anandamide (ATC-001) / Atticus Pharma - LARVOL DELTA

N-terminal phosphatase of soluble epoxide hydrolase forms anandamide from anandamide phosphate. (PubMed, J Biol Chem) - "Enzyme kinetic analysis confirmed that species in this class, including arachidonoyl ethanolamide (anandamide) phosphate, were favorable N-phos substrates. The exogenous addition of anandamide phosphate inhibited VEC activation-associated expression of cell adhesion molecules at concentrations of 3 μM or more."

Journal • Inflammation

Atticus Pharma Awarded $2 Million NIH Phase II SBIR Grant to Advance Cutaneous Lupus Drug Candidate (Atticus Press Release) - "The grant will support further development of an endocannabinoid microparticle formulation for the topical treatment of cutaneous manifestations of lupus erythematosus, building on positive data from multiple animal models of lupus that showed resolution of lesions and dramatic improvements in skin and histopathology scores."

Financing • Cutaneous Lupus Erythematosus