propafenone / Generic mfg. - LARVOL DELTA

Current practices and knowledge of adenosine administration for paroxysmal supraventricular tachycardia: a multi-province survey in Chinese emergency departments. (PubMed, BMC Emerg Med) - "Emergency physicians, especially those in charge, have a limited understanding of SVT and the appropriate use of adenosine, necessitating further training for this demographic."

Journal • Cardiovascular • Ventricular Tachycardia

Cadmium-immobilizing bacteria utilize octanoic acid and two synthetic compounds to enhance nitrogen fixation in soybeans under cadmium stress. (PubMed, J Exp Bot) - "Our findings reveal a cooperative mechanism wherein both non-nitrogen-fixing bacteria and specific compounds support soybeans' nitrogen-fixation function under Cd stress by regulating bioavailable Cd and rhizobia abundance. Surprisingly, we also found that the synthetic compounds propafenone and levonorgestrel can confer Cd-stress protection to plants."

Journal

Repurposing of propafenone, an FDA approved anti-arrhythmic drug for antileishmanial therapy. (PubMed, Biochimie) - "Cell cycle arrest was detected at the G2/M stage. The data suggests that propafenone has antileishmanial potential and can be evaluated further in an experimental VL model."

FDA event • Journal • Infectious Disease • Metabolic Disorders

Wide complex tachycardia and brugada electrocardiographic pattern induced by propafenone: A rare and unpredictable pro-arrhythmic effect. (PubMed, J Electrocardiol) - "We present a rare patient case, where therapeutic range dosage of propafenone resulted in a wide complex tachycardia, followed by the Brugada ECG pattern during atrial fibrillation. We discuss the possible mechanisms related to this unusual ECG manifestation."

Journal • Atrial Fibrillation • Cardiovascular • Ventricular Tachycardia

Propafenone-Induced Cholestatic Liver Injury: When Diagnosis Does Not Skip a Beat. (PubMed, GE Port J Gastroenterol) - "Three months after discontinuation, the patient was asymptomatic, and all liver tests normalised. With this clinical case, we aimed to emphasise the importance of the medication history and the exclusion of other possible causes of altered liver enzymes."

Journal • Dermatology • Hepatology • Liver Failure • Pruritus

Antiarrhythmic Drug Initiation for Atrial Fibrillation in the USA: How and Where. (PubMed, J Cardiovasc Electrophysiol) - "Herein, we describe the various categories in a practical guide to initiation to make clinicians more comfortable with starting and maintaining antiarrhythmic therapy in both the inpatient and outpatient setting. The central illustration summarizes the article."

Journal • Review • Atrial Fibrillation • Cardiovascular • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Apnea • Sleep Disorder

Propafenone- vs. amiodarone-associated adverse cardiac outcomes in patients with atrial fibrillation and heart failure. (PubMed, Br J Clin Pharmacol) - "Propafenone was not significantly associated with increased risk of proarrhythmia and mortality when compared to amiodarone in atrial fibrillation patients with heart failure in contemporary real-world settings. Prospective studies are needed to determine whether propafenone should definitely be avoided in these patients."

Adverse events • Journal • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Heart Failure • Myocardial Infarction

Multi-omics Analysis Revealed the Diagnostic and Therapeutic Value of Immunogenic Cell Death-derived SCN5A in Hepatocellular Carcinoma. (PubMed, Mol Biotechnol) - "These findings position SCN5A as a novel ICD-linked biomarker and therapeutic target in HCC, with propafenone repurposing showing promising anti-tumor efficacy through SCN5A modulation. This work bridges computational biology with experimental oncology to advance ICD-targeted HCC treatment strategies."

IO biomarker • Journal • Hepatocellular Cancer • Oncology • Solid Tumor • BAX • BCL2

The effect of enhanced external counterpulsation on anxiety and depression in patients with paroxysmal atrial fibrillation: a randomized controlled trial. (PubMed, Front Cardiovasc Med) - "The control group received conventional antiarrhythmic therapy with β-blockers or propafenone, and the EECP group underwent EECP therapy in conjunction with pharmacological treatment...Anxiety and depression indicators were lower in both groups than before the intervention, and scores in the EECP group were significantly lower than those in the control group, suggesting that EECP significantly improved anxiety and depression levels. EECP, as a non-invasive treatment, is effective in improving anxiety and depression in patients with PAF."

Journal • Atrial Fibrillation • Cardiovascular • CNS Disorders • Depression • Mood Disorders • Psychiatry

Study on the 90% effective dose of phosphoprofen combined with fentanyl in adult colonoscopy using the BCD-UDM sequential method (ChiCTR) - P=N/A | N=55 | Not yet recruiting | Sponsor: Traditional Chinese Medical Hospital of Zhuji; Traditional Chinese Medical Hospital of Zhuji

New trial

CHEST PAIN IN FONTAN PHYSIOLOGY: EVALUATING ISCHEMIA IN A COMPLEX HEART - Jonathan Reyes-Rivera (ACC 2025) - "Her medications were aspirin, captopril, furosemide, propafenone and apixaban. Chest pain evaluation in ACHD patients should also consider ischemic heart disease. CCTA is useful for anatomical evaluation of epicardial coronary arteries. Conversely, cardiac MRI is the initial modality of choice in patients with chest pain and low to intermediate risk for obstructive coronary artery disease."

Cardiovascular • Coronary Artery Disease • Heart Failure • Pain • TNNI3

SAFETY OF CLASS IC VERSUS CLASS III ANTIARRHYTHMIC AGENTS IN PATIENTS WITH NON-ISCHEMIC CARDIOMYOPATHY: A RETROSPECTIVE MULTICENTER STUDY - Ahmed K. Saleh (ACC 2025) - "NICM patients treated with class IC (flecainide, propafenone) or class III AADs (sotalol, dofetilide, amiodarone) were identified using ICD-10 and RxNorm codes. NICM patients without VT, VF, ICD placement, or CAD treated with class IC AADs had greater event-free survival from all-cause death, VT, VF, and cardiac arrest compared to those treated with class III AADs. This suggests that class IC AADs may be a safer alternative in select NICM patients."

Retrospective data • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Heart Failure

AVANT GUARD: Pulsed Field Ablation (PFA) vs Anti-Arrhythmic Drug (AAD) Therapy as a First Line Treatment for Persistent Atrial Fibrillation (clinicaltrials.gov) - P=N/A | N=484 | Active, not recruiting | Sponsor: Boston Scientific Corporation | N=247 ➔ 484

Enrollment change • Atrial Fibrillation • Cardiovascular

POLYPHARMACY, DRUG RELATED NITROSAMINE CONTAMINATION (BISOPROLOL/PROPAFENONE) AND THE LINK TO LICHEN PLANUS/SUBSEQUENT DEVELOPMENT OF KERATINOCYTE AND MUCOSAL CANCER/ORAL LEUKOPLAKIA: PRESENTATION OF THE FIRST CASE AND UPDATE ON THE NEW PATHOGENETIC VISION. (PubMed, Georgian Med News) - "The association between drug-induced lichen planus - whether oral/mucosal or solely cutaneous - involves a diverse range of drugs, including ACE inhibitors, diuretics, and beta blockers, as well as quinidine, NSAIDs, hydroxychloroquine, antiretroviral medications for HIV, penicillamine, TNF inhibitors, and certain medications for type 2 diabetes. We present for the first time in the medical literature, a case of a 91-year-old patient with a 2-year history of oral lichen planus and subsequent oral leukoplakia following 2-year beta-blocker (bisoprolol) and/or anti-arrhythmic (propafenone) administration, with no history of smoking and alcohol consumption, and discuss the possible role of nitrosamines as a cofactor in the malignant transformation of ulcerative lichenoid lesions to oral leukoplakia/mucosal carcinoma. The adverse effects of these medications may be categorized into those related to 1) the active substance - potentially triggering lichen planus and those 2)..."

Journal • Dermatology • Dermatopathology • Diabetes • Human Immunodeficiency Virus • Infectious Disease • Lichen Planus • Metabolic Disorders • Oncology • Oral Cancer • Skin Cancer • Solid Tumor • Squamous Cell Carcinoma • Type 2 Diabetes Mellitus

AVANT GUARD: Pulsed Field Ablation (PFA) Vs Anti-Arrhythmic Drug (AAD) Therapy As a First Line Treatment for Persistent Atrial Fibrillation (clinicaltrials.gov) - P=N/A | N=247 | Active, not recruiting | Sponsor: Boston Scientific Corporation | Recruiting ➔ Active, not recruiting | N=520 ➔ 247

Enrollment change • Enrollment closed • Atrial Fibrillation • Cardiovascular

Suspect Screening of Pharmaceuticals and Their Transformation Products (TPs) in Wastewater during COVID-19 Infection Peak: Identification of New TPs and Elevated Risks. (PubMed, Environ Sci Technol) - "Interestingly, the consumption of propafenone increased after the infection peak, possibly linked to long COVID-19 symptoms. Risks were further evaluated based on concentration, detection frequency, and PMT (persistence, mobility, and toxicity) properties, revealing that TPs of aminopyrine, acetaminophen, etc. showed even greater ToxPi scores than their parent compounds. This study highlights the elevated risks posed by pharmaceutical discharge during epidemics and the necessity for TPs' monitoring."

Journal • Infectious Disease • Novel Coronavirus Disease

α1-Adrenoceptor Blockade by Class I Antiarrhythmic Drugs in Guinea Pig Thoracic Aorta as Revealed by Mechanical and Fluorescence Displacement Analysis. (PubMed, Biol Pharm Bull) - "Other class I antiarrhythmic drugs, disopyramide, pirmenol, procainamide, lidocaine, mexiletine, flecainide, pilsicainide, and GS-458967, affected neither the contraction by phenylephrine nor the fluorescent staining by prazosin. These results indicate that among the class I antiarrhythmic drugs, cibenzoline, aprindine, and propafenone, as well as quinidine and ranolazine, have α1-adrenoceptor-blocking activity at therapeutically relevant concentrations."

Journal

Traditional Chinese medicine for premature ventricular contraction caused by obstructive sleep apnea: A case report and literature review. (PubMed, Medicine (Baltimore)) - "After treatment with TCM, the patient's palpitations disappeared completely and snoring improved, which proved that TCM can treat PVC caused by OSA. To verify this conclusion, more high-quality research is necessary to establish the efficacy and underlying mechanisms of TCM in treating PVC caused by OSA."

Journal • Review • Cardiovascular • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders • Obstructive Sleep Apnea • Respiratory Diseases • Sleep Disorder

The Safety Profile of Amiodarone Among Older Adults (age ≥ 75 years): A Pharmacovigilance Study from the FDA Data. (PubMed, Am J Med) - "In this global postmarketing study, interstitial lung disease and bradycardia were more frequently reported in older adults treated with amiodarone. These findings support vigilant monitoring for these adverse events, particularly in older patients."

Adverse events • Journal • Cardiovascular • Endocrine Disorders • Hepatology • Interstitial Lung Disease • Liver Failure • Pain • Pulmonary Disease • Respiratory Diseases • ROR1

Kir2.1 mutations differentially increase the risk of flecainide proarrhythmia in Andersen Tawil Syndrome. (PubMed, medRxiv) - "In five cardiac-specific ATS1 mouse models (Kir2.1 Δ314-315 , Kir2.1 C122Y , Kir2.1 G215D and Kir2.1 R67W and Kir2.1 S136F ), flecainide or propafenone (40 mg/Kg i.p.) differentially prolonged the P wave, and the PR, QRS and QTc intervals compared to Kir2.1 WT ; Kir2.1 S136F had milder effects. In-silico molecular docking studies predicted that the Cys 311 pharmacophore binding site and flecainide accessibility are altered in mutated Kir2.1 channels, leading to premature channel closure and arrhythmias. We conclude that class-Ic AADs are only partially effective and might be proarrhythmic in some ATS1 patients.These findings raise concern about the use of class-Ic AADs in ATS1 patients and highlight the need for further studies to guide personalized therapy."

Journal • Cardiovascular • NAV1

Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma. (PubMed, J Immunother Cancer) - "Taken together, our findings suggest that propafenone holds promise as a candidate drug for enhancing the efficacy of immunotherapy and other ferroptosis-targeted therapies in the treatment of melanoma."

Journal • Cardiovascular • Melanoma • Oncology • Solid Tumor • GPX4 • HMOX1

Long-term clinical course of patients with catecholaminergic polymorphic ventricular tachycardia: A more than 10-year follow-up cohort study. (PubMed, Ann Pediatr Cardiol) - "Combination therapy with a beta-blocker and an IC antiarrhythmic drug shows promise. An individualized approach to the selection of treatment strategies is essential."

Journal • Atrial Fibrillation • Cardiovascular • Genetic Disorders • Ventricular Tachycardia • RYR2

Ventricular Pre-excitation Related Cardiac Dysfunction Secondary to Accessory Pathway in the Absence of Tachyarrhythmia: A Systematic Review (AHA 2024) - "Amiodarone and propafenone achieved improvement in HF status by causing AP block and restoring ventricular synchrony in pediatric patients deemed unfit for catheter ablation (CA). Ablation of APs usually restores cardiac function largely; however, irreversible myocardial fibrosis can ensue. Based on these data, early CA of the APs associated with LV dysfunction is, therefore, recommended."

Review • Cardiovascular • Fibrosis • Heart Failure • Immunology • Movement Disorders • Pediatrics

Class 1C Antiarrhythmic Drugs are Safe in Patients with Arrhythmia-induced Cardiomyopathy Following Recovery of Left Ventricular Ejection Fraction (AHA 2024) - "Background: Class 1C antiarrhythmic drugs (AADs), such as flecainide and propafenone, are effective first-line agents for rhythm control in atrial tachyarrhythmias. Class 1C AADs appear safe in patients with atrial tachyarrhythmias and AiCM following recovery of LVEF, comparable to those without prior cardiomyopathy. However, AiCM patients exhibited higher rates of medication discontinuation, indicating potential challenges in treatment adherence. Further large-scale studies are needed to confirm these findings."

Clinical • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Heart Failure • Myocardial Ischemia

Bleeding Associated With Antiarrhythmic Drugs in Patients With Atrial Fibrillation Using Direct Oral Anticoagulants: A Nationwide Population Cohort Study. (PubMed, J Am Heart Assoc) - "Concomitant use of DOACs with amiodarone, but not dronedarone or propafenone, increases the risk of major bleeding, particularly intracranial bleeding. This study provides new evidence to guide clinicians to tailor concomitant anticoagulation and antiarrhythmic therapy for patients with atrial fibrillation."

Journal • Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Gastroenterology • Gastrointestinal Disorder • Heart Failure