atosiban / Generic mfg. - LARVOL DELTA

Safety and efficacy of atosiban for fetomaternal resuscitation following severe placental abruption in preparation for an emergency caesarean section: a narrative review. (PubMed, Expert Opin Drug Saf) - "The contribution of maternal uterine hypertonus/tachysystole and increased uterine tone/pressure that affects fetal hypoxia/acidosis and consumption coagulopathy, strengthens the case for the use of a tocolytic to relax the uterus and improve fetal oxygenation. Due to its safety and efficacy profile, we make the case for atosiban as an agent to reduce uterine contractile frequency, tone and pressure to improve fetal oxygenation and improve fetomaternal outcome."

Journal • Review • Hematological Disorders • Metabolic Disorders

Advancing Sustainable Synthesis of Cyclic Peptides by Integrating Aqueous Fmoc/t-Bu Solid-Phase Peptide Synthesis with Disulfide Bond Formation and TFA/PFAS-Free Resin Cleavage. (PubMed, J Org Chem) - "Lett. 2024, 26, 6787-6791], we now report that ASPPS can be integrated with disulfide formation and TFA/PFA-free cleavage toward a new platform for sustainable synthesis of cyclic peptides, illustrated by synthesizing labor suppressant atosiban by both on-resin cyclization/cleavage and cleavage/solution cyclization approaches."

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Tocolysis for preterm labor with intact membranes (PubMed, Gynecol Obstet Fertil Senol) - "Nifedpine and atosiban are recommanded as first line tocolysis since the clinical guidelines published in 2016 by the French College of Obstetrics and Gynecology (CNGOF)...Beyond medication, other parameters need to be considered such as national and territorial health organization, specific to each country. A collegial opinion with a revision of the national guidelines including all the parameters is necessary before any change in preterm labor management."

Journal • Gynecology • Obstetrics

Atosiban for threatened preterm birth: the APOSTEL 8 trial. (PubMed, Lancet) - No abstract available

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Atosiban for threatened preterm birth: the APOSTEL 8 trial. (PubMed, Lancet) - No abstract available

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Atosiban for threatened preterm birth: the APOSTEL 8 trial - Authors' reply. (PubMed, Lancet) - No abstract available

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Investigating the Pharmacological Impact of Atosiban, an Oxytocin Receptor Antagonist, on Bladder and Prostate Contractions Within OBESE and Non-Obese Rats. (PubMed, Biomedicines) - " These findings indicate that oxytocin contributes to bladder and prostate hypercontractility, particularly in obesity. Targeting OXTR with atosiban may represent a novel therapeutic strategy for the management of LUTS, OAB, and BPH."

Journal • Preclinical • Benign Prostatic Hyperplasia • Genetic Disorders • Obesity • Overactive Bladder • Urinary Incontinence

On-Resin Synthesis and Late-Stage Functionalization of Macrocyclic Atosiban Mimetics via 5-Iodo-1,4-triazoles. (PubMed, Org Lett) - "Structural analysis revealed that the 5-iodo substituent influences the peptide conformation. These findings establish 5-iodo-1,4-triazoles as versatile, tunable motifs for macrocyclization and functionalization, expanding the chemical space accessible to macrocyclic peptide chemical biology tools and therapeutics."

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Comparative analysis of magnesium sulfate and atosiban in fetal neuroprotection during high-risk pregnancies. (PubMed, Pak J Pharm Sci) - "It is also observed that considering maternal safety, it has fewer side effects. Future larger population studies should be carried out to corroborate the results for higher efficient and safer intervention for fetal neuroprotection."

Clinical • Journal • Cardiovascular • Cerebral Palsy • CNS Disorders • Critical care • Developmental Disorders • Hypertension • Respiratory Diseases

Atosiban in Single Blastocyst Transfer in Patients With Previous Pregnancy Failure and Abnormal Uterine Contractions (clinicaltrials.gov) - P=N/A | N=792 | Not yet recruiting | Sponsor: Northwest Women's and Children's Hospital, Xi'an, Shaanxi

New trial • Infertility • Sexual Disorders

A neural circuit from hypothalamic paraventricular oxytocin neurons to trigeminal nucleus caudalis GABAergic neurons modulates pain sensitization in a mouse model of chronic migraine. (PubMed, Zhejiang Da Xue Xue Bao Yi Xue Ban) - "PVN OXT neurons exert a descending facilitatory effect on GABAergic neurons in the TNC via OXT release, thereby ameliorating pain sensitization in chronic migraine."

Journal • Preclinical • CNS Disorders • Migraine • Pain • FOS • OXT

The Effect of Oral Oxytocin and Atosiban on Top-down Attention ( OTAtosiban ) (clinicaltrials.gov) - P1 | N=250 | Recruiting | Sponsor: University of Electronic Science and Technology of China

New P1 trial

Dual Oxytocin Signals in Striatal Astrocytes. (PubMed, Biomolecules) - "Our main findings are as follows: oxytocin could induce dual responses in astrocyte processes, namely the inhibition and facilitation of both Ca2+ signals and glutamate release; the inhibitory and the facilitatory response appeared dependent on activation of the Gi and the Gq pathway, respectively; both inhibitory and facilitatory responses were evoked at the same nanomolar oxytocin concentrations; and the biased agonists atosiban and carbetocin could duplicate oxytocin's inhibitory and facilitatory response, respectively. In conclusion, due to the coupling of striatal astrocytic oxytocin receptors to different transduction pathways and the dual effects on Ca2+ signals and glutamate release, oxytocin could also play a crucial role in neuron-astrocyte bi-directional communication through a subtle regulation of striatal glutamatergic synapses. Therefore, astrocytic oxytocin receptors may offer pharmacological targets to regulate glutamatergic striatal transmission,..."

Journal • CNS Disorders • Mental Retardation • Psychiatry

OTAtosiban: The Effect of Oral Oxytocin and Atosiban on Social Attention (clinicaltrials.gov) - P1 | N=250 | Recruiting | Sponsor: University of Electronic Science and Technology of China

New P1 trial

Efficacy and safety of ebopiprant to delay preterm birth after oral administration in pregnant women with spontaneous preterm labor receiving atosiban: a phase 2a, double-blind, parallel group, randomized, placebo-controlled, proof of concept study. (PubMed, Eur J Obstet Gynecol Reprod Biol) - P2a | "Ebopiprant added to atosiban infusion may reduce the probability of delivering within 48 h."

Journal • P2a data • IGFBP1

Intrathecal injections of non-peptide oxytocin receptor agonists, WAY 267,464 and TC OT 39, induce significant anti-hyperalgesia in both male and female rats with inflammatory pain. (PubMed, Iran J Basic Med Sci) - "Atosiban, an OTR antagonist, was also co-administered with these compounds to confirm their involvement in OTR activation...These compounds induced significant anti-hyperalgesia without any sex differences, suggesting that the inhibition of IRAP degradation eliminated the variation in oxytocin's effects based on sex. Therefore, we propose these compounds as promising candidates for treating inflammatory hyperalgesia in clinical applications."

Journal • Preclinical • Pain

Oxytocin Receptor Regulates the Hippo/YAP Axis to Drive Hepatocarcinogenesis. (PubMed, Cancer Res) - "ChIP assays showed that YAP bound to the enhancer region of OXTR and facilitated its transcription, creating a positive feedback loop. Together, this study uncovered the interplay between Hippo signaling and the OXTR pathway in hepatocarcinogenesis and established OXTR inhibition with atosiban as a promising strategy for treating HCC."

Journal • Hepatocellular Cancer • Liver Cancer • Oncology • Solid Tumor

Exometabolome of Pantoea targets pathogen associated scytalone dehydratase and XopQ for suppression of foliar blast and bacterial blight in rice. (PubMed, Int J Biol Macromol) - "UPLC-QToF-ESI profiling identified metabolites such as dapdiamide and pantocins, which exhibited strong antimicrobial properties...The combined effects of direct antimicrobial action, suppression of pathogen virulence, and activation of host defenses highlight the potential of Pantoea exometabolomes as a biocontrol strategy. This study underscores their role in sustainable disease management and presents a viable alternative to chemical-based crop protection methods."

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Mechanism of Zuogui Pills in regulating bone metabolism through OXT/OXTR feed-forward loop based on theory of "all marrows dominated by brain" (PubMed, Zhongguo Zhong Yao Za Zhi) - "A PMOP rat model was established using ovariectomy, and 70 Sprague-Dawley female rats were randomly divided into the following groups: sham operation group, model group, estradiol group(17β-estradiol, 0.05 mg·kg~(-1)·d~(-1)), Zuogui Pills low, medium, and high dose groups(0.2, 0.4, 0.8 g·kg~(-1)·d~(-1), respectively), and an antagonist group(atosiban 0.9 mg·kg~(-1)·d~(-1) + 17β-estradiol 0.05 mg·kg~(-1)·d~(-1) + Zuogui Pills 0.4 g·kg~(-1)·d~(-1))...The therapeutic effect of the Zuogui Pills high dose group was partially inhibited when an OXTR antagonist was administered. These findings suggest that Zuogui Pills can regulate the OXT/OXTR feed-forward loop, activate the phosphorylation of the downstream Ras/Raf1/MEK/ERK signaling pathway, and ultimately improve bone mineral density, thereby exerting therapeutic effects in PMOP."

Journal • Oncology • Osteoporosis • Rheumatology • MAP2K1 • TRAP

Oxytocin attenuates demand for cocaine in female rats. (PubMed, Addict Neurosci) - "Results showed that OXT decreased motivation for cocaine; an effect greater during the high-demand phase (diestrus, low progesterone, P4) vs low demand phases (proestrus, high P4)...Finally, using ovariectomized females with P4 replacement, we show that P4's demand attenuating effects are reversed by atosiban (1.0 mg/kg, IP), an OXT antagonist...Additionally, we show critical periods for using OXT as a treatment to reduce cocaine demand in females. Our results indicate novel therapeutic treatments for SUDs must be tailored to hormonal states."

Journal • Preclinical

The effectiveness and safety of continuous and repeated treatment of atosiban in twin pregnancy with threatened preterm labor: A propensity score-matched study. (PubMed, PLoS One) - "This propensity score-matched study suggests that continuous and repeated treatment with atosiban may effectively prolong pregnancy in cases of twin pregnancies with threatened preterm labor. Continuous and repeated treatment with atosiban was associated with lower fetal distress and lower NICU admission but no effect in adverse neonatal outcomes as well as the incidence of chorioamnionitis."

Journal • Retrospective data • Critical care • Gynecology • Obstetrics

The effect of atosiban on pregnancy outcomes in different FET cycles: a single-center matched retrospective cohort study. (PubMed, Front Endocrinol (Lausanne)) - "These results suggested that adding atosiban in the standard FET cycles might not improve the live birth rate. To confirm this conclusion, more thorough, prospective randomized controlled studies of sizable sample sizes with good design are required."

Journal • Retrospective data

Phylloplane Bacterial Exometabolites Suppress Xanthomonas axonopodis pv. punicae: Metabolomic and Genomic Insights for Bacterial Blight Management in Pomegranate. (PubMed, Microb Pathog) - "LC-MS/MS profiling revealed the presence of bioactive metabolites such as Bacillomycin D, Fengycin, and Iturin A in Bacillus spp.; Macrolactin (6.3 μg/mL), Macrolactin W (4.1 μg/mL), and sucrose palmitate (2.8 μg/mL) in Erwinia; and Cyclo(l-Pro-l-Tyr), Tryptophol, Dapdiamide A and B, and Pantocin A and B in Pantoea...Phylogenetic analysis based on 100 conserved protein-coding genes placed P. dispersa Pg-Slp6 in a distinct clade, underscoring its unique genomic identity. These findings establish P. dispersa Pg-Slp6 as a robust candidate for developing phylloplane-adapted microbial formulations aimed at the eco-friendly and effective management of bacterial blight in pomegranate."

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The interplay between oxytocin receptor and YAP in regulating gastric cancer progression. (PubMed, Oncogene) - "The use of the OXTR antagonist Atosiban to inhibit OXTR activity promotes the phosphorylation of LATS1 by ARRB2, which subsequently suppresses YAP phosphorylation. This results in the sequestration of YAP in the cytoplasm, thereby inhibiting the progression of gastric cancer."

Journal • Gastric Cancer • Oncology • Solid Tumor • LATS1

Analysis of the effect of oxytocin analogues on a mouse contextual fear-conditioning behavior (CINP-AsCNP 2025) - "Aims & Objectives: In the present study, we examined whether oxytocin and its analog (carbetocin and atosiban) could reduce fear-conditioning behavior of mice that is often applied in the studies of dental phobia. The results of this study suggest that intranasal administration of carbetocin immediately after electric shock session effectively reduces fear memory formation in mice. Carbetocin selectively activates the Gq protein-related response of the oxytocin receptor, suggesting that selective responses downstream of the oxytocin receptor may contribute to the reduction of the fear conditioning effect. However, further analysis is needed to clarify which neural nuclei and neural circuits carbetocin targets."

Preclinical • FOS