amphotericin b liposome / Generic mfg. - LARVOL DELTA

Combined intracavitary, systemic antifungal and surgical treatment of Chronic Pulmonary Aspergillosis: experience from an immunocompromised patient. (PubMed, Med Mycol Case Rep) - "Initial treatment with voriconazole was limited due to adverse effects and emerging azole resistance.Aspergillus Subsequent therapy with intravenous and intracavitary amphotericin B was also poorly tolerated and clinically insufficient...As a novel approach, the patient recieved Post-surgical instillation of liposomal amphotericin B directly into the resected cavity, combined with systemic antifungal therapy...Subsequently the patient recovered with long-term remission. This case highlights the potential role of post-operative intracavitary antifungal instillation as an adjunctive strategy in refractory CPA, particularly when conventional medical therapy fails.2012 Elsevier Ltd."

Journal • Infectious Disease • Pulmonary Disease • Rare Diseases • Respiratory Diseases • Vasculitis

Virus-associated pulmonary aspergillosis: A rising challenge in respiratory infections. (PubMed, Am J Med Sci) - "Azole antifungals are the first-line treatment, with liposomal amphotericin B serving as an alternative in regions with azole resistance...This review article discusses the pathophysiological mechanisms, clinical characteristics, diagnosis, and treatment of IAPA and CAPA. Additionally, it highlights key knowledge gaps and suggests potential areas for future research."

Journal • Review • Critical care • Hematological Disorders • Hematological Malignancies • Infectious Disease • Influenza • Novel Coronavirus Disease • Oncology • Pulmonary Disease • Respiratory Diseases • Solid Organ Transplantation • Transplantation

From Reaction to Resolution: Amphotericin B Desensitization in a High-Risk Host (ACAAI 2025) - "Abstract Introduction Liposomal amphotericin B (amphoB) is a polyene antimycotic agent frequently used to treat invasive fungal diseases in immunocompromised patients...The patient underwent a 3-bag, 12-step amphoB desensitization protocol (Figure 1) in the ICU with pre-medications (diphenhydramine, famotidine and systemic steroids) with only subjective symptoms (mild facial flushing on steps 1 and 11; throat pruritus on step 12) treated with diphenhydramine...Successful administration using a 3-bag, 12-step desensitization protocol highlights the feasibility of safely reintroducing amphoB, particularly when no alternative antifungal agents are suitable. Desensitization can be consider for either IgE-mediated or cytokine release storm related anaphylaxis."

Back Pain • Dermatology • Febrile Neutropenia • Hematological Malignancies • Hypotension • Infectious Disease • Lymphoma • Musculoskeletal Pain • Peripheral T-cell Lymphoma • Pneumonia • Pruritus • Respiratory Diseases • T Cell Non-Hodgkin Lymphoma

Diagnostic and therapeutic capacity for fungal infections: An ESCMID-EFISG nationwide multicentre assessment of mycological healthcare in Colombia. (PubMed, Int J Infect Dis) - "Conventional mycological methods remain the cornerstone of fungal diagnosis in Colombia. Significant disparities in IFD management capacity persist, with metropolitan centres and transplant recipients disproportionately benefiting from advanced resources. Although Colombia has established clinical guidelines incorporating World Health Organization (WHO)-recommended diagnostics and treatments, urgent nationwide implementation efforts are required to translate these recommendations into routine clinical practice and address persistent geographic and socioeconomic inequities in patient care."

Journal • Bone Marrow Transplantation • Infectious Disease • Solid Organ Transplantation • Transplantation

"CLINICAL INSIGHTS INTO MUCORMYCOSIS AMONG IMMUNOSUPPRESSED PATIENTS: A MULTICENTRE EXPERIENCE FROM ARGENTINA" (DGHO 2025) - "In conclusion, survival was strongly associated with effective clinical management and the use of targeted antifungal therapy, including liposomal amphotericin B as the first-line treatment and posaconazole as salvage therapy. This highlights the critical role of timely and guideline-driven interventions in improving patient outcomes."

Clinical • Diabetes • Infectious Disease • Metabolic Disorders • Otorhinolaryngology • Solid Organ Transplantation

Survival of trichospores asahii fungemia and cutaneous infiltration in allogeneic haematopoietic stem cell transplantation for refractory acute myeloid leukaemia: a rare case report (DGHO 2025) - "The 25-year-old man required transfer to the intensive care unit (ICU) and needed orotracheal intubation and invasive ventilation for six days, as well as dual high-dose catecholamine therapy (noradrenaline and vasopressin).Voriconazole and liposomal amphotericin B administration resulted in significant clinical improvement and patient survival.The survival of our patient underlines the importance of early diagnosis and appropriate treatment of trichosporonosis as well as full support in the intensive care unit. In this case, the early regeneration of leukocytes after allogeneic stem cell transplantation may be helpful."

Case report • Clinical • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Hematological Malignancies • Infectious Disease • Leukemia • Transplantation

Treatment of Cutaneous Leishmaniasis with Liposomal Amphotericin B in the Elderly: A Randomized Clinical Trial. (PubMed, Am J Trop Med Hyg) - "Clinical and laboratory evaluations were carried out during a period of 180 days (day 0, day 15, day 30, day 60, day 90, and day 180). The highest cure rate (89%) was in group 3 (differences were not statistically significant) along with the lowest incidence of side effects (11%), suggesting that 24 mg/kg is the best dose of LAB to treat CL in elderly patients."

Clinical • Journal • Dermatology • Infectious Disease

Diffuse Cutaneous Leishmaniasis Caused by Leishmania major as the Initial Presentation of HIV Misdiagnosed as Scabies and Kaposi's Sarcoma: A Case Report. (PubMed, Iran J Parasitol) - "Liposomal amphotericin B was initiated as first-line therapy...It highlights the critical need for heightened clinical suspicion, better diagnostic tools, and improved physician awareness in endemic and emerging transmission areas. In the context of rising HIV rates and growing domestic tourism to endemic zones, early screening and structured public health interventions are essential to reduce disease burden and improve patient outcomes in Uzbekistan."

Journal • Dermatology • Human Immunodeficiency Virus • Infectious Disease • Kaposi Sarcoma • Oncology • Pediatrics • Sarcoma • Solid Tumor

Application of Liposomal Amphotericin B (L-AmB) in Veno-Venous Extracorporeal Membrane Oxygenation (VV-ECMO) Patients with Invasive Fungal Disease (IFD) (ChiCTR) - P4 | N=50 | Not yet recruiting | Sponsor: The Affiliated Hospital of Medical College Qingdao University, China; The Affiliated Hospital of Medical College Qingdao University, China

New P4 trial • Infectious Disease

A Rare Complication of TNF-α Inhibitor With Histoplasmosis Associated Necrotizing Granulomatous Hepatitis (ACG 2025) - "Clinical presentation includes fever, malaise, jaundice, abdominal pain, and cholestatic liver enzyme abnormalities.Case Description/ A 62-year-old man from Mexico with rheumatoid arthritis, previously on infliximab, was admitted with abdominal pain...He was readmitted and started on liposomal amphotericin B. His anti-tuberculosis regimen was consolidated. Fluconazole was stopped...He was discharged with itraconazole for 12 months. Histoplasmosis associated necrotizing granulomatous hepatitis is a rare complication in patients on tumor necrosis factor-α inhibitor...Necrotizing granuloma (H&E)Figure 2B. Histoplasma microorganisms (PAS)"

Fatigue • Gastroenterology • Gastrointestinal Disorder • Hepatitis C • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Respiratory Diseases • Rheumatoid Arthritis • Rheumatology • Tuberculosis

Fever of Unknown Origin With Severe Hepatosplenomegaly in an Immunocompetent Female (ACG 2025) - "The patient was started on liposomal amphotericin B and her fever resolved within 3 days of treatment. She was switched to oral itraconazole therapy after 2 weeks and there has been no recurrence of fever...Clinicians should have high suspicion for histoplasmosis in patients with both fever of unknown origin and HSM. Thorough history-taking should include exposure to soil and bird droppings."

Anemia • Cardiovascular • Cytomegalovirus Infection • Diabetes • Hematological Disorders • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Influenza • Metabolic Disorders • Pneumonia • Pulmonary Embolism • Respiratory Diseases • Rheumatology

Invasive Gastric Mucormycosis With Concomitant Cytomegalovirus (CMV) and Herpes Simplex Virus (HSV) Gastritis: A Rare Complication of Immunosuppression (ACG 2025) - "He was started on a multi-drug antifungal regimen including liposomal amphotericin B, micafungin, posaconazole and intravenous ganciclovir.Despite aggressive medical therapy, the patient continued to deteriorate and then decided to transition to hospice care. Invasive fungal infections involving the gastrointestinal (GI) tract are exceedingly rare and predominantly occur in immunosuppressed individuals. This case illustrates the complexity and severity of polymicrobial gastric infections in immunocompromised hosts and the importance of early endoscopic/histologic evaluation in cases with gastrointestinal symptomatology.Figure: One oozing small gastric ulcer with rolled margins was found on the anterior wall of the stomach. Figure: One oozing cratered very large gastric ulcer was found in the proximal gastric body."

Acute Kidney Injury • B Cell Lymphoma • Cytomegalovirus Infection • Diffuse Large B Cell Lymphoma • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Herpes Simplex • Infectious Disease • Lymphoma • Metabolic Disorders • Nephrology • Non-Hodgkin’s Lymphoma • Peptic Ulcer • Renal Disease • Respiratory Diseases

Unexpected Cause of Acute Gastrointestinal Bleeding: Disseminated Histoplasmosis of the Gastrointestinal Tract (ACG 2025) - "The patient was treated with 14 days of liposomal amphotericin B, followed by itraconazole and antiretroviral therapy, with resolution of bleeding and stabilization of hemoglobin. Histoplasmosis with GI involvement occurs about 70-90% of time in patients with AIDS. Outcomes are favorable with timely treatment using liposomal amphotericin followed by itraconazole for 12 months. This case highlights the unusual presentation and it can help clinicians broaden their differentials when evaluating GI bleeding in HIV patients."

Anemia • Fatigue • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Human Immunodeficiency Virus • Infectious Disease • Lymphoma

Mucormycosis In Renal Transplant Recipients-A Case Series Highlighting Early Detection And Management Strategies (ASTMH 2025) - "Induction Therapy Was with Basiliximab for 2 Patients and Anti Thymocyte Globulin for 3 Patients Based on Immunological Risk...All Patients Received Intravenous Liposomal Amphotericin B (5 mg/kg) for at Least 14 Days, Followed by Oral Posaconazole (300 mg BD) for a Median of 5.5 Months...Mucormycosis in Renal Transplant Recipients Is Associated with High Mortality, Particularly in Disseminated Disease. Early Diagnosis, Surgical Debridement, and Appropriately Dosed Antifungal Therapy Are Crucial for Improving Outcomes and Preserving Graft Function Among Renal Transplant Recipients."

Clinical • Glomerulonephritis • Infectious Disease • Lupus Nephritis • Nephrology • Otorhinolaryngology • Respiratory Diseases • Sinusitis • Transplantation

DOUBLE JEOPARDY: FUNGAL CHORIORETINITIS AND SEVERE ARDS FROM CORONA VIRUS 229E IN A CIRRHOTIC PATIENT: A DIAGNOSTIC DILEMMA (CHEST 2025) - "Initial treatment included pressors, hydrocortisone, cefepime, and remdesivir.On Day Candida glabrata was isolated from sputum cultures, a finding typically dismissed as contamination but concerning in this immunocompromised patient. Antifungal therapy with micafungin was initiated, and cefepime was replaced with meropenem...Blood cultures on Day 10 confirmed yeast growth, prompting central line removal and escalation to liposomal amphotericin B, flucytosine, and intravitreal voriconazole... This case illustrates the heightened vulnerability of cirrhotic patients to invasive fungal infections, especially under the influence of immunosuppressants such as prednisone for alcoholic hepatitis and Guselkumab for psoriasis... Early diagnosis and aggressive antifungal treatment are essential to prevent severe complications, including vision loss. This case highlights the need for heightened clinical awareness and a proactive diagnostic approach to improve outcomes in this..."

Clinical • Acute Respiratory Distress Syndrome • Dermatology • Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Inflammation • Liver Cirrhosis • Novel Coronavirus Disease • Ocular Inflammation • Pneumonia • Psoriasis • Pulmonary Disease • Respiratory Diseases • Retinal Disorders • Septic Shock • Uveitis

Scedosporium Boydii disseminated infection complicating severe SARS-CoV-2 infection in an immunocompetent patient: a case report. (PubMed, BMC Infect Dis) - "Invasive fungal infections (IFIs) by molds are an emerging condition in patients with COVID-19. Cases of aspergillosis, candidiasis and mucormycosis were increasingly reported during the COVID-19 pandemic. This is the first report of a fatal disseminated infection due to Scedosporium boydii preceded by a severe SARS CoV-2 infection."

Journal • Anesthesia • Candidiasis • Cardiovascular • CNS Disorders • Genetic Disorders • Human Immunodeficiency Virus • Hypertension • Infectious Disease • Novel Coronavirus Disease • Obesity • Pneumonia • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Clinical and health economic impact of isavuconazole for treatment of invasive aspergillosis and mucormycosis: a retrospective, matched multicentre cohort study in Germany. (PubMed, Infection) - "Our real-world analysis confirmed that first-line treatment initiated with isavuconazole resulted in clinical outcomes equivalent to those of L-AmB and/or voriconazole in patients with IA or IM. However, treatment costs during the in-patient stay were higher with isavuconazole."

HEOR • Journal • Retrospective data • Hematological Disorders • Hematological Malignancies • Infectious Disease • Oncology • Pulmonary Disease • Respiratory Diseases

Navigating therapeutic challenges: Voriconazole pharmacokinetics and CYP2C19 genetic polymorphism-A case report and literature review. (PubMed, Br J Clin Pharmacol) - "Alternative agents to voriconazole, independent of CYP2C19 (isavuconazole, liposomal amphotericin B or posaconazole) were recommended for current and future therapy. Genotyping may help guide dosage adjustments, predict potential drug interactions and improve treatment efficacy whilst reducing adverse effects. The integration of pharmacogenomic testing, along with therapeutic drug monitoring (TDM), can enhance individualized therapy for both antifungal treatment and prophylaxis in complex clinical scenarios."

Journal • PK/PD data • Infectious Disease • Transplantation • CYP2C19

PEDIATRIC RHINO-ORBITO-CEREBRAL MUCORMYCOSIS IN IMMUNOCOMPROMISED PATIENTS: A FOUR-CASE RETROSPECTIVE REVIEW AND CLINICAL INSIGHTS (SIOP 2025) - "Three patients had been on voriconazole prophylaxis at some point of their disease course; the fourth had received itraconazole or fluconazole prior to mucormycosis. Once mucormycosis was confirmed, prophylaxis strategies were shifted toward liposomal amphotericin B or posaconazole... Early recognition of mucormycosis is crucial in pediatric cancer populations. Combined surgical and antifungal therapy—particularly liposomal amphotericin B—was essential for controlling infection. Prophylactic regimens using azoles did not prevent mucormycosis in highly immunocompromised patients, underscoring the importance of heightened clinical vigilance."

Retrospective data • Review • Hematological Malignancies • Infectious Disease • Pediatrics • Solid Tumor

Antifungal prophylaxis in patients with FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD)-positive acute myeloid leukaemia receiving sorafenib during initial induction and consolidation treatment in ALLG AMLM16 trial. (PubMed, J Antimicrob Chemother) - "LAMB with or without subsequent azole prophylaxis could be an alternative option for fungal prophylaxis for patients with AML in whom azoles are contraindicated or not tolerated. Sorafenib does not appear to be associated with an increased risk of IFD."

Clinical • Journal • Acute Myelogenous Leukemia • Hematological Malignancies • Infectious Disease • Leukemia • Oncology • FLT3

Disseminated rhino-orbital-cerebral mucormycosis in Philadelphia chromosome-positive mixed phenotype acute leukemia: a case report and literature review. (PubMed, Front Med (Lausanne)) - "She was treated with imatinib and received acute lymphoblastic leukemia (ALL)-like chemotherapy, and used voriconazole to prevent fungal infections...We administered liposomal amphotericin B (L-AmB) in a timely manner and effectively controlled the infection...Our case reports support the limitations of voriconazole in preventing Mucorales infections and emphasizes the importance of broad coverage in antifungal prevention strategies, early diagnosis, and timely treatment. In addition, we reviewed 27 other cases of rhinocerebral mucormycosis in patients with acute leukemia and provide an analysis of these cases."

Journal • Acute Lymphocytic Leukemia • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Oncology • Pain

THE MYSTERIOUS AFFAIR AT CAVITIES: MRSA AND ASPERGILLUS UNRAVELED (CHEST 2025) - "CASE PRESENTATION: A 39-year-old obese male with severe eosinophilic asthma with recurrent exacerbations requiring steroids, previously treated with mepolizumab and dupilumab and currently on triple therapy, presented with progressive dyspnea and wheezing following a trip to Las Vegas and Arizona, where he played golf and was exposed to bird feces...He was started on broad-spectrum antibiotics (vancomycin and piperacillin-tazobactam) due to a positive MRSA nasal swab. Infectious disease consultation led to the addition of liposomal amphotericin B for suspected fungal infection...Respiratory PCR detected Mycoplasma pneumoniae, prompting azithromycin initiation...His pneumothorax resolved, the chest tube was removed, and he was discharged on a prolonged prednisone taper, voriconazole for 12 weeks, and a 4-week course of anti-MRSA antibiotics... This case emphasizes the need for high suspicion of concurrent infections in patients with atypical radiologic findings, and the..."

Asthma • Atrial Fibrillation • Cardiovascular • Cough • Immunology • Infectious Disease • Obesity • Pneumonia • Pulmonary Disease • Respiratory Diseases

When Hepatitis Masks Visceral Leishmaniasis: A Case of Secondary HLH in a Low-Endemic Region. (PubMed, Clin Case Rep) - "The patient was treated with intravenous dexamethasone and a six-day course of liposomal amphotericin B, along with supportive care. VL-HLH should be considered in patients with hepatitis-like presentations, even in low-endemic areas. Early recognition and treatment targeting the underlying infection with amphotericin B plus corticosteroids can achieve favorable outcomes, even when etoposide is contraindicated."

Journal • Autoimmune Hepatitis • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Hepatology • Immunology • Infectious Disease • Inflammation • Liver Failure • Rare Diseases

DIAGNOSTIC CHALLENGES BETWEEN THE 3 HS: HIV, HISTOPLASMOSIS, AND HLH (CHEST 2025) - "CASE PRESENTATION: A 31-year-old Guatemalan man with newly diagnosed HIV initially started on Bictegravir/ emtricitabine/tenofovir alafenamide, presented from an outside hospital with persistent fevers and pancytopenia despite appropriate pneumonia treatment. During his prior hospitalization, he underwent a bone marrow biopsy and received four doses of intravenous immunoglobulin and solumedrol...Liposomal amphotericin B was initiated... Our case illustrates the diagnostic challenge posed by the overlapping clinical features of disseminated Histoplasmosis and HLH in an immunocompromised patient. A comprehensive diagnostic approach should be used to distinguish between these life-threatening illnesses."

Acute Respiratory Distress Syndrome • Cough • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Human Immunodeficiency Virus • Immunology • Infectious Disease • Pneumonia • Pulmonary Disease • Rare Diseases • Respiratory Diseases • Septic Shock • IL2RA

PULMONARY MUCORMYCOSIS: WHAT MORE CAN WE DO? (CHEST 2025) - "He had not been compliant with prescribed metformin prior to presentation...Patient was then admitted for treatment of diabetic ketoacidosis and given empiric Ceftriaxone and Azithromycin for community-acquired pneumonia...Given lack of improvement Isavuconazonium sulfate and Minocycline were also added to anti-fungal regimen...Early initiation of Liposomal Amphotericin B with surgery is essential for management of mucormycosis... Pulmonary mucormycosis is life-threatening and requires prompt treatment. While options may be limited, it is important to be aware of literature that highlights additional means of treating pulmonary mucormycosis. Optimal chances of survival are dependent on early diagnosis, reversal of underlying host defects and early initiation of therapy."

Cough • Diabetes • Infectious Disease • Metabolic Disorders • Pneumococcal Infections • Pneumonia • Pulmonary Disease • Respiratory Diseases • Septic Shock • Type 2 Diabetes Mellitus