Granulostim (filgrastim biosimilar) / UCB - LARVOL DELTA

Pediatric Mixed Phenotype Acute Leukemia With Lineage Evolution: A Case Series (ASPHO 2026) - "A second complete remission was achieved with Decitabine/Vorinostat/Fludarabine, Cytarabine, and Filgrastim regimen prior to HSCT... This series documents a rare case of B/T MPAL with initial good response to ALL-type therapy but subsequent evolution to trilineage B/T/myeloid disease at relapse. However, HSCT outcomes highlight both curative potential and substantial transplant-related mortality. This emphasizes the heterogeneity of pediatric MPAL, the potential for lineage evolution at relapse, and the impact of transplant related toxicity on overall outcomes."

Clinical • Acute Graft versus Host Disease • Acute Lymphocytic Leukemia • Bone Marrow Transplantation • CNS Disorders • Graft versus Host Disease • Hematological Malignancies • Hepatology • Immunology • Infectious Disease • Leukemia • Pediatrics

[VIRTUAL] EARLY DETECTION AND STEM CELL TRANSPLANTATION OF A RARE IMMUNODEFICIENCY (ASPHO 2021) - "Flow cytometry was remarkable for decreased CD3+ T cells (305 cells/microL), CD19+ B cells (398 cells/microL), and naïve CD45RA+ T cells (18%, normal 64 -95%), and severe neutropenia (0.3x109cells/L) refractory to filgrastim...At age 3 months, the patient underwent 5/6-matched UCB SCT with alemtuzumab, fludarabine, and melphalan conditioning. SCT was complicated by sinusoidal obstructive syndrome, treated with defibrotide, and grade 2 acute graft-versus-host disease of her skin, steroid-responsive... Phenotypic variability in patients with PMG3 deficiency can include isolated neutropenia and immunodeficiency. TREC screening allows prompt identification of newborns with rare immunodeficiencies associated with T cell lymphopenia. Reduced-intensity UCB SCT can achieve an excellent outcome in PGM3 deficiency, with resolution of neutropenia and improvement in immune status."

IO biomarker • Aplastic Anemia • Dermatology • Genetic Disorders • Graft versus Host Disease • Hematological Disorders • Immunology • Infectious Disease • Neutropenia • Primary Immunodeficiency • Transplantation • CD19