amoxicillin / Generic mfg. - LARVOL DELTA

Subcutaneous and Periorbital Emphysema Following a Dental Procedure. (PubMed, Cureus) - "The patient received prophylactic amoxicillin, and the lesion resolved completely in one week. Prompt clinical suspicion and a thorough evaluation of the signs and symptoms, including a detailed clinical history, are crucial for diagnosing subcutaneous emphysema following a dental procedure."

Journal • Pulmonary Disease • Respiratory Diseases

Comparison of Vonoprazan Triple Therapy, Bismuth Quadruple Therapy, and Amoxicillin Therapy for Helicobacter pylori Infection: A Systematic Review. (PubMed, Cureus) - "However, high doses of amoxicillin emerge as the safest and most effective treatment, especially where clarithromycin resistance is prevalent. Personalized treatment, taking into account patient preferences, tolerability, and concerns about resistance, will likely continue to offer the best chance for successful eradication. Ultimately, the goal is to select the most suitable therapy for each patient, ensuring both the effectiveness and comfort of the treatment."

Journal • Review • Critical care • Infectious Disease

A retrospective study on the impact of different antibiotic regimens in non-surgical periodontal therapy on microbial loads and therapy outcomes. (PubMed, Front Oral Health) - "202 patients were treated without the adjunctive use of systemic antibiotics, 18 received amoxicillin (AMOX) as well as metronidazole (MET) and 39 only MET...As antibiotic treatment with both MET and MET + AMOX similarly reduced microbial loads of PAB, treatment with MET alone may be sufficiently effective as adjunctive to non-surgical periodontal treatment. To confirm this, further prospective studies with bigger sample size are needed."

Journal • Retrospective data • Dental Disorders • Periodontitis

Antimicrobial Susceptibility Profiles of Erysipelothrix rhusiopathiae and Riemerella anatipestifer Isolates from Clinical Cases of Waterfowl in Hungary Between 2022 and 2023. (PubMed, Antibiotics (Basel)) - "Among the E. rhusiopathiae isolates, resistance to amoxicillin (89%) and enrofloxacin (61%) was notable, whereas ceftriaxone and doxycycline exhibited moderate antibacterial effects. Beta-lactam antibiotics remain effective, whereas rising resistance to fluoroquinolones and aminoglycosides raise serious concerns. Routine AMR surveillance and the adoption of alternative strategies are crucial for controlling infections and maintaining flock health."

Journal • Infectious Disease

Stability of Nine Time-Dependent Antibiotics for Outpatient Parenteral Antimicrobial Therapy (OPAT) Use. (PubMed, Antibiotics (Basel)) - " Solutions showing stability for 24 h are composed of 12.5 mg/mL cefiderocol in NS (normal saline) and 50-133 mg/mL piperacillin in NS-D5W (5% dextrose). Additionally, 12.5 mg/mL amoxicillin in NS; 12.5 mg/mL cefepime in NS-D5W; 12.5 mg/mL cefiderocol in D5W; 25 mg/mL cefiderocol in NS-D5W; 12.5 mg/mL cefotaxime in NS-D5W; 12.5 mg/mL cefoxitin in NS-D5W; 12.5 mg/mL ceftazidime in NS-D5W; 25 mg/mL ceftazidime in NS; 25 mg/mL cloxacillin in NS-D5W; and 25-50 mg/mL oxacillin in NS were shown to be stable for 12 h. Notably, 25 mg/mL amoxicillin in NS, 50 mg/mL cloxacillin in NS and 25 mg/mL oxacillin in D5W were shown to be stable for 8 h. These 12-24 h stability data indicate that these antibiotics can be administered by continuous infusion using only one-two elastomeric devices per day, facilitating outpatient parenteral antimicrobial therapy (OPAT)."

Journal

In Vitro Activity of Imipenem/Relebactam Alone and in Combination Against Cystic Fibrosis Isolates of Mycobacterium abscessus. (PubMed, Antibiotics (Basel)) - "These findings suggest that imipenem/relebactam may offer a significant advancement in the management of MABS infections in PwCF. The promising efficacy of multidrug regimens combining imipenem/relebactam with agents like cefoxitin, azithromycin, moxifloxacin, clofazimine, and rifabutin highlights potential therapeutic strategies."

Journal • Preclinical • Cystic Fibrosis • Genetic Disorders • Immunology • Infectious Disease • Pulmonary Disease • Respiratory Diseases

Helicobacter pylori Antibiotic Resistance in Russia: A Systematic Review and Meta-Analysis. (PubMed, Antibiotics (Basel)) - "Metronidazole showed consistently high pooled resistance (33.309%), while amoxicillin (1.828%), levofloxacin (19.014%), tetracycline (1.328%), and rifampicin (5.803%) maintained low resistance rates, and dual clarithromycin-metronidazole resistance was observed in 2.793% of isolates. Russia surpasses the Maastricht VI Consensus resistance threshold for clarithromycin (15%), necessitating revision of empirical treatment strategies. The significant increase in clarithromycin resistance, potentially exacerbated by antibiotic use during the COVID-19 pandemic, underscores the urgent need for resistance-guided therapies and ongoing national surveillance programs to optimize H. pylori management."

Journal • Retrospective data • Review • Infectious Disease • Novel Coronavirus Disease

Clinical Effectiveness of Penicillin-Free Therapies in First-Line and Rescue Treatments for Helicobacter pylori: A Systematic Review. (PubMed, Antibiotics (Basel)) - "Background and Aims: Amoxicillin is one of the most effective antibiotics for treating Helicobacter pylori infections and is widely used in first-line treatment regimens...Key findings demonstrated high eradication rates with bismuth-based quadruple therapies (88-97%), doxycycline-based regimens (86%), and quinolone-based therapies (75-100%), with Sitafloxacin exceeding 90% efficacy. Minocycline-based regimens also showed promising outcomes, with eradication rates between 80% and 85%...Vonoprazan-based therapy is an effective regimen. Combined with clarithromycin and metronidazole, vonoprazan enhances eradication rates and demonstrates effectiveness, including in clarithromycin-resistant strains."

Journal • Review • Allergy • Immunology • Infectious Disease

Antimicrobial Susceptibility Profiles of Escherichia coli Isolates from Clinical Cases of Ducks in Hungary Between 2022 and 2023. (PubMed, Antibiotics (Basel)) - "Strong cross-resistance associations were detected between neomycin and spectinomycin, as well as amoxicillin and doxycycline. The alarming MDR prevalence in E. coli isolates from ducks reinforces the importance of targeted surveillance and antimicrobial stewardship. Predictive models, including decision trees and neural networks, provide valuable insights into resistance trends, while Monte Carlo simulations further validate these findings, emphasizing the need for proactive antimicrobial management."

Journal

Antimicrobial Activity, Genetic Diversity and Safety Assessment of Lactic Acid Bacteria Isolated from European Hakes (Merluccius merluccius, L.) Caught in the Northeast Atlantic Ocean. (PubMed, Antibiotics (Basel)) - " All LAB isolates were biofilm producers and susceptible to chloramphenicol, oxytetracycline, flumequine and amoxicillin. Among the isolated strains, five LAB strains exhibiting the highest antimicrobial activity against aquaculture-relevant ichthyopathogens, taxonomically identified as Streptococcus salivarius, Enterococcus avium and Latilactobacillus sakei, were selected for further characterisation as potential probiotic candidates to promote sustainable aquaculture. To our knowledge, this is the first study to report that hake intestines and faeces represent viable ecological niches for the isolation of LAB strains with antimicrobial activity."

Journal • Infectious Disease

Therapeutic drug monitoring for antimicrobial agents for people living with HIV (TAP). (PubMed, Wellcome Open Res) - "This prospective observational study will enroll adult PLWH receiving amoxicillin, azithromycin, ciprofloxacin, rifampicin, isoniazid, or ceftriaxone. We anticipate that the findings from this research will characterize pharmacokinetic and pharmacodynamics relationships to predict treatment response for optimal antimicrobial therapeutic and anti-tuberculosis dosing among people living with HIV (PLWH). The study is registered with Pan African Clinical Trials Registry, registration number PACTR202409710100607, registration date 07 August 2024, pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=31764."

Journal • Human Immunodeficiency Virus • Infectious Disease • Oncology • Pulmonary Disease • Respiratory Diseases • Tuberculosis

A Cost-Effective Liquid Chromatography Method with Ultraviolet Detection for Identity Screening and Assay of Injectable Antibiotics. (PubMed, Molecules) - "The present study aimed to develop and validate a liquid chromatography method with ultraviolet detection (LC-UV) for the identity screening and assay of 13 different injectable antibiotics, i.e., cefepime, amoxicillin, cefazolin, ampicillin, chloramphenicol, ceftazidime, ceftriaxone, cefotaxime, vancomycin, flucloxacillin, cloxacillin, benzylpenicillin, and meropenem in pharmaceutical formulations. The method was applied to analyze 17 injectable antibiotics collected from the Ethiopian market. All commercial samples analyzed contained the correct API and met USP content specifications."

HEOR • Journal

Amoxicillin-metronidazole disk for antimicrobial susceptibility testing of subgingival bacteria. (PubMed, J Oral Microbiol) - "The IZD of AMX-MET was comparable to that of AMX and MET for important periodontal pathogens, which opens for studies on direct AST of oral samples with a mixed microbiota. The amoxicillin-metronidazole disk for antimicrobial susceptibility testing results in comparable inhibition zone diameters to that of AMX and MET for important periodontal pathogens."

Journal • Dental Disorders • Periodontitis

Antimicrobial Susceptibility Profiles of Escherichia coli Isolates from Clinical Cases of Geese in Hungary Between 2022 and 2023. (PubMed, Antibiotics (Basel)) - "Co-resistance analysis revealed a strong correlation between neomycin and spectinomycin resistance, as well as amoxicillin and doxycycline resistance. The high prevalence of MDR and XDR strains highlights the urgent need to reassess antibiotic usage strategies in goose farming. These findings underscore the importance of targeted antibiotic use, continuous microbiological surveillance, and the exploration of alternative therapeutic approaches to mitigate AMR."

Journal

Development of Chrome-Doped Hydroxyapatite in a PVA Matrix Enriched with Amoxicillin for Biomedical Applications. (PubMed, Antibiotics (Basel)) - " Our results underline the stability of the analyzed samples. Moreover, our physico-chemical and biological studies highlight that CrHApAPV and CrHApAPV-Ax coatings could be considered promising materials for biomedical uses."

Journal

Uncommon Urinary Actinomycosis Mimicking Upper Urinary Tract Urothelial Tumor: Case Report and Literature Review. (PubMed, Microorganisms) - "Consequently, antibiotic therapy with oral amoxicillin 2 g every 12 h was initiated, leading to a good clinical response. Despite its low incidence, urinary actinomycosis should be considered as a differential diagnosis in cases suspected of urothelial tumors in the upper urinary tract. Increased awareness of this rare condition may help prevent unnecessary surgical interventions."

Journal • Diabetes • Hepatology • Infectious Disease • Liver Failure • Metabolic Disorders • Nephrology • Oncology • Pain • Solid Tumor • Type 2 Diabetes Mellitus • Urothelial Cancer

Characterization of antimicrobial resistance among Proteus mirabilis isolates from catheter-associated urinary tract infections and non-catheter-associated urinary tract infections in Egypt. (PubMed, BMC Infect Dis) - "The high frequency of MDR P. mirabilis strains isolated from UTIs in Egypt, particularly among catheterized patients, is a major concern, especially with disseminating class 1 and 2 integrons among isolates. The study also highlights the decreased susceptibility to sulphonamides, 3rd generation cephalosporins, and imipenem, commonly used to treat UTIs. Increased dissemination of ESBL-producing Proteus isolates among CAUTIs complicates their treatments. This important pathogen deserves more attention in the future for a better understanding of resistance mechanisms and the dissemination potential of resistant strains."

Journal • Infectious Disease • Nephrology

Waste PET Plastic-Derived UIO-66(Zr)-MOF Adsorbent for Dispersive Solid Phase Extraction and Removal of Penicillin Antibiotics Water Systems. (PubMed, Anal Sci Adv) - "As a result, UiO-66(Zr)-MOF derived from recycled waste PET bottles (PET-derived UiO-66(Zr)-MOF) was investigated for enrichment and removal of amoxicillin (AMX) and penicillin G (PNG) in water bodies. The AMX and PNG were detected in wastewater samples in the ranges of 1.51-4.71 µg/L and 0.195-1.19 µg/L for influent and effluent. The spike recoveries ranged from 89.9% to 101%, while the precision (intraday and interday) of the method was less than 5%."

Journal

Establishment and application of a new method for the detection of drug antibodies by flow cytometry. (PubMed, Transfusion) - "This approach offers several advantages, including ease of operation, rapid detection time, high specificity and sensitivity, and excellent interference resistance. This new approach will be suitable for determining drug antibodies in clinical laboratories."

Journal • Hematological Disorders

Versatile Polycaprolactone-Based Drug Delivery System with Enhanced Cytocompatibility and Antibacterial Activity. (PubMed, J Funct Biomater) - "It was shown that the incorporation of four distinct antibiotic classes (amoxicillin, doxycycline, metronidazole and rifampicin), with very high mass fractions ranging up to 20 wt%, was feasible within the PCL matrix. The DDS demonstrated a markedly diminished cytotoxic impact owing to sustained release in comparison to pure antibiotics, while simultaneously maintaining their antibacterial efficacy. In conclusion, DDSs are a more tolerable form of antibiotics administration due to the hydrophobic PCL matrix causing a slower diffusion-controlled release, proven as a release mechanism via the Peppa-Sahlin model."

Journal • Infectious Disease

The role of syphilis in exacerbating axial spondyloarthritis symptoms: A case report on diagnosis and management. (PubMed, Mod Rheumatol Case Rep) - "Targeted antibiotic therapy with penicillin G and amoxicillin-probenecid led to significant clinical and radiological improvement. Recognizing syphilis in patients with unexplained axial inflammation can prevent unnecessary immunosuppressive therapy and guide effective management. With the rising incidence of syphilis, prompt diagnosis and treatment are critical for preventing spinal pathology progression and improving outcomes."

Journal • Ankylosing Spondylitis • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Musculoskeletal Diseases • Seronegative Spondyloarthropathies • Spondylarthritis

Odontogenic Cutaneous Fistula in Pregnant Woman: Is Long-Term Antibiotic Therapy the Solution? (PubMed, Cureus) - "Amoxicillin was initially prescribed; however, due to the progression of the infection, the treatment was switched to clarithromycin after consultation with a dermatologist. The pregnancy progressed without complications, and the patient gave birth to a healthy baby. This case underscores the challenges of managing odontogenic infections during pregnancy and highlights the importance of tailored antibiotic therapy to ensure the safety of both the mother and fetus."

Journal • Infectious Disease • Inflammation

Aerobic Vaginitis Caused By Streptococcus Β- Hemolyticus and Staphylococcus Epidermidis in a 26-Year-Old Woman with a History of Frequent Antibiotics Administration. (PubMed, Int J Womens Health) - "The treatment process includes the administration of amoxicillin 500 mg three times daily for 14 days...Subsequently, a history of frequent antibiotic use was reported, however, the specific names of previously administered antibiotics remain unknown, except for clindamycin, which is the only agent specifically recalled. The patient also had a history of high exposure to stressors and underwent a bacterial culture examination taken from the vaginal introitus, which showed the presence of Streptococcus β-hemolyticus and Staphylococcus epidermidis. This case highlights the significance of AV in the differential diagnosis of vaginal infections, especially in atypical patient populations, and emphasizes the need for appropriate diagnostic measures such as bacterial culture to guide effective treatment strategies."

Journal • Dermatology • Gynecology • Infectious Disease • Inflammation • Pruritus • Vaginitis

Toxicity analysis of amoxicillin, polyphosphate ester and its complex with amoxicillin on mice. (PubMed, Sci Rep) - "Thus, polyphosphate ester P4 can serve as a safe drug carrier for antimicrobial drugs. It is planned to carry out more extensive studies on other animal species to study its biocompatibility and effectiveness of antimicrobial activity in a complex with antimicrobials."

Adverse events • Journal • Preclinical • Inflammation

Evaluation of antibiotic therapy in the treatment of hidradenitis suppurativa (SID 2025) - "To evaluate this, eleven cohorts were created within TriNetX using International Classification of Disease (ICD)-10 codes, each composed of patients prescribed either oral doxycycline, oral minocycline, oral and topical clindamycin, oral amoxicillin, oral and topical metronidazole, oral moxifloxacin, oral rifampin, or oral and topical dapsone within three years of HS diagnosis. Each cohort was excluded from usage of the other measured medications, adalimumab, secukinumab, or bimekizumab, and excluded from a history of deroofing procedures...These results question the efficacy of doxycycline monotherapy as a first-line therapy in the treatment of HS. Additional studies should be conducted to further analyze the efficacy of both oral and topical antibiotic monotherapies in the treatment of HS."

Late-breaking abstract • Dermatology • Hidradenitis Suppurativa • Immunology