AK0705 / Ark Biosci, Scripps Research Institute - LARVOL DELTA

An inhaled AK0705 modulates PI3K/AKT/MAPK/NF-κB signaling to alleviate LPS-NETs-induced inflammation and pyroptosis in acute lung injury. (PubMed, Int Immunopharmacol) - "Mechanistically, the protective effect of AK0705 may be associated with modulation of the PI3K/AKT/MAPK/NF-κB signaling pathway. Our findings supported that AK0705 significantly inhibited NE, NET formation, and pyroptosis in LPS-induced ALI by suppressing inflammation and targeting NE with inhaled AK0705 is a novel strategy for treating ALI, with potential implications for ARDS."

Journal • Acute Lung Injury • Acute Respiratory Distress Syndrome • Inflammation • Pulmonary Disease • Respiratory Diseases • ELANE