adapalene / Generic mfg. - LARVOL DELTA

Granulomatous Reaction in Unilateral Favre–Racouchot Syndrome: A Diagnostic Pitfall (EADV 2026) - "Topical adapalene was initiated, leading to marked clinical improvement, supporting the diagnosis of unilateral Favre–Racouchot syndrome with granulomatous reaction...Unilateral FRS with granulomatous inflammation is exceptionally rare. This case underscores the primacy of chronic actinic damage in FRS pathogenesis, even in the absence of smoking, and highlights the importance of recognizing atypical histological presentations to avoid misdiagnosis."

Cataract • Dermatology • Infectious Disease • Inflammation • Inflammatory Arthritis • Lupus • Ophthalmology • Respiratory Diseases • Rosacea • Sarcoidosis • Tuberculosis

Clinical Features and Treatment of Acanthosis Nigricans: A Systematic Review (EADV 2026) - "Topical retinoids (tretinoin 0.025-0.05%, adapalene 0.1%; 11 studies, n=234) demonstrated an overall response rate of 90.5% (complete 56.7%, partial 33.8%)...Oral insulin sensitizers including metformin and alpha-lipoic acid combination therapy (1 study, n=41) produced significant improvements in AN severity scores in both arms (p<0.001), though patient-level responses were not extractable...These findings are limited by heterogeneity in study design and outcome reporting. Standardized outcome measures and larger controlled trials are needed to establish evidence-based guidelines for AN management."

Clinical • Review • Aesthetic Medicine • Genetic Disorders • Obesity

Title: Therapeutic Outcomes in Adolescents with Acne Vulgaris: A Retrospective Analysis of Topical and Combined Treatment Approaches in 2025 (EADV 2026) - "Topical therapy consisted of 20% azelaic acid applied once daily in the morning and adapalene 0.1 gel applied in the evening (three times weekly in females and four times weekly in males). Topical therapy alone demonstrated significantly higher efficacy in female patients compared to males, whereas combined therapy with oral isotretinoin yielded high and comparable response rates in both sexes. These findings highlight the benefit of combined therapy in achieving optimal clinical outcomes, particularly in patients with reduced response to topical treatment alone."

Retrospective data • Acne Vulgaris • Dermatology • Inflammation • AR

New Therapeutic Approach with Cold Atmospheric Plasma in the Treatment of Acne Papulopustulosa (EADV 2026) - "Both groups self-applied 0.1% of adapalene cream daily and received weekly skin-cleansing by a physician combined with either CAP verum-device treatments or placebo-device applications instead...Source: Bae et al., Dermatologic Therapy, 2025. Conclusions Conclusively, CAP proved to be an efficient and well-tolerable add-on therapy for the treatment of mild acne papulopustulosa."

Acne Vulgaris • Inflammation

Effectiveness , safety and tolerability of Ozenoxacin 2% lotion vs Clindamycin 1% lotion in mild to moderate truncal acne : An open label randomized controlled clinical trial (EADV 2026) - "Both groups received adapalene 0.1% gel once daily at bedtime. Both treatments were well tolerated, with only mild and transient adverse effects reported. Summary of the progress of total lesion count, inflammatory lesion count and non inflammatory lesion count, Cardiff Acne Disability Index, Investigator Global Assessment and DLQI scores for the two groups Conclusions Ozenoxacin 2% lotion is as effective and well tolerated as clindamycin 1% lotion in mild to moderate truncal acne and may serve as a suitable alternative topical antibiotic in routine clinical practice."

Clinical • Acne Vulgaris

Real-world experience with topical clascoterone (Winlevi) for acne vulgaris in the United Kingdom: aretrospective case series (EADV 2026) - "Clascoterone was used as part of combination regimens in all cases, most commonly with topical retinoids (trifarotene/adapalene, n=27), spironolactone (n=8), oral antibiotics (n=6) and deramtologist-recommended skincare regimen (n=12). At most recent follow-up, 10 patients (33%) achieved disease control, 4 (13%) demonstrated improvement without full control, and 13 (43%) required treatment escalation — 10 to isotretinoin and 3 to spironolactone...The inclusion of patients across Fitzpatrick phototypes I–V, including those with PIH, reflects the diversity of UK acne populations. Further prospective studies with standardised outcome measures and longer follow-up are warranted."

Real-world • Real-world evidence • Retrospective data • Acne Vulgaris • Dermatology

Changes in sebaceous gland activity during isotretinoin therapy in patients with acne vulgaris (EADV 2026) - "Conclusions In this small cohort, systemic isotretinoin combined with topical adapalene was associated with reduced sebaceous gland activity and improvement in acne severity over 2 months. Sebum analysis may serve as an objective adjunctive tool for monitoring treatment response during retinoid therapy in acne vulgaris."

Clinical • Acne Vulgaris • CNS Disorders • Dermatology

Efficacy and tolerability of a new repairing moisturizing dermocosmetic cream, containing Glycerine and Glycyrrhetinic acid in adult and adolescent subjects with facial acne treated by oral or topical acne treatment (EADV 2026) - "Materials and Methods 44 female and male subjects, aged from 12 to 30 years (68% adults, 32% adolescents), with facial acne vulgaris treated by oral isotretinoin (39% of subjects) or by a topical treatment (benzoyl peroxide (BPO) 5% or 10%, adapalene, tretinoin; 61% of subjects) and presenting physical signs (erythema, dryness, desquamation) and functional signs (itching, tightness), of mild intensity at least, were enrolled in a 4 week clinical study. After 4 weeks of use, they assessed a positive effect of the study product, in alleviating side effects of the acne treatment allowing a better treatment adherence. Conclusions Efficacy and tolerability results, as well as the good cosmetic acceptability, of this new repairing moisturizing dermocosmetic cream containing Glycerine and Glycyrrhetinic acid have demonstrated its interest as a supportive care in adult and adolescent patients, with facial acne, treated by oral or topical acne treatment."

Clinical • Acne Vulgaris • Pruritus

A systematic review assessing the use of topical benzoyl peroxide in dermatology (EADV 2026) - "Adapalene-BPO combination showed superior outcomes to monotherapy (P<0.001) among 2453 patients, though with increased irritation...In rosacea, BPO-clindamycin reduced papules and pustules up to 71%...Conclusions BPO remains an effective, well-tolerated topical agent with predominantly mild and self-limiting AEs. Further well-designed RCTs using validated, standardised outcome measures are required to better define its efficacy, tolerability and comparative effectiveness across other dermatological conditions."

Review • Acne Vulgaris • Dermatitis • Dermatology • Immunology • Rosacea

Clinical Improvement of Pediatric Epidermodysplasia Verruciformis Following Topical Adapalene and Adjunctive Homeopathic Therapy (EADV 2026) - "To our knowledge, reports describing this combined therapeutic approach in pediatric epidermodysplasia verruciformis are exceedingly rare. Further studies are required to clarify the potential role of adjunctive therapies in the management of EV."

Clinical • Pediatrics • Skin Cancer

Radiofrequency Treatment Versus Topical Therapy for Facial Acne Vulgaris (clinicaltrials.gov) - P=N/A | N=60 | Recruiting | Sponsor: Jeisys Medical Inc

New trial • Acne Vulgaris • Dermatology

Synthesis of Pyridin-2(1H)-ones and Isoquinolin-1(2H)-ones Using Calcium Carbide as an Acetylene Source under Redox-Neutral Conditions. (PubMed, Org Lett) - "On the basis of this method, a number of pyridin-2(1H)-one and isoquinolin-1(2H)-one derivatives, including some hybrid products containing the essential skeleton of probenecid, ataluren, or adapalene, were obtained. In general, this protocol features simple and economical substrates, a safe and convenient acetylene source, the absence of an external oxidant, good compatibility with labile functional groups, excellent step and atom economy, and ready scalability. Moreover, some products possess strong anticancer activities."

Journal • Hepatitis C • Infectious Disease • Oncology

Effectiveness, safety and tolerability of Ozenoxacin 2% lotion vs Clindamycin 1% lotion in mild to moderate truncal acne: An open label randomized controlled clinical trial. (PubMed, Clin Exp Dermatol) - "Ozenoxacin demonstrated comparable efficacy and tolerability to clindamycin when used in combination with adapalene, in truncal acne."

Clinical • Journal • Acne Vulgaris • Dermatology

Old molecule, new scrutiny: Benzoyl peroxide in dermatology. (PubMed, Clin Exp Dermatol) - "BPO has a favourable safety profile with predominantly mild, localised AEs. Further randomised controlled trials using validated outcome measures are required to establish efficacy in other dermatological conditions."

Journal • Acne Vulgaris • Dermatitis • Dermatology • Immunology • Oncology • Rosacea

Patient Expectations, Safety Concerns, and Adherence to Topical Acne Medications: Findings from a Web-Based Survey. (PubMed, Patient Prefer Adherence) - "Topical medications were commonly used, most frequently adapalene (40.92%), tretinoin (32.93%), benzoyl peroxide (24.75%), and clindamycin (20.96%). Young patients demonstrated limited comprehension of AV and lacked knowledge of topical medications and their appropriate application, as well as unrealistic expectations regarding onset time. Enhanced education on the nature of AV, along with detailed instructions on topical medication use, is crucial for improving patients' disease awareness and treatment adherence."

Journal • Acne Vulgaris • Cognitive Disorders • Dermatology

Adapalene inhibits the activity of CD44, a cancer stem cell biomarker in Triple negative breast cancer. (PubMed, Mol Biol Rep) - "Overall, this study highlights how CD44 overexpression accelerates the growth of breast cancer and transforms drug-resistant cells into stem cells, and that targeting CD44 with Adapalene may significantly enhance therapy results and defer the onset of drug resistance in breast cancer patients."

Biomarker • Journal • Acne Vulgaris • Breast Cancer • Oncology • Solid Tumor • Triple Negative Breast Cancer • CD44

Partition-controlled drug release from polymeric nanocapsules: A physically consistent framework with formulation-specific corrections. (PubMed, Eur J Pharm Biopharm) - "The model is further evaluated using four release datasets (adapalene in two oily cores, capsaicin, and dihydrocapsaicin), yielding R2 values between 0.925 and 0.969 with Cmax fixed at the final experimental value. These results support partition-controlled release as a physically plausible and dimensionally consistent framework for describing drug release from polymeric nanocapsules."

Journal

Clinician Awareness of Dermatology Drug Costs (BAD 2026) - "Between April and June 2025, an audit identified the most frequently prescribed dermatological medications in one UK region: lymecycline, mometasone furoate 0.1% w/w cream, adapalene 1 mg (0.1% w/w) and benzoyl peroxide (2.5% w/w) gel, prednisolone, isotretinoin, acitretin, methotrexate and trimethoprim. Enhancing prescriber cost literacy and embedding cost information into electronic prescribing may support valuebased decision making and NHS financial sustainability. Integrating cost-awareness training into dermatology curricula represents a feasible strategy to address this need."

Clinical • Drug cost • HEOR • Dermatology

A case of Trichodysplasia Spinulosa: a rare cutaneous eruption in immunosuppressed patients (BAD 2026) - "The lesions began 1 year after transplantation and were asymptomatic, but worsened following a change in immunosuppression from mycophenolate mofetil (discontinued after 11 months due to leucopenia and gastrointestinal intolerance) to azathioprine, which had been continued for the last year...Treatment with oral valganciclovir 450 mg twice daily, keratolytic emollients and adapalene was initiated...No standardized Abstracts i187 treatment exists; reported therapies include topical cidofovir 3%, oral valganciclovir and reduced immunosuppression. Awareness of TS is essential for early diagnosis and management in immunosuppressed patients."

Clinical • Alopecia • Dermatitis • Immunology • Leukopenia • Nephrology • Rare Diseases • Solid Organ Transplantation • TCHH

Comparison of Topical Clascoterone and Adapalene for Mild Acne Vulgaris (clinicaltrials.gov) - P1 | N=60 | Not yet recruiting | Sponsor: Khyber Teaching Hospital

New P1 trial • Acne Vulgaris • Dermatology

Trichodysplasia Spinulosa in a Japanese Pediatric Patient. (PubMed, J Dermatol) - No abstract available

Journal • Pediatrics • Transplantation

Efficacy and Safety of Clascoterone Cream 1% and Adapalene Gel 0.3% in Patients With Acne. (PubMed, J Drugs Dermatol) - P4 | "This open-label pilot study shows promising results for combination treatment with clascoterone cream 1% and adapalene gel 0.3% for the treatment of patients with acne. &nbsp."

Journal • Acne Vulgaris • Dermatology

Allergic Contact Dermatitis to Adapalene: A Rare Adverse Effect. (PubMed, Contact Dermatitis) - No abstract available

Adverse events • Journal • Acne Vulgaris • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Pediatric Genital Endemic Kaposi Sarcoma with Partial Response to Adapalene. (PubMed, Am J Trop Med Hyg) - "Treatment with topical adapalene resulted in rapid resolution of smaller cutaneous lesions. This case highlights diagnostic challenges in resource-limited settings and supports the potential role of topical retinoids as a low-cost palliative therapy for cutaneous KS."

Journal • Epstein-Barr Virus Infections • Hepatology • Kaposi Sarcoma • Oncology • Palliative care • Pediatrics • Sarcoma • Solid Tumor

Efficacy and Tolerability of a Triple Acid-Containing Serum Combined With 0.1% Adapalene in Mild-to-Moderate Acne Vulgaris: A Randomized, Open-Label Controlled Trial. (PubMed, J Cosmet Dermatol) - "TAS in combination with AG was shown to improve mild-to-moderate acne with good tolerability and may effectively reduce the recurrence rate when applied as a maintenance treatment post-AG."

Clinical • Journal • Acne Vulgaris • Dermatology