aminophylline / Generic mfg. - LARVOL DELTA

Comparative efficacy of doxophylline-ambroxol combination versus aminophylline in the management of acute exacerbations of COPD: A retrospective case-control study. (PubMed, Pak J Pharm Sci) - "Doxophylline-ambroxol combination therapy is more effective than aminophylline in improving pulmonary function and reducing inflammation in AECOPD, with equivalent safety."

Clinical • Journal • Retrospective data • Chronic Obstructive Pulmonary Disease • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases

Methylxanthine Treatment in Neonates Admitted to the Special Care Unit: An Observational Study in Low-Resource Settings. (PubMed, Children (Basel)) - "Overall, the treatment was appropriately given to most eligible neonates, although a considerable subgroup of very preterm infants did not receive aminophylline prophylaxis. Further studies may investigate the reasons for protocol incompliance regarding aminophylline treatment and healthcare staff's opinions on such an aspect."

Journal • Observational data

Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures (clinicaltrials.gov) - P=N/A | N=106 | Recruiting | Sponsor: Cairo University | Not yet recruiting ➔ Recruiting

Enrollment open

Diuretic Effect of Aminophylline and Furosemide in Adult Patients Undergoing Cardiac Surgical Procedures (clinicaltrials.gov) - P=N/A | N=106 | Not yet recruiting | Sponsor: Cairo University

New trial

Determination of Non-Cytotoxic Antiviral Concentrations of Phosphoric Acid Derivatives and Nucleotide Base Analogues In Vitro. (PubMed, Bull Exp Biol Med) - "Overall, purine and indole analogues were less toxic for cultured mammalian cells than the test phosphoric acid derivatives. Purine analogue aminophylline had the lowest cytotoxicity, but exhibited maximum antiviral activity."

Journal • Preclinical

Anaphylaxis and Cardiac Arrest Induced by Initial Intravenous Ceftriaxone: A Case Report. (PubMed, Am J Case Rep) - "She had been taking cefuroxime and aminophylline, with no known antibiotic allergies. No complications were noted at 1-month follow-up. CONCLUSIONS An initial intravenous dose of ceftriaxone may trigger rare but serious anaphylactic reactions, even in patients without a history of drug allergy, underscoring the need for vigilant monitoring during administration."

Journal • Allergy • Cardiovascular • Cough • Critical care • Dermatology • Immunology • Infectious Disease • Pneumonia • Respiratory Diseases • Urticaria

Pharmacological treatment for apnoea of prematurity-the need for an individualised approach. (PubMed, Front Pediatr) - "Caffeine (or in some developing countries, aminophylline or theophylline) is usually given as first-line treatment, whereas doxapram is sometimes used as an adjunct therapy. We propose potential pharmacodynamic biomarkers and explore avenues for future research which will enable the testing and translation of these biomarkers for use in the neonatal unit. A personalised approach for apnoea treatment is essential to mitigate the negative short and long-term effects of both apnoea and its treatment in premature infants, ensuring that treatment can be provided at the right time and with the correct dose."

Journal • Review

Prophylactic efficacy and safety of intravenous aminophylline compared to intravenous normal saline for post-dural puncture headache in cesarean section patients: A systematic review and metaanalysis (EHF-EHC 2025) - "IV aminophylline use was associated with reduced PDPH incidence at 48 hours and shortened PDPH duration in cesarean patients, suggesting a lowcost prophylactic option. No consistent effect was seen on severity or intensity, and AE data remain inconclusive. These findings are hoped to inform PDPH protocols regarding low-cost alternatives to techniques such as epidural blood patches."

Retrospective data • Review • Pain

Characterization of Aminophylline Use for Methotrexate Toxicity in Pediatric Oncology Patients (ASHP 2025) - No abstract available

Clinical • Pediatrics

A Retrospective Study Exploring Aminophylline Therapy and Renal Outcomes in Critically Ill Pediatric Patients (ASHP 2025) - No abstract available

Retrospective data • Pediatrics

Characterization of Aminophylline Use for Methotrexate Toxicity in Pediatric Oncology Patients (ASHP 2025) - "Hosted by the Section of Clinical Specialists and Scientists"

Clinical • Pediatrics

Comparative Effects of Aminophylline, Caffeine, and Doxapram in Hypoxic Neonatal Dogs Born by Cesarean Section. (PubMed, Animals (Basel)) - "Aminophylline, caffeine, and doxapram supported postnatal resuscitation in hypoxic neonatal puppies; however, caffeine demonstrated superior improvement in Apgar recovery, suggesting its potential as a preferred pharmacological adjunct in neonatal canine resuscitation protocols."

Journal • Anesthesia • CNS Disorders • Depression • Obstetrics • Psychiatry • TNNI3

Methylxanthines: The Major Impact of Caffeine in Clinical Practice in Patients Diagnosed with Apnea of Prematurity. (PubMed, J Clin Med) - "Methylxanthines, including caffeine, theophylline, and aminophylline, have emerged as the primary pharmacological intervention for this condition...No external funding was received for this review. No registration record exists for this systematic review."

Journal • Review • Bronchopulmonary Dysplasia • Critical care • Pulmonary Disease • Respiratory Diseases

S100A12 as a key biomarker in a neutrophil-associated gene prediction model for sepsis diagnosis. (PubMed, Medicine (Baltimore)) - "SHAP analysis highlighted S100A12 as the most influential driver gene and identified theophylline, aspirin, and aminophylline as potential targeting compounds. In conclusion, sepsis patients show increased peripheral neutrophils, an RF model based on 4 neutrophil-associated genes demonstrates strong diagnostic ability, and S100A12 serves as a key biomarker for sepsis."

Biomarker • Journal • Critical care • Infectious Disease • Septic Shock • HLA-DMB • RETN • S100A12

Early aminophylline is a potential therapy for preventing bronchopulmonary dysplasia in premature infants: a retrospective study. (PubMed, BMC Pediatr) - "In conclusion, early use of aminophylline may be associated with a decreased incidence of BPD in premature infants without significant adverse reactions."

Journal • Retrospective data • Bronchopulmonary Dysplasia • Pulmonary Disease • Respiratory Diseases

ACUTE/SUBACUTE METHOTREXATE NEUROTOXICITY IN CHILDHOOD ALL: 13-YEAR EXPERIENCE AT A PEDIATRIC ONCOLOGY REFERENCE CENTER (SIOP 2025) - "Background and Aims: Methotrexate (MTX) is a folate antagonist widely used in the treatment of pediatric Acute Lymphoblastic Leukemia (ALL), playing a crucial role in the prophylaxis and treatment particularly the central nervous system (CNS). MTX-induced NT is a serious complication in the treatment of pediatric ALL. Cranial MRI, particularly FLAIR and diffusion-weighted sequences, is essential for early diagnosis and differentiation from other neurological conditions. Prophylactic treatment with aminophylline has shown efficacy in preventing and reducing acute neurotoxicity symptoms, allowing uninterrupted MTX treatment."

Clinical • Acute Lymphocytic Leukemia • CNS Disorders • Epilepsy • Hematological Malignancies • Infectious Disease • Leukemia • Pediatrics

ADHERENCE TO REVEFENACIN ASSOCIATED WITH REDUCTIONS IN EXACERBATIONS AND HEALTH CARE COSTS FOLLOWING A COPD-RELATED HOSPITALIZATION (CHEST 2025) - "Moderate exacerbations were defined as an outpatient COPD visit accompanied by a filled prescription for a course of theophylline, aminophylline, or an oral corticosteroid or oral antibiotic within 7 days of the outpatient visit. Patients with COPD who were hospitalized, prescribed nebulized revefenacin post-discharge, and adhered to their medication demonstrated statistically significant reductions in both exacerbations and healthcare costs compared to patients who did not adhere to prescribed revefenacin. CLINICAL IMPLICATIONS: Results demonstrate that revefenacin can be effective in reducing COPD exacerbations and the associated costs, though adherence to medication remains critical."

Adherence • Clinical • HEOR • Chronic Obstructive Pulmonary Disease • Immunology • Respiratory Diseases • Squamous Cell Carcinoma

REAL-WORLD EFFECTIVENESS OF BUDESONIDE/GLYCOPYRROLATE/FORMOTEROL FUMARATE ON COPD EXACERBATIONS AMONG US MEDICARE PATIENTS: RESULTS FROM THE US ARCTOS STUDY (CHEST 2025) - "Moderate exacerbations were defined as an outpatient COPD visit accompanied by a filled prescription for a course of theophylline, aminophylline, or an oral corticosteroid or oral antibiotic within 7 days of the outpatient visit... Medicare Fee-for-Service patients with a diagnosis of COPD who were treated with BGF demonstrated meaningful reductions in the rate of COPD exacerbations, inclusive of severe exacerbations, in a real-world setting. CLINICAL IMPLICATIONS: Results suggest that BGF is an excellent treatment option to reduce exacerbations in patients who meet GOLD E criteria and can potentially inform clinical guidelines and future research. Funding: The funding for this study was provided by AstraZeneca PLC"

Clinical • Medicare • Real-world • Real-world effectiveness • Real-world evidence • Reimbursement • US reimbursement • Chronic Obstructive Pulmonary Disease • Immunology • Respiratory Diseases

Mulberry (Morus alba l.) leaf improves arachidonic acid metabolism disorder in chronic obstructive pulmonary disease. (PubMed, Phytomedicine) - "ARA metabolic dysregulation contributes to COPD pathogenesis, and (±)12-HETE, 15(S)-HETE, and (±)11-HETE may serve as potential biomarkers for COPD. MLWE exert therapeutic effects by modulating ARA metabolism, ameliorating oxidative stress, and suppressing inflammatory responses, offering a novel strategy for COPD prevention and treatment."

Journal • Chronic Obstructive Pulmonary Disease • Immunology • Metabolic Disorders • Oncology • Pulmonary Disease • Respiratory Diseases • ALOX15 • CAT • IL10 • IL1B • IL6 • LOX • TNFA

Clinical characteristics of hospitalized children with bronchiolitis before and after the COVID-19 pandemic: a single-center study. (PubMed, Med Glas (Zenica)) - "There was a significant reduction in antibiotic in the post-COVID group (p=0.0173), and a significant increase in the use of aminophylline and inhalation therapy drugs in the post-COVID group...Conclusion This study reveals a significant increase in the severity of bronchiolitis and an increase in RSV cases after the COVID-19 pandemic. Keywords: anti-bacterial agents,coinfection, oxygen inhalation therapy,respiratory syncytial virus infections, vaccination."

Journal • Retrospective data • Infectious Disease • Novel Coronavirus Disease • Pediatrics • Pulmonary Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections

Prevention of Cisplatin-induced Nephrotoxicity (clinicaltrials.gov) - P2/3 | N=24 | Not yet recruiting | Sponsor: Mahidol University | Trial completion date: Sep 2025 ➔ Sep 2026 | Trial primary completion date: Sep 2025 ➔ Sep 2026

Trial completion date • Trial primary completion date • Acute Kidney Injury • Nephrology • Pediatrics • Renal Disease

Management of water submersion in pre-hospital (EUSEM 2025) - "The treatment included the administration of hydrocortisone hemisuccinate to prevent airway inflammation and an infusion of NaCl 0.9% with aminophylline for bronchodilation. Following an allergy test, 1g Ceftriaxone was administered to prevent sepsis.The patient was transferred to the ambulance, where the decision for endotracheal intubation was made to allow aspiration of the water from the lungs. The procedure was initiated with 2 mg Midazolam for anxiolysis, followed by preoxygenation and rapid sequence intubation (RSI) with Fentanyl, Etomidate, and Succinylcholine...Aspiration and lavage of the lungs were performed to prevent potential complications such as sepsis and acute respiratory failure.Following these procedures, the patient was reassessed, awakened, extubated, and transported to the hospital conscious and cooperative, GCS being 15.The patient had a favorable evolution, was discharged in good health without complications. We chose to present this case to..."

Clinical • Immunology • Infectious Disease • Inflammation • Respiratory Diseases • Septic Shock

Methotrexate-induced acute neurotoxicity in patients with osteosarcoma: a case report. (PubMed, J Med Case Rep) - "To the knowledge of these authors, this is the largest compilation of cases of methotrexate-induced neurotoxicity involving patients with osteosarcoma. There is no standard treatment for methotrexate-induced neurotoxicity. In our review we discuss dextromethorphan, aminophylline, and ketamine use in the treatment of methotrexate-induced neurotoxicity. Methotrexate is a crucial, first-line treatment for osteosarcoma and if safe, would be beneficial to continue even after acute neurotoxicity. Unfortunately, methotrexate is often discontinued after the first episode of neurotoxicity, owing to fear of recurrence on rechallenge. In our review, 5 of 16 patients were known to be rechallenged with methotrexate. None had recurrence of neurotoxicity with subsequent methotrexate treatment. While our study is limited by the number of cases, our findings suggest that methotrexate rechallenge in patients with osteosarcoma could be considered. Our review adds to the limited existing..."

Journal • Review • Acute Lymphocytic Leukemia • CNS Disorders • Epilepsy • Gastrointestinal Disorder • Hematological Malignancies • Leukemia • Oncology • Osteosarcoma • Sarcoma • Solid Tumor

Electromotive Drug Administration in the Porcine Ureter: First In Vivo Application for Ureteral Dilation. (PubMed, J Endourol) - "Neither aminophylline nor isoproterenol with EMDA resulted in a significant increase in ureteral size compared with their respective NS controls (aminophylline vs NS, 0.3 Fr vs -0.6 Fr, p = 0.344; isoproterenol vs NS, 0.1 Fr vs -0.4 Fr, p = 0.125). In this first report, EMDA-mediated in vivo delivery of alfuzosin into the porcine ureter acutely increased ureteral distensibility."

Journal • Preclinical

Mortality in the Sepsis-3 Era: A Systematic Review of Multicenter Randomized Controlled Trials. (PubMed, Shock) - "These included three studies from China-two evaluating herbal anti-inflammatory compounds and one evaluating aminophylline-and one European study assessing corticosteroid therapy in vasopressor-dependent septic shock...These findings suggest that despite extensive efforts, most interventions have not reduced mortality in multicenter sepsis trials. Future research should focus on optimizing trial design, refining patient selection, and incorporating patient-centered outcomes beyond mortality."

Journal • Critical care • Infectious Disease • Septic Shock