auremolimab (INCA034460) / Incyte - LARVOL DELTA

Corporate and Business Development Updates (Businesswire) - "Based on ongoing pipeline prioritization efforts, the Company has paused further development of the INCA034460 (anti-CD122) and INCB57643 (BET inhibitor) programs, as well as the development of povorcitinib in chronic spontaneous urticaria (CSU)."

Discontinued • Chronic Spontaneous Urticaria • Myelodysplastic Syndrome • Myelofibrosis • Vitiligo

Antimicrobial and Cytotoxic Secondary Metabolites from a Marine-Derived Fungus Penicillium Citrinum VM6. (PubMed, Curr Microbiol) - "All compounds (1-8) exhibited selective antimicrobial activity against the tested Gram-positive bacteria and Candida albicans with MICs of 32-256 µg/mL. Compounds 1 and 8 exhibited cytotoxicity against all tested cell lines A549, MCF7, MDA-MB-231, Hela, and AGS with IC values of 6.7 ± 0.2 to 29.6 ± 2.2 µg/mL, whereas compound 5 had selective cytotoxicity against the MCF7 cell lines with IC of 98.1 ± 7.8 µg/mL."

Journal • Infectious Disease