Geninax (garenoxacin) / BMS, Fujifilm Holdings - LARVOL DELTA

A Case of Legionella Pneumonia Suspected as Typical Pneumonia After Lung Cancer Surgery, Diagnosed by a Repeat Urinary Legionella Antigen Test. (PubMed, Cureus) - "Outpatient urinary antigen tests for pneumococcus and Legionella were negative, and oral garenoxacin was initiated...Broad-spectrum β-lactams (sulbactam/ampicillin, followed by piperacillin/tazobactam) were ineffective...Subsequent targeted therapy with azithromycin (days 6-8 and 13-15), alongside levofloxacin, resulted in clinical improvement...This case report highlights that a single negative urinary antigen test does not rule out Legionella infection. We accordingly recommend early repeat antigen testing, ideally within one week, for postoperative pneumonia unresponsive to β-lactams, together with prompt macrolide or fluoroquinolone therapy."

Journal • Acute Kidney Injury • Cardiovascular • Diabetes • Infectious Disease • Inflammation • Lung Cancer • Metabolic Disorders • Nephrology • Oncology • Pneumococcal Infections • Pneumonia • Renal Disease • Respiratory Diseases • Solid Tumor

Women's preferences for how health practitioners respond to coercive control by a partner: Open-ended survey qualitative analysis. (PubMed, Aust J Gen Pract) - "An open-ended question in an online survey asked women who had experienced coercive control: 'What words could your health practitioner say that you would find helpful and supportive?'. Responses (n = 682) were analysed using directed content analysis. Findings align with two global frameworks: LIVES (Listen-Inquire-Validate-Enhance safety-Support) and CARE (Choice and control-Action and advocacy-Recognition and understanding-Emotional connection). Specific script health messaging is provided for healthcare practitioners to use in conversations with victim-survivors of intimate partner violence, including to counter coercively controlling tactics by abusive partners. Findings re-inforce the need for health practitioners to provide a sensitive first-line response, with tailored messaging to counteract affects of coercive control. Training and system support are needed to build health practitioner capacity to identify and respond to coercive control in the..."

Journal • Women's Health

Instructive Interaction between Myelodysplastic Hematopoiesis and the Bone Marrow Microenvironment at Single Cell Level (ASH 2023) - "Myelodysplastic Neoplasms (MDS) are hypothesized to re-model their bone marrow (BM) microenvironment to re-inforce conditions for their propagation...In conclusion, we show that murine BM stroma is re-programmed by exposure to human MDS xenografts to upregulate extracellular matrix (ECM) re-modeling and HSC supporting factors. In native human MDS BM in vivo, rare primary mesenchymal cells are re-programmed to increase hematopoietic support in a patient-individual manner pointing to altered MSC subpopulations with increased growth factor expression profiles in a subgroup of MDS patients."

Hematological Malignancies • Myelodysplastic Syndrome • CD31 • COL1A2 • CXCL12 • IGFBP5 • IL7 • NGFR • PECAM1

A systematic review and meta-analysis of the global prevalence of fluoroquinolone resistant Morganella morganii clinical isolates. (PubMed, Sci Rep) - "The resistance rate also differed according to the type of fluoroquinolone, with the highest resistance recorded against the earlier-generation pefloxacin (88%), followed by nalidixic acid (27%), levofloxacin (25%), and ciprofloxacin (22%). There was no or lower resistance to newer fluoroquinolones, such as garenoxacin (0%)...Despite this variability, the results remain robust. Further studies are needed to explore the molecular mechanisms driving this resistance and potential therapeutic interventions."

Clinical • Journal • Retrospective data • Review

Susceptibility of Neisseria gonorrhoeae to Zoliflodacin and Quinolones in Hyogo Prefecture, Japan. (PubMed, Pathogens) - "In addition to ZFD, we investigated the susceptibility of N. gonorrhoeae strains to ceftriaxone (CTRX), ciprofloxacin (CPFX), garenoxacin (GRNX), and sitafloxacin (STFX). ZFD showed potent antimicrobial activity against N. gonorrhoeae strains that are highly resistant to quinolones. It may become a new option in the treatment of gonococcal infections."

Journal • Infectious Disease

Enhancing Preoperative Assessment in OSCC: The Prognostic Impact of Mandibular Invasion and Combined Imaging (BAHNO 2025) - "Survival analysis underscored the prog- nostic significance of mandibular invasion, with marrow involvement associated with the poorest outcomes. 113 These results support the integration of combined imaging for more accurate preoperative assessment and re- inforce the need for tailored treatment approaches based on the extent of bone invasion."

Oncology • Oral Cancer • Squamous Cell Carcinoma

Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio. (PubMed, Pharm Res) - "The use of clinical Dose/FV was important for improving the correlation between the biorelevant dissolution profiles and Fa for salt-form drugs."

Journal

Effects of injectable trace minerals (Se, Zn, Cu, and Mn) administration on the immune response elicited by primary intranasal modified-live virus vaccination in dairy calves. (PubMed, Vet Res Commun) - "A total of 60 calves (1 month old) were administered an IN MLV vaccine containing BHV1, BRSV, BPI3V (Inforce 3®) and randomly assigned to one of two experimental groups: ITM (n = 30; Multimin®90, containing Se, Cu, Zn, and Mn) or SAL (n = 30; sterile saline)...Administration of ITM was also associated with lower clinical scores and respiratory disease morbidity and mortality. Treatment with ITM did not affect SNA titers to BHV1 and BPI3V or the BHV1-specific IgA level in nasal secretions."

Journal • Infectious Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections

Circulating T cell subpopulations in dairy calves infected with Bovine viral diarrhea virus 2 and Bovine herpes virus 1 following modified-live virus booster vaccination: Effects of the administration route and trace mineral supplementation. (PubMed, Vet Immunol Immunopathol) - "Forty-eight calves were administered a MLV intranasal (IN) vaccine containing BHV1, BRSV, BPI3V (Inforce 3®), and randomly assigned to subcutaneous (SC) administration of injectable trace minerals (ITM, n = 24) or saline (SAL, n = 24)...In conclusion, vaccine administration route and use of injectable trace minerals concurrent with vaccination affected the number CD4+ and CD8+ T cells in response to BVDV2 +BHV1 infection. Trace minerals supplementation concurrent with MLV vaccination might generate an improved cellular immunity against viral infections involved in respiratory disease."

Journal • Hematological Disorders • Infectious Disease • Leukopenia • Respiratory Diseases • CD4 • CD8 • IL2RA • ISG20

Solar Photodegradation of a Novel des-F(6)-Fluoroquinolone, Garenoxacin, and Ecotoxicity of Its Phototransformation Products. (PubMed, Environ Sci Technol) - "Toxicity tests with Vibrio fischeri and Chlorella vulgaris consistently indicate that the generation of hydroxylation and decarboxylation products during photodegradation of GRNX increased the acute toxicity. These findings not only provide insights into the fate of GRNX in sunlit surface water but also reveal the potentially significant risk of its photodegradation products to the aquatic ecosystem."

Journal

Pregnancy outcomes after first-trimester exposure to fluoroquinolones: Findings based on an integrated database from two Japanese institutions. (PubMed, Congenit Anom (Kyoto)) - "Logistic regression showed that fluoroquinolone exposure is not a significant risk factor for major congenital anomalies. In conclusion, first-trimester exposure to fluoroquinolone antibiotics was not associated with increased maternal or fetal risks."

Journal

ADHERENCE TO bDMARDs IN BIOLOGIC-EXPERIENCED RHEUMATOID ARTHRITIS: RESULTS FROM A SYSTEMATIC LITERATURE REVIEW (EULAR 2024) - "Three studies assessed anti-TNF therapies and one study assessed tocilizumab. Abatacept was evaluated in three papers as part of the same observational study, with differing population cohorts... This review supports that non-adherence to bDMARDs is common in biologic-experienced patients and with subsequent biologic therapies. Sustained non-adherence can undermine the full efficacious potential of bDMARDs. Our findings re-inforce the need to introduce and maintain interventions to diminish non-adherence specifically in the biologic experienced cohort."

Adherence • Review • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Fixed drug eruption due to tipepidine hibenzate and garenoxacin mesylate hydrate: an unusual case of polysensitivity. (PubMed, Eur J Dermatol) - No abstract available

Journal

The Drug-Specific Propensity Regarding the Acquisition of Fluoroquinolone Resistance in Escherichia coli: An in vitro Challenge and DNA Mutation Analysis. (PubMed, Infect Drug Resist) - "Eleven E. coli clinical isolates were exposed to each fluoroquinolone, ie, ciprofloxacin, levofloxacin, sitafloxacin, garenoxacin, and lascufloxacin, with the concentration of the mutant selection window for 5 days; these procedures were repeated 5-times. However, resistance acquisition was detected frequently after 15- to 25-days of exposure. Among fluoroquinolones, lascufloxacn had the least impact on the resistance acquisition in E. coli."

Journal • Preclinical

Threat of respiratory syncytial virus infection knocking the door: a proposed potential drug candidate through molecular dynamics simulations, a future alternative. (PubMed, J Mol Model) - "This study showed garenoxacin could prevent RSV infection better than ribavirin. In pursuing a more effective RSV control drug, additional research into these chemicals in vitro and in vivo is essential."

Journal • Infectious Disease • Respiratory Diseases • Respiratory Syncytial Virus Infections

"Yes, used once, But not necessary as structures are tougher, thick enough for sustaining cardiac pressures., And moreover, IMO, with contraction, available chorde tendinae attachments could further re-inforce strength on the repair during peak pressures." (@docarjuna)

Chemokine Ligand 14 Is a Pro-Fibrotic Stimulus in CKD Progression Through Regulating the GATA2 Transcription Factor (KIDNEY WEEK 2022) - "For in vivo validation, we used C57BL/6 unilateral ureteral obstruction (UUO) model to re-inforce the CCL14/CCR1/GATA2 pathway in chronic kidney disease progression...Conclusion CCL14 could play a pro-fibrotic role in CKD progression via regulations of CCR1 receptor and GATA2 transcription factor. Since CCL14 acts not only as a biomarker of increased expression in CKD progression, but also as a direct pro-fibrotic stimulus, it can be considered as a target for the treatment of chronic kidney disease."

Chronic Kidney Disease • Fibrosis • Nephrology • Renal Disease • CCR1 • CDH1 • FN1 • GATA2 • POSTN

"Turkey to re-inforce military presence in northern Cyprus -Erdogan https://t.co/E6lxnZRYMo" (@Reuters)

Respiratory quinolones can eradicate amoxicillin-induced mature biofilms and nontypeable Haemophilus influenzae in biofilms. (PubMed, J Infect Chemother) - "NTHi persists in biofilms, even after exposure to AMPC. These findings may eventually lead to a better understanding of effective use of antibiotics to eradicate NTHi growing as biofilms, or even to the development of novel therapeutic agents for treating patients with mucosal NTHi biofilm infections. Meanwhile, respiratory quinolones are attractive agents in reducing NTHi biofilm formation and destroying established biofilm."

Journal • Infectious Disease • Respiratory Diseases

QbD Based Development and Validation of Novel Stability Indicating Method for the Assay and Dissolution of Garenoxacin in Garenoxacin Tablets. (PubMed, J AOAC Int) - "QbD based RP-HPLC method (using Design Expert Software version 11) and studied peak purity of Garenoxacin peak using photo diode array detector (for all degradation samples, control sample and standard solution) and the same method is validated following USP and ICH guidelines. LC-MS compatible volatile buffer solution is used in the mobile phase preparation of the novel Stability indicating RP-HPLC assay method."

Journal

Medical gas plasma as an innovative technology in the therapy and immune modulation of skin cancer (ADO 2021) - "Imiquimod, a known TLR7/8 agonist, combined with gas plasma treatment markedly elevated the numbers of intratumoral DCs and activated T cells. Our data provide a novel role of gas plasma technology in skin cancer treatment and re-inforce the idea of therapeutic ROS/RNS as critical modulators of the TME. This work is supported by the German Federal Ministry of Education and Research (BMBF, grant numbers 03Z22DN11 & 03Z22Di1), and the European Social Fund (“ONKOTHER-H”; ESF/14-BM-A55-0001/18 & 0006/18) and the Ministry of Education, Science and Culture of Mecklenburg-Vorpommern, Germany."

IO biomarker • Dermatology • Genetic Disorders • Immune Modulation • Immunology • Inflammation • Melanoma • Oncology • Skin Cancer • Solid Tumor • CALR • CD4 • HSP90AA1

Effectiveness of antibacterial agents against cell-invading bacteria such as Streptococcus pyogenes and Haemophilus influenzae. (PubMed, BMC Microbiol) - "GRNX was the most effective agent against bacteria invading cells."

Journal • Infectious Disease • Otorhinolaryngology • Respiratory Diseases

"TO INFORCE THEM" (@nahaltin_)

The Blonde d'Aquitaine T3811>G3811 mutation in the myostatin gene: association with growth, carcass and muscle phenotypes in veal calves. (PubMed, J Anim Sci) - "The characteristics of the Triceps brachii muscles were affected by the mutation (P<0.001), with lower ICDH activity (oxidative) and a higher proportion of myosin type 2X muscle fibers (fast twitch). The effects of the TG3811 mutation were similar to those of other known myostatin mutations, although the Blonde d'Aquitaine animals, which are predominantly [G/G] homozygous, do not exhibit extreme double muscling."

Journal

[VIRTUAL] QUARTET: A SIOP EUROPE PROJECT FOR QUALITY AND EXCELLENCE IN RADIOTHERAPY AND IMAGING FOR CHILDREN AND ADOLESCENTS WITH CANCER (SIOP 2020) - "Feedback via conferences, publications, the SIOPE Radiation Oncology Working Group, and disease-specific study groups will therefore be essential. Dissemination of findings will re-inforce and improve standards of care."

Clinical • Medulloblastoma • Neuroblastoma • Oncology • Pediatrics • Rhabdomyosarcoma • Sarcoma • Solid Tumor