amphotericin b liposome / Generic mfg. - LARVOL DELTA

Leflunomide-associated fatal cryptococcal meningoencephalitis presenting as rapidly progressive dementia: a case report. (PubMed, Eur Rev Med Pharmacol Sci) - "This case highlights the diagnostic challenges of cryptococcal meningoencephalitis with atypical neurological presentation and its potential association with leflunomide-induced immunosuppression. Early clinical suspicion and a multimodal diagnostic approach are essential for improving prognosis."

Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Dementia • Hypertension • Immunology • Infectious Disease • Inflammatory Arthritis • Movement Disorders • Rheumatoid Arthritis • Rheumatology

Cutaneous cryptococcosis as the first manifestation of disseminated infection (EADV 2026) - "With the diagnosis of disseminated cryptococcosis, lenalidomide was discontinued and the patient received induction therapy with liposomal amphotericin B, flucytosine and high-dose fluconazole for 14 days, followed by oral fluconazole maintenance therapy. Lenalidomide is not a direct anti-TNF agent but it has complex immunomodulatory effects modulating cytokine responses, particularly TNF-α . Moreover, underlying multiple myeloma with hypogammaglobulinaemia and lymphopenia could contribute to infection after ambiental exposure to bird droppings."

Chronic Cough • Cough • Hematological Malignancies • Human Immunodeficiency Virus • Infectious Disease • Mood Disorders • Multiple Myeloma • Respiratory Diseases

DISSEMINATED HISTOPLASMOSIS IN THE CONTEXT OF SEVERE IMMUNOSUPPRESSION: REPORT OF TWO CASES (EADV 2026) - "Treatment consisted of liposomal Amphotericin B for 14 days, followed by maintenance therapy with Itraconazole. According to the literature, skin biopsy with special stains (such as Grocott-Gomori or PAS) is essential for definitive diagnosis, since clinical presentation alone is nonspecific and represents a major diagnostic challenge in medical practice. Furthermore, it is important to emphasize that therapeutic success depends not only on antifungal therapy with Amphotericin B and Itraconazole, but also on the careful management of drug interactions, toxicities, and immune restoration."

Clinical • Gastrointestinal Disorder • Human Immunodeficiency Virus • Infectious Disease • Respiratory Diseases • Tuberculosis • CD4

A neglected fungal disease behind refractory cutaneous lesions: an atypical presentation of paracoccidioidomycosis (EADV 2026) - "The lesions were refractory to potent topical corticosteroids, antibiotics, and systemic prednisone (1 mg/kg/day), with continuous clinical worsening...Treatment with liposomal amphotericin B (5 mg/kg/day for 14 days) followed by itraconazole (200 mg/day) was initiated, with progressive clinical and serological improvement, including a 50% reduction in antibody titers after two months...Failure to recognize endemic systemic mycoses may result in inappropriate immunosuppression and disease progression. Early histopathological evaluation should be strongly considered in refractory cutaneous disease, particularly in endemic regions, to avoid diagnostic delay and therapeutic escalation."

Cutaneous Lupus Erythematosus • Dermatopathology • Hematological Disorders • Immunology • Infectious Disease • Inflammatory Arthritis • Lupus • Pemphigus Vulgaris • Respiratory Diseases • Sarcoidosis • CRP

Cutaneous Aspergillosis Due to Aspergillus flavus in a Neutropenic Child with Relapsed B-ALL (EADV 2026) - "Investigations confirmed relapsed ALL, and salvage chemotherapy was initiated with fludarabine, cytarabine, idarubicin, and inotuzumab. Despite escalating broad-spectrum antibacterial coverage with piperacillin-tazobactam and meropenem, fever persisted, prompting the addition of empiric liposomal amphotericin B. Shortly thereafter, necrotizing skin lesions developed on the left hand and right arm; lesions on the right arm followed the trajectory of a prior intravenous access site, raising suspicion for primary cutaneous inoculation...Voriconazole-based treatment achieved a favorable clinical response with progressive resolution of cutaneous and pulmonary findings. A high index of suspicion for invasive fungal infection should be maintained in severely immunocompromised children with persistent fever and atypical skin lesions, particularly in settings with elevated environmental fungal exposure."

Clinical • Febrile Neutropenia • Hematological Malignancies • Infectious Disease • Mood Disorders • Neutropenia • Respiratory Diseases • Thermal Injury

Tintelnotia destructans Invasive Rhinosinusitis in an Immunocompromised Child: A Case Report and Review of the Literature. (PubMed, Open Forum Infect Dis) - "Combined endoscopic surgical debridement, antifungal therapy (liposomal amphotericin B and isavuconazole), and immune reconstitution after emergency haploidentical hematopoietic stem cell transplant ultimately led to complete recovery without recurrence 18 months after treatment, despite continued therapeutic immunosuppression for graft-vs-host disease. This case expands the known pathogenic spectrum of T. destructans, demonstrating its potential to cause invasive disease in severely immunocompromised hosts. Advances in molecular diagnostic tools may expand the spectrum of fungi causing invasive fungal infections by identification of novel pathogenic species."

Journal • Aplastic Anemia • Bone Marrow Transplantation • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Keratitis • Ocular Inflammation • Ophthalmology • Otorhinolaryngology • Respiratory Diseases • Sinusitis • Transplantation

When facial cellulitis doesn't respond: Fulminant odontogenic Mucormycosis in a Diabetic patient (EADV 2026) - "Case Presentation A 52-year-old male with poorly controlled type 2 diabetes presented with right facial edema, hyperemia, and oppressive palatal pain following recent upper molar extraction treated with outpatient levofloxacin...Empirical vancomycin and clindamycin were initiated...Despite tigecycline and acyclovir, the patient developed septic shock...Successful management requires immediate multidisciplinary coordination (internal medicine, dermatology, infectious diseases, maxillofacial surgery, otolaryngology, ophthalmology) with urgent initiation of liposomal amphotericin B, early biopsy for histopathological confirmation, aggressive surgical debridement, and correction of hyperglycemia and acidosis. In diabetic patients with blood glucose >360 mg/dL, fever, and ophthalmological findings after dental procedures, mucormycosis should be considered until proven otherwise."

Clinical • Cardiovascular • Dermatology • Diabetes • Hematological Disorders • Infectious Disease • Metabolic Disorders • Ophthalmology • Otorhinolaryngology • Septic Shock • Thrombosis • Type 2 Diabetes Mellitus

A Case of Tuberculosis Verrucosa Cutis Clinically and Histopathologically Mimicking Sporotrichosis: Successfully Treated with Standard Antituberculosis Drugs (EADV 2026) - "Due to the absence of clinical response after 6 weeks of itraconazole treatment, the treatment was discontinued, and liposomal amphotericin B was initiated...The patient received two months of quadruple tuberculosis therapy (rifampicin, isoniazid, ethambutol, pyrazinamide) followed by four months of dual tuberculosis therapy (isoniazid, rifampicin)...It should be noted that histopathological findings may overlap among granulomatous disorders and may not always be characteristic. This case underscores the importance of clinicopathological and microbiological correlation for establishing an accurate diagnosis."

Clinical • Dermatitis • Hematological Disorders • Immunology • Infectious Disease • Respiratory Diseases • Tuberculosis

Rhinocerebral Mucormycosis in a Patient with Myelofibrosis: Clinical Significance of the Black Eschar (EADV 2026) - "Management included urgent surgical debridement and systemic treatment with liposomal amphotericin B. Conclusion This case highlights the importance of maintaining a high index of suspicion for mucormycosis in patients with hematological systemic diseases who present with facial necrosis. The "black eschar" is a characteristic clinical sign that necessitates immediate histopathological confirmation and multidisciplinary intervention. Early recognition remains a critical factor in managing this severe infection."

Clinical • Chronic Kidney Disease • Infectious Disease • Inflammation • Myelofibrosis • Nephrology • Renal Disease

Cutaneous leishmaniasis: experience of a Spanish tertiary hospital (EADV 2026) - "Systemic treatment was used in 15 patients (45.5%), with intravenous liposomal amphotericin B (LAB) and MGA being the most used...Other treatments used included: miltefosine (n=2), topical paromomycin (n=2), imiquimod (n=1), fluconazole (n=1), surgery (n=1) and photodynamic therapy (n=1)...Intralesional MGA remains an effective and well-tolerated first-line treatment for many patients, while systemic therapies (mainly intravenous ABL and MGA) are reserved for more complex cases and show acceptable safety profiles. In conclusion, outcomes were favourable, with high cure rates and no relapses."

Clinical • Dermatology • Infectious Disease

Auricular cutaneous lesions as the first clue to fatal disseminated coccidioidomycosis: a diagnostic challenge (EADV 2026) - "Treatment with liposomal amphotericin B and high-dose fluconazole was initiated; however, the patient had an unfavorable outcome...Early recognition, repeat biopsy when clinicopathological correlation is incongruent, and consideration of epidemiological exposure are essential to avoid fatal outcomes. Dermatologists must maintain a high index of suspicion when evaluating chronic, atypical, or treatment-refractory dermatoses, as early recognition may be life-saving."

Hematological Disorders • Infectious Disease • Otorhinolaryngology • Pulmonary Disease • Rare Diseases • Respiratory Diseases

Cardiac arrest due to acute hyperkalemia during liposomal amphotericin B infusion in an infant: A case report. (PubMed, Farm Hosp) - No abstract available

Journal • Cardiovascular

Localised cutaneous leishmaniasis in an immunosuppressed host: the role for adjuvant photodynamic therapy after incomplete amphotericin B response. (PubMed, BMJ Case Rep) - "Systemic liposomal amphotericin B achieved partial regression...One month after the final session, the lesion showed near-complete re-epithelialisation with functional recovery. This case underscores the importance of early biopsy in atypical CL and suggests that MAL-PDT may be a useful adjuvant to amphotericin B in complex CL caused by the L. donovani complex."

Journal • Dermatology • Infectious Disease • Oncology • Squamous Cell Carcinoma

Mixed Invasive Aspergillus-Mucorales Pulmonary Coinfection in a Diabetic Patient: An Uncommon Dual Fungal Pneumonia and Literature Review. (PubMed, Respirol Case Rep) - "He developed massive hemoptysis, septic shock, and eventually succumbed despite treatment with antibiotics, liposomal amphotericin B and posaconazole. This case underscores the importance of early diagnosis, antifungal therapy and vigilant monitoring in high-risk patients."

Journal • Cough • Diabetes • Diabetic Nephropathy • Infectious Disease • Metabolic Disorders • Nephrology • Pneumonia • Pulmonary Disease • Renal Disease • Respiratory Diseases • Septic Shock

VISCERAL LEISHMANIASIS-ASSOCIATED HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN A PATIENT WITH CROHN'S DISEASE IN THERAPY WITH ANTI-TNFΑ: A CHALLENGING DIAGNOSTIC CASE REPORT (UEGW 2026) - "Liposomal amphotericin B prompted rapid clinical and biochemical improvement, with complete resolution of HLH. Anti-TNFα was discontinued and replaced with anti–IL-12/23 therapy to maintain IBD control while minimizing infectious risk.This case underscores the diagnostic complexity of HLH in immunosuppressed IBD patients and highlights the necessity of considering rare infectious triggers such as VL even in low-prevalence regions. The stepwise evolution of hypotheses, from IBD flare to sepsis to malignancy to HLH, illustrates the need for flexible diagnostic reasoning, and multidisciplinary collaboration to optimize patient outcomes."

Case report • Clinical • Crohn's disease • Cytomegalovirus Infection • Dyslipidemia • Epstein-Barr Virus Infections • Gastroenterology • Gastrointestinal Disorder • Hemophagocytic lymphohistiocytosis • Hypertriglyceridemia • Immunology • Infectious Disease • Inflammatory Bowel Disease • Rare Diseases • Septic Shock • IL12A

LEISHMANIASIS UNDER ANTI-TNF THERAPY: A DIAGNOSTIC PITFALL (UEGW 2026) - "After loss of response to adalimumab, he had been receiving infliximab for six years with good disease control...AmBisome (3 mg/kg/day) was started, but treatment was discontinued prematurely after acute kidney failure...Immunosuppressed IBD patients treated with biologics are at increased risk of severe or atypical presentations. Although Belgium is only minimally endemic, this case emphasizes the need to consider, and in some cases screen for, leishmaniasis in patients originating from or regularly travelling to endemic regions before initiating immunosuppressive therapy."

Acute Kidney Injury • Crohn's disease • Gastroenterology • Immunology • Infectious Disease • Inflammatory Bowel Disease • Merkel Cell Carcinoma • Nephrology • Non-melanoma Skin Cancer • Renal Disease • Skin Cancer • Solid Tumor

PANCREATIC INVOLVEMENT OF VISCERAL LEISHMANIASIS MIMICKING MALIGNANCY IN A PATIENT WITH WALDENSTRÖM MACROGLOBULINEMIA: DIAGNOSIS BY ENDOSCOPIC ULTRASOUND-GUIDED FINE-NEEDLE BIOPSY (UEGW 2026) - "Treatment with liposomal amphotericin B resulted in rapid clinical and laboratory improvement.This case highlights visceral leishmaniasis presenting as a pancreatic malignancy mimic in an immunocompromised patient, with pancreatic involvement of VL that is rarely described. It underscores the diagnostic challenge of concurrent infectious and hematologic disease and emphasizes the pivotal role of EUS-FNB in characterizing atypical pancreatic lesions and preventing misdiagnosis."

Biopsy • Clinical • Hepatology • Infectious Disease • Lymphoma • Lymphoplasmacytic Lymphoma • Oncology • Waldenstrom Macroglobulinemia • CD1a • CD20

Community-Acquired Kodamaea ohmeri Fungemia in an Immunocompetent Host Coexisting With Severe Leptospirosis: A Case Report and Review of Community-Acquired Fungemia Cases. (PubMed, Cureus) - "Antifungal susceptibility testing demonstrated high susceptibility to amphotericin B, voriconazole, and caspofungin, whereas fluconazole showed reduced susceptibility. Due to severe hepatic and renal dysfunction, liposomal amphotericin B was preferred, resulting in rapid clinical improvement and clearance of fungemia...Accurate species identification, repeated blood culture confirmation, and timely antifungal therapy are critical for favourable outcomes. This case expands the clinical spectrum of K. ohmeri infection and suggests that severe leptospirosis may be a possible predisposing condition."

Journal • Infectious Disease • Nephrology • Renal Disease

L-AmB as the Real First-Line Therapy for Paediatric Visceral Leishmaniasis: A Multicentre Retrospective Study from an Endemic Area of Southern Italy. (PubMed, Antibiotics (Basel)) - "Although pentavalent antimonials have historically been considered first-line therapy for VL, their use in Italy has become increasingly limited because of restricted availability, safety concerns, and the widespread adoption of liposomal amphotericin B (L-AmB)...Notably, no patient received pentavalent antimonials, reflecting their complete replacement in routine clinical practice. these findings provide real-world evidence that L-AmB has effectively become the contemporary first-line treatment and standard of care for paediatric VL in an endemic Mediterranean setting, highlighting the discrepancy between historical therapeutic paradigms and current clinical practice."

Journal • Retrospective data • Hematological Disorders • Infectious Disease • Pediatrics

Pharmacovigilance in the treatment of cutaneous leishmaniasis: adverse event profile at a reference center. (PubMed, Rev Soc Bras Med Trop) - "The different profiles highlight the importance of pharmacovigilance in real-world settings."

Adverse events • Journal • Observational data • Dermatology • Infectious Disease

Fulminant bilateral blindness despite initially normal neuroimaging in rhinocerebral mucormycosis. (PubMed, IDCases) - "Liposomal amphotericin B was started without delay; however, the disease had already extended into the orbit and frontal brain parenchyma, making surgical debridement impossible...Rhinocerebral mucormycosis should be suspected immediately in diabetic ketoacidosis patients who develop acute cranial neuropathies or sudden vision loss, even when initial neuroimaging is unrevealing. Clinical deterioration may precede radiological abnormalities in fulminant rhinocerebral mucormycosis, and delayed recognition may rapidly eliminate the possibility of surgical intervention."

Journal • Diabetes • Giant Cell Arteritis • Immunology • Infectious Disease • Metabolic Disorders • Ophthalmology • Otorhinolaryngology • Respiratory Diseases

Disseminated Histoplasmosis Mimicking Cytomegalovirus Disease in a Liver Transplant Recipient With Hemophagocytic Lymphohistiocytosis (ACG 2026) - "Empiric antimicrobials and intravenous ganciclovir were started for presumed CMV colitis...Dexamethasone was initiated...Liposomal amphotericin B was started; however, her course was complicated by renal failure and bilateral subarachnoid hemorrhage...Bone marrow and liver biopsy, Histoplasma antigen testing, and molecular diagnostics were critical in establishing the diagnosis. This case highlights the need for a broad differential when evaluating HLH in transplant recipients."

Clinical • Anorexia • Cytomegalovirus Infection • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hemophagocytic lymphohistiocytosis • Hepatitis C • Hepatocellular Cancer • Hepatology • Immunology • Infectious Disease • Malaria • Neutropenia • Rare Diseases • Renal Disease • Respiratory Diseases • Solid Tumor • Subarachnoid Hemorrhage • Transplantation

Colonic EBV-Associated Smooth Muscle Tumor Concurrent With Disseminated Histoplasmosis in Advanced AIDS (ACG 2026) - "In addition, disseminated histoplasmosis was treated by four weeks of liposomal amphotericin B, followed by itraconazole maintenance therapy. Targeted immunohistochemistry with EBV ISH is essential for diagnosis, particularly when concurrent opportunistic infections are present. Figure: Figure 1: Colonoscopy findings: large nodular masses in the ascending colon and cecum with normal terminal ileum."

Metastases • Colorectal Cancer • Cough • Epstein-Barr Virus Infections • Gastroenterology • Gastrointestinal Disorder • Human Immunodeficiency Virus • Infectious Disease • Leiomyosarcoma • Oncology • Respiratory Diseases • Sarcoma • Solid Tumor • CALD • CD4

Fatal Angioinvasive Gastrointestinal Mucormycosis Following One Week of Autologous Hematopoietic Stem Cell Transplantation (ACG 2026) - "Liposomal amphotericin B and isavuconazole were initiated. Figure: Figure 1 A-B. Large cratered ulcers in the duodenum (1A) and duodenum (1B) Figure: Figure 2 A-C: Atypical circumferential ulceration in the cecum and proximal ascending colon"

Bone Marrow Transplantation • Cytomegalovirus Infection • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Infectious Disease • Multiple Myeloma • Neutropenia • Peptic Ulcer • Pulmonary Disease • Respiratory Diseases • Transplantation

Seronegative Disseminated Aspergillosis Mimicking Multiorgan Malignancy: When Culture Trumps Serology (ACG 2026) - "Urine Histoplasma antigen returned positive, and liposomal amphotericin B was initiated for presumed histoplasmosis...Voriconazole was initiated, achieving near-complete resolution on repeat PET-CT...Figure: FDG PET-CT demonstrating intensely avid circumferential sigmoid wall thickening with exophytic necrotic component and adjacent FDG-avid pelvic lesion, mimicking disseminated colorectal malignancy. Figure: Whole body FDG PET-CT showing multiorgan FDG-avid lesions involving sigmoid colon, lung, and breast, mimicking disseminated malignancy."

Colorectal Cancer • Cough • Endocrine Disorders • Gastrointestinal Disorder • Infectious Disease • Nephrology • Oncology • Renal Disease • Respiratory Diseases