amphetamine / Generic mfg. - LARVOL DELTA

Crosstalk Between Dopamine and the Epigenetic Enzyme LSD1/KDM1a: Implications for Amphetamine Response. (PubMed, J Neurochem) - "On the other hand, while a single dose of the AMPH did not alter uLSD1 and neuroLSD1 isoforms' expression, repeated AMPH administration led to a transient increase followed by a reduction of neuroLSD1 transcripts' abundance in the striatum and hippocampus. In conclusion, our data reveal a critical interplay between dopaminergic neurotransmission and the expression of LSD1 isoforms in the brain, highlighting their potential role in modulating dopamine-dependent behaviors."

Journal • Tobacco Addiction • KDM1A

Adolescent stress differentially modulates the affective, psychomotor, and neural responses to a first amphetamine exposure in male Wistar rats. (PubMed, Pharmacol Biochem Behav) - "Conversely, the expression of Rho GTPase-activating protein 32 (P250gap), cAMP-response element binding protein (Creb), and DNA methyltransferase 3A (Dnmt3a) was cross-sensitized in the NAc. The coexistence of cross-sensitization and cross-tolerance neurobehavioral effects between CUS and amphetamine supports the idea that ELA can simultaneously blunt and heighten different brain substrates, collectively increasing the risk of drug dependence."

Journal • Preclinical • ACTR2 • BDNF • DNMT3A • NTRK2

Global, regional and national burden of drug use disorders, 1990-2021: decomposition analysis, health inequality analysis and predictions to 2035. (PubMed, Front Public Health) - "The burden of DUDs varies among the five drug use disorders due to factors such as population aging, population changes, and age distribution. The findings reveal absolute and relative inequalities in DALYs associated with drug use disorders, which are concentrated in high-income regions."

Journal • Substance Abuse

A Diagnostic Dilemma-Severe Hyperthermia and Rigidity in a Young Man with Polysubstance Use: A Case Report. (PubMed, Clin Pract Cases Emerg Med) - "This case underscores the importance of considering neuroleptic malignant syndrome in patients with atypical presentations, suspicion for comorbid psychiatric conditions, and substance use disorder. Timely diagnosis, discontinuation of the offending agent, and targeted therapies such as dantrolene are critical in preventing complications. We highlight the diagnostic challenges and management strategies for NMS in the context of a limited history and severe hyperthermia."

Journal • Anesthesia • Cardiovascular • CNS Disorders • Critical care • Immunology • Metabolic Disorders • Psychiatry • Schizophrenia • Systemic Inflammatory Response Syndrome

Real-Time In Vivo Monitoring of Cholinergic Neurotransmission in the Mouse Brain Using a Microelectrochemical Choline Biosensor. (PubMed, Eur J Neurosci) - "Systemic administration of donepezil produced a pronounced decrease in current in both the prefrontal cortex and hippocampus, with scopolamine and amphetamine resulting in signal increases that were not observed in animals with selective saporin lesioning (murine-p75) of the cholinergic basal forebrain. Furthermore, continuous biosensor recording in both regions displayed diurnal oscillations across repetitive light-dark phases. All are consistent with successful monitoring of endogenous changes in cholinergic neurotransmission."

Journal • Preclinical

Escalating Mortality from Amphetamine-Associated Heart Failure in the United States (2003–2022): A Nationwide Analysis of Regional and Demographic Disparities (AHA 2025) - "Deaths in which amphetamine use disorder contributes to HF have surged significantly across all demographic and geographic sectors, with disproportionate increases in young adults, rural populations, and racial minorities. The especially steep trends in non metro regions and among American Indian/Alaska Native communities signal urgent need for tailored public health initiatives, focusing on stimulant use prevention, cardiovascular screening, and substance use rehabilitation integrated with cardiac care."

Cardiovascular • Congestive Heart Failure • Heart Failure

Individual Differences in Frequency Modulated 50-kHz Ultrasonic Vocalizations Reflect but Do Not Predict Cocaine Self-Administration in Rats. (PubMed, Behav Brain Res) - "Twenty singly housed rats underwent behavioral testing (elevated plus maze, novel object recognition, and tickling-induced vocalizations) and amphetamine sensitization...However, anticipatory FM 50-kHz USVs do not provide a reliable indicator of SA intensity. Accurate interpretation of FM 50-kHz USVs requires integration with behavioral and neurobiological markers to effectively identify addiction risk phenotypes."

Journal • Preclinical • CNS Disorders • Psychiatry

The impact of opioid agonist treatment on the incidence of bacterial sexually transmitted infection notifications among people with a history of opioid dependence in New South Wales, Australia: A retrospective data linkage study. (PubMed, Drug Alcohol Depend) - "OAT services are well-positioned to offer STI screening to people with opioid dependence and detect undiagnosed or untreated infections early during treatment. Subsequent testing to identify further, incident infections should be informed by individual risk factors, including sex and meth/amphetamine use."

Journal • Retrospective data • Addiction (Opioid and Alcohol) • Infectious Disease

A Rare Presentation of Gastric Ischemia Manifesting as Gastric Pneumatosis in the Context of Amphetamine Use (ACG 2025) - "A nasogastric tube was placed for decompression, and the patient was started on ceftriaxone and metronidazole. Our case highlights the need to consider gastric ischemia in patients with amphetamine use disorder presenting with nonspecific gastrointestinal symptoms and imaging suggestive of gastric pneumatosis. Early recognition of gastric pneumatosis is crucial to improve patient outcomes, as it may indicate ischemia and carries a risk of increased mortality.Figure: Axial computed tomography image of the abdomen demonstrating gastric pneumatosis, indicated by red arrows."

Cardiovascular • Gastrointestinal Disorder • Hypotension • Infectious Disease • Ischemic stroke

Beyond Varices: Left Gastric Pseudoaneurysm as a Rare Cause of Upper GI Bleed in Cirrhosis (ACG 2025) - "Several interventions, including hemostasis powders, epinephrine, and ethanolamine, were unsuccessful, so a fully-covered stent was placed to tamponade the bleed. It is possible that the pseudoaneurysm developed due to severe local inflammation from the amphetamine-induced esophagitis. Worsening esophagitis and coagulopathy likely caused the pseudoaneurysm to rupture, resulting in a bleed refractory to endoscopic intervention and requiring embolization.Figure: Figure 1: CT Angiography Demonstrating the Pseudoaneurysm in the Gastroesophageal Branch of the Left Gastric Artery"

Atherosclerosis • Cardiovascular • Fibrosis • Gastrointestinal Disorder • Hematological Disorders • Hepatitis B • Hepatitis C • Hepatology • Immunology • Infectious Disease • Inflammation • Mood Disorders • Pancreatitis • Varicose Veins

Revisiting the Role of Serotonin in ADHD (AACAP 2025) - "In addition, several medications that positively impact ADHD symptoms (eg, amphetamine, viloxazine, and monoamine oxidase [MAO] inhibitors) are associated with enhanced serotonergic activity...Of note, human fMRI studies indicate that fluoxetine challenge produces changes in activation within the prefrontal cortex similar to what is seen with ADHD medications (Chantiluike et al, 2015). We conclude that 5-HT has an important role in key associated features of ADHD and indirectly contributes to the regulation of core features of the disorder. Implications for treatment will be discussed."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Depression • Psychiatry

Does Initiating Stimulants in Adults With ADHD Increase the Risk for Subsequent Stimulant or Other Substance Use Disorders? (AACAP 2025) - "Starting stimulants for ADHD in adulthood was not associated with an increased risk for StimUD or SUD. Our results, while reassuring, require replication in other healthcare settings and in those with preexisting SUDs.ADHD, STIM, SUD"

Clinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

To Stimulate or Supplement: A Nationwide Review of Long-Term Outcomes in Patients With ADHD (AACAP 2025) - "Current AACAP guidelines include stimulants such as methylphenidate or amphetamine-based medications as first-line therapy. In this cohort study, combined therapy was associated with increased risks of MDD, GAD, CD, and SI compared to stimulants or supplements alone. Interestingly, compared to supplement monotherapy, stimulant monotherapy was associated with increased risks of MDD, GAD, and CD. Further study is needed to clarify the effects of supplements in mental health outcomes of patients with ADHD, including interactions with stimulant medications.EBP, STIM, MAE"

Clinical • Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Behavior Disorders • CNS Disorders • Developmental Disorders • General Anxiety Disorder • Mood Disorders • Pediatrics • Psychiatry • Suicidal Ideation

Inducing Striatal Overgrowth in Mice to Model Autism-Linked Neurodevelopmental Changes (AACAP 2025) - "Adult offspring completed a behavioral battery including open field, rotarod motor learning, water T-maze habit and reversal learning, and amphetamine (AMPH)-induced stereotypy assays... These findings provide the first direct evidence that prenatal activation of mGluR5 via CHPG ICV injection induces striatal cellular overgrowth and leads to enduring changes in striatal-dependent behavior. This model offers a tractable platform for exploring mechanisms linking early striatal overgrowth to ASD-relevant behavioral phenotypes and may inform future therapeutic targets.ASD, NEURODEV, ANI"

Neurodevelopmental • Preclinical • Autism Spectrum Disorder • Genetic Disorders • Mood Disorders • Psychiatry

Prescribing Patterns and Clinical Outcomes in Youth With ADHD and Co-Occurring PTSD: A Nationwide Study (AACAP 2025) - "Methylphenidate use slightly declined (RR 0.97), while amphetamine use remained stable. Youth with ADHD and PTSD represent a high-risk group with complex needs. Following PTSD diagnosis, clinicians appear more likely to shift away from CNS stimulants despite evidence of superior long-term clinical outcomes. Findings highlight the need for evidence-based treatment guidelines for this population.ADHD, PTSD, PPC"

Clinical • Clinical data • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Post-traumatic Stress Disorder • Psychiatry

Optimizing ADHD Medication Management: From Stimulants to Nonstimulants in Children and Adolescents (AACAP 2025) - "Specifically, the presentation will cover dosing regimens, side effects, and monitoring considerations for CNS stimulants (eg, methylphenidate, amphetamine salts), alpha-2 adrenergic agonists (eg, guanfacine, clonidine), and NRIs (eg, atomoxetine, viloxazine). CNS stimulants remain the first-line treatment for ADHD, with a 70%-80% response rate in children... Effective ADHD management requires a personalized approach, balancing medication efficacy with tolerability. Clinicians must closely monitor side effects and ensure that treatment aligns with the patient's developmental stage, comorbidities, and individual needs. Continued collaboration with families and frequent follow-up are critical to optimizing long-term outcomes for children and adolescents with ADHD.ADHD, PPC, TREAT"

Clinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry • Suicidal Ideation

From Mass to Class: Classification of Amphetamines MS/MS Spectra via Graph Neural Networks. (PubMed, J Chem Inf Model) - "Evaluation of model performance on a randomly selected 10% test subset yielded a recall of 0.86 and a precision of 0.11. The model successfully detected the spiked amphetamine derivative in a human plasma sample, achieving a 1% false positive rate and demonstrating its applicability to complex biological matrices."

Journal

Molecular basis of vesicular monoamine transport and neurological drug interactions. (PubMed, Cell Rep) - "Here, we report cryo-electron microscopy structures of human VMAT2 capturing a cytoplasmic-open state with reserpine and lumenal-facing states with serotonin and histamine in open, amphetamine in less open, tetrabenazine in fully occluded, and unbound VMAT2 in partially occluded conformations. Liposome-based analyses demonstrate that amphetamine directly induces the release of a fluorescent monoamine analog via VMAT2, consistent with an exchange mechanism underlying psychostimulation. These findings reveal the molecular basis of monoamine storage and drug interactions by VMAT2, informing therapeutic development for neurological diseases and substance abuse."

Journal • CNS Disorders • Substance Abuse

Food restriction and amphetamine exposure synergistically enhance accumbal dopamine D1 receptor-mediated locomotor activity. (PubMed, Neurochem Int) - "These results demonstrate that FR conditions interact with drugs of abuse via the accumbal ghrelin and D1R systems, thereby contributing to the expression of addictive behaviors. Notably, these findings suggest that dietary status should be considered during addiction treatment."

Journal • CNS Disorders • Psychiatry • Tobacco Addiction

Global Trends in ADHD Medication Use: Multiple Contexts and Rising Concerns-A Narrative Review. (PubMed, J Clin Med) - "Methylphenidate remained the most widely prescribed drug, although the use of lisdexamfetamine and guanfacine has expanded in recent years...Increasing use of ADHD medications raises important questions about equitable access to treatment, potential overdiagnosis, and the risk of stimulant misuse. These findings highlight the need for continued monitoring of utilization patterns to ensure safe, rational, and equitable ADHD care worldwide."

Journal • Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Sleep Paralysis Among Higher Education Students: A Possible Role of Antidepressant and Recreational Stimulant Use. (PubMed, Medicina (Kaunas)) - " Our study suggests that SP is prevalent among students with a tendency to recur. We report a correlational association between SP and the use of antidepressants or stimulant drugs, suggesting the need to further explore the possible role of psychoactive agents in this disorder."

Journal • Mood Disorders • Psychiatry • Sleep Disorder

The Effect of Intraocular Haloperidol on Motor Function in Models of Two Neuropsychiatric Disorders: Implications for the Origin and Treatment of Parkinson's Disease, Psychosis and Drug Addiction. (PubMed, Brain Sci) - " Motor tests included open field performance and the latency to perform three motor tests after the IVIT injection of haloperidol with and without amphetamine pretreatment. These results illustrate that IVIT injections of DA and melatonin receptor antagonists can differentially alter motor function via the retina. This suggests that the retina may be a treatment target not only for PD but also for other DA- and melatonin-mediated disorders such as drug addiction, psychosis and schizophrenia."

Journal • CNS Disorders • Mental Retardation • Movement Disorders • Parkinson's Disease • Psychiatry • Schizophrenia • Substance Abuse

Fenfluramine treatment beyond dravet and lennox-gastaut syndromes - A retrospective study suggesting a novel use in genetic, developmental and epileptic encephalopathies (DEEs). (PubMed, Seizure) - "This retrospective report suggests that FFA may be an effective add-on therapeutic option in children with rare, genetic epilepsies where efficacy was notable early on in drug initiation and titration. A trial of FFA for drug-resistant seizures may be considered to assess efficacy in the DEE population beyond DS and LGS."

Journal • Retrospective data • Cardiovascular • CNS Disorders • Epilepsy • Heart Failure • Hypertension • Pediatrics • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Changes in Risk Behaviour Among People With Recent Injecting Drug Use in Oslo 2002-2024. (PubMed, Drug Alcohol Rev) - "A decline in the prevalence of recent risk behaviour among people who inject drugs in Oslo was observed between 2002 and 2024. Risk behaviour remains common among younger individuals."

Journal • Hepatitis B • Infectious Disease • Inflammation

AMYL NITRITE-INDUCED METHEMOGLOBINEMIA FOLLOWING THE INGESTION OF VCR CLEANER (CHEST 2025) - "A urine drug screen was positive for alcohol, amphetamine, and THC; however, the patient has prescriptions for methylphenidate and THC...He was treated with methylene blue (MB), ascorbic acid, intravenous fluid, sodium bicarbonate drip, thiamine, and ampicillin/sulbactam... This case highlights the serious complications of MetHb following the ingestion of amyl nitrite-containing VCR cleaner. MetHb can present with a wide range of symptoms, depending on the levels of methemoglobin. Our patient presented to the hospital with altered mental status, nausea, and dizziness and was found to have a MetHb level of 57.1%."

Cardiovascular • CNS Disorders • Epilepsy • Hematological Disorders • Metabolic Disorders • Pulmonary Disease