amantadine / Generic mfg. - LARVOL DELTA

Sensitive detection of amantadine in food matrices using DTT-functionalized gold nanoparticles. (PubMed, RSC Adv) - "Validation through standard addition recovery experiments in AMD-spiked food samples confirmed the assay's accuracy and precision. Overall, this fluorometric platform offers a rapid, reliable, and cost-effective approach for AMD monitoring, supporting its practical application in food quality control and regulatory surveillance programs."

Journal

Antibiotic resistance genes in multi-matrices of Chaohu Lake: Spatiotemporal variation and correlation with pesticides and PPCPs. (PubMed, J Hazard Mater) - "Non-antibiotic pollutants, such as amantadine and terbuthylazine, displayed significant positive correlations with ARGs, similar to sulfamethoxazole and clindamycin. Our findings highlight the important roles of seasonal hydrological changes and non-antibiotic pollutants in the dissemination of ARGs."

Journal

A Study of Amantadine for Cognitive Dysfunction in Patients With Long-Covid (clinicaltrials.gov) - P2 | N=0 | Withdrawn | Sponsor: University of Texas Southwestern Medical Center | N=30 ➔ 0 | Recruiting ➔ Withdrawn

Enrollment change • Trial withdrawal • Cognitive Disorders • Infectious Disease • Novel Coronavirus Disease

Design, syntheses and comparative QSAR analyses of aryl adamantylamines and aryl bicyclo[2.2.2]octylamines as uncompetitive NMDAR antagonists (ACS-Fall 2025) - "To address this issue, uncompetitive NMDAR antagonism continues to be a worthwhile pursuit, as demonstrated by FDA approval of three compounds in that class – memantine for treatment of AD, amantadine for treatment of Parkinson's Disease (PD), and the recentapproval of Ketamine for treatment resistant major depressive disorder...Binding affinities for the NMDAR will be measured via competitive radioligand binding assays using 3H-MK-801.Preliminary SAR trends of the aryl admantylamine series indicate increased potency when introducing N-substitution, where variation in the aromatic ring system from benzene to thiophene also leads to increased binding potency...Design of the arylbiclo[2.2.2]octylamine library is currently ongoing and final compounds selection for syntheses will be informed by computational insight from molecular docking and QSAR design. These probes will ultimately be used in the generation of a pharmacophore and QSAR model for uncompetitive NMDAR..."

CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Movement Disorders • Parkinson's Disease • Psychiatry

Efficacy and Safety of Twelve Anti-Dyskinetic Drugs in Parkinson's Disease: A Bayesian Network Meta-Analysis of Randomized Controlled Trials. (PubMed, Eur J Neurol) - "Amantadine ER improved dyskinesia significantly versus amantadine IR. Both formulations of amantadine were superior as OFF time-reducing agents compared to other anti-dyskinetic drugs, whereas amantadine IR non-significantly reduced OFF time versus amantadine ER."

Journal • Retrospective data • Review • CNS Disorders • Movement Disorders • Parkinson's Disease

Ketamine and other NMDA receptor antagonists for chronic pain. (PubMed, Cochrane Database Syst Rev) - "Limited low- to very low-certainty evidence limits conclusions about the effects of ketamine, memantine, dextromethorphan, amantadine, and magnesium on pain intensity. Intravenous ketamine may increase the risk of adverse events, but the harms of ketamine and other NMDA receptor antagonists are generally unclear. Adequately powered RCTs are needed to determine the benefits and harms of ketamine and other NMDA receptor antagonists for chronic pain."

Journal • Review • CNS Disorders • Depression • Oncology • Pain

MR-301-T-001: Study to Assess the Safety of Amantadine Hydrochloride (HCl) Intravenous (IV) Solution (MR-301) in Patients With Severe Traumatic Brain Injury (TBI). (clinicaltrials.gov) - P2 | N=45 | Active, not recruiting | Sponsor: SHINKEI Therapeutics, Inc | Recruiting ➔ Active, not recruiting

Enrollment closed • CNS Disorders • Vascular Neurology

A Study Comparing Propranolol and Amantadine for Reducing Tremors in People With Parkinson's Disease (clinicaltrials.gov) - P=N/A | N=220 | Completed | Sponsor: Multan Medical And Dental College

New trial • CNS Disorders • Movement Disorders • Parkinson's Disease

Comparative efficacy of antidepressant augmentation with amantadine vs pramipexole in treatment-resistant unipolar depression: A randomised controlled trial. (PubMed, J Affect Disord) - P4 | "Augmentation with amantadine and pramipexole were safe and effective in TRD. Additionally, pramipexole showed better efficacy to amantadine and quetiapine. Clinical improvements corroborated with improved BDNF and NGF levels. However, larger multi-centric studies are warranted for generalisability. (ClinicalTrials.gov: NCT04936126)."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry • BDNF • NGF

Benzoxazoles Derived from Eugenol as Potential Agents against Arboviruses: Synthesis, Antiviral Studies, and Mechanistic Insights. (PubMed, ChemMedChem) - "Derivative 16 shows the highest potency and selectivity indices: 25 for ZIKV (EC50: 6.1 µM), 11 for CHIKV (EC50: 14.2 µM), and 24 for MAYV (EC50: 6.3 µM), 68 times more potent than ribavirin and amantadine drugs...Molecular dynamics and MM/GBSA binding energy analysis of compound 16 on viral replication targets identified the capsid protein and nsP3 as the most promising targets, with binding free energies of -31.21 and -29.55 kcal/mol, respectively. The ligand remained deeply buried and well-confined in both binding sites, with minimal positional drift and a marked reduction in solvent-accessible surface area."

Journal • Chikungunya • Infectious Disease

Computational exploration and molecular dynamics simulations for investigating the potential inhibitory mechanism of amantadine on the ion channel activity of bovine viral diarrhea virus p7. (PubMed, J Comput Aided Mol Des) - "The binding of amantadine to residues Y25 and L28 likely disrupts ion transport. Our findings provide possible structural insights into the BVDV p7 ion channel and offer a mechanistic explanation for the inhibitory of amantadine on BVDV p7-mediated ion channel conductance, though experimental validation remains necessary."

Journal • Infectious Disease

Efficacy and safety of oral amantadine in Parkinson's disease with dyskinesia and motor fluctuations: a systematic review and meta-analysis of randomised controlled trials. (PubMed, BMJ Neurol Open) - "Additionally, DR/ER improved motor fluctuations, while IR demonstrated benefits, although the evidence is limited by short study durations. CRD42024513081."

Journal • Retrospective data • CNS Disorders • Constipation • Gastroenterology • Gastrointestinal Disorder • Movement Disorders • Parkinson's Disease • Xerostomia

Efficacy and safety of amantadine for functional recovery in adults with traumatic brain injuries: A comprehensive systematic review and meta-analysis. (PubMed, Clin Neurol Neurosurg) - "Amantadine might be an adjuvant to standard care for adults with TBI, but further randomized research is required regarding its effects in the short and long-term periods."

Journal • Retrospective data • CNS Disorders • Epilepsy • Vascular Neurology

Repurposing of Some Nucleoside Analogs Targeting Some Key Proteins of the Avian H5N1 Clade 2.3.4.4b to Combat the Circulating HPAI in Birds: An In Silico Approach. (PubMed, Viruses) - "(3) Molecular docking revealed strong binding affinities for both sofosbuvir and GS441524, particularly with the NA and PB2/CBD protein targets...The MM-GBSA binding free energy calculations further supported these findings, as GS441524 displayed more favorable binding energies compared to several known standard inhibitors, including F0045S for HA, Zanamivir for NA, Rimantadine and Amantadine for M2, and PB2-39 for PB2/CBD...These results further support the potential repurposing of GS441524 as a promising therapeutic candidate against H5N1 avian influenza clade 2.3.4.4b. However, further functional studies are required to validate these in silico predictions and support the inhibitory action of GS441524 against the targeted proteins of H5N1, specifically clade 2.3.4.4b."

Journal • Infectious Disease • Influenza • Novel Coronavirus Disease • Respiratory Diseases

Aryl benzoyl hydrazide derivatives as potent inhibitors of the NS2B-NS3 protease and RNA-dependent RNA polymerase of the zika virus. (PubMed, In Silico Pharmacol) - "To identify molecules that can strongly bind to the substrate binding site of the NS2B-NS3 protease of the ZIKV, interactions of several aryl benzoyl hydrazide (ABH) derivatives (10b, 10c, 10g, 11p, and 11q) and some anti-influenza drugs (Zanamivir, Laninamivir, Baloxavir, Oseltamivir, Rimantadine, Peramivir, and Amantadine) with the ZIKV NS2B-NS3 protease are studied herein by using combined density functional theoretic, docking, molecular dynamics (100 ns MD simulations), and free-energy methods...Computed ADMET parameters, Lipinski's rule of five, and binding affinities suggest that 11q would be a better drug candidate against ZIKV infections. The online version contains supplementary material available at 10.1007/s40203-025-00395-5."

Journal • Infectious Disease • Influenza • Respiratory Diseases

Unveiling Lipid Droplet Dynamics in Parkinson's Disease via a Polarity-Responsive Alkenyl Indole-Based Fluorophore. (PubMed, Anal Chem) - "Furthermore, PD3-enabled evaluation of PD drugs demonstrated that amantadine (AMA) and pramipexole (PPX) restored LD homeostasis, linking their therapeutic effects to LD modulation. Ex vivo studies in methyl-phenyl-tetrahydropyridine (MPTP)-induced PD mice confirmed LD accumulation in brain tissues, correlating with motor deficits and neuronal loss in the substantia nigra. This work establishes PD3 as a powerful tool for deciphering LD-associated PD pathology and advancing LD-targeted therapeutic strategies."

Journal • CNS Disorders • Movement Disorders • Parkinson's Disease

Investigating on Therapeutic Potential of Amantadine in mitigation of Burn Injury-Induced Chronic Pain (NeuPSIG 2025) - No abstract available

CNS Disorders • Pain

A potential strategy for improving offspring behavior in maternal immune activation: Amantadine-mediated suppression of neuroinflammation. (PubMed, Animal Model Exp Med) - "AMA can prevent the development of neuropsychiatric disorders in MIA offspring. This effect may be related to its ability to attenuate neuronal damage, reduce neuronal apoptosis, and inhibit neuroinflammation, indicating that the antiviral drug AMA may be a potential treatment for MIA."

IO biomarker • Journal • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Genetic Disorders • Infectious Disease • Inflammation • Mental Retardation • Oncology • Psychiatry • BCL2 • CASP3 • CD68 • IL1B • IL6 • TNFA

BIOTECHNOLOGICALLY PRODUCED NEUROSTIMULANTS MAY CONTRIBUTE TO PROLONGED IMPROVEMENTS IN MOTOR PERFORMANCE: A NARRATIVE REVIEW. (PubMed, Georgian Med News) - "Unlike traditional pharmacological neurostimulants such as modafinil, amantadine, or methylphenidate, which primarily target monoaminergic systems, bacterial melanin demonstrates neuroprotective, neuroregenerative, and electrophysiologically stimulating properties across various CNS regions, including the substantia nigra. This chapter critically examines the physiological basis and translational potential of such novel neurostimulants by integrating findings from optogenetic stimulation, pharmacological trials, and neurobehavioral rehabilitation paradigms. The convergence of microbial biotechnology and neurostimulant pharmacology may redefine clinical approaches to motor dysfunction and neuroplastic recovery following central nervous system injury."

Journal • Review

Amantadine Continuation After Hospital Discharge for Acute Stroke Requiring Inpatient Rehabilitation: A Long-term Follow-up Study. (PubMed, Arch Rehabil Res Clin Transl) - "Amantadine appeared well tolerated during and after inpatient rehabilitation, and most (22/28) patients were prescribed amantadine at discharge. Strategies to guide long-term use of amantadine after acute stroke require further prospective study."

Journal • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Critical care • Fatigue • Hematological Disorders • Insomnia • Ischemic stroke • Movement Disorders • Sleep Disorder • Subarachnoid Hemorrhage • Vascular Neurology

Amantadine Can Treat Blepharospasm in Levodopa Peak-Dose Dyskinesia. (PubMed, Mov Disord Clin Pract) - No abstract available

Journal • CNS Disorders • Movement Disorders

Amantadine as a therapeutic option for neuropathic pain in dogs with degenerative lumbosacral stenosis. (PubMed, BMC Vet Res) - "The results suggest that amantadine, either alone or in combination with meloxicam, improves GRFs in dogs with degenerative lumbosacral stenosis and, may be a valuable component of its multimodal therapy, though additional research is necessary to validate these findings."

Journal • Neuralgia • Pain

Amantadine reduces sepsis-induced brain injury via NLRP3/caspase-1 inflammasome activation. (PubMed, Iran J Basic Med Sci) - "Our findings suggest that amantadine reduces neuronal injury in the brain by alleviating oxidative stress and inflammation. Notably, amantadine's efficacy appears to extend beyond NMDA receptors, implicating involvement in alternative pathways, such as Cas-1 activation by the NLRP3 inflammasome."

Journal • Anesthesia • CNS Disorders • Hematological Disorders • Infectious Disease • Inflammation • Oncology • Septic Shock • Vascular Neurology • CASP1 • CASP3 • IFNA1 • IL18 • IL1B • NLRP3 • TNFA

Identification of biomarkers for treatment escalation of ulcerative colitis based on untargeted metabolomics and machine learning algorithms: a prospective cohort study (IDDF 2025) - "Of these, levels of 8 metabolites were decreased, including 12-hydroxydodecanoic acid, canthaxanthin, phenylacetaldehyde, 3,5-dihydroxybenzoic acid, benzene, amantadine, azelaic acid, and theophylline...The areas under the receiver operating characteristic curve of the SVM, RF, KNN, and logistic regression models based on metabolic biomarkers were 0.909, 0.999, 0.918, and 0.900, respectively.Conclusions The plasma metabolome represents a promising source of biomarkers for the prediction of treatment escalation in active UC. Metabolic biomarkers, combined with machine learning algorithms, could be efficient for risk assessment and early identification of UC treatment escalation."

Biomarker • Clinical • Machine learning • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Metabolic Disorders • Ulcerative Colitis

Isolation, characterization and phylogenetic analyses of avian influenza A (H9N2) viruses isolated from poultry between 2019 and 2023 in Egypt. (PubMed, BMC Vet Res) - "In addition, genetic analysis of the NA and M encoding proteins revealed the absence of substitutions associated with resistance to oseltamivir and amantadine...The HA gene was under positive selection pressure especially at sites 198 and 235 of RBS, while other internal genes were under negative selection pressure. The study highlights the importance of continuous monitoring of H9N2 virus to enable timely implementation of control measures in poultry populations in Egypt."

Journal • Infectious Disease • Influenza • Respiratory Diseases