amoxicillin / Generic mfg. - LARVOL DELTA

Efficacy and safety of dostarlimab in elderly patients with multiple comorbidities and allergic diathesis: case report. (PubMed, AME Case Rep) - "Medical history was positive for arterial hypertension, autoimmune thrombocytopenia and allergy to amoxicillin and levofloxacin. The administration of dostarlimab is safe and feasible in elderly people with multiple pathologies and multiple allergies with recurrent dMMR/MSI EC. The drug is well tolerated and able to give a good quality of life to patients."

dMMR • Journal • MSI-H • Allergy • Cardiovascular • Endometrial Cancer • Hematological Disorders • Hypertension • Immune Thrombocytopenic Purpura • Immunology • Microsatellite Instability • Oncology • Pulmonary Arterial Hypertension • Solid Tumor • Thrombocytopenia • Thrombocytopenic Purpura • MSI

Expansion of the pharmaceutical assays available to DPAL (ACS-Fall 2025) - "Herein, we discuss the efforts of our undergraduate research program to expand DPAL analytical assays to include the use of LC-MS and gas chromatography (GC). Simple, user-friendly methods have been developed for the accurate and precise analyses of amoxicillin and hydroxyurea to within 1% error."

Beyond the Usual Suspects: Cracking the Case of AA Amyloidosis in the Gut (ACG 2025) - "We present a case of chronic diarrhea secondary to gastric amyloidosis.Case Description/ A 76-year-old female with a history of Waldenström macroglobulinemia (MYD88 mutation), renal amyloidosis, prior pulmonary embolism (on rivaroxaban), and stage IV marginal zone lymphoma (treated with R-CHOP in 2013), was transferred from a care facility due to hypotension. She reported a 10-month history of chronic diarrhea, characterized by 2–3 episodes daily, which began after a course of amoxicillin...A3, B3, C3, D3. When Congo Red stain is polarized, the amorphous material demonstrates apple green birefringence consistent with Amyloidosis in stomach, duodenum, jejunum, and colon, respectively."

Clinical • Amyloidosis • Cardiovascular • Colorectal Cancer • Gastrointestinal Disorder • Hematological Disorders • Hematological Malignancies • Hypotension • Lymphoma • Lymphoplasmacytic Lymphoma • Marginal Zone Lymphoma • Pulmonary Embolism • Respiratory Diseases • Waldenstrom Macroglobulinemia • GAST • MYD88

SUBLYME: Effect of Saccharomyces Boulardii CNCM I-745 on Gut Microbiota in Patients Undergoing Antibiotic Therapy (in the Context of Erythema Migrans (Early Skin Form of Lyme Borreliosis)) (clinicaltrials.gov) - P4 | N=120 | Recruiting | Sponsor: Biocodex | Not yet recruiting ➔ Recruiting | Trial completion date: Dec 2025 ➔ Dec 2026 | Trial primary completion date: Dec 2025 ➔ Dec 2026

Enrollment open • Trial completion date • Trial primary completion date • Dermatology • Infectious Disease • Inflammatory Arthritis • Lyme Disease

to Assess the Eradication Rate of 14-day Bismuth/Amoxicillin/PCAB Triple Therapy for the Treatment of Helicobacter Pylori Infection (clinicaltrials.gov) - P=N/A | N=200 | Enrolling by invitation | Sponsor: Kaohsiung Medical University

New trial • Infectious Disease

Effects of Different Antibiotic Regimens in Preterm Premature Rupture of Membranes (clinicaltrials.gov) - P=N/A | N=40 | Completed | Sponsor: Yuzuncu Yıl University

New trial

Pharmaceutical quantification by UPLC-MS (ACS-Fall 2025) - "Amoxicillin, a widely used antibiotic, and leucovorin, an antidote to the harmful effects of chemotherapy, are frequently found to be substandard, leading to harmful consequences such as increased antimicrobial resistance and poor patient health outcomes. By optimizing injection volumes, generating reliable calibration curves, and evaluating matrix effects, our methods enable reproducible active pharmaceutical ingredient (API) detection at nanomolar concentrations. By leveraging UPLC-MS, DPAL enhances its capacity to detect a broader range of pharmaceutical quality issues, ultimately supporting global efforts to improve medicinal safety and public health."

Ten years of the distributed pharmaceutical analysis laboratory (DPAL) (ACS-Fall 2025) - "DPAL partners in LMICs provide samples of pharmaceutical products such as amoxicillin capsules, ciprofloxacin tablets, and dosage units of MESNA or leucovorin calcium, and analytical chemistry students perform system suitability testing, evaluate the quality of the pharmaceutical dosage forms, and may apply other analytical techniques to learn more about products that fail assay. Sample metadata, provenance, and test results are shared between the LMIC collection sites and the DPAL laboratories through a secure database called VERIFY. This presentation will highlight how the program has evolved over a decade."

Prevalence of self-medication with antibiotics among nonmedical students at Kabul University, Afghanistan: A cross-sectional study. (PubMed, Medicine (Baltimore)) - "The most commonly self-medicated antibiotics were Amoxicillin 277 (75.1%), Azithromycin 138 (37.4%), and Penicillin 108 (29.3%), which were most commonly used for sore throat 190 (51.5%), common cold 181 (49.1%), and runny nose 166 (45%). Most advice on antibiotics comes from informal sources, such as friends and family, and the internet is also influential. Emphasis should now be placed on strengthening health education and improving access to healthcare services to mitigate the risks associated with the improper use of antibiotics."

Journal • Observational data • Infectious Disease • Otorhinolaryngology • Respiratory Diseases

Vonoprazan vs. high-dose esomeprazole in bismuth-containing quadruple therapy for Helicobacter pylori rescue treatment: a retrospective cohort study. (PubMed, Gut Pathog) - "Both high-dose esomeprazole-containing quadruple therapy and VON-containing quadruple therapy have demonstrated effective as rescue treatments for H. pylori infection. Additionally, antibiotic selection informed by local epidemiological data demonstrated comparable effective to culture-based methods in this cohort, though future large-scale studies are needed to validate its generalizability."

Journal • Retrospective data • Infectious Disease

Detection and antimicrobial susceptibility of E. coli O157:H7 in the milk supply chain, milking environments and humans in Woliata Sodo, Ethiopia. (PubMed, BMC Microbiol) - "This study confirmed the presence of multidrug resistant E. coli O157:H7 in the tested sample. Notably, the highest prevalence was detected in milk samples from collection centers, underscoring post harvest contamination as a critical point of intervention. Identification of the pathogen on milkers' hands, farm floors, and human stool samples highlights potential transmission pathways and suggests a tangible risk of foodborne infections. These findings emphasize the critical need for targeted public health strategies, including comprehensive education on hygienic practices and the implementation of effective contamination control measures, to reduce the risk of infection and protect consumer health."

Journal • Infectious Disease

Effects of antibiotic prophylaxis during labour on maternal and neonatal outcomes in women planning vaginal birth. (PubMed, Cochrane Database Syst Rev) - "Offering a single oral dose of prophylactic antibiotics to pregnant women in labour after 28 gestational weeks or more probably reduces maternal sepsis. It likely results in little to no difference in maternal mortality, and results in little to no difference in neonatal sepsis, neonatal mortality, perineal wound infection, and NICU admission. Evidence on antimicrobial resistance is very uncertain: short-term increases in resistant organisms were observed in some maternal samples, but no persisting between-group differences were found at 11 to 13 months' follow-up. Implementation should be cautious and accompanied by antimicrobial stewardship and AMR surveillance, and future research should better quantify AMR effects and identify optimal antibiotic strategies."

Journal • Review • Critical care • Infectious Disease • Septic Shock

Accelerated bioremediation of antibiotics and nutrients in complex matrices using self-acclimatized, cost-effective microalgae‑bacteria consortia: a comprehensive comparison with standalone systems. (PubMed, Environ Sci Pollut Res Int) - "This study explored the simultaneous removal of major antibiotics (amoxicillin (AMX), ciprofloxacin (CIP), and sulfamethoxazole (SMX)) and nutrients using microalgae, bacteria, and their consortia. The study highlights the potential of consortia (dominated by Proteobacteria, Cyanobacteria, and Tetradesmus) for efficient removal of both antibiotics and nutrients in complex matrices. Overall, consortia reduce the need for aeration and illumination while producing beneficial by-products like EPS and lipids, contributing to more sustainable and cleaner water treatment solutions."

HEOR • Journal • CAT

The high-dose dual therapy for eradication of Helicobacter pylori: efficacy and safety (PubMed, Ter Arkh) - "The efficacy of the Era-RebAmIPP regimen is comparable to conventional triple therapy with bismuth. To assess the effectiveness of this regimen, larger-scale studies are required in various regions of our country."

Clinical • Journal • Infectious Disease

From Gut to Systemic: IgE and Hypereosinophilia in H. pylori Infection (ACG 2025) - "The patient was started on standard 14-day triple therapy with amoxicillin, clarithromycin, and pantoprazole. D. Gastroesophageal Junction"

Eosinophilia • Gastroenterology • Gastrointestinal Disorder • Hematological Malignancies • Infectious Disease • ABL1 • BCR • JAK2

H. pylori Therapy: Susceptibility-Based Proton Pump Inhibitor Triple Therapy Is Less Expensive and More Effective Than Empiric Vonoprazan Triple Therapy (ACG 2025) - "The costs for generic esomeprazole-clarithromycin triple therapy is ~$50...When vonoprazan-amoxicillin dual therapy is optimized to reliably produce cure rates >90% it would be an effective but very expensive empiric treatment option.1... The price of empiric vonoprazan-clarithromycin triple therapy is approximately twice that of equally or more effective, susceptibility-based tailored PPI-containing triple therapy (e.g., $1,000 vs. $550). NGS susceptibility testing provides data regarding susceptibility to all available antibiotics (eg, provides more treatment options)."

Infectious Disease

Sarcina Esophagitis Complicating a Large Hiatal Hernia (ACG 2025) - "The patient was treated with oral amoxicillin and metronidazole for 7 days with eventual resolution of symptoms...Treatment with antibiotics is effective, and important to avoid disease complications. Most literature has focused on impaired gastric dysmotility as a risk factor for Sarcina related disease, but other conditions that promote food stasis in the esophagus, such as hiatal hernias, may play a role in the pathogenesis of Sarcina related disease."

Dermatology • Gastroenterology • Gastrointestinal Disorder • Human Immunodeficiency Virus • Hypotension • Infectious Disease • Nephrology • Renal Disease • Respiratory Diseases • Septic Shock

Assessing Helicobacter pylori Testing and Treatment by Providers at an Academic Tertiary Medical Center: A Quality Improvement Project (ACG 2025) - "To assess baseline knowledge, in 2018 we performed an IRB approved survey of primary care and GI providers and found 20% were considering serology as a diagnostic option, 50% were treating asymptomatic patients with HPI, 15% were primarily treating with PPI-Bismuth-Metronidazole-Tetracycline (PBMT), 38% were always checking for eradication and 98% said local resistance information for HPI would be helpful. 108 providers participated in the re-assessment survey (Table 1). Key results include that 8% of providers are using serology for diagnosis, 69% are treating asymptomatic patients with HPI, 81% primarily prescribe PBMT and 78% always tested for eradication (Table 2). 14 % of providers are primarily prescribing PPI-amoxicillin-clarithromycin (PAC). Compared to 2018, 5 times more providers are primarily prescribing PBMT and almost 2 times more are consistently testing for eradication, likely as a result of updated national guidelines and local educational and..."

Infectious Disease • Pediatrics

Real-World Clinical Study for Effectiveness and Safety of Vonoprazan-Based Dual Therapy Versus PPI-Based Triple Therapy for Helicobacter pylori Eradication (ACG 2025) - "This study assesses the effectiveness of vonoprazan–amoxicillin (VA) dual therapy versus proton pump inhibitor (PPI)-amoxicillin-clarithromycin (PAC) based triple therapy in routine clinical practice, based on H. pylori eradication assessed by the rapid urease test (RUT). This was a single-centre, open-label, observational, real-world comparative study conducted at Kolkata Gastro Care, Dumdum, Kolkata, India, from July 2024 to March 2025. A total of 94 patients with H. pylori infection were analyzed, with 45 initiated on VA dual therapy and 49 on PAC regimen. The mean age (SD) was 38.96 (±13.18) years in VA and 43.49 (±11.34) years in PAC group. Chronic gastritis was the most frequent diagnosis across both groups (53.33% in VA, 59.18% in PAC)."

Clinical • Real-world • Real-world evidence • Gastrointestinal Disorder • Infectious Disease

The Golden Spice That May Deceive! (ACG 2025) - "Introduction: Drug induced liver injury(DILI) is commonly due to prescription medications like amoxicillin...This rare cause of hepatic injury emphasizes the importance of broad differentials and comprehensive medication reconciliation, including OTCs and supplements. With the popularity of turmeric supplementation rising, this may become a more common occurrence."

Gastroenterology • Hepatitis B • Hepatitis C • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Liver Failure

A Case of Gastrointestinal Kaposi's Sarcoma​ (ACG 2025) - "He was recently seen at an urgent care and given amoxicillin for sinusitis. He reported compliance with Biktarvy, however, he was not taking recently prescribed Bactrim...Treatment includes antiretroviral therapy +/- systemic chemotherapy, such as liposomal doxorubicin, in the setting of advanced or progressive disease. Future studies are needed to investigate the utility of performing screening endoscopies in select patients for early detection and treatment of GI-KS.Figure: Image A: Bleeding, fungating 2 cm mass with malignant appearance in the body of the stomach.Figure: Image B: Villous, nonbleeding 1 cm mass with a benign appearance seen in the fundus."

Clinical • Bipolar Disorder • Cardiovascular • CNS Disorders • Constipation • Depression • Epstein-Barr Virus Infections • Gastroenterology • Gastrointestinal Disorder • Human Immunodeficiency Virus • Hypertension • Infectious Disease • Kaposi Sarcoma • Mood Disorders • Otorhinolaryngology • Peptic Ulcer • Pneumonia • Psychiatry • Respiratory Diseases • Sarcoma • Sinusitis • Solid Tumor • CD34

Cholecystitis Complicated by Pyogenic Liver Abscess and Hepatic Vein Thrombosis: A Rare Lactobacillus Infection (ACG 2025) - "She was started on IV Zosyn pending culture results...With resolution of leukocytosis, improved liver function, and hemodynamic stability, the patient was discharged on oral amoxicillin 1 g every eight hours for four weeks with outpatient follow-up for elective cholecystectomy...Anticoagulation with apixaban was initiated per vascular recommendations, with outpatient re-evaluation planned. PLA with underlying infected biliary system is unusual but has been reported in literature...Advances in the imaging have increased detection of venous thrombosis,however, hepatic or portal vein thrombosis with concurrent APL can mimic hepatic malignancy and should be considered keenly. Prompt multidisciplinary approach for urgent intervention including surgery, drainage and broad antibiotics should be immediately considered to prevent high risk complications.Figure: A= Liver abscess on initial encounter B= Repeat interval CT with increased size of liver abscess C= CT scan with IR..."

Anorexia • Cardiovascular • Diabetes • Gastroenterology • Hepatocellular Cancer • Hepatology • Infectious Disease • Thrombocytopenia • Thrombosis

Helicobacter pylori-Associated Pyloric Stenosis Presenting as Duodenal Obstruction in an Adult (ACG 2025) - "He was discharged with triple therapy with Amoxicillin, clarithromycin, and Pantoprazole for 14 days for eradication of H pylori. The pyloriclumen was approximately 3 mm lumen in diameter.Figure: Figure 2: Endoscopic findings showing lumen of the Pylorus Post Dilation. A dilator catheterwas used to dilate the lumen to approximately 18 mm."

Clinical • Cardiovascular • Diabetes • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Genetic Disorders • Human Immunodeficiency Virus • Hypertension • Immunology • Infectious Disease • Metabolic Disorders • Obesity • Peptic Ulcer • Type 2 Diabetes Mellitus

A Case of COVID-19 Enteritis Mimicking Crohn's Disease (ACG 2025) - "Two weeks prior, she started levofloxacin for cough, then changed to amoxicillin after one week...She received IV fluids, pantoprazole, and sucralfate...She completed 5 days of remdesivir and was discharged...Long thickened segment of proximal Roux limb (arrow)Figure: Figure 2. Efferent limb segment with erythema, edema and exudates"

Clinical • Anorexia • Cough • Crohn's disease • Dermatology • Gastroenterology • Gastrointestinal Disorder • Immunology • Infectious Disease • Inflammation • Inflammatory Bowel Disease • Novel Coronavirus Disease • Respiratory Diseases

The Chameleon Effect: Distinguishing Drug Induced Liver Injury from Hepatitis C in Hurler Syndrome (ACG 2025) - "The patient was started on N-acetylcysteine (NAC) and steroids for suspected DILI...Here, amoxicillin alone (or combined with hibiscus tea/acetaminophen), alongside HCV and Hurler syndrome, likely caused DILI...DILI is a leading cause of acute liver failure in Western countries. High clinical suspicion based on medication timing and transaminitis is vital for prompt treatment due to high fatality rates.Figure: Figure 1: Liver histology findings suggestive of Drug Induced Liver InjuryFigure: Figure 2: Timeline of tread of liver enzymes"

Genetic Disorders • Hepatitis C • Hepatology • Human Immunodeficiency Virus • Hurler Syndrome • Infectious Disease • Inflammation • Liver Failure • Obesity • Respiratory Diseases