methimazole / Generic mfg. - LARVOL DELTA

Thyrotoxicosis-Induced Chordal Rupture Causing Severe Mitral Regurgitation: Surgical Management and Outpatient Recovery. (PubMed, JACC Case Rep) - "Thyrotoxicosis can cause chordal rupture and flail leaflet. Repair is preferred, but replacement is appropriate when repair is not durable. Management requires endocrine-cardiac coordination and individualized antithrombotic therapy. Expect early ejection-fraction decline after surgical correction."

Journal • Atrial Fibrillation • Cardiovascular • Endocrine Cancer • Heart Failure

Methimazole-triggered pancytopenia in a long-term methotrexate user: Dual-agent myelotoxicity (ASH 2025) - "Dual-agent myelotoxicity must be considered when pancytopenia develops in patients on MTX and MMI, even if one agent has been long tolerated. This case highlights the importance of early recognition of cytopenic symptoms, interdisciplinary coordination, and cautious reintroduction of necessary therapies in high-risk patients. While MTX may have emerging roles in endocrine disease, this case underscores the necessity of individualized risk-benefit assessment in polypharmacy."

Agranulocytosis • Chronic Kidney Disease • Diabetes • Endocrine Disorders • Febrile Neutropenia • Granulocytopenia • Grave’s Disease • Hematological Malignancies • Immunology • Inflammatory Arthritis • Metabolic Disorders • Mucositis • Nephrology • Renal Disease • Rheumatoid Arthritis • Rheumatology • Type 2 Diabetes Mellitus

Case Series of de novo occurrence of Graves' Disease Following Thermal Ablation for Benign Thyroid Nodules: An uncommon event that should be considered. (PubMed, Eur Thyroid J) - "One case occurred during pregnancy and was managed with propylthiouracil; the others received antithyroid treatment with methimazole. Routine TRAb screening before TA is not currently justified; however, clinical awareness is essential to distinguish transient post-ablation thyrotoxicosis from true GD and to ensure timely initiation of antithyroid therapy when appropriate. Despite these rare cases, the overall incidence remains very low, confirming the excellent safety profile of TA for benign thyroid nodules."

Journal • Endocrine Disorders • Grave’s Disease

Reversible splenial lesion syndrome associated with Graves' disease and hepatic dysfunction: a case report. (PubMed, Front Neurosci) - "This study presents a case of a patient with RESLES characterized by Graves' disease and liver function abnormalities, who was sensitive to anti-thyroid drug (methimazole) and hormone therapy (methylprednisolone sodium succinate) and had a favorable prognosis. This study contributed to expanding the clinical understanding of RESLES and suggests that, in clinical practice, autoimmune hyperthyroidism may be a novel trigger for RESLES, while concurrent liver dysfunction in this context requires further investigation."

Journal • CNS Disorders • Endocrine Disorders • Epilepsy • Grave’s Disease • Hepatology • Immunology • Infectious Disease • Liver Failure • Metabolic Disorders • Pain • Psychiatry

Hirata Syndrome Clinical Presentation and Management: A Single-Centre Experience. (PubMed, J ASEAN Fed Endocr Soc) - "Six IAS cases were identified, with most linked to α-lipoic acid in multivitamins and one to methimazole...Management included discontinuation of causative drugs, dietary changes with frequent complex carbohydrate meals, and pharmacotherapy (acarbose or prednisolone)...Early diagnosis using IAA measurement and appropriate management, including drug discontinuation, dietary adjustments, and pharmacotherapy, is essential. Further research is needed to refine treatment strategies and understand the pathogenesis of this rare syndrome."

Journal • Hypoglycemia • Immunology

Could increased thiamazole sales among children in Belgium during the pandemic indicate a surge in Graves' disease cases? (PubMed, J Endocrinol Invest) - No abstract available

Journal • Endocrine Disorders • Grave’s Disease • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Targeting transsulfuration via suppression of thyroid hormone signaling: a modified phase 1/2 and pharmacodynamic trial of methimazole in patients with progressive WHO grade 4 gliomas (SNO 2025) - "Patients may have received unlimited prior regimens including bevacizumab. Conclusions : Induction of subclinical hypothyroidism is feasible and safe in rGBM with significant increases in plasma but not tumor HPC. Further tumor correlative data for the dose-escalated methimazole will be presented."

Clinical • P1/2 data • PK/PD data • Brain Cancer • Endocrine Disorders • Glioblastoma • Glioma • Solid Tumor

Predictors of a response to radioactive iodine therapy in hyperthyroidism - ablative dose concept: a 23-year single center 914-patient experience. (PubMed, Rev Esp Med Nucl Imagen Mol (Engl Ed)) - "GD and a shorter duration of previous ATD therapy are independent predictors of post-therapeutic hypothyroidism in patients treated for hyperthyroidism with RAI, with younger age also being an independent predictor of a late response."

Journal • Endocrine Disorders • Grave’s Disease

Use of Carbimazole, Methimazole and Propylthiouracil in Women of Childbearing Age and Exposed Pregnancies in Germany: A Population-Based Study. (PubMed, Drugs Real World Outcomes) - "The prescription prevalence of ATD overall and specifically of CMZ/MMI in girls and women of childbearing age decreased between 2005 and 2020 in Germany. The decrease in exposure to CMZ/MMI at pregnancy onset indicates that physicians became increasingly aware of the potential risks of CMZ/MMI to the unborn child."

Journal • Endocrine Disorders • Obstetrics

In vitro and in vivo thyroid hormone system disruption by perfluorooctane sulfonate (PFOS) and tetrabromobisphenol A (TBBPA). (PubMed, Toxicology) - "While current in vivo test methods reliably detect disruptions from potent antithyroid drugs such as propylthiouracil (PTU) and methimazole (MMI) through thyroid gland histopathology, they may lack sensitivity for less potent chemicals or those acting through alternative mechanisms. These findings demonstrate distinct TH-disrupting profiles of PFOS and TBBPA, differing from classic antithyroid compounds PTU and MMI. Our results highlight the need for more comprehensive systems-approaches to capture TH disrupting chemicals acting through diverse mechanisms."

Journal • Preclinical

Targeting transsulfuration via suppression of thyroid hormone signaling: a modified phase 1/2 and pharmacodynamic trial of methimazole in patients with progressive WHO grade 4 gliomas (WFNOS 2025) - "Patients may have received unlimited prior regimens including bevacizumab. Conclusions : Induction of subclinical hypothyroidism is feasible and safe in rGBM with significant increases in plasma but not tumor HPC. Further tumor correlative data for the dose-escalated methimazole will be presented."

Clinical • P1/2 data • PK/PD data • Brain Cancer • Endocrine Disorders • Glioblastoma • Glioma • Oncology • Solid Tumor

Guiding methimazole therapy of autoimmune thyroid disease with thyroid antibody profiles: A predictive and causal inference study. (PubMed, Pak J Pharm Sci) - "Thyroid-stimulating hormone receptor antibody positivity was highly predictive of the clinical decision to start Methimazole treatment in Graves' disease. The findings suggest that anti-thyroid peroxidase antibody preference for screening and thyroid antibody profile use in treatment planning can guide clinical decision-making, within the constraints of causal inference assumption employed."

Journal • Retrospective data • Endocrine Disorders • Grave’s Disease • Immunology

Thyrotoxicosis Secondary to Gestational Trophoblastic Disease: A Rare Complication With Clinical Relevance. (PubMed, Cureus) - "Management included antithyroid therapy with methimazole (thionamide), beta-blockers, and systemic chemotherapy, given the characteristics of the neoplasm. This case highlights the importance of a multidisciplinary approach in rare conditions such as GTD associated with thyrotoxicosis, where endocrine stabilization and targeted chemotherapy are the fundamental pillars for optimizing clinical and oncological prognosis."

Journal • Endocrine Disorders • Gestational Trophoblastic Neoplasia • Oncology

ANCA Alert: A Curious Case of Amikacin-Induced Vasculitis (KIDNEY WEEK 2025) - "Introduction Drug induced-antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is commonly caused by medications such as hydralazine, propylthiouracil, methimazole, and minocycline, but to date, amikacin has not been reported in the literature.We present the first case of AAV with renal involvement with amikacin as the unusual culprit...Empiric piperacillin-tazobactam and intravenous fluids were started...The patient was discharged on prednisone with plans for outpatient rituximab and avacopan...Plasma exchange and steroids resulted in significant improvement in renal function shortly after initiation which can be associated with return of renal function and creatinine apheresis. As we learn more about renal involvement in AAV, the list of causative agents expands."

Clinical • ANCA Vasculitis • Benign Prostatic Hyperplasia • Chronic Kidney Disease • Glomerulonephritis • Infectious Disease • Lupus Nephritis • Nephrology • Renal Disease • Vasculitis • MPO

Atypical Anti-GBM Disease: Importance of Biopsy and Pathway Towards New Epitopes (KIDNEY WEEK 2025) - "Case Description A 46 y.o. male with hypertension and uncontrolled Graves’ disease on methimazole presented with several days of nausea and vomiting and sudden onset lower extremity edema...He was treated with IV steroids and IV cyclophosphamide and discharged on a steroid taper...It also underscores the importance of kidney biopsy in the setting of an active urine sediment, even when kidney function is improving. Our case offers additional insight into this rare disease and may speed discovery of previously unknown GBM epitopes that contribute to disease."

Biopsy • Acute Kidney Injury • ANCA Vasculitis • Cardiovascular • Endocrine Disorders • Focal Segmental Glomerulosclerosis • Glioblastoma • Glomerulonephritis • Grave’s Disease • Human Immunodeficiency Virus • Hypertension • Infectious Disease • Lupus Nephritis • Nephrology • Rare Diseases • Renal Disease • Vasculitis

Cerebral Infarction As a Complication of a Hypercoagulable State in the Setting of Hyperthyroidism: A Case Presentation (ASH 2024) - "He was initiated on propranolol, methimazole, and hydrocortisone. Clinicians should maintain a high index of suspicion for hyperthyroidism as a potential cause of thromboembolic events. Prompt treatment of hyperthyroidism is essential to prevent complications."

Clinical • Asthma • Atrial Fibrillation • Cardiomyopathy • Cardiovascular • CNS Disorders • Diabetes • Endocrine Disorders • Epilepsy • Grave’s Disease • Hematological Disorders • Immunology • Inflammatory Arthritis • Ischemic stroke • Metabolic Disorders • Pulmonary Embolism • Respiratory Diseases • Type 1 Diabetes Mellitus

A Rare Case of Warm Autoimmune Hemolytic Anemia and Massive Splenomegaly in Uncontrolled Grave's Disease (ASH 2024) - "Clinical signs include anemia, jaundice, and mild to moderate splenomegaly.Case Presentation : A 36-year-old man with a history of Graves' disease (GD) (on methimazole) presented with jaundice...He was started on filgrastim 300 mcg 2 times a week for his leukopenia...The patient was discharged on daily prednisone and planned weekly rituximab infusions for AIHA...The response to treatment for AIHA suggests an autoimmune nature of the condition, but the underlying GD did not respond to medical therapy. Overall, this case adds to the literature, as a unique hematologic presentation of an uncontrolled autoimmune disorder."

Clinical • Anemia • Autoimmune Hemolytic Anemia • Endocrine Disorders • Grave’s Disease • Hematological Disorders • Hematological Malignancies • Hepatology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Leukemia • Leukopenia • Lymphoma • Myelodysplastic Syndrome • Non-Hodgkin’s Lymphoma • Oncology • HP

A de novo pathogenic variant in TSHR expanding the phenotype of persistent sporadic congenital non-autoimmune hyperthyroidism: a case report and literature review. (PubMed, Transl Pediatr) - "Multidisciplinary management included methimazole, metoprolol, diuretics, and staged procedures: emergent ventriculoperitoneal shunting preceding mitral valvuloplasty with chordal reconstruction under cardiopulmonary bypass...Early pharmacologic intervention coupled with valve-sparing surgery can restore valvular integrity. The necessity for further neurosurgical intervention in the subsequent management of cerebellar tonsillar herniation requires further longitudinal follow-up."

Journal • Cardiovascular • CNS Disorders • Endocrine Disorders • Heart Failure • Immunology • Pediatrics • Pulmonary Disease • Ventriculomegaly • TSHR

Selenium status and supplementation in thyroid disorders: A narrative review of current evidence. (PubMed, J Trace Elem Med Biol) - "In GD and GO, Se supplementation, especially when combined with methimazole, has been shown to enhance hormone normalization and antioxidant capacity, although results vary across studies. In AIT and HT, consistent reductions in thyroid autoantibodies and inflammatory markers have been observed following Se supplementation, particularly with selenomethionine...In conclusion, Se supplementation offers potential therapeutic benefits, particularly in autoimmune thyroid diseases. However, further well-designed randomized-controlled trials are necessary to define the optimal form, dose, and duration of supplementation and to clarify its role across diverse thyroid conditions."

Journal • Review • Endocrine Disorders • Grave’s Disease • Immunology • Oncology • Solid Tumor • Thyroid Eye Disease • Thyroid Gland Carcinoma

Severe lymphocytopenia induced by methimazole tablets: A rare case report. (PubMed, Medicine (Baltimore)) - "Through the assessment of adverse drug reactions correlation and analysis of susceptibility factors, we recognized the importance of medication education and demonstrated that changes in clinical practice can save lives."

Journal • Agranulocytosis • Endocrine Disorders • Granulocytopenia • Hematological Disorders • Infectious Disease • Inflammation • Leukopenia • Otorhinolaryngology

Autoimmune Hemolytic Anemia in a Euthyroid Grave's Disease Patient on Methimazole (ACAAI 2025) - "He was initiated on prednisone (19.8 mg/m 2 /day) with blood transfusions but developed progressively severe anemia...His hemolysis stabilized by day 7, and he was discharged home on propylthiouracil and weekly rituximab (goal: four total doses) with plan for future radioactive iodine treatment...4 A single case report documents an association with hemolytic anemia and short-term methimazole use. 5 This is the first case report to describe AIHA in a euthyroid GD patient on long-term methimazole treatment."

Clinical • Anemia • Autoimmune Hemolytic Anemia • Endocrine Disorders • Grave’s Disease • Hematological Disorders • Hepatology • Immunology

A Case Report of Thyroid Storm with Cardiovascular Collapse After Propranolol Administration. (PubMed, Clin Pract Cases Emerg Med) - "Beta-blocker use in the management of thyrotoxicosis can potentially cause cardiovascular collapse. We suggest consideration of shorter acting beta blockers, such as esmolol or landiolol."

Journal • Cardiomyopathy • Cardiovascular • Critical care • Gastroenterology • Gastrointestinal Disorder • Grave’s Disease • Infectious Disease • Myocardial Infarction

Post-COVID-19 Painless Thyroiditis: A Case Study on Thyrotoxicosis Management. (PubMed, Am J Case Rep) - "The patient was diagnosed with post-COVID-19 painless thyroiditis and managed with beta blockers, methimazole, and corticosteroids...Prompt recognition and treatment with beta blockers, anti-thyroid drugs, and corticosteroids can lead to symptom resolution. Regular follow-up is crucial to detect and manage potential long-term thyroid dysfunction."

Journal • Cardiovascular • Diabetes • Endocrine Disorders • Hypertension • Infectious Disease • Inflammation • Metabolic Disorders • Movement Disorders • Myocardial Infarction • Novel Coronavirus Disease • Pain • Respiratory Diseases

A Prospective, Randomized, Controlled Study on Thermal Ablation Combined with Methimazole to Reduce Recurrence in Patients with Graves' Disease (ChiCTR) - P=N/A | N=50 | Recruiting | Sponsor: Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine; Shanghai Ninth People's Hospital, Shanghai Jiao Tong University Sc

New trial • Endocrine Disorders • Grave’s Disease

Pioneering Pericarditis Management in Pregnancy (AHA 2025) - "We report a case of a 29-year-old woman, G1P0 at 21 weeks gestation, presenting with recurrent pericarditis complicated by early signs of cardiac tamponade.A 29-year-old (G1P0) female with a history of Graves' disease on methimazole, drug-induced lupus, and recent pericarditis presented to the hospital at 21-weeks gestation due to recurrent chest pain...After two weeks of serial echocardiograms, the patient was gradually tapered to aspirin 81 mg daily, prednisone 15 mg daily, and colchicine 0.6 mg daily and discharged. This case highlights the complexities of managing pericarditis in pregnant patients with autoimmune conditions. Medical management and serial TTE were useful in managing early tamponade while minimizing risks to both the mother and fetus."

Cardiovascular • Endocrine Disorders • Grave’s Disease • Immunology • Inflammatory Arthritis • Lupus • Obstetrics