MRT-50969
/ Monte Rosa Therap
- LARVOL DELTA
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October 23, 2024
Monte Rosa Therapeutics Presents Preclinical Data at the 36th EORTC-NCI-AACR Symposium on the Potential of its Cyclin E1-directed Molecular Glue Degraders for the Treatment of CCNE1-Amplified Solid Tumors
(GlobeNewswire)
- "MRT-50969 selectively inhibited proliferation and induced G1-S cell cycle arrest and senescence in CCNE1-amplified cancer cell lines, while sparing cell lines without amplification. When dosed orally as a single agent in preclinical models of CCNE1-amplified breast cancer and gastric cancer, the cyclin E1-directed MGD MRT-50969 induced robust tumor growth suppression and regression."
Preclinical • Solid Tumor
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