CX-1942 / RespireRx - LARVOL DELTA

Preclinical characterization of a water-soluble low-impact ampakine prodrug, CX1942 and its active moiety, CX1763. (PubMed, Future Med Chem) - "CX1763 increases attention in the 5CSRTT in rats and reduces amphetamine-induced hyperactivity in mice. CX1763 lacked epileptogenicity up to 1500 mg/kg in rats. These data document that CX1942 and CX1763 are active and without prominent side effects in multiple pre-clinical assays. CX1942 could serve as a prodrug for CX1763 with the advantage of high water solubility as in an intravenous formulation."

Journal • Preclinical • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Depression • Developmental Disorders • Epilepsy • Mental Retardation • Psychiatry

Automated Classification of Whole Body Plethysmography Waveforms to Quantify Breathing Patterns. (PubMed, Front Physiol) - "We next used this clustering method to quantify breathing after opioid (fentanyl) overdose and treatment with ampakine CX1942, an allosteric modulator of AMPA receptors. We conclude that this method allows for rapid assessment of breathing patterns across extended data recordings. Expanding analyses to include larger portions of recorded WBP data may provide insight on how breathing is affected by disease or therapy."

Journal • Addiction (Opioid and Alcohol) • Immunology