Onmel (itraconazole) / Merz Pharma - LARVOL DELTA

KOMET-001: First in Human Study of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia (clinicaltrials.gov) - P1/2 | N=263 | Recruiting | Sponsor: Kura Oncology, Inc. | N=199 ➔ 263

Enrollment change • Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology • KMT2A • NPM1

Dupilumab-associated head and neck dermatitis resolves temporarily with itraconazole therapy and rapidly with transition to upadacitinib, with Malassezia-specific immunoglobulin E levels mirroring cli (ACD-ASM 2023) - "Dupilumab associated head and neck dermatitis (DAHND) (also known as Dupilumab Red Face and persistent facial erythema) is defined as persistent or worsening eczematous eruption of the head and neck during Dupilumab therapy....Treatment with Itraconazole provides temporary reduction in clinical symptoms however transition to Upadactinib results in rapid and sustained resolution."

A Cautionary Tale of Treatment Resistance at Annual Meeting (DermatologyTimes) - "'Onychomycosis should only be treated if there is a confirmatory diagnosis [via] fungal culture or PCR [polymerase chain reaction] positive of a dermatophyte confirmatory culture, and identification of pathogen is ideal,' Boni E. Elewski, MD..."

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What’s New and Hot in Nail and Hair Treatments (DermatologyTimes) - "Presenter Boni E. Elewski...started her presentation on 'What's new and hot in nail and hair' by sharing a number of media reports noting the impressive results of low-dose minoxidil for hair loss...Elewski next discussed using the severity of alopecia tool (SALT) in evaluating a patient, a global severity score that captures percentage of hair loss. It is a weighted sum of the percentage of hair loss in the 4 quadrants of the scalp, ranging from 0 (no hair loss) to 100 (complete hair loss). Simply put, a SALT score of 0 would mean no hair loss; 50 would mean 50% hair loss, etc."

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Acute Lymphoblastic Leukemia (ALL) Treatment Protocols (Medscape) - "Febrile neutropenic patients require prompt initiation of broad-spectrum antibiotics. Suggested regimens include a third- or fourth-generation cephalosporin or carbapenem with or without vancomycin. Antibiotics can be modified based on response to therapy; additional antibiotics might be needed for resistant organisms (eg, vancomycin-resistant enterococci [VRE]) or suspected fungal infections."

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Can Statins Cause Brain Fog? (WebMD) - "'One might need to ask the question: 'Is it really the drug?' Or is there something else going on here that would require formal evaluation with a neuropsychiatric specialist,' Rosenson says."

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