pantoprazole / Generic mfg. - LARVOL DELTA

Development and Comparison of Stability-Indicating HPLC and UPLC Methods for the Determination and Validation of Pantoprazole Sodium Impurities. (PubMed, J AOAC Int) - "As a result of shorter analysis times, a significant cost reduction has also been proven with numerical data. In addition, a performance-cost comparison of two different analytical technologies was made."

Journal

Anticoagulation dilemma in a patient with nephrotic syndrome and bleeding of unknown origin: A case-based approach to risk-benefit decision-making (ASH 2025) - "She received four units of packed red blood cells, one dose of Venofer 200 mg, and was started on pantoprazole 40 mg IV twice daily... This case highlights the complexities of anticoagulation management in patients with nephrotic syndrome. Despite the indication for anticoagulation, the absence of a documented thrombotic event, stabilization of hemoglobin following Apixaban cessation, and a moderate bleeding risk favored cessation of therapy. Multidisciplinary input and shared decision-making were essential in aligning the treatment plan with the patient's evolving clinical status and preferences."

Benefit-risk assessment • Clinical • Cardiovascular • Chronic Kidney Disease • Gastroenterology • Gastrointestinal Disorder • Glomerulonephritis • Hematological Disorders • Immunology • Inflammation • Nephrology • Peripheral Arterial Disease • Renal Disease • Thrombosis

Long-term proton pump inhibitor use and risk of dementia: a focused review on pantoprazole. (PubMed, Ann Med Surg (Lond)) - "Further prospective studies and randomized controlled trials are needed to clarify causality. Clinicians should exercise caution, reassess long-term PPI necessity, and consider alternatives to mitigate potential risks."

Journal • Review • Alzheimer's Disease • CNS Disorders • Dementia

Proton pump inhibitor increases intestinal epithelial paracellular permeability via the p38-MAPK/NF-κB signaling pathway. (PubMed, Mol Biol Rep) - "Although the absence of macroscopic intestinal lesions, PPI directly enhances intestinal epithelial paracellular permeability by decreasing the expression of the tight junction protein occludin, mediated by the p38-MAPK/NF-κB signaling pathway. These findings highlight that the potential and insidious side effects of PPI on the intestinal epithelial barrier warrant increased attention and caution from clinicians when prescribing PPIs for various gastrointestinal diseases."

Journal • Gastroenterology • Gastrointestinal Disorder • Infectious Disease • Musculoskeletal Diseases • Oncology • Orthopedics • Solid Tumor • OCLN

Analysis of infection-related adverse events induced by proton pump inhibitors based on the FAERS and JADER databases. (PubMed, Medicine (Baltimore)) - "In the use of PPIs, we should pay attention to the occurrence of related adverse reactions, especially the damage to the infection-related adverse effects, monitor the relevant indicators, and take timely intervention measures to ensure the safety of medication."

Adverse events • Journal • Gastrointestinal Disorder • Infectious Disease • Pneumonia • Respiratory Diseases

Renal Toxicity of Rosuvastatin: A Case Report. (PubMed, Cureus) - "He had initially been treated with simvastatin, though it was changed to rosuvastatin for stronger effects on cholesterol and cardiovascular risk reduction. He had severe esophageal disease, which was at risk of a flare with coming off the pantoprazole, so we elected to stop rosuvastatin first. After stopping rosuvastatin, the kidney function returned to baseline, and the abnormal urine testing resolved."

Journal • Acute Kidney Injury • Cardiovascular • Coronary Artery Disease • Dyslipidemia • Gastrointestinal Disorder • Hypertension • Nephrology • Renal Disease

Pharmacokinetics of Clozapine and Norclozapine and the Effect of Pantoprazole (clinicaltrials.gov) - P1 | N=33 | Completed | Sponsor: Universiti Sains Malaysia

New P1 trial

Cost-Effectiveness of Pantoprazole to Prevent Upper Gastrointestinal Bleeding in Mechanically Ventilated Patients. (PubMed, JAMA Netw Open) - "In 99% of simulations, the strategy of using pantoprazole was more effective and less costly than no pantoprazole. In this economic evaluation, daily pantoprazole for invasively mechanically ventilated patients was less costly and more effective than care without pantoprazole, indicating both clinical benefits and economic value for the health care system."

HEOR • Journal • Critical care • Gastroenterology

Pantoprazole Inhibited Metastasis and Angiogenesis Through Wnt/β-Catenin Signaling Pathway in Gastric Cancer Stem-Like Cells. (PubMed, Adv Biomed Res) - "We showed that pantoprazole may reduce the tumorigenicity of GCSCs through the Wnt signaling pathway. Therefore, pantoprazole may be an assistance treatment for gastric cancer therapy."

Journal • Gastric Cancer • Oncology • Solid Tumor • CTNNB1 • SMARCD1 • SUFU

Step-down Therapy Evaluation of Pantoprazole in Eosinophilic Esophagitis (STEP-EoE): A randomised trial of Pantoprazole at 40mg orally once daily compared to 20mg orally once daily in patients with Eosinophilic esophagitis (EoE) who initially respond to Pantoprazole 40mg orally twice daily. (ANZCTR) - P4 | N=72 | Not yet recruiting | Sponsor: Northern Adelaide Local Health Network

New P4 trial • Eosinophilic Esophagitis • Gastrointestinal Disorder • Immunology

Sydenham Chorea as the Presenting sign of Rheumatic Heart Disease in a 12 Year old (AHA 2025) - "The patient was started on Phenoxymethyl Penicillin, Carbamazepine and Pantoprazole after which her choreiform movements started to ameliorate significantly.DiscussionDespite progress in earlier diagnosis and treatment of streptococcal infection, Sydenham Chorea is still an essential feature of acute rheumatic fever in developing nations. Carditis is another severe manifestation of ARF. The cardiac lesion frequently encountered in ARF is mitral regurgitation, aortic regurgitation is the other frequently observed valvular disease."

Cardiovascular • Heart Failure • Immunology • Infectious Disease • Movement Disorders • Otorhinolaryngology

Rapid accumulation of fluorophores and fast kill identify drugs with bactericidal effects against Gram-negative bacteria. (PubMed, Microbiology (Reading)) - "This was confirmed with growth inhibitory assays in both E. coli and A. baylyi for pantoprazole, theophylline and zoledronic acid. This represents an approach to the large-scale screening of small molecules with the potential to deliver fast-acting molecules that target cell membranes in Gram-negative bacteria."

Journal • Infectious Disease

Protocol for an economic evaluation alongside the Re-Evaluating the Inhibition of Stress Erosions (E-REVISE) trial. (PubMed, BMJ Open) - P3 | "The objective of this paper is to present the protocol for a health economic evaluation comparing the cost-effectiveness of prophylactic treatment using pantoprazole 40 mg daily compared with no pantoprazole to prevent upper gastrointestinal (GI) bleed among invasively ventilated patients...End-of-study knowledge translation will include rounds, videoconferences, abstracts and slide-decks for intensive care unit quality councils and healthcare organisations, and open-access publications. Patient and family partners will co-create lay language summaries for traditional and social media to help inform all interest groups."

HEOR • Journal • Critical care

Zinc Phosphide Poisoning in Pregnancy: A Rare Case Report From Nepal. (PubMed, Clin Case Rep) - "Her vital signs were stable (BP 110/80 mmHg, GCS 15/15), but she experienced transitory hepatic dysfunction that improved on Day 4 with supportive therapy such as coconut oil gastric lavage, intravenous fluids, and pantoprazole...The high mortality of Zn3P2 (37%-100%) is caused by phosphine gas-induced suppression of mitochondrial respiration. This case emphasizes the lack of a particular antidote and the significance of immediate decontamination, hepatic monitoring, and mental follow-up following purposeful consumption."

Journal • Hepatology • Liver Failure

The impact of proton pump inhibitor exposure on pneumonia: an updated meta-analysis based on randomized controlled trials. (PubMed, Front Pharmacol) - "The use of PPI might increase the risk of pneumonia in general population, especially among Asians (in Iran and in the Asian users of pantoprazole), HAP. Identifier, CRD420251021884."

Journal • Retrospective data • Review • Critical care • Infectious Disease • Pneumonia • Respiratory Diseases

Helicobacter pylori eradication and associated factors: dual therapy versus standard triple therapy in Lima, Peru (PubMed, Rev Gastroenterol Peru) - "The H. pylori eradication rate with dual therapy was superior to standard triple therapy. The proton pump inhibitor with the highest eradication rate was esomeprazole. There were no significant differences in eradication according to sex, age, or comorbidities."

Journal • Cardiovascular • Diabetes • Dyslipidemia • Gastric Cancer • Hypertension • Infectious Disease • Metabolic Disorders • Oncology • Solid Tumor

Proton pump inhibitors-induced thrombocytopenia: A systematic literature analysis of case reports. (PubMed, Open Med (Wars)) - "The PPIs associated with thrombocytopenia included pantoprazole (11 cases), lansoprazole (4 cases), omeprazole (2 cases), and esomeprazole (1 case). Clinicians should enhance their awareness when evaluating potential cases of thrombocytopenia. Once PPIs are suspected, immediate discontinuation of the drugs and initiation of appropriate treatments are recommended."

Journal • Hematological Disorders • Thrombocytopenia

Identification of hypoxia-associated genes as potential diagnostic biomarkers for ulcerative colitis. (PubMed, Arab J Gastroenterol) - "HRGs play a pivotal part in UC occurrence and progression. Nine hub genes may be promising diagnostic biomarkers for UC."

Biomarker • Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammatory Bowel Disease • Ulcerative Colitis • PPARGC1A

Efficacy and safety of the immunomodulator spleen aminopeptide combined with bismuth in the treatment of Helicobacter pylori infection: A randomized controlled trial. (PubMed, Medicine (Baltimore)) - "The combination of spleen aminopeptide and bismuth quadruple therapy has a high eradication rate, fewer adverse events, and better immune function improvement."

Clinical • Journal • Infectious Disease • CD4 • CD8

Recurred pantoprazole anaphylaxis: a rare case report from Nepal. (PubMed, Ann Med Surg (Lond)) - "A 57-year-old woman presented to the emergency department with an acute onset of generalized rashes and chest tightness after intake of an over-the-counter oral pantoprazole and domperidone combination tablet. Physicians should be aware of cross-hypersensitivity among PPIs, and a safe alternative should be decided after a skin allergy workup. It is necessary to extensively extract drug and allergy history, and even the most commonly used drugs with rarely any side effects should also be used cautiously."

Journal • Allergy • Dermatology • Hypotension • Immunology • Pain • Urticaria

Risk Factors for Drug-Induced Acute Generalized Exanthematous Pustulosis(AGEP) from 2004 to 2024: A Real-World Study Based on the FAERS. (PubMed, Clin Cosmet Investig Dermatol) - "LASSO and multivariate logistic regression identified 17 drugs as risk factors for AGEP, including ceftriaxone (OR = 49.87), pantoprazole (OR = 31.39), and hydroxychloroquine (OR = 28.38). The findings highlight a higher susceptibility in middle-aged and younger populations and underscore the importance of enhanced monitoring for high-risk medications. Given the inherent limitations of spontaneous reporting systems, further prospective studies are needed to confirm these associations and explore underlying mechanisms."

Journal • Real-world evidence • Immunology

Management of Esophageal Perforation During Variceal Hemorrhage With Endoscopic Suturing (ACG 2025) - "She was given ceftriaxone, intravenous pantoprazole, and infusions of octreotide and norepinephrine. Her diet was advanced, and she now tolerates soft foods. Even with portal hypertension, active variceal hemorrhage, and a large esophageal perforation, endoscopic suturing can be used to close the perforation and achieve hemostasis. Endoscopic suturing should be considered a viable salvage technique."

Cardiovascular • Fibrosis • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Hepatology • Hypotension • Immunology • Portal Hypertension

Acquired Double Pylorus as a Sequela of NSAID Use, Alcohol, and Helicobacter pylori (ACG 2025) - "He endorsed frequent ibuprofen use and daily alcohol intake...He received IV fluids, packed red blood cell transfusion, and IV pantoprazole...Endoscopic image of the pylorus with presence of a gastroduodenal fistula (double pylorus)Figure: Figure 2. Endoscopic image of the pre-pyloric region demonstrating a large cratered gastric ulcer with surrounding fibrinous exudate and a gastroduodenal fistula (double pylorus) seen at the inferior margin"

Addiction (Opioid and Alcohol) • Cardiovascular • Dyslipidemia • Gastroenterology • Gastrointestinal Disorder • Hypertension • Infectious Disease • Peptic Ulcer

Incidental Detection of Metastatic Melanoma in the Stomach During Evaluation for Persistent Dysphagia (ACG 2025) - "He was started on pantoprazole 40 mg daily with symptomatic improvement...Treatment includes systemic immunotherapy or targeted therapy, with local endoscopic resection reserved for symptom relief or localized disease. This case also illustrates how common GI complaints may occasionally lead to the discovery of advanced malignancy with poor prognosis, reinforcing the importance of individualized goals-of-care discussions.Figure: A 7 mm sessile polyp with a dark rim in the gastric body"

Metastases • Anemia • Gastrointestinal Disorder • Melanoma • Solid Tumor

The Uncommon Culprit: Helicobacter heilmannii Gastritis in a Young Adult With Significant Nausea and Weight Loss (ACG 2025) - "The patient was treated with two-week quadruple therapy: bismuth subsalicylate 525 mg qid, metronidazole 250 mg qid, doxycycline 100 mg bid and pantoprazole 40 mg daily. This case illustrates the need to broaden the differential diagnosis to include rare pathogens like H. heilmannii, especially in patients with animal exposure. Early identification enables timely treatment and prevents complications."

Clinical • Celiac Disease • Extranodal Marginal Zone Lymphoma • Gastroenterology • Gastrointestinal Disorder • Hematological Malignancies • Immunology • Infectious Disease • Lymphoma • Marginal Zone Lymphoma • Peptic Ulcer