I-Drop / IMED AB - LARVOL DELTA

Effect of Lactobacillus reuteri NCIMB 30351 drops on symptoms of infantile functional gastrointestinal disorders and gut microbiota in early infants: Results from a randomized, placebo-controlled clinical trial. (PubMed, Eur J Pediatr) - P=N/A | "What is New: • The uptake of L. reuteri NCIMB 30351 leads to a significant reduction in the number of regurgitations, feeding-induced constipations, and diarrhea as well as mean daily numbers of crying and crying duration in infants during the first months of life. • L. reuteri positively influences the proportions of prevalent species, while it negatively affects both conditionally pathogenic and commensal microbes in gut microbiota."

Clinical • Journal • Constipation • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Mood Disorders • Psychiatry

Second life of water and wastewater in the context of circular economy - Do the membrane bioreactor technology and storage reservoirs make the recycled water safe for further use? (PubMed, Sci Total Environ) - "Although the MBR/UV light wastewater treatment substantially reduced the numbers of E. coli and E. faecalis (from e.g. 32,000 CFU/100 ml to 20 CFU/100 ml and 15,000 CFU/100 ml to nearly 0 CFU/ml), bacteria resistant to ampicillin, aztreonam, cefepime, ceftazidime, ertapenem and tigecycline, as well as ESBL-positive and multidrug resistant E. coli were highly prevalent in MBR-treated wastewater (88.9 %, 55.6 %, 33.3 %, 22.2 % and 11.1 % and 44.4 and 55.6 %, respectively). Retaining water in storage reservoirs nearly eliminated bacterial contaminants (e.g. E. coli dropped from 350 CFU/100 ml to 10 CFU/100 ml), antibiotic resistant bacteria, resistance genes (none detected in the storage reservoir) and antibiotics (only enrofloxacin detected once in the concentration of 3.20 ng/l). Findings of this study point to the limitations of solely culture-based assessment of reclaimed water and wastewater while they may prove useful in risk management and prevention in wastewater..."

Journal

Opuntioideae cactus stem Bioimaging analysis: Bridging taxonomy and antimicrobial research. (PubMed, Microsc Res Tech) - "Investigating the antimicrobial potential of compounds found within Opuntioideae cactus stems. Correlations between the unique structural features observed through SEM and the antimicrobial activity of Opuntioideae cactus stem extracts."

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Adalimumab and Etanercept Serum Levels in Rheumatoid Arthritis Patients with and Without a Disease Flare During Tapering (ACR Convergence 2023) - "Eligible patients were randomized into gradual tapering csDMARD (mainly methotrexate) followed by the TNFi (ETN or ADL), or vice versa. For both ADL and ETN, the critical serum level below which flares occur seems to be 1 ug/ml. TDM might prevent disease flares during tapering by allowing personalized TNFi dosing targeting levels above this critical threshold. In line with the longer half-live ADL remains longer in the blood circulation after stopping compared to ETN."

Clinical • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Reinforcement of Different Sands by Low-pH Bio-Mineralization. (PubMed, Materials (Basel)) - "(3) Low pH temporarily suppresses urease activity, delaying calcium carbonate flocculation and enhancing reinforcement uniformity. To achieve optimal reinforcement effects, adjusting the actual optimal pH values of bacterial solution based on sand properties is essential in engineering applications."

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Higher power achieves greater local impedance drop, shorter ablation time, and more transmural lesion formation in comparison to lower power in local impedance guided radiofrequency ablation of atrial fibrillation. (PubMed, J Cardiovasc Electrophysiol) - "In LI-guided ablation, the HP could achieve a larger LI drop and shorter time to minimum LI, which may result in more transmural lesion formation compared to a LP setting."

Journal • Atrial Fibrillation • Cardiovascular

Insight into contact force local impedance technology for predicting effective pulmonary vein isolation. (PubMed, Front Cardiovasc Med) - P=N/A | "The combination of good CF and adequate LI drop allows a significant reduction in RF DT. http://clinicaltrials.gov/, identifier: NCT03793998."

Journal • Atrial Fibrillation • Cardiovascular

Microbiological Characterization of Protected Designation of Origin Serra da Estrela Cheese. (PubMed, Foods) - "A correspondence analysis showed that L. paracasei, L. lactis, E. durans, E. faecium and L. mesenteroides are transversal in Serra da Estrela cheese manufacturing and were closely associated with milk, curd and cheese matrices. Additionally, L. casei, L. plantarum and L. curvatus were specifically associated with cheese matrices, possibly active during ripening and contributing for the development of these cheeses' organoleptic characteristics."

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Comparison of Nutrition Indices for Prognostic Utility in Patients with Sepsis: A Real-World Observational Study. (PubMed, Diagnostics (Basel)) - "In sepsis management, GNRI and PNI values may potentially be helpful in identifying patients with a high risk of death."

Journal • Observational data • Real-world • Real-world evidence • Critical care • Infectious Disease • Septic Shock

Combining contact force and local impedance to treat idiopathic premature ventricular contractions from the outflow tracts: impact of ablation strategy on outcomes. (PubMed, J Interv Card Electrophysiol) - P=N/A | "The use of ablation catheters that combine CF and LI information is associated with increased success in the RF ablation of PVCs from the OTs. LI drop is the most important predictor of effective lesions, but its behavior depends on the ablation site: in the coronary cusps, unlike the RVOT/LVOT region, longer RF application times are needed in order to achieve LI drops associated with successful outcomes. REGISTRY AND REGISTRATION NO."

Journal

"You claimed the airdrop?? @idafuwajr2 @StarDHD @NtuthukoNxumal6 @heyu0630 @ilhanakbas @boback @Diqiubenqiux @mstf_mutlu @bubba_dubbs824 @RudyKadoch @suleymanccelik" (@xiscamorro)

The mechanisms of arterial signal intensity profile in non-contrast coronary MRA (NC-MRCA): a 3D printed phantom investigation and clinical translations. (PubMed, Int J Cardiovasc Imaging) - P=N/A | "The SI drop did not reflect the actual stenosis position and not suitable for the stenosis localization. The R2 cutoff represents an alternative method to detect stenoses on NC-MRCA at vessel level.Trial registration: ClinicalTrials.gov; NCT03768999, registered on December 7, 2018."

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Combined contact force and local impedance dynamics during repeat atrial fibrillation catheter ablation. (PubMed, Front Physiol) - "Combined CF and baseline LI predicted ∆LI > 20 Ω (area under the receiver operating characteristic curve (AUC) 0.75) better compared to baseline LI (AUC 0.72), mean CF (AUC 0.60), force-time integral (AUC 0.59) and local bipolar voltage (0.55). Combination of CF and LI may aid monitoring real-time catheter-tissue electro-mechanical coupling and lesion formation within heterogenous atrial arrhythmia substrate in patients with repeat AF or atrial tachycardia ablation."

Journal • Atrial Fibrillation • Cardiovascular • CNS Disorders

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Role of catheter location on local impedance measurements and clinical outcome with the new direct sense technology in cardiac ablation procedures. (PubMed, Int J Cardiol Heart Vasc) - "We provide detailed information on LI measures in electrophysiological procedures with significant differences within the cardiac chambers highlighting that RFA-related LI drop can serve as a promising surrogate for real-time assessment of lesion generation. Guiding the electrophysiologist in RFA procedures, this additional information promises to improve safety profile and success rates in the interventional treatment of arrhythmias."

Clinical data • Journal • Atrial Fibrillation • Cardiovascular • Ventricular Tachycardia

Nature-based coagulants for drinking water treatment: An ecotoxicological overview. (PubMed, Water Environ Res) - "Lower pH and A. subulate and S. anteuphorbium were the most efficient coagulants Toxicity effects were plant extracts-based and dose function. A. subulate and S. anteuphorbium were the least toxic extracts."

Journal

Qishen Yiqi dropping pills improve isoproterenol-induced cardiomyocyte hypertrophy by regulating X-inactive specific transcript (XIST) expression in rats. (PubMed, J Thorac Dis) - "Finally, this study confirmed that QYDP treatment improved the ISO-induced decrease in proliferation, apoptosis, and promotion of oxidative stress and inflammatory response in cardiomyocytes, whereas ov of XIST partially negated the effect of QYDPs. QYDPs protected H9c2 cells from ISO-induced damage by downregulating XIST expression."

Journal • Preclinical • Cardiovascular • Congestive Heart Failure • Heart Failure • Immunology • Inflammation • Oncology • IL6 • TNFA • XIST

Predictors of phosphodiesterase type 5 Inhibitors (PDE5I)-discontinuation – Is a previous PDE5I-exposure at first clinical evaluation related with a higher PDE5I-drop-out risk? (EAU 2022) - "Those patients having been previously exposed to PDE5Is before first specialist evaluation present with different features vs. the PDE5I-naïve , and they may be more prone to drug discontinuation regardless of their clinical response to PDE5Is. More efforts should be put in tailoring patients’ therapeutic work-up and in identifying an optimal management strategy to deal with a higher drop-out risk."

Clinical • Erectile Dysfunction • Sexual Disorders

Qishen Yiqi Dropping Pill facilitates post-stroke recovery of motion and memory loss by modulating ICAM-1-mediated neuroinflammation. (PubMed, Biomed Pharmacother) - "QSYQ effectively accelerates the recovery of motor impairment and memory loss in rats after stroke via downregulation of ICAM-1-mediated neuroinflammation, and rosmarinic acid is one of its main active components."

Journal • Cardiovascular • Immunology • Inflammation • Ischemic stroke • Reperfusion Injury • ICAM1 • IL1B • IL6 • TNFA

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Enhancing Night and Day Circadian Contrast through Sleep Education in Prediabetes and Type 2 Diabetes Mellitus: A Randomized Controlled Trial. (PubMed, Biology (Basel)) - "The proposed intervention is effective for improving sleep quality, length and efficiency, and for decreasing fasting glucose and HbA1c levels in only 3 months. These findings support the importance of sleep and circadian rhythm education focused on improving IFG and T2DM."

Journal • Diabetes • Metabolic Disorders • Type 2 Diabetes Mellitus

Optimized radiofrequency lesions through local impedance guidance for effective CTI ablation in right atrial flutter. (PubMed, Pacing Clin Electrophysiol) - P | "A LI-guided approach to CTI ablation was safe and effective in treating RAFL. The magnitude of LI drop was associated with effective lesion formation and BDB and could be used as a marker of ablation efficacy."

Journal • Atrial Fibrillation • Cardiovascular • Ventricular Tachycardia

A Profiling Compendium of Ferroptotic Inhibitors Map Key Pathways That Regulate Trophoblast Ferroptosis. (SRI 2022) - "Our study provides novel insights into the cellular mechanisms that may regulate trophoblast ferroptosis. Our approach suggests potential candidates for drug repurposing, aimed at inhibiting ferroptotic injury in human pregnancy."

The correlation between local impedance drop and catheter contact in clinical pulmonary vein isolation use. (PubMed, Pacing Clin Electrophysiol) - "vs. 19.6 ± 6.4 ?, P<0.001) In clinical PVI use, both CF and CA were correlated with LI drop. More parallel CA could induce higher LI drop, which may lead to effective lesion formation."

Journal • Atrial Fibrillation • Cardiovascular