amphetamine / Generic mfg. - LARVOL DELTA

Stimulant Medications and Sleepiness in ADHD: Insights from a Sleep Deprivation Study (WSS 2025) - "Stimulant medications, such as Methylphenidate and Amphetamine, effectively mitigate excessive sleepiness experienced by young men diagnosed with ADHD, even under conditions of extended sleep deprivation. These findings have important clinical and theoretical implications. Given the negative effects of sleepiness on cognition and emotional regulation, these results suggest that the beneficial effects of stimulant medications in ADHD may partially stem from their effect on sleepiness."

ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry • Sleep Disorder

Treatment Considerations in Co-morbid Schizophrenia and Narcolepsy: A Case Report (WSS 2025) - "Some alertness promoting medications used in narcolepsy treatment, such as modafinil, methylphenidate and amphetamine, may exacerbate psychosis by increasing dopamine activity...He was previously intolerant to modafinil (emotional numbing) and Concerta (appetite suppression) as per chart review.Paliperidone was effective for psychosis but worsened sleepiness, which was disabling... In conclusion, some traditional stimulants may worsen psychosis in PWN. Pitolisant, an inverse H3 agonist, which does not theoretically affect dopamine pathways, may be a suitable treatment for sleepiness and cataplexy in comorbid psychosis."

Case report • Clinical • Cataplexy • CNS Disorders • Narcolepsy • Psychiatry • Schizophrenia • Sleep Disorder

Evidence of Nose-To-Brain Delivery of Lithium: Implications for Mood Disorders and Beyond (WFSBP 2025) - "(3) in vivo rat model showed that intranasal lithium delivery produced same behavioural response than intraperitoneal lithium delivery in an amphetamine model of mania... This study provides the first evidence of successful nose-to-brain delivery of lithium using nanoparticle network hydrogels. The results also suggest that intranasal lithium can exert significant behavioural changes with significantly less circulating serum levels. These results have important implications for translational research in mood disorders, given the need for long-term treatments with potential for systemic side effects."

Bipolar Disorder • CNS Disorders • Mood Disorders • Psychiatry

Diagnostic Changes in Amphetamine-Induced Psychotic Disorder: A Retrospective Study (WFSBP 2025) - "A substantial proportion of patients with AIPD experience diagnostic changes over time. Several hospitalizations and antipsychotic use are significant predictors of diagnostic changes. These findings highlight the dynamic nature of amphetamine-induced psychosis and emphasize the need for careful longitudinal assessment and flexible treatment approaches."

Retrospective data • Bipolar Disorder • CNS Disorders • Mental Retardation • Mood Disorders • Personality Disorder • Psychiatry • Schizophrenia

Intraday trends of chemical biomarkers in wastewater monitored through automated real-time surveillance. (PubMed, Water Res) - "Population biomarkers exhibited distinct temporal profiles: paraxanthine remained stable during working hours, while candesartan declined even at peak population times - highlighting implications for normalization, particularly with day visitors...During the special events, MDMA, ketamine, and amphetamine loads rose with distinct profiles - one event showing a gradual overnight rise, the other a morning peak...Levamisole loads rose on weekends and during events, mirroring benzoylecgonine, indicating continued presence as harmful cocaine adulterant. Automated analysis reveals short-term intraday trends, providing additional insights into the sources of chemical marker loads - such as consumption, excretion, and contributions from transient populations - that are typically averaged out in standard 24-hour composite samples."

Biomarker • Journal

A Rare Presentation of Gastric Ischemia Manifesting as Gastric Pneumatosis in the Context of Amphetamine Use (ACG 2025) - "A nasogastric tube was placed for decompression, and the patient was started on ceftriaxone and metronidazole. Our case highlights the need to consider gastric ischemia in patients with amphetamine use disorder presenting with nonspecific gastrointestinal symptoms and imaging suggestive of gastric pneumatosis. Early recognition of gastric pneumatosis is crucial to improve patient outcomes, as it may indicate ischemia and carries a risk of increased mortality.Figure: Axial computed tomography image of the abdomen demonstrating gastric pneumatosis, indicated by red arrows."

Cardiovascular • Gastrointestinal Disorder • Hypotension • Infectious Disease • Ischemic stroke

Beyond Varices: Left Gastric Pseudoaneurysm as a Rare Cause of Upper GI Bleed in Cirrhosis (ACG 2025) - "Several interventions, including hemostasis powders, epinephrine, and ethanolamine, were unsuccessful, so a fully-covered stent was placed to tamponade the bleed. It is possible that the pseudoaneurysm developed due to severe local inflammation from the amphetamine-induced esophagitis. Worsening esophagitis and coagulopathy likely caused the pseudoaneurysm to rupture, resulting in a bleed refractory to endoscopic intervention and requiring embolization.Figure: Figure 1: CT Angiography Demonstrating the Pseudoaneurysm in the Gastroesophageal Branch of the Left Gastric Artery"

Atherosclerosis • Cardiovascular • Fibrosis • Gastrointestinal Disorder • Hematological Disorders • Hepatitis B • Hepatitis C • Hepatology • Immunology • Infectious Disease • Inflammation • Mood Disorders • Pancreatitis • Varicose Veins

In brief: New warning for extended-release stimulants for ADHD. (PubMed, Med Lett Drugs Ther) - No abstract available

Journal • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Assessment of risk factors associated with methadone-induced deaths: A population study based on forensic autopsies (2003-2022). (PubMed, Forensic Sci Int) - "This forensic study reveals that poly-drug use is a major contributor to methadone-related fatalities. Concomitant use of methadone with benzodiazepines or psychostimulants is particularly hazardous. Pharmacological interactions must be carefully assessed in methadone users. Our findings underscore the value of forensic data in identifying lethal drug combinations and supporting safer prescribing practices and public health strategies."

Journal

Gold-Containing Compound Auranofin Ameliorates 6-OHDA Induced Neurotoxicity in Rats: Via Targeting PI3K/Akt/GSK-3β Signalling. (PubMed, Clin Exp Pharmacol Physiol) - "After performing the amphetamine challenge test, rodents were treated with AUF (10 mg/kg) and AUFHNPs (5 and 10 mg/kg) for 21 days...It also restored morphological changes and increased expression of pPI3K/pAKT, followed by inhibition of GSK-3β. Thus, the AUFHNPs were more significant than AUF alone and exerted neuroprotection via modulation of PI3K/AKT/GSK-3β signalling pathways."

Journal • Preclinical • CNS Disorders • Movement Disorders • Parkinson's Disease • GSK3B

Global burden of disease due to opioid, amphetamine, cocaine, and cannabis use disorders, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. (PubMed, PLoS One) - "Sex and geographical variations were notable, with males and world regions like high-income North America, Australasia, and Eastern/Western Europe showing disproportionately higher rates. Overall, these findings highlight rising mortality and morbidity rates despite a modest decline in incidence, underscoring the need for tailored public health interventions, advancing harm reduction programs, and expanding access to treatment."

HEOR • Journal • Addiction (Opioid and Alcohol) • Substance Abuse

A novel cost-benefit decision-making task involving cued punishment; effects of sex and psychostimulant administration. (PubMed, Behav Brain Res) - "Similar to acute amphetamine, acute systemic administration of the D2/3 dopamine receptor agonist bromocriptine reduced preference for the large reward across all groups. These findings highlight the contributions of punishment cues to decision making, as well as the importance of sex as a biological variable in investigating cognitive alterations caused by chronic substance use."

HEOR • Journal

From garden to product: Scientific strategies for identity verification of botanical constituents (ACS-Fall 2025) - "For example, 1,3-dimethylamylamine (1,3-DMAA), an amphetamine derivative,was purported to be present in certain geranium plants, such as Pelargonium graveolens...In this poster, we will discuss some factors toconsider when verifying that a chemical compound is a constituent of a botanical and present some best practices to address these factors. Case examples will be provided to illustrate the intricacies surrounding chemical characterization of complex botanical mixtures."

Trace amine-associated receptor 1 agonists differentially regulate dopamine transporter function. (PubMed, Mol Pharmacol) - "RO5166017, but not RO5256390 or ulotaront, increased amphetamine-induced dopamine efflux in a TAAR1-dependent manner. All 3 affected DAT transport and/or trafficking, with each exhibiting a unique profile of direct and heterologous effects, some of which were TAAR1-dependent. These issues should be considered with therapeutic design and clinical use of TAAR1 agonists."

Journal • CNS Disorders • Psychiatry • Schizophrenia

The role of agomelatine in appetite regulation and body weight in rats. (PubMed, Exp Physiol) - "Hypothalamic orexigenic neuropeptides neuropeptide Y (NPY) and agouti-related peptide (AgRP) were suppressed (NPY, Ago40: 0.61 ± 0.02 vs. Control: 1.36 ± 0.1321; AgRP, Ago40: 0.52 ± 0.03 vs. Control: 1.49 ± 0.27, P < 0.05), while anorexigenic cocaine- and amphetamine-regulated transcript (CART) and proopiomelanocortin (POMC) were elevated (CART: Ago40: 1.19 ± 0.08 vs. Control: 0.92 ± 0.06; POMC: Ago40: 1.49 ± 0.17 vs. Control: 0.67 ± 0.10, P < 0.05). These findings suggest agomelatine promotes weight loss by modulating appetite-related hormones and hypothalamic neuropeptides, highlighting its potential as a therapeutic for obesity and metabolic disorders."

Journal • Preclinical • Genetic Disorders • Metabolic Disorders • Obesity • POMC-null Obesity • LEP

COCAINE- AND AMPHETAMINE-REGULATED TRANSCRIPT (CART) PEPTIDE MEDIATES INTRACELLULAR CA2+ RELEASE IN SENSORY NEURONS AND INDUCES FIRING OF THE COLON-INNERVATING LUMBAR SPLANCHNIC NERVE (UEGW 2025) - No abstract available

A novel cost-benefit decision-making task involving cued punishment; effects of sex and psychostimulant administration. (PubMed, bioRxiv) - "Similar to acute amphetamine, acute systemic administration of the D2/3 dopamine receptor agonist bromocriptine reduced preference for the large reward across all groups. These findings highlight the contributions of punishment cues to decision making, as well as the importance of sex as a biological variable in investigating cognitive alterations caused by chronic substance use."

HEOR • Journal

Preparation of phenyl-based stationary phase gradient on in-house packed HPLC columns using control rate infusion (ACS-Fall 2025) - "Additionally, the applicability of the gradient column was further tested with amphetamine derivatives, where it exhibited enhanced separation performance compared to the unmodified column. Overall, this study highlights the potential of cSPGs in liquid chromatography applications, providing a powerful strategy for achieving enhanced selectivity and resolution in chemical separations."

Expanding the Public Health Role of Pediatric Trauma Centers: Drug Screening for Adolescent Trauma Patients. (PubMed, J Am Coll Surg) - "Despite increasing overdose deaths, drug screening at pediatric trauma centers is decreasing. Expanded trauma center drug screening may identify problematic substance use, preventing future overdose deaths."

Journal • Addiction (Opioid and Alcohol) • Pediatrics

Global and Cross-Country Inequalities in the Fatal and Non-Fatal Burden Attributable to Drug Use Disorders and Subtypes: Findings from the Global Burden of Disease Study 2021. (PubMed, Iran J Public Health) - "India and the global population experienced rising age-standardized fatal and non-fatal rates due to DUDs-while China demonstrated progress. The trend varied by DUD subtypes, age group, and gender, with amphetamine use disorders disproportionately affecting India and China and females showing improved outcomes across all regions."

HEOR • Journal

Using a rich-lean transition procedure to evaluate putative antianxiety medications. (PubMed, J Pharmacol Exp Ther) - "Acute administration of benzodiazepines (midazolam, alprazolam) and an imidazotriazine (TPA-023B) selectively reduced pausing in rich-lean transitions, a behavioral effect consistent with clinically effective antianxiety drugs in other preclinical anxiolysis procedures. Morphine and (+)amphetamine selectively increased rich-lean pausing, an effect consistent with an anxiogenic response in other anxiolysis procedures...SIGNIFICANCE STATEMENT: Transitions from favorable to unfavorable (ie, rich-lean) schedules of reinforcement reliably disrupts operant behavior, and these disruptions can be ameliorated via benzodiazepine administration. Our results indicate that the rich-lean transition procedure has utility in the assessment of putative antianxiety medications."

Journal • Mood Disorders • Psychiatry

Challenges in amphetamine medication availability for individuals with ADHD: a narrative review of the current state of evidence. (PubMed, Front Psychiatry) - "Methylphenidate is the predominant stimulant prescribed for ADHD, while AMPH-based medications, such as lisdexamfetamine, are under prescribed due to regulatory restrictions, limited formulary inclusion, and supply inconsistencies. in Saudi Arabia, despite global and local evidence supporting their efficacy. Our findings suggest the need for enhancing regulatory pathways regarding AMPH access and availability, which requires policy interventions targeting regulatory reform, formulary expansion, and improved awareness among AMPH prescribers."

Journal • Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Developmental Disorders • Psychiatry

Altered striatal dopamine regulation in ADGRL3 knockout mice. (PubMed, bioRxiv) - "This reduction was not due to impaired dopamine availability, as amphetamine-evoked release was unchanged. These findings suggest ADGRL3 modulates dopamine release in complex ways via different pre- and postsynaptic mechanisms."

Journal • Preclinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Mental Retardation • Psychiatry

Pentilludin reduces rat amphetamine and remifentail self-administration with good pharmacologic and toxicologic profiles. (PubMed, bioRxiv) - "Treatment with 20 mg/kg sc pentilludin prior to every other M-W-F self-administration session substantially reduces self-administration of amphetamine and more modestly reduces self-administration of remifentanil. Pentilludin provides a novel means for reducing self-administration of psychostimulant and, modestly, opiate drugs in ways that could enhance abstinence in humans."

Journal • Preclinical • Hematological Disorders

AMPHETAMINE-INDUCED ACUTE EOSINOPHILIC PNEUMONIA AND ASSOCIATED PNEUMOMEDIASTINUM (CHEST 2025) - No abstract available

Infectious Disease • Pneumonia • Respiratory Diseases