amphotericin b liposome / Generic mfg. - LARVOL DELTA

New advances and future prospect in antifungal therapy for invasive pulmonary aspergillosis (PubMed, Zhonghua Jie He He Hu Xi Za Zhi) - "New antifungal agents, such as isavuconazole, new formulations of posaconazole, liposomal amphotericin B, rezafungin, and eravacycline, exhibit distinct pharmacokinetic, pharmacodynamic, and safety profiles. Nanoparticle delivery systems and inhaled formulations have increased drug concentrations at the airway site while reducing systemic adverse effects. Future research will focus on new drug development targeting fungal protein targets, multi-target approaches, and immunomodulatory therapies."

Journal • Review • Pulmonary Disease • Respiratory Diseases

Treatment of pulmonary mucormycosis: current concepts. (PubMed, Expert Rev Anti Infect Ther) - "We emphasize aggressive host factor optimization (glycemic control, immunosuppression reduction) and outline the evidence-based antifungal strategy: liposomal amphotericin B (L-AMB) for induction, followed by oral maintenance (posaconazole or isavuconazole)...Combination antifungal therapy lacks definite evidence and should be reserved for severe or refractory cases. Future research priorities include prospective evaluation of treatment strategies, host-directed therapies, emerging antifungals (oral nanocrystal amphotericin, fosmanogepix, etc.), and systematic assessment of adjunctive modalities."

Journal • Review • Immunology • Infectious Disease • Nephrology • Renal Disease • Transplantation

Fatal Ultra-Early-Onset Rhino-Cerebral Mucormycosis Caused by Rhizomucor miehei Following Umbilical Cord Blood Transplantation and Review of Published Literature. (PubMed, Mycopathologia) - "Given the extraordinarily early onset and neurological involvement, fungal meningitis, including mucormycosis, was suspected, and empirical high-dose liposomal amphotericin B (10 mg/kg/day) was initiated...To our knowledge, this represents the first reported case of R. miehei infection occurring within days after transplantation, preceding neutrophil engraftment. This case highlights the importance of recognizing mucormycosis even in the immediate post-transplant period and underscores the limitations of antifungal therapy in the absence of surgical debridement."

Journal • Review • CNS Disorders • Hematological Malignancies • Infectious Disease • Myelodysplastic Syndrome • Oncology • Pain • Transplantation

Successful Treatment of Probable Disseminated Mucormycosis Using Liposomal Amphotericin B and Isavuconazole in Myelodysplastic Syndrome: A Case Report and Literature Review. (PubMed, Int J Infect Dis) - "Our case highlights the importance of prompt diagnosis and timely initiation of therapy for mucormycosis and indicates that combination antifungal therapy may be an effective approach to managing severe disseminated mucormycosis in immunocompromised patients."

Journal • Hematological Malignancies • Infectious Disease • Myelodysplastic Syndrome • Oncology

A Rare Case of Rhizomucor pusillus Infection in a 3-Year-Old Child with Acute Lymphoblastic Leukemia, Presenting with Lung and Brain Abscesses-Case Report. (PubMed, Infect Dis Rep) - "The present treatment protocol includes extensive and radical surgical debridement and systemic antifungal therapy with Liposomal Amphotericin B (L-AmB), Posaconazole, and Isavuconazole, either combined or as monotherapy. The patient underwent lung and brain surgery and is recovering well with no further complications. The two-year follow-up period shows no signs of recurrence of the disease."

Journal • Acute Lymphocytic Leukemia • CNS Disorders • Hematological Disorders • Hematological Malignancies • Infectious Disease • Leukemia • Neutropenia • Novel Coronavirus Disease • Oncology

Limb Mucormycosis in the Early Postoperative Period Following Kidney Transplantation: A Case Report. (PubMed, Transplant Proc) - "Antifungal therapy included liposomal amphotericin B and isavuconazole alongside immunosuppression reduction. This case underscores the aggressive nature of mucormycosis in immunocompromised hosts, highlighting the critical need for‌ early diagnosis, radical surgical intervention, combined antifungal therapy, and most importantly sustained vigilance by transplant teams for this fungal infection, as delayed intervention could lead to catastrophic consequences."

Journal • Cardiovascular • Diabetic Nephropathy • Hematological Disorders • Infectious Disease • Thrombosis • Transplantation

Antifungal treatment strategies in intensive care unit patients. (PubMed, Eur J Clin Invest) - "Optimizing antifungal stewardship through individualized therapy and early diagnosis remains essential to improve outcomes in this high-risk population."

Journal • Review • Candidiasis • Critical care • Human Immunodeficiency Virus • Infectious Disease • Pneumonia • Pulmonary Disease • Respiratory Diseases

Pulmonary mucormycosis complicated with transplant renal dysfunction: A case report. (PubMed, Respir Med Case Rep) - "Initially, moxifloxacin was given as empirical anti-infection, and after diagnosis, due to combined renal insufficiency after renal transplantation, gradual incremental amphotericin B liposome (5mg→40mg/d) treatment was given, combined with nebulized amphotericin B, which was adjusted to amphotericin B cholesterol sulfate complex due to persistent elevation of creatinine (peak value of 193μmol/L)...Chest CT showed shrinkage of the cavity after 28 days of treatment, and 2-year follow-up showed significant resorption of the lung lesions, reduction of blood creatinine from 245 μmol/L to 129.10 μmol/L, and maintenance of stable renal function. Transplant nephrology, endocrinology, infectious diseases, and pulmonology specialists."

Journal • Anorexia • Cardiovascular • Chronic Kidney Disease • Cough • Diabetes • Endocrine Disorders • Hypertension • Infectious Disease • Metabolic Disorders • Nephrology • Renal Disease • Respiratory Diseases • Transplantation • Type 2 Diabetes Mellitus

Invasive Pulmonary Aspergillosis in Non-Neutropenic Patients: An Evolving Clinical Paradigm. (PubMed, Diagnostics (Basel)) - "Voriconazole remains the first-line treatment, though therapeutic drug monitoring is essential to ensure efficacy and minimize toxicity. Isavuconazole represents an effective alternative, offering comparable efficacy, improved safety, predictable pharmacokinetics, and convenient once-daily dosing. Liposomal amphotericin B serves as a valuable option in severe or refractory cases due to its broad-spectrum activity and reduced nephrotoxicity...Emerging antifungal agents, including olorofim, ibrexafungerp, and fosmanogepix, show promise against resistant Aspergillus species, expanding treatment options. Overall, IPA management in non-neutropenic patients requires a multidisciplinary, patient-centered approach integrating established antifungals, supportive care, and novel therapeutic advances."

Journal • Review • Hematological Disorders • Infectious Disease • Neutropenia • Pulmonary Disease • Respiratory Diseases

Misleading presentation of tuberculosis in a child with CGD revealing invasive aspergillosis: A molecularly confirmed case. (PubMed, IDCases) - "Molecular identification confirmed the isolates as A. fumigatus. According to the antifungal susceptibility testing, amphotericin B and posaconazole demonstrated strongest activity and the patient was successfully treated by liposomal amphotericin B (50 mg/day) and caspofungin (35 mg/day)."

Journal • Dermatology • Immunology • Infectious Disease • Pneumonia • Primary Immunodeficiency • Pulmonary Disease • Respiratory Diseases • Tuberculosis

Molecular Identification and Evaluation of Resistance to Antifungal Drugs in Candida Species Isolated From Diaper Rash of Neonates. (PubMed, Health Sci Rep) - "Nystatin, posaconazole, voriconazole, amphotericin B, ketoconazole, and clotrimazole showed high activity against all species (Minimum Inhibitory Concentration ≤ 0.125 µg/mL). The treatment of recurrent invasive candidiasis, needing repeated course of fluconazole or itraconazole, could be a risk factor for selecting resistant isolates. In addition, as the liposomal amphotericin B is no more commercialized in our country, a higher drug selection pressure for azoles may be expected in the future."

Journal • Candidiasis • Contact Dermatitis • Dermatitis • Dermatology • Immunology • Infectious Disease • Pediatrics

Liposomal amphotericin B in the treatment of pediatric gastrointestinal basidiobolomycosis. (PubMed, J Med Case Rep) - "This case highlights the diagnostic challenges of pediatric gastrointestinal basidiobolomycosis and demonstrates successful management with liposomal amphotericin B followed by itraconazole. It underscores the ongoing gap in establishing standardized treatment and supports further prospective studies to define optimal antifungal and surgical strategies for this rare entity."

Journal • Anorexia • Cardiovascular • Constipation • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammatory Bowel Disease • Oncology • Pain • Pediatrics

A Case of Persistent Candida Keyfr Bloodstream Infection in a Lung Transplant Recipient. (PubMed, Transplant Proc) - "Despite empiric antimicrobial coverage with vancomycin, meropenem, micafungin, and posaconazole, she continued to require high-dose vasopressors and remained unable to wean from veno-venous extracorporeal membrane oxygenation (ECMO)...Micafungin and posaconazole doses were increased, and intravenous (IV) liposomal amphotericin B was added...Micafungin and posaconazole were discontinued and IV voriconazole was started for eye penetration...To our knowledge, there are no documented cases in the literature of possible donor-derived C. kefyr leading to blood stream infection in the recipient. This case highlights the need for heightened clinical vigilance and prompt multidisciplinary management to mitigate the impact of post-transplant complications."

Journal • Cardiovascular • Genetic Disorders • Idiopathic Pulmonary Fibrosis • Immunology • Infectious Disease • Ocular Inflammation • Ophthalmology • Pulmonary Disease • Respiratory Diseases • Retinal Disorders • Septic Shock • Solid Organ Transplantation • Transplantation • Uveitis

Case Report: Intra-abdominal Mucormycosis Diagnosed at the Time of Liver Transplantation for Surgically Induced Acute Liver Failure. (PubMed, Transplant Proc) - "She received systemic antifungal therapy with liposomal amphotericin B and azoles guided by susceptibility testing...She completed 6 months of antifungal therapy and remains free from infection with excellent graft function at 1 year. This case underscores the importance of early diagnosis of intra-abdominal mucormycosis and highlights that aggressive surgical debridement, tailored antifungal therapy, and careful immunosuppression management are essential to achieving a successful outcome."

Journal • Hepatology • Infectious Disease • Liver Failure • Peptic Ulcer • Solid Organ Transplantation • Transplantation

Breakthrough probable invasive aspergillosis with cutaneous involvement in a neutropenic child with relapsed pre-B ALL under liposomal amphotericin-B prophylaxis (ESCMID Global 2026) - No abstract available

Clinical • Respiratory Diseases

Safety profile of liposomal amphotericin B in invasive Candidozyma auris infection: a multi-centre real-world cohort (ESCMID Global 2026) - No abstract available

Clinical • Real-world • Real-world evidence • Infectious Disease

Real-world use, clinical characteristics and outcomes of liposomal amphotericin B for invasive Candidozyma auris infection: a multi-centre cohort (ESCMID Global 2026) - No abstract available

Clinical • Real-world • Real-world evidence • Infectious Disease

Comedication patterns in the haemato-oncology setting suggest manageable renal safety profile of liposomal amphotericin B in the real-world setting (ESCMID Global 2026) - No abstract available

Clinical • Real-world • Real-world evidence • Oncology

Combination therapy success in refractory pediatric visceral leishmaniasis with hemophagocytic lymphohistiocytosis: A case report. (PubMed, Medicine (Baltimore)) - "This case highlights the importance of early recognition of HLH in VL, the role of multidisciplinary management, and the potential efficacy of combination therapy in refractory pediatric cases, particularly in resource-limited settings."

Journal • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Immunology • Infectious Disease • Pediatrics • Rare Diseases

STAT1 gain-of-function mutation leading to disseminated Talaromyces marneffei infection combined with hemophagocytic syndrome: a case report (PubMed, Zhonghua Jie He He Hu Xi Za Zhi) - "Following a two-week course of intravenous amphotericin B liposome (5 mg/kg per day), followed by oral voriconazole maintenance therapy (200 mg, twice daily), the patient exhibited significant improvements in clinical symptoms and laboratory parameters. Notably, the marked resolution of HLH was closely linked to the successful eradication of the fungal infection. This case highlights three critical clinical implications: (1) Patients with a predisposition to primary immunodeficiency disorders (e.g., STAT1-GOF mutations) should be evaluated for disseminated TM infections, even if they are HIV-negative; (2) mNGS is instrumental in etiological diagnosis and facilitates early intervention for fungal infections; (3) early identification of genetic defects establishes a theoretical basis for precision medicine and guides targeted therapeutic strategies."

Journal • Bronchiectasis • Hemophagocytic lymphohistiocytosis • Human Immunodeficiency Virus • Immunology • Infectious Disease • Primary Immunodeficiency • Pulmonary Disease • Rare Diseases • Respiratory Diseases • STAT1

Amphotericin B loaded liposomes (AmBisome ®) A prospective, open randomized, single center, superiority study on the efficacy and safety of aerosol inhalation in the treatment of chronic pulmonary aspergillosis (ChiCTR) - P=N/A | N=84 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Guangzhou Medical University; The First Affiliated Hospital of Guangzhou Medical University

New trial • Pulmonary Disease • Respiratory Diseases

Efficacy and Safety of Different Doses of Amphotericin B Liposomes in the Treatment of Disseminated Cryptococcus neoformans Infection: A Multicentre, Prospective, Open-Label Randomized Controlled Trial. (ChiCTR) - P=N/A | N=60 | Not yet recruiting | Sponsor: The First Affiliated Hospital of Guangzhou Medical University; The First Affiliated Hospital of Guangzhou Medical University

New trial • Infectious Disease

Human Bioequivalence Study of Liposomal Amphotericin B for Injection (clinicaltrials.gov) - P=N/A | N=42 | Active, not recruiting | Sponsor: Sichuan Huiyu Pharmaceutical Co., Ltd | Recruiting ➔ Active, not recruiting

Enrollment closed • Febrile Neutropenia • Infectious Disease

Coronavirus disease 2019-associated mucormycosis and cytomegalovirus infection: a case report. (PubMed, J Med Case Rep) - "This case illustrates the need for prompt recognition and treatment of concurrent opportunistic infections in patients who are immunocompromised owing to coronavirus disease 2019. A multidisciplinary proactive approach will be necessary to improve survival and patient outcomes in similarly complex patient cases."

Journal • Cardiovascular • Cytomegalovirus Infection • Diabetes • Hypertension • Infectious Disease • Metabolic Disorders • Novel Coronavirus Disease • Pneumonia • Respiratory Diseases • Septic Shock

Adrenal Insufficiency due to Disseminated Cryptococcus in an Immunocompetent Individual. (PubMed, Case Rep Endocrinol) - "The patient was commenced on hydrocortisone and fludrocortisone, with improvement in symptoms. Treatment involved induction therapy with intravenous liposomal amphotericin-B 4 mg/kg daily and 5-flucytosine 25 mg/kg four times daily for 2 weeks, followed by consolidation therapy with fluconazole. This case highlights the importance of considering disseminated cryptococcosis in immunocompetent individuals presenting with adrenal insufficiency. Early diagnosis and appropriate antifungal therapy are crucial."

Journal • Endocrine Disorders • Fatigue • Infectious Disease • Nephrology • Renal Disease