Psoralen / EMD Serono - LARVOL DELTA

Selective Kv1.3 inhibition promotes M2 microglial polarization, accelerates hematoma resolution, and improves neurological recovery following collagenase-induced spontaneous intracerebral hemorrhage in mice. (PubMed, Vet World) - "This study investigated whether selective Kv1.3 inhibition with 5-(4-phenoxybutoxy) psoralen (PAP-1) could promote immuno-modulatory microglial polarization, attenuate brain injury, and improve neurological recovery in a collagenase-induced mouse model of sICH...The integration of histological, immunological, and functional outcomes provides strong evidence supporting Kv1.3 as a promising therapeutic target for early intervention after hemorrhagic stroke. Although the study was limited to male mice, was restricted to a 7-day observation period, and lacked detailed downstream mechanistic analyses, the findings establish a robust preclinical foundation for future investigations into long-term functional recovery, molecular signaling pathways, and translational evaluation of Kv1.3-targeted therapies in sICH."

Journal • Preclinical • Cardiovascular • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Inflammation • Vascular Neurology • MRC1

Hyaluronic acid-based core-shell microneedles for staged local delivery of psoralen toward anti-inflammatory and cartilage-protective therapy of rheumatoid arthritis. (PubMed, Carbohydr Polym) - "In vitro and in vivo results showed that Mi@PSO/HPA MNs reduced inflammatory marker expression, modulated macrophage polarization-related markers toward an anti-inflammatory profile, preserved cartilage matrix-related markers, and alleviated joint damage in CIA mice under the tested treatment regimen. Overall, this work presents a hyaluronic acid-based polymer-engineered core-shell microneedle platform that combines minimally invasive administration, staged local delivery, inflammation control, and cartilage protection, offering a promising strategy for RA management."

Journal • Immunology • Inflammation • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Squamous Cell Carcinoma Arising Within a Mycosis Fungoides Plaque: A Case Report. (PubMed, Clin Cosmet Investig Dermatol) - "A 71-year-old man with a 30-year history of MF, no prior systemic therapy, psoralen plus ultraviolet A phototherapy, or topical chemotherapy, and limited prediagnostic narrowband ultraviolet B exposure developed a rapidly enlarging ulcerated mass within a lumbar MF plaque...A rapidly growing, ulcerated, or otherwise changing lesion within longstanding MF warrants prompt biopsy to exclude a second cutaneous malignancy. Compartment-specific interpretation of immunohistochemical findings is essential, and surgical excision can be feasible in MF-affected skin."

Journal • Cutaneous T-cell Lymphoma • Dermatology • Hematological Malignancies • Lymphoma • Mycosis Fungoides • Oncology • Skin Cancer • Squamous Cell Carcinoma • T Cell Non-Hodgkin Lymphoma • CD4

RAP-RNA: A Methodological Approach to Study Base-Pairing Between Endogenous RNAs. (PubMed, Methods Mol Biol) - "This chapter presents RNA Antisense Purification-RNA coupled to psoralen crosslinking (RAP-RNA[AMT]), a targeted method to capture direct RNA-RNA base-paired partners of a chosen lncRNA in its native cellular context...The protocol provides practical guidance on probe design, crosslinking parameters, essential controls, and quantitative analysis. Together, the step-by-step workflow enables high-specificity mapping of lncRNA-centered RRIs and can be adapted for focused validation across diverse targets and cell types."

Journal

Comprehensive determination of 17 furanocoumarins in umbelliferous vegetables, citrus fruits, and their processed products using QuEChERS–UHPLC–QqQ–MS/MS | Poster Board #1048 (ACS-Fall 2026) - "A QuEChERS-based extraction method coupled with ultra-high-performance liquid chromatography–triple quadrupole mass spectrometry (UHPLC–QqQ–MS/MS) was optimized for the quantitation of 17 furanocoumarins, including psoralen and angelicin...Overall, the results demonstrate that the proposed method provides a rapid and effective approach for furanocoumarin determination. This method is expected to serve as a valuable tool for future monitoring and risk assessment studies."

Phototherapy for Skin of Color in the Biologic Era: A Cross-Sectional Survey of Moroccan Dermatologists' Knowledge and Practice. (PubMed, Cureus) - "Most respondents rated their knowledge of indications as sufficient or better; however, only 17% (95% CI: 8-30%) identified the guideline-based psoralen plus ultraviolet A risk-monitoring threshold, and 34% (95% CI: 22-48%) identified the recommended minimum age for narrowband ultraviolet B. Most (70%) considered phototherapy to retain a major role alongside biologic and targeted therapies, and a majority reported offering it before escalation in psoriasis (83%), vitiligo (76%), and atopic dermatitis (62%)...Conclusions Moroccan dermatologists express strong support for phototherapy and report offering it before biologic and targeted therapies across major indications, but deficits in equipment access, guideline-based knowledge, and postgraduate training represent barriers to optimal practice. These findings highlight the need for further research, including objective competency assessments and clinical outcome studies, to inform strategies for equipment deployment,..."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Psoriasis • Vitiligo

A Review of Randomized Controlled Trials for Vitiligo Therapies Published Between 2013 and 2023. (PubMed, Cureus) - "We further narrowed our focus to studies that could be aggregated into the intervention categories: phototherapy and systemic combination therapy (n=10), topical and topical combination therapy (n=15), and systemic monotherapy (n=5).  Treated versus control subjects showed statistically improved VASI after the following interventions were added to phototherapy: oral psoralen, oral minipulsed prednisone, implanted afamelanotide, topical ethyl vanillate, topical bimatoprost, and oral vitamins A and E. Effective topical therapies were ruxolitinib, calcipotriol and betamethasone, tacrolimus and mometasone, and microdermabrasion and tacrolimus. None of the systemic monotherapies was superior to their corresponding comparator."

Journal • Review • Aesthetic Medicine • Dermatology • Immunology • Vitiligo

Psoralen promotes osteogenic differentiation of MC3T3-E1 cells by regulating mitophagy via PINK1/Parkin pathway (PubMed, Zhongguo Zhong Yao Za Zhi) - "Molecular docking results showed that the binding energy between psoralen and PINK1 was-7.024 kcal·mol~(-1), and 100 ns molecular dynamics simulations further confirmed the structural stability of the formed complex with persistent hydrogen bond interactions. In conclusion, psoralen directly targets and activates the PINK1/Parkin pathway to mediate mitophagy, clear damaged mitochondria, improve the oxidative stress microenvironment, promote the expression of osteogenic marker proteins and mineralization, thereby enhancing osteogenic differentiation of MC3T3-E1 cells, providing a new target and candidate drug for the prevention and treatment of osteoporosis."

Journal • Osteoporosis • Rheumatology • ANXA5 • PINK1 • RUNX2

Psoralen inhibits liver metastasis of colorectal cancer by regulating Notch/Snail pathway (PubMed, Zhongguo Zhong Yao Za Zhi) - "Mice were assigned into a normal group, a model group, low-, medium-, and high-dose psoralen groups, a 5-fluorouracil(5-FU) group, and a high-dose psoralen + Jagged1 group, with 12 mice in each group. Psoralen did not cause significant toxicity to hematopoietic, liver, or kidney functions at the tested doses. In conclusion, psoralen may inhibit liver metastasis of colorectal cancer by suppressing the Notch/Snail pathway."

Journal • Colorectal Cancer • Oncology • Solid Tumor • CDH1 • CDH2 • MMP2 • MMP9 • NOTCH1

Narrowband ultraviolet B and psoralen plus ultraviolet A phototherapy treatment for mycosis fungoides: a 17-year retrospective cohort study in a university teaching hospital, 2007-24. (PubMed, Skin Health Dis) - "NB-UVB and PUVA are effective and well tolerated for the treatment of MF. Hypopigmented variants and -early-disease stage predicted better outcomes."

Journal • Retrospective data • Cutaneous T-cell Lymphoma • Dermatology • Hematological Malignancies • Lymphoma • Mycosis Fungoides • Oncology • T Cell Non-Hodgkin Lymphoma

Valorization of Ficus carica Pruning Residues as Selective Botanical Insecticides: Optimized Furanocoumarin Extraction, Efficacy Against Neotropical Stink Bugs, and Mechanistic Insights via Molecular Docking. (PubMed, Arch Insect Biochem Physiol) - "Eight extracts were prepared under varying solvent, temperature, and acidity conditions, and analyzed for total phenolic content (TPC) and the key furanocoumarins psoralen and bergapten...The present work demonstrates that valorizing agro-industrial waste from F. carica can yield potent, selective, and environmentally safer insecticidal agents. The integration of extraction optimization, biological evaluation, and molecular modeling provides a robust framework for developing sustainable botanical insecticides, advancing circular economy principles in pest management and offering promising alternatives to synthetic neurotoxins."

Journal • Pain

Comparison of narrowband ultraviolet B with psoralen plus ultraviolet A phototherapy for patients with early-stage mycosis fungoides: a systematic review and meta-analysis. (PubMed, Skin Health Dis) - "Adverse effects, including erythema, nausea, pruritus, burning, hyperpigmentation, pain, phototoxic reactions and polymorphic light eruption, showed no significant differences between groups. Both PUVA and NB-UVB are effective, but PUVA may be preferred when sustained remission is the primary therapeutic goal."

Journal • Retrospective data • Review • Cutaneous T-cell Lymphoma • Dermatology • Hematological Malignancies • Lymphoma • Mycosis Fungoides • Oncology • Pain • Pediatrics • Pruritus • T Cell Non-Hodgkin Lymphoma

Psoralen and Seselin Stabilize the α-helix Structure in Lysozyme and Inhibit the α-helix to β-sheet Exchange: An Efficient Anti-Amyloidogenic Mechanism. (PubMed, Adv Pharm Bull) - "In agreement with experimental results, the molecular docking studies confirmed the conformational changes of HEWL upon interaction with psoralen and seselin. This study adds to the body of knowledge about rational drug design against the amyloidogenesis process."

Journal • CNS Disorders

In Vivo Evaluation of Psoralen in a Copper Sulfate-Induced Chick (Gallus gallus domesticus) Emesis Model and In Silico Analysis of Its Interaction With D2, 5-HT3 A, and Muscarinic Receptors. (PubMed, ChemistryOpen) - "A dose-dependent experimental design was employed with PSN (5, 10, and 20 mg/kg), alongside standard antiemetics (domperidone 6 mg/kg, ondansetron (OND) 5 mg/kg, and hyoscine 21 mg/kg) and combination treatments. PSN demonstrates significant antiemetic activity in a validated chick emesis model, supported by moderate binding affinity toward key emesis-related receptors. While docking findings suggest possible receptor interactions, further mechanistic and translational studies are required to confirm the molecular basis of its activity."

Journal • Preclinical

Psoralen regulates bone degenerative diseases by inhibiting APP phosphorylation to regulate MAPK and STAT3 signaling. (PubMed, Am J Transl Res) - "The phosphorylation of APP promotes the occurrence and progression of bone degenerative diseases. Psoralen regulates bone degenerative diseases by inhibiting APP phosphorylation, and regulating the MAPK and STAT3 signaling pathways."

Journal • Immunology • Osteoarthritis • Osteoporosis • Pain • Rheumatology • APP • Aβ42 • TNFA

Psoralen enhances direct cardiac reprogramming via activating PPARα and driving mitochondrial fission and improves cardiac function after myocardial infarction. (PubMed, Stem Cell Res Ther) - "Psoralen enhances chemical direct cardiac reprogramming by activating metabolic and structural maturation programs through mitochondrial fission and PPARα-dependent signaling. The combined treatment provides functional benefits in myocardial infarction, highlighting psoralen as a promising small molecule for cardiac regeneration."

Journal • Cardiovascular • Fibrosis • Immunology • Myocardial Infarction • PPARA

The effects of lactic acid bacteria fermentation on the conversion of tartary buckwheat flavonoids and their inhibitory activity on starch-digesting enzymes. (PubMed, Food Microbiol) - "Metabolomic analysis further revealed the generation of novel flavones such as psoralen, quercetagetin, and scutellarein. The fermented tartary buckwheat exhibited potent inhibition against key starch digestive enzymes, with inhibition rates of 46.43% against α-glucosidase and 54.09% against α-amylase. This work systematically elucidates how mixed fermentation enhances the anti-digestive function of tartary buckwheat by driving flavonoid biotransformation, providing both theoretical foundation and practical microbial resources for developing high-bioavailability tartary buckwheat functional foods with low-glycemic properties."

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Analysis of Angelica Root Marker Constituents and Furocoumarins in a Dietary Supplement Containing Angelica gigas by Liquid Chromatograph-Mass Spectrometer with a Photodiode Array Detector (PubMed, Shokuhin Eiseigaku Zasshi) - "For confirmation of each compound, the mass spectrometer's selected ion monitoring conditions were optimized. The analytes, ferulic acid, nodakenin, psoralen, xanthotoxin, bergapten, decursin, and decursinol angelate, were detected in the dietary supplement via this analytical method."

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Pharmacokinetic Study of Five Lead Components of Psoraleae Fructus in Human Serum by UHPLC-Q-TOF-MS and UHPLC-QqQ-MS/MS after Oral Administration of Qing'e Pills. (PubMed, J Sep Sci) - "For quantitative evaluation, a sensitive and selective UHPLC-triple quadrupole-tandem MS (UHPLC-QqQ-MS/MS) method was developed and fully validated for simultaneous determination of five representative analytes (psoralen, isopsoralen [IP], bavachin, neobavaisoflavone, and corylin) in human serum, with osalmid as the internal standard...Isopsoralen was rapidly absorbed (detectable within 0.5 h), reached a maximum concentration of 85.47 ± 28.96 ng/mL at 1.5 h, and exhibited an area under the curve of 619.52 ± 160.25 ng·h/mL with a terminal half-life of 5.06 ± 0.28 h, suggesting limited systemic exposure with moderate elimination. Collectively, this validated UHPLC-QqQ-MS/MS platform provides a practical approach for chemical profiling and human PK evaluation of coumarins and flavonoids from Qing'e Pills."

Journal • PK/PD data

Granulomatous Mogamulizumab-Associated Rash Mimicking Disease Progression in Erythrodermic Mycosis Fungoides (BAD 2026) - "Previous treatments included narrowband ultraviolet B, oral psoralen–ultraviolet A and bexarotene...Mogamulizumab was discontinued due to the severity of cutaneous involvement, and the patient was treated with topical clobetasol propionate and methotrexate 20 mg weekly, resulting in clinical improvement...Cutaneous side effects are commonly reported with mogamulizumab; however, cases of scalp damage with alopecia are rarer. Recognition of MAR is essential to avoid misdiagnosis and initiate inappropriate escalation of lymphoma-directed therapy."

IO biomarker • Alopecia • Cutaneous T-cell Lymphoma • Dermatology • Hematological Malignancies • Immunology • Lymphoma • Mycosis Fungoides • Oncology • Sezary Syndrome • CCR4 • CD2 • CD4 • CD7 • CD8 • TNFRSF8

Folliculotropic mycosis fungoides in a patient with facial implants: a role for chronic antigenic stimulation? (BAD 2026) - "The patient achieved a partial response following 40 sessions of psoralen– ultraviolet A therapy and is currently being treated with pegylated interferon...Although FMF has a recognized predilection for the head and neck, the marked localization and accentuation of disease adjacent to the implants raise the possibility that chronic antigen-driven immune activation may contribute to tumour evolution. While causality cannot be established, this case and literature review support a potential role for chronic antigenic stimulation in CTCL pathogenesis and highlight the need for increased clinical awareness and further research."

Clinical • Cutaneous T-cell Lymphoma • Dermatology • Hematological Malignancies • Lymphoma • Mycosis Fungoides • Non-Hodgkin’s Lymphoma • Oncology • Sezary Syndrome • T Cell Non-Hodgkin Lymphoma • CD4

The contribution of Hume Street Hospital to Patch testing in Ireland (BAD 2026) - "She pursued dermatology in Leeds, Belfast and Newcastle upon Tyne, where her Medical Research Councilfunded clinical trial comparing psoralen plus ultraviolet A vs. dithranol for psoriasis was published in The Lancet...The Dr Paul Collins Fellowship supports Irish dermatology trainees undertaking overseas patch-testing fellowships, while the Rogers Prize recognizes her contribution to dermatology research. They both contributed enormously to dermatology in Ireland both clinically and academically."

Clinical • Contact Dermatitis • Dermatitis • Immunology • Psoriasis

High-Resolution Mapping of RNA-RNA Interactions Across the HIV-1 Genome With HicapR. (PubMed, Bio Protoc) - "Here, we describe HiCapR, a protocol integrating in vivo psoralen crosslinking, RNA fragmentation, proximity ligation, and hybridization capture to specifically enrich viral RNA-RNA interactions...• This protocol efficiently captures low-abundance RNA from complex samples. • This protocol provides a new, accurate, and highly sensitive platform for detecting and analyzing specific RNA-RNA interactions, such as those in viral RNAs."

Journal • Human Immunodeficiency Virus • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Swiss Practice Recommendations for Chronic Prurigo Including Prurigo Nodularis. (PubMed, Int J Dermatol) - ""We recommend" applies to topical corticosteroids, narrow-band ultraviolet B (NB-UVB), dupilumab, and nemolizumab; "We suggest" to topical calcineurin inhibitors, zinc oxide dressings, cryotherapy, intralesional corticosteroids, gabapentinoids, antidepressants, methotrexate, ciclosporin, μ-opioid receptor antagonists, Janus kinase inhibitors, and cognitive behavioral techniques; and "Can be considered" to capsaicin, ultraviolet A1 (UVA1), psoralen plus ultraviolet A (PUVA), and sedating antihistamines for sleep. No recommendation could be made for azathioprine, non-sedating antihistamines, κ-opioid receptor agonists, retinoids, neurokinin-1 receptor antagonists, thalidomide, or lenalidomide. These recommendations provide comprehensive, up-to-date guidance for CPG, supporting clinicians in Switzerland and internationally."

Journal • Review • Dermatology • Immunology • Prurigo Nodularis • Pruritus

Segmental PASI Evaluation Reveals Reduced PUVA Responsiveness of Lower-Limb Psoriasis in Patients with Internal Organ Malignancy. (PubMed, J Clin Med) - "While Psoralen and Ultraviolet A (PUVA) photochemotherapy remains a valuable non-immunosuppressive alternative, regional variations in therapeutic response are not well-characterized in this population...Nevertheless, lower-limb psoriasis is relatively recalcitrant and contributes disproportionately to residual disease burden and relapse. These findings support the use of regional PASI assessment to guide individualized management and clinical expectations in this complex patient group."

Journal • Dermatology • Immunology • Oncology • Psoriasis