amphetamine / Generic mfg. - LARVOL DELTA

TD-ESI-MS/MS for High-Throughput Screening of 13 Common Drugs and 4 Etomidate Analogs in Hair: Method Validation and Forensic Applications. (PubMed, Toxics) - "This study established a dual analytical workflow integrating thermal desorption-electrospray ionization-tandem mass spectrometry (TD-ESI-MS/MS) for rapid qualitative screening and ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) for confirmatory quantification of 17 psychoactive substances and metabolites across six classes (opioids, amphetamine-type stimulants, cocaine, ketamine-type drugs, cannabinoids, and etomidate analogs) in hair matrices. Despite limitations in the temporal resolution and representativeness of the cohort, this study demonstrated the viability of TD-ESI-MS/MS for bridging forensic and public health priorities. Future work should focus on optimizing the durability of the ion source for TD-ESI and validating this method across diverse populations to enhance its generalizability."

Journal

Behavioral manifestations and underlying mechanisms of amphetamine in constructing animal models of mania: a comprehensive review. (PubMed, Front Neurosci) - "In summary, the AMPH-induced mania animal model is crucial for studying mania's pathogenesis. However, further in-depth studies on neurotransmitter regulation, signaling pathway intervention, and neurotrophic factors are needed to develop more effective and personalized treatment plans."

Journal • Preclinical • Review • Alzheimer's Disease • Bipolar Disorder • CNS Disorders • Cognitive Disorders • Inflammation • Mood Disorders

Serotonergic Compounds With Psychedelic Effects and Fluoxetine Differentially Interact With TrkB Receptors (APA 2025) - "We tested LSD, psilocin, N,N-dimethyltryptamine (DMT), mescaline, 2,5-dimethoxy-4-iodoamphetamine (DOI), N-2-methoxybenzyl-phenethylamine (25B-NBOMe), 4-bromo-2,5-dimethoxyphenethylamine (2C-B), methylenedioxy amphetamine (MDA), and the selective serotonin reuptake inhibitor fluoxetine. LSD, 25B-NBOMe, and fluoxetine activated the TrkB receptor at pharmacologically relevant concentrations as partial agonists whereas psilocin, DMT, mescaline, and 2C-B did not. The combination of BDNF with fixed concentrations of the tested compounds led to reduced activation efficacy of BDNF, suggesting partial antagonism of all compounds tested. LSD potentiated the BDNF-induced TrkB activation."

CNS Disorders • Depression • General Anxiety Disorder • Major Depressive Disorder • Mood Disorders • Psychiatry • BDNF • NTRK2

Equity in Action: The Consultant's Role in Guiding Primary Teams Through Implicit Bias (APA 2025) - "Her history was significant for amphetamine use and homelessness...We explore how we can utilize implicit bias training framework as a way to reveal and correct bias that providers may have towards patients. We highlight the role of the consulting psychiatrist in addressing implicit biases utilizing frameworks pioneered in implicit bias research to better patient care."

Psychiatry

A Comprehensive Review of the Role of Nutritional Supplements in ADHD Management (APA 2025) - "Methylphenidate, Amphetamine salts and other stimulant medicines are frequently used as standard treatments. Large-scale, long-term studies should be prioritised in future research to develop standardised supplement procedures and assess long-term efficacy in ADHD treatment. A thorough approach to treating ADHD may be provided by investigating the beneficial effects of incorporating dietary supplements with pharmaceutical therapies."

Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Analyzing the Effects of the Stimulant Shortage on Prescription Fill Trends in the Mountain West (APA 2025) - "Data was stratified by year, class of stimulant (methylphenidate vs amphetamine), age 18 and under and 19 and over, and whether the prescription was filled in the same zip code as the patient's residence or a different zip code. Patients' increased filling of prescriptions in zip codes outside of their residence indicates increased travel, time, and effort. The stimulant has likely exacerbated socioeconomic and geographic disparities among patients, advantaging those of a higher socioeconomic status and those who live in urban areas with more bandwidth to seek out stimulant prescriptions further from home."

Amphetamine Induced Group I Pulmonary Hypertension: A Case Report of Unforseen Consequences (ATS 2025) - "This abstract is funded by: None Introduction: Pulmonary hypertension (PH) is a medical condition in which there is hypertension in the lungs. In patients classified as intermediate-high risk based on their REVEAL score, PAH therapy should be initiated with endothelin receptor antagonist (bosentan), phosphodiesterase type 5 inhibitor (sildenafil), soluble guanylate cyclase stimulator (riociguat), prostanoid (epoprostenol), and/or prostacyclin agents (selexipag, and treprostinil). Treatment of PAH can be challenging as hemodynamics can be compromised with induction of these vasodilative agents; however, is necessary to prevent disease progression."

Case report • Clinical • Asthma • Cardiovascular • CNS Disorders • Congestive Heart Failure • Endocrine Disorders • Gastrointestinal Disorder • General Anxiety Disorder • Heart Failure • Hypertension • Immunology • Mood Disorders • Nephrology • Nicotine Addiction • Psychiatry • Pulmonary Arterial Hypertension • Pulmonary Disease • Renal Disease • Respiratory Diseases • Septic Shock • Tobacco Addiction

A Fatal Case of Bupropion Overdose (ATS 2025) - "Case Report A 48-year-old woman with of past medical history anxiety, depression and alcohol use disorder presented lethargic to the emergency department (ED) for bupropion overdose after reportedly ingesting 15-20 Bupropion 300mg tablets and unknown propranolol with Vodka with a witness 45-second seizure that resolved without intervention...Initial investigation revealed bupropion level of 1436 ng/mL, elevated lactate of 4.1 mmol/L, positive amphetamine metabolites on toxicology screen and arterial blood gas consistent with metabolic acidosis...Role of VA ECMO in poison patient is with severe cardiogenic shock is still unclear and need to be studied well. Fig: EKG in the ED ."

Clinical • Addiction (Opioid and Alcohol) • Cardiovascular • CNS Disorders • Constipation • Depression • Epilepsy • Gastroenterology • Gastrointestinal Disorder • Hypotension • Major Depressive Disorder • Metabolic Disorders • Mood Disorders • Pain • Psychiatry • Tobacco Cessation • Ventricular Tachycardia • Xerostomia

Opioid use disorder among females with breast cancer: A comprehensive analysis of prevalence in the United States and associated factors. (ASCO 2025) - "Moreover, substance use such as cocaine (aOR 5.252, 95% CI 4.708-5.859, p < 0.01) and amphetamine (aOR 3.948, 95% CI 3.443-4.527, p < 0.01) was also associated with higher odds, while cannabis users (aOR 0.876, 95% CI 0.793-0.968, p < 0.01) had lower odds of OUD... This study showcases the significant prevalence and impact of OUD among BC patients, identifying socioeconomic and racial disparities, and key risk factors such as NRP, psychiatric comorbidities, and concurrent substance use, like cocaine and amphetamines. Interestingly, cannabis use was associated with a lower risk of OUD, which may reflect its role as an alternative pain management strategy. Overall, this study suggests the need to adopt crucial preventative measures against OUD in patients exhibiting these characteristics."

Addiction (Opioid and Alcohol) • Bipolar Disorder • Breast Cancer • Depression • Mood Disorders • Oncology • Pain • Palliative care • Solid Tumor • Substance Abuse

Amphetamine use and Parkinson's disease: integration of artificial intelligence prediction, clinical corroboration, and mechanism of action analyses. (PubMed, PLoS One) - "Pathway enrichment analysis confirmed that amphetamine targets many of the biochemical processes implicated in PD, such as dopaminergic synapses and neurodegeneration. Together, these observational findings suggest that therapeutic and legal amphetamine use may reduce the risk of developing PD, in contrast to previous work that found the inverse relationship in patients using amphetamine recreationally."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Movement Disorders • Parkinson's Disease • Psychiatry

Sex differences in 6-OHDA lesioned rats in a preclinical model for Parkinson's disease. (PubMed, Behav Brain Res) - "Our study revealed distinct neurochemical and behavioral profiles in male and female animals, including sex-specific responses to amphetamine and apomorphine challenges...Moreover, we considered individual variability often overlooked in animal models, which could provide critical insights into resilience or susceptibility to dopaminergic loss. These findings underscore the importance of incorporating sex as a biological variable in PD research to better understand the disease's underlying mechanisms and to improve strategies for early diagnosis and therapeutic intervention."

Journal • Preclinical • CNS Disorders • Movement Disorders • Parkinson's Disease

EHR Trends in First-Time ADHD Diagnoses and Amphetamine Prescriptions Across Age Groups (2021-2024) (ISPOR 2025) - "We observed increases in first-time ADHD diagnoses and amphetamine prescriptions amongst adult populations. These findings highlight the need for further research to understand the drivers behind these trends and their implications for healthcare delivery and public health."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Psychedelic-like effects induced by 2,5-dimethoxy-4-iodoamphetamine, lysergic acid diethylamide, and psilocybin in male and female C57BL/6J mice. (PubMed, Psychopharmacology (Berl)) - "The present results overall show no substantial sex differences in the potencies to induce HTRs for DOI, LSD, and psilocybin in C57BL/6J mice. However, females uniformly displayed more HTRs at high doses administered across chemotypes. The results further suggest that commonly used doses of psychedelics induce comparable psychedelic-like effects in male and female C57BL/6J mice, but modest differences may emerge at high doses."

Journal • Preclinical

Diagnosis and Management of Attention-Deficit/Hyperactivity Disorder: A Practitioner's Perspective. (PubMed, J Clin Med) - "Interestingly, only 7.0% prescribed amphetamine-based stimulants due to the lack of clear guidelines...Major barriers to ADHD diagnosis and treatment in Saudi Arabia include extended referral waiting lists, limited availability of psychostimulant medications, and standardized clinical guidelines. A national ADHD protocol must be advocated, and access to diverse treatment options should be improved."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Developmental Disorders • Mental Retardation • Pediatrics • Psychiatry

Perioperative Stroke in MCA Aneurysm Surgery: The Hidden Risks of Amphetamine Use. (PubMed, J Clin Med) - " This case highlights the need for preoperative evaluation, including routine toxicology screening, in patients with a history of substance abuse. Amphetamine use may present perioperative challenges and increase the risk of complications like vasospasm and stroke."

Journal • Cardiovascular • Substance Abuse • Vascular Neurology

Attention-Deficit/Hyperactivity Disorder Medication Use in Pregnancy and Risk of Preterm Birth: A Population-Based Cohort Study. (PubMed, Paediatr Perinat Epidemiol) - "ADHD medication may modestly increase the risk of preterm birth, especially with atomoxetine early and methylphenidate late in pregnancy, and with longer durations of use."

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Intravenous non-medical mephentermine use among young men: A consecutive case series from a tertiary addiction treatment facility in India. (PubMed, Asian J Psychiatr) - "This series highlights an emerging pattern of intravenous mephentermine misuse among young men in performance-oriented contexts. Given the associated psychosis and cardiovascular risks, clinicians should routinely screen for stimulant use. Community awareness campaigns and stricter regulation of over-the-counter stimulants are crucial for harm reduction."

Journal • Cardiovascular • CNS Disorders • Mental Retardation • Psychiatry

INFLUENCE OF COMORBIDITIES ON COLORECTAL CANCER SCREENING PARTICIPATION AND MORTALITY (DDW 2025) - "Significant comorbidity was defined as having at least one of the following: albumin10,000 copies or CD44 mg/dL, platelets4 µmol/L, NH3>20, positive urine amphetamine or cocaine, serum ethanol>80, hemoglobin A1C>10%, and stage 3 or 4 cancer...These patients also had higher all-cause mortality. Tailoring programmatic population outreach to account for significant comorbidities should improve the delivery of organized screening services."

Colorectal Cancer • Human Immunodeficiency Virus • Infectious Disease • Oncology • Solid Tumor • CD4

Plasticity of ventral tegmental area disturbance during abstinence after repeated amphetamine exposure: restoration by selective activation of group II metabotropic glutamate receptors. (PubMed, Front Pharmacol) - "The involvement VTA afferent regions with respect to AMPH actions was analyzed either by local instillation of drugs or through inactivation by tetrodotoxin. AMPH re-exposure after abstinence turned VTA activity down, but this suppression involved alternative circuits and could no longer be rescued by mGluR activation. Thus, abstinence from repeated AMPH intake drives VTA activity from hypo-into hyperdopaminergic states, and both can be readjusted towards physiological levels via different members of group II mGluRs."

Journal • Psychiatry

Successful treatment of pulmonary hypertension due to HIV infection and amphetamine snorting: a case report. (PubMed, Front Med (Lausanne)) - "In this study, we report a case of pulmonary hypertension with several concomitant risk factors who experienced a complete clinical improvement after drug rehabilitation, application of anti-retroviral therapy (ART), and sildenafil. Our case intends to raise awareness that PH should be suspected among HIV-positive patients with unexplained dyspnea. It is notable that investigating the coexistent risk factors and a multidisciplinary team are crucial for early diagnosis and better prognosis of HIV-related PH."

Journal • Cardiovascular • Hepatology • Human Immunodeficiency Virus • Hypertension • Infectious Disease • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases

Initial exposure to addictive drugs activates polysialylated NCAM-mediated hippocampal memory-associated synaptic plasticity in the rat prior to the emergence of dependence behaviour. (PubMed, Prog Neuropsychopharmacol Biol Psychiatry) - "Using a rodent model, we assessed hippocampal NCAM PSA expression and synaptic remodelling in response to acute and repeated administration of heroin, cocaine, and amphetamine...These results identify hippocampal memory machinery as a key early target of addictive drugs and suggest that drug-associated memories may co-opt normal learning processes, contributing to the persistent and intrusive nature of drug cravings. The study provides novel insights into the mechanisms by which early drug experiences shape enduring behavioural vulnerability to addiction."

Journal • Preclinical • CNS Disorders • Psychiatry • KLK3 • NCAM1

Effects of Repetitive Transcranial Magnetic Stimulations in Patients With Amphetamine Use Disorders (clinicaltrials.gov) - P=N/A | N=20 | Not yet recruiting | Sponsor: TsaoTun Psychiatric Center, Department of Health, Taiwan

Biomarker • New trial

Reduced Sensitivity to Negative Feedback May Lead to Risky Decision-Making in Amphetamine Users. (PubMed, Addict Biol) - "Amphetamine users were less sensitive to punitive or aversive stimuli. This reduced sensitivity might lead to a higher tendency for risky decision-making, with them less able to learn from mistakes and thus repeatedly engage in risky behaviours."

Journal

Exploring landscape of drug abuse trends in Pakistan: A decade and a half of clinical laboratory big data analysis. (PubMed, PLOS Glob Public Health) - "The panel includes screening of common drugs, amphetamine (AMP), benzodiazepine (BZO), barbiturates (BAR), cannabinoids (THC), cocaine (COC), and opioids (OPI) as well as blood alcohol (ALC) levels...Yearly trend analysis shows an increasing number of THC tests requested over time, with THC exhibiting the highest positivity rate, followed by BZO, OPI, and ALC.The 15-year patterns depict the rising prevalence of drug consumption which is subsequently increasing the demand for drug screening tests. The study highlights Pakistan's growing drug prevalence and calls for targeted policies to address its use, including strengthened prevention programs, improved regulation and better management and rehabilitation access."

Journal

Use of antidotes in cases of poisoning from drugs of abuse treated in Spanish emergency departments. (PubMed, Emergencias) - "Antidotes, usually naloxone and flumazenil, were used to treat a high percentage of patients poisoned by drugs of abuse who are attended by Spanish EDs belonging to the REDUrHE. In a third of these cases, both antidotes were used. Use was associated with diminished consciousness. Use of the antidote, especially flumazenil, was inappropriate in most of the episodes."

Journal • Anesthesia • CNS Disorders • Critical care • Epilepsy