P015 / Convalife - LARVOL DELTA

P015, a highly selective PARP7&12 dual inhibitor (AACR 2026) - "We have identified and preliminarily characterized P015, a small-molecule inhibitor with sub-10 nM IC50 values against PARP7&12 at the enzymatic level. Although current experimental data are primarily derived from in vitro enzyme activity assays, the results suggest that P015 has significant potential for further cellular and in vivo pharmacological and mechanistic studies, and may be developed as a novel anti-cancer candidate drug targeting the PARP7&12 pathway."

Oncology • PARP12 • TIPARP