adapalene / Generic mfg. - LARVOL DELTA

Persistent methaemoglobinaemia due to unsupervised use of topical dapsone-adapalene. (PubMed, BMJ Case Rep) - "Discontinuation of the cream resulted in complete and sustained clinical resolution. This case highlights persistent methaemoglobinaemia due to ongoing topical oxidant exposure and underscores the importance of considering inadequate decontamination in refractory cases."

Journal • Alzheimer's Disease • Cognitive Disorders • Dermatology

Multifunctional Biomaterial Strategies to Regulate Inflammation and Promote Kidney Repair. (PubMed, Biomater Res) - "We developed a biofunctional hybrid scaffold (PMEAR/MM/uEV) combining a porous poly(lactic-co-glycolic acid)-porcine extracellular matrix, ricinoleic acid-modified magnesium hydroxide, metanephric mesenchyme-like cells, and ureteric bud-derived extracellular vesicles, with resveratrol and adapalene to confer antioxidant and pro-regenerative properties...mRNA sequencing revealed activation of angiogenesis, extracellular matrix remodeling, oxidative defense, and immune modulation, with Kyoto Encyclopedia of Genes and Genomes enrichment in tumor necrosis factor and interleukin-17 signaling and nuclear factor kappa B-associated pathways. These findings establish PMEAR/MM/uEV as an effective, multimodal platform for kidney regeneration."

Journal • Chronic Kidney Disease • Fibrosis • Immune Modulation • Immunology • Inflammation • Nephrology • Oncology • Renal Disease • IL17A • IL4 • IL6 • PAX2 • TNFA

Divergent System Organ Class Safety Profiles of Isotretinoin Versus Topical Retinoids: An EudraVigilance Disproportionality Analysis. (PubMed, Pharmaceuticals (Basel)) - " Aggregated ADR data for isotretinoin and four topical retinoids (tretinoin, adapalene, tazarotene, trifarotene) were retrieved from the EMA ADRreports portal (April 2025). Isotretinoin presents a distinct safety profile characterized by consistently elevated reporting of psychiatric, gastrointestinal, and musculoskeletal adverse events, independent of age and sex. These results refine the comparative safety landscape of systemic versus topical retinoids and support focused pharmacovigilance monitoring."

Journal • Acne Vulgaris • Cardiovascular • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Mental Retardation • Musculoskeletal Diseases • Oncology • Otorhinolaryngology • Psychiatry • Rheumatology

Auricular Acupressure Combined With Adapalene for the Treatment of Acne Vulgaris (clinicaltrials.gov) - P=N/A | N=64 | Completed | Sponsor: University of Medicine and Pharmacy at Ho Chi Minh City

New trial • Acne Vulgaris • Dermatology

Integrated in vitro - in vivo evaluation of Angelica sinensis essential oil as an anti-acne agent: Mechanistic insights into bioactive compounds and multi-target therapeutic actions. (PubMed, J Ethnopharmacol) - "These findings demonstrate that 5%-10% AEO is a promising topical treatment for acne, offering efficacy with improved safety."

Journal • Preclinical • Acne Vulgaris • Dermatology • Inflammation • IL10 • IL1B • NR3C1 • TLR4

Skin-Derived Precursors-Derived Exosomes Alleviated Acne Inflammation via TLR2/MyD88/NF-κB Signaling Pathway: In Vitro and In Vivo Studies. (PubMed, FASEB J) - "The effect was comparable with topical adapalene gel application. The current study initiated mSKPs-exo research and provided theoretical support and experimental data for their potential application in inflammation regulation, acne treatment, and novel therapeutic targets identification."

Journal • Preclinical • Acne Vulgaris • Dermatitis • Dermatology • Inflammation • CD86 • IL6 • MMP3 • MYD88 • TLR2 • TNFA

Discovery of Essential Genes as Possible Targets for Prostate Cancer Drug Development. (PubMed, Int J Genomics) - "Following that, we considered these possible genes as targets for drugs, performed docking analysis with 255 meta-drug agents, and identified the top 10 candidate drugs (adapalene, ergotamine, imatinib, dutasteride, vistusertib, risperidone, zafirlukast, irinotecan hydrochloride, drospirenone, and telmisartan). This study uniquely combines multidataset transcriptomic integration, HubG prioritization, and MD validation to propose novel biomarker-drug pairings for PCa. The findings offer promising leads for future experimental and clinical validation."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • BIRC5 • CDCA5 • NUSAP1

Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% to Treat Acne Induced by Janus Kinase Inhibitor Treatment: A Case Report. (PubMed, J Clin Aesthet Dermatol) - "A 15-year-old female patient was administered the oral JAKi upadacitinib (15mg daily) for 16 weeks to treat atopic dermatitis that inadequately responded to dupilumab. Treatment guidelines for AV often recommend oral drugs, such as isotretinoin, for moderate-to-severe acne. This case presented here, however, demonstrates that topical CAB gel can treat moderate to severe JAKi-induced inflammatory acne."

Journal • Acne Vulgaris • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

The CML and the ALL inducing isoforms of BCR::ABL1 differ for the induction of genomic instablity (ASH 2025) - "These two isoforms differin the presence of the oncogenic pleckstrin- and DBL-homology domains (DH and PH) in p210BCR::ABL1...It is not yet clear whether GI may be independent of ABL1 kinase activity, a target ofTKI. It has to be confirmed by clinical studies."

Acute Lymphocytic Leukemia • Chronic Myeloid Leukemia • Hematological Malignancies • Leukemia • ABL1 • ETV6 • PBX1 • PLEK

BC01 Isotretinoin plus 420-nm intense pulsed light vs. isotretinoin alone for the treatment of acne vulgaris: a randomized, controlled study of efficacy, safety and patient satisfaction. (PubMed, Br J Dermatol) - "Topical agents for both groups included adapalene 0.1% gel and fusidic acid 2% cream. Other major advantages included lightening basic skin tone and relieving erythema. It achieved clinical improvement within a limited treatment duration, and may have a particularly beneficial effect in patients who expect a rapid remission."

Clinical • Journal • Acne Vulgaris • Dermatology

Identification and validation of microglia-associated genes in ischemic stroke using single-cell and bulk RNA-seq. (PubMed, Mol Brain) - "Interestingly, Tlr2 and Adapalene exhibited a strong binding affinity (- 9.73 kcal/mol). qRT-PCR analysis revealed significantly elevated mRNA expression levels of Cd14, Csf1, and Tlr2 in tMCAO mice compared to sham-operated controls (p < 0.01). This study identified and validated 3 key genes (Cd14, Csf1, and Tlr2) associated with IS, which may serve as novel targets for IS diagnosis and treatment strategies."

Journal • Cardiovascular • CNS Disorders • Infectious Disease • Ischemic stroke • Vascular Neurology • CD14 • CSF1 • TLR2

Impaired retinoic acid signaling mediated Rbm20 downregulation induces aberrant splicing of CaV1.2 calcium channel: Implications in myocardial hypertrophy. (PubMed, J Mol Cell Cardiol) - "Our findings reveal impaired RARβ drives CaV1.2 aberrant splicing by downregulating Rbm20, establishing a feedforward loop of intracellular calcium imbalances and hypertrophic remodeling. Significantly, ADP restores CaV1.2 AS and intracellular calcium homeostasis by activating RARβ in cardiomyocytes, highlighting a novel therapeutic approach for myocardial hypertrophy."

Journal • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertrophic Cardiomyopathy

Assessment of the Efficacy of Topical Ketoconazole 2% Cream in Comparison With Topical Retinoids in the Treatment of Mild Comedonal and Papulopustular Acne (clinicaltrials.gov) - P=N/A | N=52 | Active, not recruiting | Sponsor: Cairo University

New trial • Acne Vulgaris

Dual drug co-encapsulation into liposomes and liposome-derived nanosystems for improved synergistic treatment of skin diseases. (PubMed, Drug Deliv Transl Res) - "Conventional and modified liposomes, niosomes, transfersomes, ethosomes, invasomes, cerosomes, liposomal gels, and niosomal gels were developed, co-encapsulating synthetic and nature-derived substances such as adapalene, amphotericin B, benzoyl peroxide, bicalutamide, bupivacaine, buprenorphine, curcumin, ginger, glycyrrhetinic acid, metformin, methotrexate, microRNA-21, minoxidil, nicotinamide, Nigella sativa seed oil, pentamidine, psoralen, resveratrol, simvastatin, tocopherol acetate, tretinoin, and virgin coconut oil. By co-encapsulating active substances with distinct mechanisms of action, the developed nanosystems provide synergistic therapeutic effects, leading to reduced toxicity and enhanced bioavailability, potentially resulting in improved clinical outcomes, and presenting a promising alternative to conventional treatments. Through addressing clinical and regulatory framework aspects, these innovative therapies might one day transition from bench to market to..."

Journal • Review • Acne Vulgaris • Alopecia • Dermatology • Immunology • Infectious Disease • Psoriasis • Vitiligo • MIR21

Eco-friendly, stability-indicating micellar HPLC-UV method for simultaneous determination of clindamycin phosphate and adapalene in gel formulations. (PubMed, BMC Chem) - "The greenness of the method was further confirmed through assessment with the Green Analytical Procedure Index (GAPI). The method was also validated as a stability-indicating assay for clindamycin phosphate and adapalene under various stress conditions, demonstrating its robustness and applicability for routine quality control."

Journal

Antifungal Monotherapy in Acne: Topical Ketoconazole 2% Cream Versus Adapalene Gel in Treating Acne Vulgaris: A Comparative Study. (PubMed, J Cutan Med Surg) - "Topical ketoconazole 2% can provide very promising results as monotherapy in acne comparable to topical retinoid."

Journal • Monotherapy • Acne Vulgaris • Dermatology

Identification of potent high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using deep docking. (PubMed, Mol Syst Biol) - "The two most potent compounds showed potency better than adapalene, a previously reported potent inhibitor of Aβ aggregation. Consistent with the intended mechanism of action, these two compounds also proved to be high-affinity binders of Aβ fibrils with an equilibrium dissociation constant in the low nanomolar range in surface plasmon resonance experiments. These results provide evidence that structure-based docking methods based on deep learning represent a cost-effective and rapid strategy to identify potent hits for drug development targeting protein misfolding diseases."

Journal • Alzheimer's Disease • CNS Disorders • Proteinopathy • Aβ42

The Dark Side of Oral Antibiotics: Adverse Events of Consideration in Dermatology. (PubMed, J Drugs Dermatol) - "To mitigate these risks, dermatologists should prioritize narrow-spectrum antibiotics and incorporate combination topical therapies containing benzoyl peroxide (BPO), such as the triple-combination of clindamycin, adapalene, and BPO, to help curb antibiotic resistance. Prudent antibiotic use, combined with topical regimens utilizing BPO, optimizes treatment outcomes while minimizing systemic adverse effects and resistance. Ongoing education and research are essential to refine prescribing practices that balance therapeutic benefits with long-term patient and public health."

Adverse events • Journal • Review • Acne Vulgaris • Dermatology • Hidradenitis Suppurativa • Immunology • Infectious Disease • Oncology

Virtual screening of drugs against multiple targets of Alzheimer's disease. (PubMed, J Alzheimers Dis) - "BackgroundDrug repurposing offers a rapid, cost-effective approach for discovering therapies against multiple targets.ObjectiveHere, we screen virtual ligand libraries consisting of 3468 approved drugs against 11 protein targets associated with Alzheimer's disease (AD).MethodsWe employ blind molecular docking, and target amyloid-β (Aβ), microtubule-associated protein tau (MAPT), Apolipoprotein E4 (APOE4), acetylcholinesterase (AChE), butyrylcholinesterase (BChE), amyloid-β protein precursor (AβPP), β-secretase (BACE1), brain-derived neurotrophic factor (BDNF), presenilin 1 (PSEN1) and 2 (PSEN2), and α-synuclein (SNCA) proteins using AutoDock Vina.ResultsNotably, multitarget binding recurs among the top-10 ligands with Ergotamine and Dihydroergotamine potentially binding 8; Dutasteride 7; Drospirenone and Nilotinib 6; Adapalene and Conivaptan 5; Bromocriptine 4; and Rolapitant, Irinotecan, Plerixafor, Saquinavir, and Telmisartan 3, out of 11 protein targets. Likewise,..."

Journal • Alzheimer's Disease • Cardiovascular • CNS Disorders • Hypertension • Inflammation • Pain • APOE • BDNF • MAPT • SNCA

A Novel Cationic Niosome Formulation for Topical Delivery of Adapalene. (PubMed, Biomed Res Int) - "The in vitro release profile showed that 73 ± 2.1% of Ada was released from the niosomal hydrogel within 24 h. Results from the cell viability and Draize tests indicated that the Ada-Nio hydrogel can be considered a safe and effective dermal agent for acne treatment. Niosomal hydrogel formulations appear to be safe, effective, and promising nanocarriers for the dermal delivery of Ada."

Journal • Acne Vulgaris

Adapalene as an Anticancer Agent: A Systematic Review and Meta-Analysis of In Vitro and In Vivo Studies. (PubMed, Eur J Pharmacol) - "In conclusion, Adapalene shows potential as a promising drug repurposing candidate with anti-cancer activity. However, the heterogeneity and publication bias in the included studies highlight the need for further research."

Journal • Preclinical • Retrospective data • Review • Acne Vulgaris • Eye Cancer • Oncology • Retinal Disorders • Solid Tumor

13-cis-retinoic acid modulates porcine ovarian granulosa cell differentiation via retinoic acid signaling-FoxA1 axis: Implications for ovarian follicular development and luteinization. (PubMed, Theriogenology) - "13cRA promoted RARβ/RXRβ receptor heterodimer formation, with pharmacological activation (Adapalene) potentiating LHR and PGR expression and receptor knockdown diminishing their expression...13cRA-mediated FoxA1 expression suppression occurred through CRABP2-dependent nuclear shuttling and RARβ/RXRβ receptor heterodimer activating, with combinatorial modulation of CRABP1/CYP26 system components (CYP26A1 and CYP26B1) significantly altering FoxA1 regulatory dynamics. Finally, we conclude that 13cRA can inhibit FoxA1 expression through RA signaling molecules (CRABP2, RARβ/RXRβ heterodimer, CRABP1, CYP26A1 and CYP26B1) and thus promote the differentiation of porcine ovarian granulosa cells."

Journal • Preclinical • Oncology • CRABP2 • CYP26A1 • FOXA1 • PGR

Clascoterone Stability When Combined with Topical Acne Medications In Vitro. (PubMed, Dermatol Ther (Heidelb)) - "Clascoterone demonstrated consistent and reproducible stability in the presence of other topical acne medications."

Journal • Preclinical • Acne Vulgaris • Dermatology

A Comprehensive Review of Azelaic Acid Pharmacological Properties, Clinical Applications, and Innovative Topical Formulations. (PubMed, Pharmaceuticals (Basel)) - "For acne vulgaris, reductions in inflammatory and noninflammatory lesions were comparable to those of topical retinoids/adapalene, and tolerability was superior in some studies...In melasma and other dyschromias, 20% cream demonstrated efficacy similar to hydroquinone, exhibiting a favorable safety profile...AzA remains a versatile and well-tolerated dermatologic agent whose performance is strongly vehicle-dependent. Rational selection and engineering of carriers, particularly DES-integrated polymeric and lipid systems, can mitigate solubility and permeability limitations, enhance skin targeting, and reduce irritation in the treatment of acne and rosacea."

Journal • Review • Acne Vulgaris • Dermatology • Dermatopathology • Rosacea

A Mechanistic Physiologically Based Pharmacokinetic/Pharmacodynamic Modeling Approach Informed by In Vitro and Clinical Studies for Topical Administration of Adapalene Gels. (PubMed, Pharmaceutics) - "Clinical evaluation revealed formulation-dependent differences in adapalene's effects on measured skin parameters, with distinct pharmacodynamic profiles observed for each gel formulation. The overall study gave us a detailed insight into potential effects of formulation on the dermal pharmacokinetics and pharmacodynamics of adapalene using three marketed gels."

Journal • PK/PD data • Preclinical • Acne Vulgaris • Dermatology