with longer length of stays are more likely to be discharged on anti-reflux or pro-motility medications. An interesting finding is the positive association of the use of these medications with growth velocity prior to discharge specifically among SV patients. This suggests that these infants may have additional benefit from utilization of these medications at discharge."

Clinical • Cardiovascular • Gastroenterology • Gastroesophageal Reflux Disease • Heart Failure • Pediatrics

Mycoplasma cynos-Associated Canine Infectious Respiratory Disease Complex Pneumonia in 13 Dogs. (PubMed, J Vet Emerg Crit Care (San Antonio)) - "Mycoplasma cynos was detected as the sole or co-occurring infection during this 3-week period, indicating it may be an important agent in some CIRDC clusters."

Journal • Cough • Infectious Disease • Pneumonia • Respiratory Diseases

Rare but Real: Doxycycline-Induced Hepatocellular Liver Injury (ACG 2025) - "Several antibiotics are commonly associated with DILI, such as amoxicillin-clavulanate, sulfonamides, and isoniazid. This case emphasizes the importance of high suspicion of DILI, even with antibiotics considered relatively safe.Figure: Figure 1. Trend of LFTs improvement after doxycycline discontinuation"

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Fatigue • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Liver Failure • Lyme Disease • Psychiatry

A Rare Complication of Hepatic Cysts in Advanced Autosomal Dominant Polycystic Kidney and Liver Disease (ACG 2025) - "Patient was empirically started on intravenous meropenem and later de-escalated to ampicillin-sulbactam...The patient improved clinically and was discharged on oral amoxicillin-clavulanate, with plans for outpatient dialysis, and outpatient kidney and liver transplant evaluation. This case highlights a rare, but serious complication of ADPKD/PLD: hepatic cyst infection leading to sepsis and AKI on CKD...Figure: Figure 1: Non-contrast CT Imaging of the Abdomen Showing Extensive Polycystic Changes in Both Kidneys and Liver, Consistent with Advanced Autosomal Dominant Polycystic Kidney and Liver Disease. Liver cyst with measurement (13.8 cm x 11 cm) indicates the hepatic cyst that was drained percutaneously, with 1000 mL serous drainage output."

Metastases • Autosomal Dominant Polycystic Kidney Disease • Chronic Kidney Disease • Genetic Disorders • Hepatology • Infectious Disease • Nephrology • Polycystic Kidney Disease • Renal Disease • Septic Shock