atosiban / Generic mfg. - LARVOL DELTA

The Effect of Oral Oxytocin and Atosiban on Top-down Attention ( OTAtosiban ) (clinicaltrials.gov) - P1 | N=250 | Recruiting | Sponsor: University of Electronic Science and Technology of China

New P1 trial

Dual Oxytocin Signals in Striatal Astrocytes. (PubMed, Biomolecules) - "Our main findings are as follows: oxytocin could induce dual responses in astrocyte processes, namely the inhibition and facilitation of both Ca2+ signals and glutamate release; the inhibitory and the facilitatory response appeared dependent on activation of the Gi and the Gq pathway, respectively; both inhibitory and facilitatory responses were evoked at the same nanomolar oxytocin concentrations; and the biased agonists atosiban and carbetocin could duplicate oxytocin's inhibitory and facilitatory response, respectively. In conclusion, due to the coupling of striatal astrocytic oxytocin receptors to different transduction pathways and the dual effects on Ca2+ signals and glutamate release, oxytocin could also play a crucial role in neuron-astrocyte bi-directional communication through a subtle regulation of striatal glutamatergic synapses. Therefore, astrocytic oxytocin receptors may offer pharmacological targets to regulate glutamatergic striatal transmission,..."

Journal • CNS Disorders • Mental Retardation • Psychiatry

OTAtosiban: The Effect of Oral Oxytocin and Atosiban on Social Attention (clinicaltrials.gov) - P1 | N=250 | Recruiting | Sponsor: University of Electronic Science and Technology of China

New P1 trial

Efficacy and safety of ebopiprant to delay preterm birth after oral administration in pregnant women with spontaneous preterm labor receiving atosiban: a phase 2a, double-blind, parallel group, randomized, placebo-controlled, proof of concept study. (PubMed, Eur J Obstet Gynecol Reprod Biol) - P2a | "Ebopiprant added to atosiban infusion may reduce the probability of delivering within 48 h."

Journal • P2a data • IGFBP1

Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain. (PubMed, Iran J Basic Med Sci) - "Atosiban, an OTR antagonist, was also co-administered with these compounds to confirm their involvement in OTR activation...These compounds induced significant anti-hyperalgesia without any sex differences, suggesting that the inhibition of IRAP degradation eliminated the variation in oxytocin's effects based on sex. Therefore, we propose these compounds as promising candidates for treating inflammatory hyperalgesia in clinical applications."

Journal • Preclinical • Pain

Oxytocin Receptor Regulates the Hippo/YAP Axis to Drive Hepatocarcinogenesis. (PubMed, Cancer Res) - "ChIP assays showed that YAP bound to the enhancer region of OXTR and facilitated its transcription, creating a positive feedback loop. Together, this study uncovered the interplay between Hippo signaling and the OXTR pathway in hepatocarcinogenesis and established OXTR inhibition with atosiban as a promising strategy for treating HCC."

Journal • Hepatocellular Cancer • Liver Cancer • Oncology • Solid Tumor

Exometabolome of Pantoea targets pathogen associated scytalone dehydratase and XopQ for suppression of foliar blast and bacterial blight in rice. (PubMed, Int J Biol Macromol) - "UPLC-QToF-ESI profiling identified metabolites such as dapdiamide and pantocins, which exhibited strong antimicrobial properties...The combined effects of direct antimicrobial action, suppression of pathogen virulence, and activation of host defenses highlight the potential of Pantoea exometabolomes as a biocontrol strategy. This study underscores their role in sustainable disease management and presents a viable alternative to chemical-based crop protection methods."

Journal

Mechanism of Zuogui Pills in regulating bone metabolism through OXT/OXTR feed-forward loop based on theory of "all marrows dominated by brain" (PubMed, Zhongguo Zhong Yao Za Zhi) - "A PMOP rat model was established using ovariectomy, and 70 Sprague-Dawley female rats were randomly divided into the following groups: sham operation group, model group, estradiol group(17β-estradiol, 0.05 mg·kg~(-1)·d~(-1)), Zuogui Pills low, medium, and high dose groups(0.2, 0.4, 0.8 g·kg~(-1)·d~(-1), respectively), and an antagonist group(atosiban 0.9 mg·kg~(-1)·d~(-1) + 17β-estradiol 0.05 mg·kg~(-1)·d~(-1) + Zuogui Pills 0.4 g·kg~(-1)·d~(-1))...The therapeutic effect of the Zuogui Pills high dose group was partially inhibited when an OXTR antagonist was administered. These findings suggest that Zuogui Pills can regulate the OXT/OXTR feed-forward loop, activate the phosphorylation of the downstream Ras/Raf1/MEK/ERK signaling pathway, and ultimately improve bone mineral density, thereby exerting therapeutic effects in PMOP."

Journal • Oncology • Osteoporosis • Rheumatology • MAP2K1 • TRAP

Oxytocin attenuates demand for cocaine in female rats. (PubMed, Addict Neurosci) - "Results showed that OXT decreased motivation for cocaine; an effect greater during the high-demand phase (diestrus, low progesterone, P4) vs low demand phases (proestrus, high P4)...Finally, using ovariectomized females with P4 replacement, we show that P4's demand attenuating effects are reversed by atosiban (1.0 mg/kg, IP), an OXT antagonist...Additionally, we show critical periods for using OXT as a treatment to reduce cocaine demand in females. Our results indicate novel therapeutic treatments for SUDs must be tailored to hormonal states."

Journal • Preclinical

The effectiveness and safety of continuous and repeated treatment of atosiban in twin pregnancy with threatened preterm labor: A propensity score-matched study. (PubMed, PLoS One) - "This propensity score-matched study suggests that continuous and repeated treatment with atosiban may effectively prolong pregnancy in cases of twin pregnancies with threatened preterm labor. Continuous and repeated treatment with atosiban was associated with lower fetal distress and lower NICU admission but no effect in adverse neonatal outcomes as well as the incidence of chorioamnionitis."

Journal • Retrospective data • Critical care • Gynecology • Obstetrics

The effect of atosiban on pregnancy outcomes in different FET cycles: a single-center matched retrospective cohort study. (PubMed, Front Endocrinol (Lausanne)) - "These results suggested that adding atosiban in the standard FET cycles might not improve the live birth rate. To confirm this conclusion, more thorough, prospective randomized controlled studies of sizable sample sizes with good design are required."

Journal • Retrospective data

Phylloplane Bacterial Exometabolites Suppress Xanthomonas axonopodis pv. punicae: Metabolomic and Genomic Insights for Bacterial Blight Management in Pomegranate. (PubMed, Microb Pathog) - "LC-MS/MS profiling revealed the presence of bioactive metabolites such as Bacillomycin D, Fengycin, and Iturin A in Bacillus spp.; Macrolactin (6.3 μg/mL), Macrolactin W (4.1 μg/mL), and sucrose palmitate (2.8 μg/mL) in Erwinia; and Cyclo(l-Pro-l-Tyr), Tryptophol, Dapdiamide A and B, and Pantocin A and B in Pantoea...Phylogenetic analysis based on 100 conserved protein-coding genes placed P. dispersa Pg-Slp6 in a distinct clade, underscoring its unique genomic identity. These findings establish P. dispersa Pg-Slp6 as a robust candidate for developing phylloplane-adapted microbial formulations aimed at the eco-friendly and effective management of bacterial blight in pomegranate."

Journal

The interplay between oxytocin receptor and YAP in regulating gastric cancer progression. (PubMed, Oncogene) - "The use of the OXTR antagonist Atosiban to inhibit OXTR activity promotes the phosphorylation of LATS1 by ARRB2, which subsequently suppresses YAP phosphorylation. This results in the sequestration of YAP in the cytoplasm, thereby inhibiting the progression of gastric cancer."

Journal • Gastric Cancer • Oncology • Solid Tumor • LATS1

Analysis of the effect of oxytocin analogues on a mouse contextual fear-conditioning behavior (CINP-AsCNP 2025) - "Aims & Objectives: In the present study, we examined whether oxytocin and its analog (carbetocin and atosiban) could reduce fear-conditioning behavior of mice that is often applied in the studies of dental phobia. The results of this study suggest that intranasal administration of carbetocin immediately after electric shock session effectively reduces fear memory formation in mice. Carbetocin selectively activates the Gq protein-related response of the oxytocin receptor, suggesting that selective responses downstream of the oxytocin receptor may contribute to the reduction of the fear conditioning effect. However, further analysis is needed to clarify which neural nuclei and neural circuits carbetocin targets."

Preclinical • FOS

Brain tumour during pregnancy: Clinical and surgical management of a challenging case (Euroanaesthesia 2025) - "Periodic fetal monitoring and tocolytic infusion with atosiban were maintained throughout.Drainage through the Ommaya chamber provided symptom relieve, and a c-section was planned at 37th week of gestation.Cesarian was performed under total intravenous anesthesia (TIVA) using propofol target-controlled infusion, RSI and videolaryngoscopy to secure the airway...C-section was uneventful, and a healthy male newborn was delivered.Two months later, the mother was submitted to suboccipital craniotomy with excision of the posterior fossa lesion, a pilocytic astrocytoma, and removal of the Ommaya reservoir, under TIVA, with no complications. An experienced team involving Neurosurgery, Obstetrics, Neonatology and Anesthesiology was crucial to ensure mother, fetus and neonate health. Optimal timing, coordination and accurate anesthetic management of the surgical procedures minimized the risk of complications and allowed a positive outcome."

Clinical • Anesthesia • Astrocytoma • Brain Cancer • Obstetrics • Oncology • Pilocytic Astrocytoma • Rare Diseases • Solid Tumor

Apelin-13 elicits lordosis behavior in female rats through the oxytocin/prostaglandin E2/GnRH signaling system. (PubMed, Horm Behav) - "The inhibitors used included atosiban (ATO), an OT receptor antagonist; acetylsalicylic acid (aspirin), a cyclooxygenase-2 (COX-2) inhibitor; ONOAE3-208 (ONO), a PGE2 receptor antagonist; RU486, an antiprogestin for the PR; and antide, a GnRH-1 receptor antagonist. In contrast, aspirin only decreased the LQ at 30 and 120 min, while the LS was reduced at all times tested. Because the OT/PGE2/GnRH pathway has been widely demonstrated in hypothalamic astrocytes as a regulator of GnRH release, it may also play a role in regulating female sexual behavior in estradiol-pretreated rats."

Journal • Preclinical

Pituitary Suppression in Conjunction with Atosiban Administration Could Improve Pregnancy Outcome of Frozen-thawed Embryo Transfer in Women with Endometriosis (WCE 2025) - "However, findings are limited by small sample sizes and lack of detailed severity assessment. Larger randomized trials stratifying by endometriosis phenotype and severity are needed to confirm effectiveness and optimize FET strategies."

Clinical • Endometriosis • Gynecology • Women's Health

Proton pump inhibition to prevent delayed chemotherapy-induced nausea and vomiting in patients receiving adjuvant or neoadjuvant breast cancer chemotherapy: a phase II, randomised double-blind crossover trial (PantoCIN). (PubMed, Support Care Cancer) - P2 | "Pantoprazole is a cost-effective and safe agent, which reduces rates of delayed nausea and should be considered as prophylaxis in patients undergoing emetogenic chemotherapy."

CINV • Journal • P2 data • Breast Cancer • Chemotherapy-Induced Nausea and Vomiting • Dyspepsia • Oncology • Solid Tumor

The biased OTR ligands -atosiban and carbetocin- differentially inhibit early or late formalin-induced nociception in rats. (PubMed, Neuropharmacology) - "Late hypersensitivity correlated with increased levels of phosphorylated S6 protein in the spinal tissue, an effect partly blocked by atosiban. These data suggest that carbetocin prevents early nociception in males via OTR-Gq, and atosiban blocks late hypersensitivity in both sexes via OTR-Gi/o, implying that OTR-biased activation underlies the sexual dimorphism observed in oxytocin-induced antinociception."

Journal • Preclinical • Immunology • Infectious Disease • Inflammation • Pain • Respiratory Diseases

Inhibition of TRPM3 by Primidone Provides a Potential Therapeutic Method for Adenomyosis Management. (PubMed, Drug Des Devel Ther) - "To test the expression profile of transient receptor potential channels (TRPs) in adenomyosis patients and evaluate the effects of primidone on tamoxifen-induced adenomyosis mice...From 10 weeks after birth, primidone (2 mg/kg/d) and atosiban (1 mg/kg/d) were given separately to adenomyotic mice by intraperitoneal injection for 3 weeks...Forty-seven DEGSSs were identifieSd after primidone treatment, and bioinformatics analysis predicted that they were enriched in the cell cycle and cell division. The expression profile of TRP channels varies significantly in adenomyosis patients, and primidone may provide a potential therapeutic method for adenomyosis management."

Journal • Endometriosis • Gynecology • Musculoskeletal Pain • Pain • Women's Health • TRPA1 • TRPM3 • TRPV1

Atosiban and managing women in preterm labour. (PubMed, Lancet) - No abstract available

Journal

Atosiban versus placebo for threatened preterm birth (APOSTEL 8): a multicentre, randomised controlled trial. (PubMed, Lancet) - P4 | "We did not demonstrate superiority of atosiban over placebo in improving neonatal outcomes as treatment for threatened preterm birth from 30+0 to 33+6 weeks of gestation. As the primary goal of tocolysis should be improvement of neonatal outcomes, our outcomes question the standardised use of atosiban as treatment for threatened preterm birth from 30+0 to 33+6 weeks of gestation. Our findings should reduce practice variation across countries and will contribute to evidence-based treatment for patients with threatened preterm birth."

Journal

Atosiban in individuals with previous implantation failure undergoing frozen blastocyst transfer: a randomized controlled trial. (PubMed, Hum Reprod) - P4 | "Our study shows do not support the routine use of intravenous Atosiban to improve pregnancy outcomes among individuals undergoing frozen embryo transfers."

Clinical • Journal • Genetic Disorders

In-silico Approach to Combat Methicillin-resistant Staphylococcus aureus: Targeting RelP Protein with Inhibitor Peptide to Mitigate Drug Resistance. (PubMed, Curr Drug Discov Technol) - "Peptide therapeutics is a novel approach researchers are presently exploring as it pro-vides prompt significant results and promotes a new insight towards dealing with conditions like MDR. Pantocin wh-1 is a peptide drug currently listed as an accessible anti-tuberculosis peptide, and this study suggests the repurposing of this drug as a viable treatment option for MRSA infections."

Journal • Infectious Disease • Pulmonary Disease • Respiratory Diseases • Tuberculosis

ROLE OF ATRIAL NATRIURETIC PEPTIDE AND OXYTOCIN IN GASTRIC EMPTYING DELAY INDUCED BY RIGHT ATRIAL STRETCH IN RATS. (PubMed, Am J Physiol Regul Integr Comp Physiol) - "One week later, rats were randomly subjected for pretreatment with NaCl 0.15 M (control), atosiban (AT, OT-antagonist), anantin (ANT, ANP-antagonist), or dexamethasone (DEX). In turn, oxytocin treatment decreased GE and increased plasma ANP, OT and CORT levels, while AT, ANT and DEX prevented OT-induced GE delay. Hence, AS delayed GE of liquid in rats, a phenomenon that involves oxytocinergic pathways and ANP activity."

Journal • Preclinical • Cardiovascular • Gastrointestinal Disorder