amisulpride / Generic mfg. - LARVOL DELTA

Bidirectional modulation of reward-guided decision making by dopamine. (PubMed, Psychopharmacology (Berl)) - "Together, our data provide evidence for a role of dopamine in controlling the influence of value parameters on choice irrespective of decision strategies."

Journal

A Review of the Literature on Case Reports Describing Post-Stroke Psychosis Treatment (APA 2025) - "All 9 patients were treated with antipsychotics, with olanzapine used in 5 cases, risperidone in 3 cases, aripiprazole in 2 cases, quetiapine in 1 case, amisulpride in 1 case, and clozapine in 1 case. Prior studies show that right hemispheric lesions, history of mental health problems, and pre-existing subcortical atrophy may be risk factors for post-stroke psychosis. This literature review included cases with right-sided or bilateral lesions. The majority of cases included patients without past psychiatric histories, which is not consistent with the literature but was based on a small sample size."

Case report • Clinical • Review • Cardiovascular • CNS Disorders • Psychiatry

Unsupervised Graph Clustering Reveals a Clinical Taxonomy of Antipsychotics (APA 2025) - "Cluster 1 contained Aripiprazole, Brexpiprazole, Cariprazine, Lurasidone, Sertindole, and Ziprasidone, and was characterized by an excellent side-effect profile but also with the lowest efficacy. Cluster 2 contained Chlorpromazine, Haloperidol, Loxapine, Molindone, Perphenazine, and Thiothixene, and showed strong efficacy in positive symptoms, but also had a high-risk for EPS, QTc prolongation and seizures. Cluster 3 contained Clozapine, Iloperidone, Olanzapine, Quetiapine, Thioridazine, and Zotepine, and showed strong overall efficacy but carried the highest risk for sedation and metabolic side effects. Cluster 4 contained Amisulpride, Asenapine, Paliperidone, Risperidone, and Sulpride, and showed excellent positive and negative symptom efficacy but carried the highest risk of hyperprolactinemia. Cluster 5 contained Flupentixol, Fluphenazine, Pimozide, and Trifluoperazine and showed the lowest efficacy with a high risk of causing EPS. Conclusion Despite traditional..."

Clinical • Anesthesia • CNS Disorders • Epilepsy • Hypotension • Psychiatry • Schizophrenia

Comparative mortality risk of antipsychotics in 41,695 patients with schizophrenia: an 11-year population-based cohort study in Hong Kong. (PubMed, Eur Neuropsychopharmacol) - "Several commonly-used second-generation-antipsychotics (olanzapine (Zyprexa)/quetiapine/risperidone (Risperdal)/aripiprazole/amisulpride) were also associated with reduced mortality-risk relative to perphenazine. Our results highlight that mortality-risk is differentially associated with various antipsychotics and regimens, and indicate the critical role of clozapine and LAI antipsychotics in alleviating excess mortality-risk. Our findings underscore the importance of ensuring early access to clozapine and LAI antipsychotics to optimize psychiatric and physical outcomes in schizophrenia patients."

Journal • CNS Disorders • Psychiatry • Schizophrenia

Development of a method for rapid determination of 98 PPCPs in drinking water by SPE-UPLC-MS/MS. (PubMed, Anal Methods) - "Residues such as amisulpride and 1,7-dimethylxanthine were detected in water samples. This method is simple, sensitive, and suitable for high-throughput detection of trace PPCPs in drinking water, providing reliable technical support for water quality monitoring."

Journal

AMISULPRIDE FOR THE TREATMENT OF IDIOPATHIC GASTROPARESIS: RESULTS OF A DOUBLE-BLINDED PLACEBO-CONTROLLED STUDY (DDW 2025) - No abstract available

Clinical • Gastrointestinal Disorder

Antipsychotics cause reversible structural brain changes within one week. (PubMed, Neuropsychopharmacology) - "Within arms, participants were randomized to receive daily doses of either the active compound (Arm 1= amisulpride 400 mg/day, N = 24; Arm 2= aripiprazole 10 mg/day, N = 24) for one week, followed by placebo or vice versa. Short-term exposure to either one of two different antipsychotics results in a transient increase in striatal volume measured with T1-weighted MRI that normalizes rapidly on stopping treatment without cortical changes. Our findings suggest that striatal volumetric MRI differences detected in people with schizophrenia taking antipsychotics are, at least in part, attributable to pharmacological effects."

Clinical • Journal • CNS Disorders • Psychiatry • Schizophrenia

Bioequivalence and Safety of Two Amisulpride Formulations in Healthy Chinese Subjects Under Fasting and Fed Conditions: A Randomized, Open‑Label, Single‑Dose, Crossover Study. (PubMed, Drugs R D) - "The test and reference amisulpride formulations were bioequivalent under fasting and fed conditions. Both formulations showed similar safety and tolerability in the population studied."

Journal • CNS Disorders

Efficacy of Adding Oral Amisulpride to Dual Prophylaxis for Postoperative Nausea and Vomiting in Patients at High Risk for Nausea and Vomiting Undergoing Gynecological Surgery (clinicaltrials.gov) - P2 | N=276 | Recruiting | Sponsor: Instituto do Cancer do Estado de São Paulo | Not yet recruiting ➔ Recruiting

Enrollment open • Gynecology

Aripiprazole alleviates the high prolactin levels induced by amisulpride via distinct molecular mechanisms: a network pharmacology and molecular docking study. (PubMed, BMC Psychiatry) - "These findings highlight the distinct signaling pathways and molecular networks involved in prolactin regulation by aripiprazole and amisulpride and provide new insights into the mechanisms of these drugs in schizophrenia treatment. Further pharmacological and clinical research is needed to validate the complex regulatory networks and in vivo effects."

Journal • CNS Disorders • Psychiatry • Schizophrenia • CDC42 • DRD2 • ER • MAPK3 • MMP9 • PPARG

Photodegradation of psychotropic medications: Impact on efficacy, safety, and drug properties. (PubMed, Comput Biol Med) - "Our results indicate that photoproducts such as amisulpride_TP166, TP246, quetiapine_D4, and quetiapine_PH1 show enhanced biological affinity and ADME-Tox profiles similar to their parent compounds, suggesting possible therapeutic advantages in their interaction with targeted receptors. However, some of the photocompounds exhibit lower predicted binding affinities when interacting with those receptors compared to their parent compounds, indicating a possible loss of function. These findings emphasize the need for further investigation into the effects and safety of drug photoproducts, particularly in the context of long-term pharmacotherapy."

Journal • Bipolar Disorder • CNS Disorders • Depression • Mood Disorders • Psychiatry • Schizophrenia

Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments(SMART-CAT) (clinicaltrials.gov) - P3 | N=762 | Completed | Sponsor: Shanghai Mental Health Center | Unknown status ➔ Completed | Phase classification: P4 ➔ P3 | N=1260 ➔ 762

Enrollment change • Phase classification • Trial completion • CNS Disorders • Psychiatry • Schizophrenia

Drug-associated hyperprolactinemia: a comprehensive disproportionality analysis based on the FAERS database. (PubMed, Eur J Pharmacol) - "Sensitivity analysis indicated that most signals remained robust, with risperidone exhibiting the strongest signal for HPRL, followed by amisulpride, paliperidone, fluphenazine, and thioridazine. In conclusion, we identified and ranked drugs associated with HPRL, primarily psychotropic medications, and observed variations in signal strength and onset time across gender and age. These findings emphasize the importance of individualized HPRL screening based on specific medications, gender, and age."

Journal • CNS Disorders

Efficacy of Adding Oral Amisulpride to Dual Prophylaxis for Postoperative Nausea and Vomiting in Patients At High Risk for Nausea and Vomiting Undergoing Gynecological Surgery (clinicaltrials.gov) - P2 | N=276 | Not yet recruiting | Sponsor: Instituto do Cancer do Estado de São Paulo

New P2 trial • Gynecology

QT Interval, Antipsychotics and Correlates Among Patients with Schizophrenia: Cross-Sectional Data from the Multicentric Real-World FACE-SZ. (PubMed, Drug Saf) - "The prescription of antipsychotics should always be accompanied by close monitoring of the QTc interval to prevent the risk of severe cardiac arrhythmia, particularly concerning clozapine."

Journal • Real-world evidence • Cardiovascular • CNS Disorders • Psychiatry • Schizophrenia

Paliperidone-induced neuroleptic malignant syndrome: A case report. (PubMed, Medicine (Baltimore)) - "Although NMS is not very common in patients using antipsychotics, it is important because it is an emergency condition that can result in death if not treated appropriately. Clinicians should consider NMS in patients taking atypical antipsychotics such as paliperidone."

Journal • Cardiovascular • CNS Disorders • Movement Disorders • Psychiatry • Schizophrenia

Aborted Sudden Cardiac Death Due to Acquired QT Prolongation: A Case Report. (PubMed, Cureus) - "We present the case of a 60-year-old woman with a history of schizoaffective disorder treated with escitalopram and amisulpride and a recent prescription for ciprofloxacin for a urinary tract infection, who was admitted following a cardiac arrest. This case highlights the importance of thorough medication review and early identification of individuals at risk for acquired LQTS to prevent potentially fatal arrhythmias. It also highlights the necessity of considering underlying genetic predisposition, especially in cases where QT prolongation persists despite the discontinuation of the offending agents and/or correction of other contributing factors, making genetic testing advisable in selected patients, as it will guide further management."

Journal • Cardiovascular • CNS Disorders • Endocrine Disorders • Heart Failure • Infectious Disease • Nephrology • Psychiatry • Schizophrenia

Comparative risk of QTc prolongation induced by second-generation antipsychotics in the real world: retrospective cohort study based on a hospital information system. (PubMed, BJPsych Open) - "Ziprasidone, amisulpride and olanzapine are associated with increased risk of QTc prolongation. Regular electrocardiogram monitoring is recommended when clinicians prescribe such drugs."

Journal • Real-world evidence • Retrospective data • Cardiovascular • CNS Disorders

Antipsychotic drug dosing and study discontinuation in schizophrenia: A systematic review and dose-response meta-analysis. (PubMed, Eur Neuropsychopharmacol) - "Dose discontinuation curves varied between the antipsychotics and included U-shaped, monotonic, and hyperbolic patterns. Future studies should consistently present disease-related and side-effect-related dropouts due to adverse events separately."

Journal • Retrospective data • Review • CNS Disorders • Psychiatry • Schizophrenia

Exploring the factors and outcomes of clozapine discontinuation in India: A retrospective analysis. (PubMed, Asian J Psychiatr) - "These results align with previous studies, showing that adverse effects and inadequate response are prominent reasons for clozapine discontinuation and demonstrate the possibility of clozapine retrial in selected patients. Managing adverse effects might result in improvement, at least to a mild degree. Clozapine discontinuation can be avoided in a cohort with non-serious adverse effects, given the superiority of clozapine in resistant schizophrenia."

Journal • Retrospective data • CNS Disorders • Psychiatry • Schizophrenia

Therapeutic effects of amisulpride in male schizophrenics: Role of short-chain fatty acids and gene expression changes. (PubMed, Physiol Behav) - "However, direct evidence linking these changes to gut-brain axis mechanisms remains insufficient. Further research is needed to elucidate the therapeutic implications of these metabolic and immunological alterations and their potential role in symptom modulation."

IO biomarker • Journal • CNS Disorders • Psychiatry • Schizophrenia • CD14 • HDAC1 • TLR2 • TLR4

A New Trick of Old Dogs: Can Kappa Opioid Receptor Antagonist Properties of Antidepressants Assist in Treating Treatment-Resistant Depression (TRD)? (PubMed, Pharmaceuticals (Basel)) - " The antidepressants mianserin and mirtazapine (separately) induced dose-dependent antinociception, each yielding a biphasic dose-response curve. Similarly, the antidepressant venlafaxine produced a potent effect and reboxetine produced a weak effect. The antipsychotics risperidone and amisulpride exhibited a dose-dependent antinociceptive effect... Clinical studies are mandatory to establish the potential efficacy of augmentation of the treatment with antidepressants with these drugs in persons with treatment-resistant depression and the optimal dosage of medications prescribed. We suggest a possible beneficial effect of antidepressants with kappa antagonistic properties."

Journal • Addiction (Opioid and Alcohol) • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Optimizing Intranasal Amisulpride Loaded Nanostructured Lipid Carriers: Formulation, Development, and Characterization Parameters. (PubMed, Pharm Nanotechnol) - "The right combination of the formulation compositions based on studying the effect of each factor on the main formulation characteristics can serve as the basis for a successful intranasal amisulpride-loaded nanostructured lipid carrier."

Journal

Developing an Ecotoxicological Classification for Frequently Used Drugs in Primary Care. (PubMed, Int J Environ Res Public Health) - "Fifteen APIs were designated as safe (category (1):paracetamol, tramadol, amisulpride, citalopram, mirtazapine, metformin, gabapentin, lamotrigine, primidone, candesartan, irbesartan, atenolol, hydrochlorothiazide, ofloxacin, sulfadiazine), eleven as intermediately safe, and nine were of concern (azithromycin, ciprofloxacin, clarithromycin, sulfamethoxazole, carbamazepine, diclofenac, ibuprofen, iomeprol, iopromide). Where data do exist, we observed significant differences in environmental impact among the same class of drugs. Our classification could therefore help guide doctors to adopt more eco-friendly prescriptions."

Journal

The Effect of Age on Antipsychotic Serum Concentration in Males and Females: A Study Based on Therapeutic Drug Monitoring Data From 19,926 Patients. (PubMed, Ther Drug Monit) - "The age-dependent increase in dose-adjusted serum concentrations among males and females varied across different antipsychotics and was highest for risperidone. These findings emphasize the importance of proper monitoring of antipsychotic use in older adults."

Journal • CNS Disorders