propafenone / Generic mfg. - LARVOL DELTA

Pharmacokinetics and Bioequivalence of Propafenone Hydrochloride Tablets under Fasting Conditions in Healthy Subjects. (PubMed, Eur J Drug Metab Pharmacokinet) - "Under fasting single-dose conditions, the test and reference propafenone hydrochloride tablets met bioequivalence criteria in healthy Chinese subjects."

Journal • PK/PD data

SAFETY AND EFFICACY OF CLASS IC VS AMIODARONE ANTIARRHYTHMIC AGENTS IN PATIENTS WITH CONGENITAL HEART DISEASE: A RETROSPECTIVE MULTI-CENTER STUDY (ACC 2026) - "Class IC antiarrhythmic drugs (AADs), flecainide and propafenone, are used but limited in CHD due to safety concerns in structural disease. In complex CHD without VT/VF, CAD, or ICD, class IC AADs provided comparable arrhythmia efficacy with significantly lower all-cause mortality than amiodarone."

Retrospective data • Atrial Fibrillation • Cardiovascular • Heart Failure

CONTINUATION VERSUS INTERRUPTION OF MAINTENANCE ANTIARRHYTHMIC THERAPY IN ADULT INTENSIVE CARE UNIT PATIENTS (ACC 2026) - "Background: For patients admitted to an intensive care unit (ICU), there is limited guidance regarding the management of maintenance antiarrhythmic drug (AAD) therapy such as flecainide, propafenone, dofetilide, dronedarone, and sotalol...For patients who developed unstable arrhythmias, acute treatment with direct current cardioversion (DCCV) or pharmacological therapy, such as amiodarone, beta or non-dihydropyridine calcium channel blockers, or digoxin, will be recorded... Research is currently ongoing with the objective of gaining insight to prescribing patterns and clinical outcomes."

Clinical • Cardiovascular • Critical care • Ventricular Tachycardia

ROLE OF ANTAZOLINE IN CARDIOVERSION OF ATRIAL FIBRILLATION: A PRISMA-COMPLIANT SYSTEMATIC REVIEW AND META-ANALYSIS (ACC 2026) - "Antazoline is more effective than propafenone and amiodarone in achieving sinus rhythm in atrial fibrillation, with no significant differences in safety outcomes. It may be considered a viable alternative for acute rhythm control."

Retrospective data • Review • Atrial Fibrillation • Cardiovascular • Hypotension

DELIVERY AS DEFINITIVE THERAPY FOR INCESSANT FOCAL ATRIAL TACHYCARDIA IN PREGNANCY (ACC 2026) - "Propafenone with metoprolol achieved partial rate control without restoring sinus rhythm... In select cases of incessant FAT in pregnancy, advancing to fetal maturity followed by elective delivery may serve as a definitive therapeutic strategy. Multidisciplinary, individualized management remains essential. Further evidence is needed for optimal guidance."

Cardiovascular • Heart Failure • Pulmonary Disease

INITIAL MANAGEMENT OF ATRIAL FIBRILLATION WITHOUT ISCHEMIC HEART DISEASE: CLASS I OR CLASS III ANTIARRHYTHMIC THERAPY? (ACC 2026) - "Patients were categorized by first-line AAD use: Class I agents (flecainide, procainamide, propafenone) or Class III agents (amiodarone, sotalol, dofetilide). In this five-year retrospective study, class I AAD was associated with better clinical outcomes than class III AAD as first-line therapy for AF among patients without IHD."

Atrial Fibrillation • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • Ischemic stroke

MANAGEMENT OF ATRIAL FIBRILLATION DURING THE PERI-TRANSPLANT PERIOD IN ELDERLY AML PATIENTS UNDERGOING ALLO-HSCT BASED ON EBMT GUIDELINES: A CASE STUDY OF NURSING CARE (EBMT 2026) - "Precision medication nursing: Oral propafenone hydrochloride + intravenous amiodarone (collaborative with physicians), with 30-minute blood pressure/heart rate monitoring to control ventricular rate at 60–80 bpm and prevent hypotension.3. The occurrence of AF in elderly AML patients during the peri-transplant period of allo-HSCT is closely related to the toxicity of conditioning regimens, underlying heart disease, and decreased physiological reserve. The integrated nursing model of "evidence-based monitoring - precision medication - complication prevention and control - psychological support and health education" constructed in accordance with EBMT guidelines has been proven to effectively control AF episodes, reduce related risks, and thus ensure the smooth progress of transplantation. This model emphasizes the special nursing needs of elderly patients undergoing allo-HSCT, refines the guideline measures by optimizing the intervention plan, and demonstrates..."

Case study • Clinical • Acute Myelogenous Leukemia • Atrial Fibrillation • Bone Marrow Transplantation • Cardiovascular • CNS Disorders • General Anxiety Disorder • Heart Failure • Hematological Disorders • Hematological Malignancies • Hypotension • Leukemia • Mood Disorders • Transplantation

OF_ETA_CT1: An open-label, randomized clinical trial comparing Etacizin versus Propafenone in Atrial Fibrillation (clinicaltrialsregister.eu) - P4 | N=30 | Not yet recruiting | Sponsor: Olpha AS

New P4 trial • Atrial Fibrillation • Cardiovascular

Propafenone-mediated gap junctional uncoupling results from aberrant connexin-43 trafficking. (PubMed, Pharmacol Rep) - No abstract available

Journal

EAST-STROKE: Early treatment of irregular heartbeat (atrial fibrillation) to prevent a recurrent stroke (clinicaltrialsregister.eu) - P4 | N=1035 | Recruiting | Sponsor: University Medical Center Hamburg-Eppendorf

New P4 trial • Atrial Fibrillation • Cardiovascular • Ischemic stroke

Ibutilide: what's clinically proven, what's being investigated? (PubMed, Indian Pacing Electrophysiol J) - "Ibutilide fumarate is a methanesulfonamide derivative that is structurally similar to sotalol without the β-adrenoreceptor blocking activity...As compared to ibutilide, coadministration with propafenone has a significantly higher success rate of for AF termination...It is safe drug to use for cardioversion in patients on chronic amiodarone therapy. The main side effect of dofetilide is torsade de pointes occurs in 4% patients and monomorphic ventricular tachycardia in 4.9% patients...Conversion rate with ibutilide infusion is only 30% in the presence of an enlarged left atrium (> 5 cm) and 37.7% in the presence of mitral valve disease (MVD), whereas the conversion rate was 82.5% in the absence of MVD and 85% in the absence of both enlarged left atrium and mitral valve disease (p = <0.001). Ibutilide can be used effectively in patients who are not a candidate for direct current cardioversion or who chose not to undergo electric cardioversion."

Journal • Review • Atrial Fibrillation • Cardiovascular • Ventricular Tachycardia

Propafenone Overdose Presenting With Brugada Phenocopy, QRS Widening, and Ventricular Fibrillation. (PubMed, JACC Case Rep) - "BrP resolves after correcting reversible triggers. In sodium-channel blocker toxicity with QRS interval widening, early sodium bicarbonate is first-line therapy."

Journal • Cardiovascular • Genetic Disorders

Opening closed inward rectifier potassium channel doors. (PubMed, Br J Pharmacol) - "Several clinically used drugs (e.g. propafenone) modulate Kir2.1 and novel compounds such as GPV0057 show improved selectivity...We emphasize the urgent need for subtype-specific KIR openers, the development of PIP2-independent mechanisms of action and comprehensive preclinical characterization to overcome translational barriers. Addressing these challenges may provide new therapeutic opportunities for rare channelopathies associated with KIR channel dysfunction."

Journal • Review

Sudden death recovered: Brugada syndrome, a wolf in sheep's clothing (PubMed, Medicina (B Aires)) - "Brugada syndrome is a hereditary channelopathy associated with a high risk of sudden cardiac death in young individuals. We present the case of a 25-yearold man with a syncopal episode, without prodromes or defenses, during physical activity and a bilateral mandible fracture, who had a recovered sudden death during surgical repair."

Journal • Cardiovascular • Genetic Disorders • Musculoskeletal Diseases • Orthopedics

Na+/Ca2+ Exchanger-Mediated Negative Inotropy of Na+ Channel Blockers Pilsicainide, Cibenzoline, and Propafenone in Guinea Pig Ventricular Myocardial Tissue Preparations. (PubMed, Biol Pharm Bull) - "The class I antiarrhythmic drugs, as well as tetrodotoxin, decreased contractile force in a concentration-dependent manner; the magnitude of the effect was propafenone > cibenzoline > pilsicainide. These results suggest that NCX facilitation secondary to Na+ channel blockade constitutes a common mechanism underlying the negative inotropic effects of class I antiarrhythmic drugs. Drugs with stronger negative inotropic effects have additional mechanisms, and the overall magnitude of negative inotropy is determined by the sum of these actions."

Journal

Polatuzumab vedotin, zanubrutinib, rituximab, lenalidomide, and prednisone (Pola-ZR2P) as frontline immunochemotherapy in previously untreated DLBCL patients (ASH 2025) - P2 | "She had a history of arrhythmia managed with intermittent propafenone. Pola-ZR2P regimen demonstrated promising efficacy and a manageable safety profile in this cohort of previously untreated DLBCL patients. This report provides clinical evidence on the efficacy and safety of Pola-ZR2P regimen as the frontline immunochemotherapy in previously untreated DLBCL patients. Further enrollment of more patients is necessary to better clarify the effectiveness and safety of Pola-ZR2P regimen as the frontline chemotherapy in DLBCL patients."

Clinical • B Cell Lymphoma • Cardiovascular • Coronary Artery Disease • Dermatology • Diffuse Large B Cell Lymphoma • Follicular Lymphoma • Gastroenterology • Hematological Disorders • Hematological Malignancies • Hypertension • Immunology • Infectious Disease • Large B Cell Lymphoma • Lymphoma • Neutropenia • Non-Hodgkin’s Lymphoma • Pruritus • Pulmonary Arterial Hypertension • Pulmonary Disease • Respiratory Diseases • Septic Shock • TP53

Ivabradine in the treatment of congenital junctional ectopic tachycardia: a case report and review of the literature. (PubMed, Cardiol Young) - "This report presents a case of neonatal-onset congenital junctional ectopic tachycardia treated with cedilanid, amiodarone, and propafenone but persisted in episodes. The review of the literature indicates that ivabradine demonstrates efficacy in the treatment of paediatric junctional ectopic tachycardia, particularly in refractory cases, without significant side effects. These findings suggest that ivabradine has broad applications in the treatment of refractory arrhythmias."

Journal • Cardiovascular • Pediatrics

DRIVE-AF: Dronedarone Rhythm Intervention for Early Atrial Fibrillation (clinicaltrials.gov) - P4 | N=1898 | Not yet recruiting | Sponsor: Inha University Hospital

HEOR • New P4 trial • Atrial Fibrillation • Cardiovascular

Nutrient Availability Dictates Cancer Metabolism-Based Therapeutic Responses to Non-oncology Drugs. (PubMed, Cancer Res) - "Furthermore, the mTOR and Hippo pathways mediated the response to combined propafenone/hypoglycemia or biguanides/hypoglycemia treatments, respectively, and mTOR or TEAD inhibitors circumvented the need for dietary interventions to enhance cancer cell death. Together, these results indicate that CM-SLP represents a promising approach for integrating metabolic profiling into precision oncology, offering therapeutic avenues tailored to individual patient needs."

Journal • Hypoglycemia • Metabolic Disorders • Oncology

Impact of Dronedarone on Early Recurrence After Catheter Ablation in Patients With Nonparoxysmal Atrial Fibrillation. (PubMed, Cardiovasc Ther) - "In this retrospective study of patients with nonparoxysmal atrial fibrillation after catheter ablation, dronedarone and amiodarone showed a trend toward better efficacy than propafenone in preventing overall early recurrence. Dronedarone demonstrated a specific advantage in preventing early recurrence of atrial flutter."

Clinical • Journal • Retrospective data • Atrial Fibrillation • Cardiovascular

Long-Term Outcomes and Post-Ablation Medication De-Escalation After Catheter Ablation for Premature Ventricular Complexes: A Nationwide Cohort Study. (PubMed, Int J Gen Med) - "Medication analysis confirmed dose de-escalation, particularly for mexiletine, propafenone, and amiodarone. Radiofrequency catheter ablation was associated with meaningful reductions in antiarrhythmic medication use, underscoring its potential therapeutic and economic benefits. These findings support radiofrequency catheter ablation as a component of long-term management strategies, while future prospective studies are needed to refine candidate selection and timing of intervention."

Journal • Cardiovascular • Congestive Heart Failure • Heart Failure

Usability of CHA2DS2VASC score in predicting the effectiveness and safety of pharmacological cardioversion - data from the multicenter cardioversion with intravenous ANTazoline study. (PubMed, Front Cardiovasc Med) - "Antazoline was used in 59% of patients, amiodarone in 53%, and propafenone in 19%. In this retrospective sub-analysis of the CANT II registry, success of pharmacological cardioversion of AF is not associated with number of comorbidities as assessed by the CHA2DS2VASc score. PCV remains a feasible and generally safe option in emergency and cardiology department practice."

Journal • Atrial Fibrillation • Cardiovascular • Hypotension

Persistent Focal Atrial Tachycardia In A Young Pregnant Woman: When Stability Isn't Safe (AHA 2025) - "Management included two doses of adenosine with transient effect, and escalating doses of metoprolol and propafenone with partial response...In >75% of reviewed cases, FAT was persistent or recurrent, often requiring multiple agents before ablation.Zero-fluoroscopy ablation is safe and effective. A prospective study of 47 pregnant patients showed 100% acute success, no 24-month recurrence, and favorable obstetric outcomes.Multidisciplinary care improves outcomes in pregnant patients with arrhythmias, where coordination among electrophysiology, cardiology, and obstetrics is essential for timely and individualized decision-making."

Clinical • Cardiomyopathy • Cardiovascular • Fatigue • Obstetrics • Pulmonary Disease

Concomitant use of direct oral anticoagulants and interacting antiarrhythmic drugs and the risk of stroke and bleeding among patients with non-valvular atrial fibrillation: a multinational cohort study. (PubMed, BMC Med) - "Concomitant use of interacting antiarrhythmic drugs does not seem to affect the effectiveness of DOACs but may increase their risk of major bleeding."

Journal • Atrial Fibrillation • Cardiovascular • Ischemic stroke

FLECAINIDE TOXICITY LEADING TO WIDE COMPLEX TACHYARRHYTHMIAS IN THE SETTING OF WORSENING CARDIOMYOPATHY (CHEST 2025) - "CASE PRESENTATION: A 71-year-old male with AF (on flecainide and carvedilol), nonischemic cardiomyopathy, and heart failure with reduced ejection fraction (EF) (with an EF of 35%) presented to the ED with near-syncope after experiencing multiple lightheaded episodes...On Day 2, he had a similar episode of WCT and IV amiodarone was commenced, leading to resolution of WCT...In patients with structural heart disease—particularly those with significantly reduced EF—Class IC agents (flecainide and propafenone) are generally contraindicated due to increased risk of mortality and proarrhythmias [1,6]... This case underscores the risk of flecainide toxicity in patients with advanced structural heart disease and reduced ejection fraction. Close monitoring of the structural status of the heart is essential in patients on class 1C antiarrhythmics."

Atrial Fibrillation • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Coronary Artery Disease • Heart Failure • Ventricular Tachycardia