pantoprazole / Generic mfg. - LARVOL DELTA

Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus associated with pantoprazole use (AAD 2026) - No abstract available

Cutaneous Lupus Erythematosus • Immunology • Inflammatory Arthritis • Lupus • Steven-Johnson Syndrome

Polymeric Matrix Mini-Tablets Based on Eudragit® S 100 and HPMC for Controlled Release of Pantoprazole. (PubMed, Pharmaceutics) - " The proposed matrix system shows potential as a robust, coating-free platform for the modified delivery of acid-labile drugs using direct compression, simplifying manufacturing. These findings support the rational design of oral modified-release formulations based on polymeric matrices."

Journal • Gastrointestinal Disorder

Drug Utilization Pattern of Proton Pump Inhibitors in Patients with Acid Peptic Disease and Comorbidities in India: A Real-World Electronic Medical Records-Based Study. (PubMed, Drugs Real World Outcomes) - "This real-world study highlighted utilization patterns of PPIs and demonstrated that all PPIs are effective and well-tolerated in managing APD symptoms in patients with comorbidities. Pantoprazole was the most co-prescribed and preferred PPI amongst the prescribed PPIs. These findings provide real-world insights into how PPIs are utilized in Indian patients with APD and comorbidities and may help clinicians make informed decisions when selecting an appropriate PPI in routine practice."

Journal • Real-world evidence

Ten Years Ago, I Would've Called This... (USCAP 2026) - "Her recent medical history was notable for hospitalization due to a perforated duodenal ulcer, which was managed conservatively with intravenous pantoprazole... This case underscores the necessity of including lymphoprolifertaive neoplasms in the differential diagnosis when evaluating reactive-appearing inflammatory infiltrates. In elderly patients with a history of monoclonal gammopathy, there should be a low threshold for performing immunohistochemical staining to further characterize lymphocytic infiltrates. Within this population, interpretation of IgG and IgG4 stains requires caution, and should be supplemented with additional markers to rule out B cell lymphoma and monotypic IgG4 production."

Acute Kidney Injury • B Cell Lymphoma • Chronic Kidney Disease • Diabetic Nephropathy • Diffuse Large B Cell Lymphoma • Fibrosis • Hematological Malignancies • Hepatitis B • Hepatology • Human Immunodeficiency Virus • Immunology • Indolent Lymphoma • Infectious Disease • Inflammatory Arthritis • Lupus • Lymphoma • Lymphoplasmacytic Lymphoma • Monoclonal Gammopathy • Nephrology • Non-Hodgkin’s Lymphoma • Peptic Ulcer • Rare Diseases • Renal Disease • Sjogren's Syndrome • Waldenstrom Macroglobulinemia

POTENTIAL FOR PHARMACOGENOMICS TO IMPROVE MEDICATION SAFETY AND EFFICACY IN AUSTRALIAN HAEMATOPOIETIC STEM CELL TRANSPLANT PATIENTS (EBMT 2026) - "Paired supportive care medications included allopurinol, sertraline, omeprazole, pantoprazole, voriconazole, ondansetron, tramadol, tacrolimus, flucloxacillin, carbamazepine and amikacin. We have demonstrated the prevalence of clinically relevant high-risk PGx phenotypes in a diverse paediatric oncology cohort. Many supportive care medications prescribed for paediatric HSCT patients are likely to be affected, with high prescribing rates observed for some medications with available PGx prescribing guidelines. These results highlight the potential for PGx guided prescribing to improve medication efficacy and reduce toxicity in a paediatric HSCT setting."

Biomarker • Clinical • Bone Marrow Transplantation • Transplantation • ABCG2 • CYP2C19 • CYP3A5 • HLA-B • NUDT15

POTENTIAL FOR PHARMACOGENOMICS TO IMPROVE MEDICATION SAFETY AND EFFICACY IN AUSTRALIAN HAEMATOPOIETIC STEM CELL TRANSPLANT PATIENTS (EBMT 2026) - "Paired supportive care medications included allopurinol, sertraline, omeprazole, pantoprazole, voriconazole, ondansetron, tramadol, tacrolimus, flucloxacillin, carbamazepine and amikacin. We have demonstrated the prevalence of clinically relevant high-risk PGx phenotypes in a diverse paediatric oncology cohort. Many supportive care medications prescribed for paediatric HSCT patients are likely to be affected, with high prescribing rates observed for some medications with available PGx prescribing guidelines. These results highlight the potential for PGx guided prescribing to improve medication efficacy and reduce toxicity in a paediatric HSCT setting."

Biomarker • Clinical • Bone Marrow Transplantation • Transplantation • ABCG2 • CYP2C19 • CYP3A5 • HLA-B • NUDT15

Considerations for environmental sustainability in clinical trials: A case study simulation of the REVISE trial. (PubMed, J Crit Care) - "This simulation demonstrates that enabling transition from intravenous pantoprazole to enteral lansoprazole may have yielded substantial reductions in both greenhouse gas emissions and costs. Considering environmental stewardship represents an important step towards more sustainable clinical trials."

Journal • Stress Ulcer

CASE REPORT: FIRST DOCUMENTED DIALYSIS-REQUIRING WEIL'S DISEASE IN GORAKHPUR, EASTERN UTTAR PRADESH — A SENTINEL REPORT OF SEVERE LEPTOSPIRA-ASSOCIATED ACUTE KIDNEY INJURY WITH FULL RECOVERY (ISN-WCN 2026) - "Without waiting for specific test results, the patient was given intravenous ceftriaxone at a dose of 1 gram twice a day, in addition to general supportive care, which included intravenous fluids and pantoprazole...Based on this finding, intravenous doxycycline was started at a dose of 100 mg twice a day...https://doi.org/10.12659/AJCR.897741.[iv] Manocha H, Ghoshal U, Singh SK, Kishore J, Ayyagari A. Frequency of leptospirosis in patients of acute febrile illness in Uttar Pradesh...Conclusion This case highlights the important need for doctors to pay closer attention to leptospirosis in people who have fever and yellowing of the skin for unknown reasons, mainly in eastern Uttar Pradesh. If it is found quickly and treated right away, including getting dialysis when needed, people can fully recover, even if they are very sick. Important situations like this one show that we still struggle to find leptospirosis in North India, which makes it even more important to include..."

Case report • Clinical • Acute Kidney Injury • Dengue Fever • Hepatology • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Malaria • Nephrology • Renal Disease

REAL-WORLD RISK OF DRUG-INDUCED TUBULOINTERSTITIAL NEPHRITIS (ISN-WCN 2026) - "As shown in Figure 1a, 11 such drugs were identified: omeprazole, ibuprofen, pantoprazole, ciprofloxacin, pembrolizumab, nivolumab, vancomycin, carboplatin, pemetrexed, tacrolimus, and esomeprazole.The relationship between TIN and these suspected drugs is illustrated in the volcano plot (Figure 1a). Individuals aged over 60 years, male, or those who have taken 9 specific drugs including omeprazole are at a higher risk of developing DITIN. The findings of this study can provide important information for the early identification of drug-related acute interstitial nephritis and lay a foundation for future research on the pathogenesis of DITIN."

Clinical • Real-world • Real-world evidence • Immunology • Infectious Disease • Nephrology • Respiratory Diseases • Tuberculosis

From gastric to neuroprotection: pantoprazole mitigates epilepsy via TrkB/BDNF and KCC2 modulation. (PubMed, Naunyn Schmiedebergs Arch Pharmacol) - "The therapy with pantoprazole also increased the mRNA expression of downregulated KCC2 and thereby restored GABAergic inhibition in the synapse and suppressed epilepsy. Together, these findings indicate that pantoprazole exhibits promising neuroprotective and antiepileptic effects via modulation of the TrkB/BDNF pathway and warrant further exploration in clinical subjects for its translation."

Journal • CNS Disorders • Epilepsy • Mood Disorders • Psychiatry • BDNF • CAT • MPO • NTRK2

Oral bioavailability of SCY-247 is not impacted by pantoprazole mediated increase in gastric pH (ESCMID Global 2026) - No abstract available

Genetic causal association between kidney stones and proton pump inhibitors. (PubMed, Int Urol Nephrol) - "In conclusion, this study found no evidence supporting a causal role for PPIs in increasing kidney stone risk, providing genetic-level evidence to support the safe use of PPIs in patients with gastric ulcers or gastroesophageal reflux disease."

Journal • Chronic Kidney Disease • Gastroenterology • Gastroesophageal Reflux Disease • Metabolic Disorders • Nephrology • Peptic Ulcer • Renal Calculi • Renal Disease • ATP4A

Discontinuation of long-term proton pump inhibitor treatment (PubMed, Ugeskr Laeger) - "This case report describes a 69-year-old woman on long-term pantoprazole therapy, initially prescribed for nonspecific upper gastrointestinal symptoms. Despite resistance to discontinuation due to rebound symptoms, a gradual dose reduction combined with patient education and use of antacids led to successful cessation. The case highlights the importance of regular medication review, patient involvement, and awareness of rebound acid hypersecretion in facilitating rational PPI use and deprescribing efforts."

Journal

Sucralfate plus Pantoprazole versus Pantoprazole alone for healing of post–endoscopic variceal ligation ulcers: an open label randomized controlled trial (EASL 2026) - No abstract available

Clinical • Cardiovascular • Fibrosis • Hepatology • Hypertension • Immunology • Portal Hypertension

Cardiac Arrest in a Healthy Child: Unmasking Long QT Syndrome Following Pantoprazole Exposure (SCCM 2026) - "This case highlights a rare but serious pediatric cardiac arrest revealing latent LQTS after pantoprazole exposureDescription: A previously healthy 3-year-old male with mild asthma (on montelukast) was admitted for viral gastroenteritis with moderate dehydration...He was intubated and transferred to the PICU, where he remained on epinephrine infusion for 24 hours.EEG showed diffuse reactive slowing; brain MRI was unremarkable...Serial ECGs and family screening were crucial for diagnosis.Clinicians should maintain vigilance regarding QT-prolonging agents, particularly in pediatric patients with unexplained events or concerning family history. Early recognition and multidisciplinary management enabled a favorable outcome in this high-risk case"

Clinical • Asthma • Cardiovascular • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Respiratory Diseases

Preventable Life-Threatening Severe Hypocalcemia: The Importance of Medication Reconciliation (SCCM 2026) - "Her pantoprazole was switched to famotidine. While severe hypocalcemia from denosumab use is relatively rare, the presence of additional risk factors can significantly increase its likelihood, most notably, CKD, PPI usage, vitamin D deficiency, and low-normal calcium level at baseline, as each of these conditions impair either absorption or regulation of calcium, compounding the effect of denosumab. There are no current guidelines recommending earlier checks even in potentially higher risk patient population. This case highlight the importance of risk factors optimization includes vitamin D and calcium supplementation if needed and thorough medication reconciliation."

Breast Cancer • Chronic Kidney Disease • CNS Disorders • Endocrine Disorders • Epilepsy • Gastroenterology • Gastroesophageal Reflux Disease • Nephrology • Renal Disease • Solid Tumor

Drug-Induced Thrombocytopenia from Proton Pump Inhibitors and H₂ Blockers: A Systematic Review and Comparative Analysis of Published Case Reports (THSNA 2026) - "Representative PPI reports (pantoprazole, lansoprazole, omeprazole/esomeprazole) and classical H₂RA reports (cimetidine, ranitidine, famotidine) were abstracted for onset (days), recovery (days), bleeding and ICU status. Case-level evidence indicates both PPIs and H₂RAs can cause abrupt, reversible thrombocytopenia with onset within days and recovery within 1–2 weeks; PPI reports show a trend toward earlier onset and higher bleeding documentation. Findings are limited by reporting bias and small numbers; prospective pharmacovigilance and mechanistic testing are needed to confirm class-specific risks. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author."

Case report • Clinical • Review • Hematological Disorders • Thrombocytopenia

Acute Esophageal Necrosis: A Rare Complication of Diabetic Ketoacidosis: A Case Report (SCCM 2026) - "Patient treated with IV pantoprazole, sucralfate, lidocaine swish/swallow, metoclopramide and after 24 hours NPO, a clear liquid diet was started, leading to significant improvement in symptoms. Acute esophageal necrosis (AEN) associated with diabetic ketoacidosis (DKA) remains an exceedingly rare clinical entity. It is critical to recognize AEN as it is associated with a mortality of 32%. Because AEN shares many symptoms with DKA, maintaining a high clinical suspicion and carefully evaluating patients in the appropriate context can help prevent serious complications and reduce mortality."

Case report • Clinical • Benign Prostatic Hyperplasia • Cardiovascular • Diabetes • Dyslipidemia • Gastrointestinal Disorder • Hypertension • Hypotension • Metabolic Disorders

Idiopathic Thrombocytopenic Purpura and Acute-on-Chronic Kidney Disease as Sequelae of Helicobacter pylori Infection and Alternative Medicine: A Case Report (THSNA 2026) - "He was managed with platelet transfusions, eltrombopag, steroids, and later azathioprine...He was started on triple eradication therapy with pantoprazole, clarithromycin, and amoxicillin for 2 weeks (7)...This case highlights the importance of considering H. pylori eradication when treating patients with co-existing ITP and CKD. No part of this publication may be reproduced, distributed, or transmitted in any form or by any means, including photocopying, recording, or other electronic or mechanical methods, without the prior written permission of the author."

Case report • Clinical • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Endocrine Disorders • Hematological Disorders • Hypertension • Immune Thrombocytopenic Purpura • Immunology • Infectious Disease • Inflammation • Ischemic stroke • Metabolic Disorders • Nephrology • Orthopedics • Renal Disease • Thrombocytopenia • Thrombocytopenic Purpura

MISSED BY ANGIOGRAPHY, CAUGHT BY LATE GADOLINIUM ENHANCEMENT: MYOCARDIAL INFARCTION WITH NON-OBSTRUCTIVE CORONARY ARTERIES IN A YOUNG FEMALE (ACC 2026) - "This case highlights the value of CMR in clarifying MINOCA etiology by identifying LGE patterns to help distinguish vasospasm (often absent/minimal) from embolic ischemia (transmural in a vascular territory)."

Cardiovascular • Coronary Artery Disease • Gastroesophageal Reflux Disease • Immunology • Myocardial Infarction

Immediate-Type PPI Hypersensitivity as a Severe Adverse Drug Reaction: Diagnostic Challenges, Cross-Reactivity, and Real-Life Outcomes. (PubMed, J Clin Med) - "CR was detected in 25% (n = 10), most often between lansoprazole and pantoprazole. In immediate-type PPI hypersensitivity, skin test sensitivity appears time-dependent, supporting early evaluation. DPT identifies safe alternatives, yet behavioral and clinician-related barriers limit real-life implementation; addressing these barriers is essential to optimize PPI allergy management."

Adverse drug reaction • Journal • Allergy • Immunology • Mood Disorders • Psychiatry

Antibiotic and Nonantibiotic Drugs Associated With Clostridioides difficile Infection Risk: a Pharmacopoeia-Wide Case-Cohort Study. (PubMed, J Infect Dis) - "This study provides insights into CDI etiology and avenues for stewardship and drug repurposing to combat CDI and antimicrobial resistance."

Journal • Infectious Disease

Hypersensitivity reactions with proton pump inhibitors: five years of clinical experience. (PubMed, Allergol Immunopathol (Madr)) - "Skin testing is a valuable tool in predicting hypersensitivity reactions associated with PPIs. Although rare, hypersensitivity reactions may occur in patients with negative skin tests."

Journal • Retrospective data • Allergy • Immunology

Prevalence of Vitamin B12 Deficiency Among Patients With Type 2 Diabetes Mellitus on Long-Term Metformin Therapy. (PubMed, Cureus) - " Patients with T2DM, especially those on long-term metformin medication, frequently lack vitamin B12. Timely supplementation and routine screening might help lower avoidable consequences."

Journal • Diabetes • Dyslipidemia • Hematological Disorders • Metabolic Disorders • Pain • Type 2 Diabetes Mellitus

Comparative efficacy and safety of potassium-competitive acid blockers and proton pump inhibitors for erosive esophagitis: a network meta-analysis of randomized controlled trials. (PubMed, EClinicalMedicine) - "At 8 weeks, zastaprazan 20 mg, vonoprazan 20 mg, and esomeprazole 40 mg demonstrated moderate-certainty superiority over rabeprazole 20 mg and omeprazole 20 mg with RDs ranging from 0.05 to 0.11, while only vonoprazan 20 mg demonstrated moderate-certainty benefit versus lansoprazole 30 mg (RD: 0.04)...Vonoprazan 20 mg and rabeprazole-ER 50 mg demonstrated moderate-certainty benefit compared with pantoprazole 40 mg (RDs: 0.12 and 0.09, respectively).At 24 weeks, vonoprazan 10 mg and 20 mg showed moderate-to-high-certainty benefit versus lansoprazole 15 mg (RDs: -0.11 and -0.13, respectively), while in direct comparisons, esomeprazole 20 mg outperformed lansoprazole 15 mg and pantoprazole 20 mg, with approximately 40-50% relative reductions in recurrence...Comparative trials evaluating newer P-CABs against optimized PPI strategies, including twice-daily dosing, are needed to evaluate efficacy and long-term safety, particularly with respect to hypergastrinemia and infection..."

Journal • Retrospective data • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Infectious Disease