aprotinin / Generic mfg. - LARVOL DELTA

PROTEOMIC CHARACTERIZATION OF APROTININ'S IMMUNE-MODULATING ROLE IN RENAL FIBROSIS FOLLOWING UUO (ISN-WCN 2026) - "These findings underscore the therapeutic potential of serine protease inhibitors in immune-driven kidney disease and highlight CTSS as a promising molecular target.Download: Download high-res image (295KB)Download: Download full-size imageA schematic summarizes aprotinin's immunomodulatory effects in UUO, highlighting CTSS downregulation and restoration of CD4+ T cell balance.I have potential conflict of interest to disclose.This study was supported by the Yunnan Fundamental Research Projects (202501AU070020), the Ten Thousand Talent Plan for Medical Expert of Yunnan Province (YNWR-MY-2018-019), and the National Natural Science Foundation of China (82460150).I used generative AI and AI-assisted technologies in the writing process.During the preparation of this work, the authors used ChatGPT (OpenAI) in order to improve the language clarity and readability. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for..."

Acute Kidney Injury • Chronic Kidney Disease • Fibrosis • Immunology • Inflammation • Nephrology • Renal Disease • CD4 • CTSS

Protease inhibitor regulation of proteins involved in heat-induced leaf senescence in creeping bentgrass. (PubMed, Ann Bot) - "The protease inhibitor regulated various proteins that could be involved in mitigating heat-induced leaf senescence. Identification of upstream molecular factors for the specific protease inhibitor-responsive proteins will provide further insight into mechanisms of controlling leaf senescence."

Journal • Targeted Protein Degradation

ICI24/00011: CLINICAL TRIAL WITH APROTININ IN THE ACUTE RESPIRATORY DISTRESS SYNDROME TREATMENT (clinicaltrialsregister.eu) - P2/3 | N=156 | Not yet recruiting | Sponsor: Fundacion Del Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion

New P2/3 trial • Acute Respiratory Distress Syndrome • Pulmonary Disease • Respiratory Diseases

Trends and Variations in the Use of Procoagulants in Pediatric Cardiac Surgery: An STS-CHSD Analysis (STS 2026) - "Methods The STS-CHSD was queried for index cardiac operations performed with the use of cardiopulmonary bypass in patients (<18y) from 2014–2023 to identify the intra-operative use of procoagulants (Activated Factor-VIIa, 3 and 4-Factor Prothrombin Complex Concentrates, 4-Factor-Prothrombin Complex Concentrates with Activated Factor-VIIa, Fibrinogen concentrate, Desmopressin, Humate-P, Antithrombin-3) and anti-fibrinolytics (Aminocaproic acid, Tranexamic acid, Aprotinin). Further studies are needed to develop evidence-based protocols for hemostatic agent use in pediatric cardiac surgery and to evaluate their associations with bleeding and resource utilization. Table Image"

Clinical • Late-breaking abstract • Surgery • Cardiovascular • Hematological Disorders • Pediatrics • STAT5

Coc-SEPP1B: Expression of Protein Tyrosine Phosphatase 1B (PTP1B) and Body Composition Modification in Patients With Septic Shock (clinicaltrials.gov) - P=N/A | N=52 | Completed | Sponsor: University Hospital, Rouen | Unknown status ➔ Completed

Trial completion • Septic Shock

Isolation and Characterization of a Biocontrol Serine Protease from Pseudomonas aeruginosa FZM498 Involved in Antagonistic Activity Against Blastocystis sp. Parasite. (PubMed, Biomolecules) - "Inhibition by PMSF, TLCK, aprotinin, benzamidine, and SBTI protease reagents suggests a serine protease family...This could be a promising, eco-friendly, natural alternative as an anti-Blastocystis agent. The objective of this study was to isolate, purify, and biochemically characterize an extracellular serine protease produced by gut-associated bacteria, as well as to assess its in vitro anti-Blastocystis efficacy as a potential natural and ecologically friendly antiparasitic therapy."

Journal • Gastrointestinal Disorder

HSP90α and KLK6 Coregulate Stress-Induced Prostate Cancer Cell Motility. (PubMed, Cells) - "Screening for protease inhibitors that would rescue stress-induced decreases in MMP-2 activity identified a single serine protease inhibitor: aprotinin...In conclusion, we identify a novel stress-induced extracellular network that regulates MMP-2 activity and cell motility. We identified KLK6 as a stress-induced extracellular protease leading to decreased MMP-2 activity and cellular invasion, while eHSP90α is required for the rescue of MMP-2 activity once KLK6 is neutralized."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • CDC37 • HSP90AA1 • KLK6 • MMP2

Effectiveness and safety of antifibrinolytic agents in off-pump coronary artery bypass grafting: a systematic review and meta-analysis. (PubMed, Braz J Anesthesiol) - "In off-pump CABG, antifibrinolytics reduced the need for blood transfusion while reducing thromboembolic events and overall mortality in RCT subgroups, while pooled analyses combining RCTs and observational studies did not demonstrate significant reductions. PROSPERO LINK: https://www.crd.york.ac.uk/PROSPERO/view/CRD42024545640."

Journal • Retrospective data • Review • Cardiovascular • Critical care

Human CELA1 has pancreatic elastase-like activity. (PubMed, Biochimie) - "We show that pro-hCELA1 cleavage by trypsin is blocked by aprotinin. We have determined the enzyme kinetics of the active fraction of recombinant hCELA1 and show that it follows steady-state kinetics with a higher substrate affinity than commercial porcine pancreatic elastase."

Journal • ELANE

HSP90α and KLK6 Co-Regulate Stress-Induced Prostate Cancer Cell Motility. (PubMed, bioRxiv) - "Screening for protease inhibitors that would rescue stress-induced decreases in MMP-2 activity identified a single serine protease inhibitor: aprotinin...We identify a novel stress-induced extracellular network that regulates MMP-2 activity and cell motility. We identified KLK6 as a stress-induced extracellular protease leading to decreased MMP-2 activity and cellular invasion, while eHSP90α is required for the rescue of MMP-2 activity once KLK6 is neutralized."

Journal • Genito-urinary Cancer • Oncology • Prostate Cancer • Solid Tumor • CDC37 • HSP90AA1 • KLK6 • MMP2

CLINICAL TRIAL WITH APROTININ IN THE ACUTE RESPIRATORY DISTRESS SYNDROME TREATMENT (clinicaltrials.gov) - P3 | N=156 | Not yet recruiting | Sponsor: Fundacion del Hospital Nacional de Paraplejicos para la Investigacion y la Integracion

New P3 trial • Acute Respiratory Distress Syndrome • Pulmonary Disease • Respiratory Diseases

Risks and Harms to Physicians Reporting Hematologic Adverse Drug Reactions (ADRs) to Health Authorities (ASH 2024) - "ADR findings resulted in drug removal (n = 7; Vioxx, Avandia, Bextra, Celebrex, Trasylol, Phenyl propanolamine, Hydroxy-ethyl starch), revised indications (n = 2) (Procrit, Aranesp 2007, 2008, 2010)) or 10-year delay in FDA-approval (n = 1) (Fereprox)...Pharmaceutical companies paid $600,000 (Fereprox) to $5.8 billion (Vioxx) in fines and settlements.Discussion : Twelve physicians experienced severe threats and/or harms after reporting hematologic-associated ADRs to Health Authorities and/or in major publications. We suggest physicians not sign secrecy agreements that might jeopardize public safety (as currently established by almost all US medical universities) and should partner with independent drug safety monitoring boards (DSMBs) on ADR evaluations to monitor safety concerns of drugs and medical devices."

Adverse drug reaction • Hematological Disorders • Oncology • Solid Tumor

Characterization of the enzymatic activities of cultured human fecal bacteria and their anti-Blastocystis effects (ASTMH 2025) - "Additionally, it was inhibited by PMSF, TLCK, aprotinin, benzamidine, and SBTI, which suggests that it belongs to the serine protease family...SEM analysis showed that most Blastocystis cells lost their integrity, suffered damage, and underwent perforation after 4 h of anaerobic incubation. This finding suggests that this protease may be a promising anti-Blastocystis natural alternative."

Gastrointestinal Disorder

Comparative Efficacy of Perioperative Blood Conservation Agents in Pediatric Cranial Vault Remodeling: A Systematic Review and Network Meta-Analysis. (PubMed, Neurosurgery) - "Our meta-analysis reveals that TXA + ACA reduce red blood cell transfusion rates and volumes, with TXA + EPO + iron and ACA + EPO being most effective. This highlights the superiority of combination therapies and underscores the need for structured multimodal protocols in perioperative blood conservation for pediatric CVR."

Journal • Retrospective data • Cardiovascular • Pediatrics

Towards Advanced Imaging of Cardiac Amyloidosis: Reassessing Aprotinin with 64 Cu Radiolabeling (EANM 2025) - "Although heat-based labeling is effective, it poses a risk of compromising protein structure and altering biological function, making laser labeling the more favorable method. Moreover, ⁶⁴Cu-labeled aprotinin would apply for PET/CT imaging offering superior diagnostic accuracy compared to early scintigraphis studies These findings are preliminary, and further refinement of reaction conditions could lead to improved outcomes."

Metastases • Amyloidosis • Cardiac Amyloidosis • Cardiomyopathy • Cardiovascular

HYPERCOAGULABLE PROFILE OF PREGNANT WOMEN WITH PREECLAMPSIA AND HYPOCOAGULABLE PROFILE OF THEIR OFFSPRING BASED ON ROTATIONAL THROMBOELASTOMETRY ASSESSMENT (FIGO 2025) - "This study evaluates the hemostatic profiles of PE women and their newborns through CCTs and ROTEM (Intrinsic-INTEM, Extrinsic-EXTEM, Fibrinogen-FIBTEM, and Aprotinin-APTEM)... CCTs for mothers and neonates do not consistently reflect hemostatic variations. PE women display a hypercoagulable state and heightened fibrinolysis compared to healthy controls, affecting clot initiation, amplification, and stability. Conversely, during the first hour of life, neonates from PE mothers exhibit a hypocoagulable profile compared to those from healthy mothers, with noted changes in amplification and propagation phases."

Clinical • Gynecology

Multiscale theoretical study of infrared spectroscopy for the thermal denaturation process of aprotinin. (PubMed, J Mol Model) - "After the simulation, the C = O stretching vibrations of peptide bonds were extracted from the trajectory files to calculate the autocorrelation function and third-order nonlinear response function, which were Fourier transformed to obtain the 1D and 2D IR spectra of aprotinin. The DSSP program in GROMACS was used to quantitatively analyze the secondary structure content of aprotinin at various temperatures, and the conformational changes under different temperature conditions were visually analyzed by using VMD software."

Journal

Therapeutic Potential of Tubular Serine Protease Inhibitors in Proteinuria. (PubMed, Am J Physiol Renal Physiol) - "Serine protease inhibitors, such as aprotinin, camostat mesylate, and nafamostat mesylate, as well as off-target effects of amiloride, have shown promise in preclinical and early clinical studies by mitigating these pathological processes. We identify key knowledge gaps, including the need for mechanistic pharmacodynamic trials, biomarker-guided patient selection using urinary serine protease activity, and long-term efficacy and safety studies. Serine protease inhibitors are a promising, underexplored therapeutic strategy in proteinuric conditions that may complement existing treatments by targeting specific pathogenic mechanisms involved in disease progression."

Journal • Chronic Kidney Disease • Fibrosis • Immunology • Inflammation • Nephrology • Renal Disease

Rotational Thromboelastometry (ROTEM) Hemostasis Profile in Pregnant Women with Preeclampsia and Their Offspring: An Observational Study. (PubMed, Diagnostics (Basel)) - "ROTEM (Intrinsic (INTEM), Extrinsic (EXTEM), Fibrinogen (FIBTEM), Aprotinin (APTEM)), and CCTs were performed...Several alterations were not reflected in CCTs. Further prospective studies should evaluate the role and clinical utility of combining ROTEM with CCTs for hemostatic monitoring in women with PE and their neonates."

Journal • Observational data • Cardiovascular • Gynecology • Hematological Disorders • Hypertension • Thrombocytopenia

A Case Description of Spontaneous Intracardiac Thrombogenesis During Mitral Valve Repair: A Complication of Aminocaproic Acid? (PubMed, A A Pract) - "Antifibrinolytic agents such as aprotinin and lysine analogs are used to mitigate hyperfibrinolysis. Although epsilon-aminocaproic acid (EACA) is generally considered safe, dosing regimens vary, and thrombotic complications are underreported in national registries. We describe a case of acute intracardiac thrombosis shortly after EACA administration during mitral valve repair in a patient with no known hematologic or hypercoagulable conditions. ."

Journal • Cardiovascular • Hematological Disorders • Inflammation • Thrombosis

Antifibrinolytics-aprotinin in cardiac surgery. (PubMed, Anaesth Intensive Care) - No abstract available

Journal • Cardiovascular

Half-dose versus full dose of aprotinin in cardiac surgery: a post-hoc analysis of the aprotinin European Registry. (PubMed, Eur J Cardiothorac Surg) - "Patients receiving the FD aprotinin regimen had less surgical re-exploration than those receiving the HD regimen. An increased risk of early postoperative AKI was observed in the FD group, mainly for patients with preoperative chronic kidney disease."

Journal • Retrospective data • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Nephrology • Renal Disease

Innovative strategies in coagulation management for cardiothoracic surgery: a narrative review of pharmacological and nonpharmacological approaches. (PubMed, J Cardiothorac Surg) - "The use of pharmacological interventions such as tranexamic acid, heparin, and aprotinin minimizes bleeding but increases the associated risks of renal impairment and seizures. Recent advancements in this context include novel hemostatic agents, prothrombin complex concentrates, and direct oral anticoagulants. Future research should not only explore the combined use of pharmacological and nonpharmacological strategies but also evaluate the long-term effects and cost-effectiveness of integrated approaches during cardiothoracic surgery, particularly in high-risk populations."

Journal • Review • CNS Disorders • Epilepsy • Hematological Disorders • Metabolic Disorders • Pediatrics • Renal Disease

Blood collection tubes with protease inhibitors to prevent falsely high renin concentrations due to cryoactivation. (PubMed, Clin Chim Acta) - "Our study shows more cryoactivation of renin in plasma aliquots stored at -20 °C compared to storage at + 4 °C. Cryoactivation of prorenin in trypsin inhibitor and protease inhibitor cocktail tubes was reversed by a 2-hours incubation at 37 °C, which may be an alternative procedure for laboratories that are not able to store renin samples in -80 °C freezers."

Journal

Variability in Oxytocin Blood Levels in Rats: A Review and Experimental Insights. (PubMed, Clin Psychopharmacol Neurosci) - "Furthermore, we investigated the effects of two anesthetic protocols (inhaled isoflurane and a combination of three anesthetics) and the proteinase inhibitor aprotinin on plasma oxytocin levels in adult male rats. Our findings revealed that neither the anesthetics nor aprotinin significantly affected plasma oxytocin levels. We also discussed potential factors contributing to the marked differences in reported rat blood oxytocin levels."

Journal • Preclinical • Anesthesia