pantoprazole / Generic mfg. - LARVOL DELTA

A 23-year-old Woman With Sepsis and Ceftriaxone Induced Thrombocytopenia (ATS 2025) - "She was pan-cultured, given 30 ml/kg IVF bolus and started on pipercillin-tazobactam, vancomycin, pantoprazole and heparin DVT prophylaxis...Her antibiotics were changed to ceftriaxone and azithromycin on the 2nd day...(4) In heparin-induced thrombocytopenia platelet factor 4 binds to heparin resulting in activation of platelets. This is unlikely due to HIT Elisa being negative and thrombosis did not occur."

Clinical • Bipolar Disorder • Cardiovascular • CNS Disorders • Hematological Disorders • Immune Thrombocytopenic Purpura • Infectious Disease • Mood Disorders • Psychiatry • Septic Shock • Thrombocytopenia • Thrombocytopenic Purpura • Thrombosis • HP

In the Genes: RTEL1 Mutation and Familial Pulmonary Fibrosis (ATS 2025) - "Case: We present a 53-year-old gentleman, with a history of hypertension, hyperlipidemia, GERD on pantoprazole, establishing care at our pulmonology office...Having identified the disease early, our patient is currently being evaluated for the initiation of nintedanib or pirfenidone...Clinical trials for therapeutics in FPF are inadequate, largely due to the lack of robust preclinical models, rarity of the condition, and the heterogeneity in genetic mutations. Therapeutic modalities such as gene therapy show promise but require further exploration and are yet to impact patient care in FPF[4]."

Cardiovascular • Cough • Dyslipidemia • Fibrosis • Gastroenterology • Gastroesophageal Reflux Disease • Gene Therapies • Head and Neck Cancer • Hepatology • Hypertension • Immunology • Interstitial Lung Disease • Liver Cirrhosis • Musculoskeletal Diseases • Musculoskeletal Pain • Oncology • Orthopedics • Pain • Pulmonary Disease • Rare Diseases • Respiratory Diseases • Rheumatology • Scleroderma • Systemic Sclerosis • RTEL1

Atypical Presentation of Takotsubo Cardiomyopathy in a Young Female (ATS 2025) - "She was given pantoprazole for abdominal pain to treat gastritis/esophagitis...Thus, at present, takotsubo syndrome remains an incompletely understood condition. Diagnosis can be challenging with substantial morbidity and mortality as a result."

Addiction (Opioid and Alcohol) • Cardiomyopathy • Cardiovascular • Coronary Artery Disease • Gastrointestinal Disorder • Hepatology • Myocardial Infarction • Pain • Pulmonary Disease

Respiratory Complications in Multiple Myeloma: A Case of Pneumonitis Induced by Daratumumab (ATS 2025) - "Her medication regimen included fluoxetine, pravastatin, morphine, trazodone, pantoprazole, valacyclovir, and levothyroxine...The patient was initially treated with IV doxycycline and cefepime for atypical pneumonia, and she also received IV solumedrol for pneumonitis with significant improvement in oxygen requirement...Acute interstitial pneumonitis is a rapidly progressive interstitial lung disease with an unclear etiology. While various medications, particularly antineoplastic agents, have been associated with DIIP, this case underscores the need to recognize rare but serious pulmonary side effects associated with immunotherapy, especially in patients with underlying malignancies."

Clinical • Bronchiectasis • Cough • Hematological Malignancies • Infectious Disease • Inflammation • Interstitial Lung Disease • Multiple Myeloma • Oncology • Pain • Pneumonia • Tuberculosis

Risk Factors for Patient-Important Upper Gastrointestinal Bleeding. (PubMed, Am J Respir Crit Care Med) - "Several factors are associated with the risk of patient-important upper gastrointestinal bleeding during invasive ventilation."

Journal • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Thrombocytopenia

Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor (clinicaltrials.gov) - P2 | N=100 | Completed | Sponsor: The University of Texas Health Science Center, Houston | Phase classification: P4 ➔ P2

Phase classification • Acute Kidney Injury • Cardiovascular • Nephrology • Renal Disease

First-in-Human Phase 1 Study to Evaluate the Clinical Pharmacology Properties of RBN-3143, a Novel Inhibitor of Mono-Adenosine Diphosphate Ribosyltransferase-PARP14. (PubMed, Clin Pharmacol Drug Dev) - "An open-label, randomized, 3-period, cross-over study evaluated the effects of food and pantoprazole (40 mg once daily [QD]) on the pharmacokinetics of RBN-3143 (500 mg), and a pharmacokinetic drug-drug interaction study with oral midazolam (2 mg) determined whether RBN-3143 (300 mg BID for 14 days) is an inducer of cytochrome P4503A4 (CYP3A4). RBN-3143 was an inducer of CYP3A4 in most but not all subjects, with mean midazolam Cmax and AUCinf ratios of 0.92 and 0.88, respectively. The clinical pharmacology properties of RBN-3143 in HVs support further development for inflammatory diseases."

Clinical • Journal • P1 data • Inflammation • Pain • CYP3A4

Preliminary Analysis of Drug-Induced Ototoxicity in South Korea: Trends From a National Sample Dataset. (PubMed, J Audiol Otol) - "These correlations and the underlying mechanisms necessitate further investigation, as several medicines have been linked to an increased risk of HL."

Journal • Cardiovascular • Diabetes • Hypertension • Metabolic Disorders • Oncology • Otorhinolaryngology • Pain

Tirzepatide-associated Interstitial Kidney Injury: A Case Report (ENDO 2025) - "Although there are biopsy proven reports of Allergic Interstitial Nephritis with older GLP-1RA's and Semaglutide, but there are no published report with Tirzepatide.Case Presentation: A 66-year-old man with type 2 diabetes, hypertension, chronic kidney disease, hyperlipidemia, obesity, osteoarthritis and GERD was on metformin (1000 mg twice daily), empagliflozin (10 mg daily), tirzepatide (10 mg weekly), lisinopril (10 mg daily), fenofibrate (160 mg daily) and pantoprazole (20 mg daily)...It was discontinued and the patient was started on prednisone...Prompt recognition, consideration of biopsy, cessation of the medication and appropriate management are critical to optimizing renal recovery.*. .*"

Case report • Clinical • Acute Kidney Injury • Cardiovascular • Chronic Kidney Disease • Diabetes • Diabetic Nephropathy • Dyslipidemia • Fibrosis • Gastroesophageal Reflux Disease • Genetic Disorders • Hypertension • Immunology • Metabolic Disorders • Nephrology • Obesity • Osteoarthritis • Pain • Renal Disease • Rheumatology • Type 2 Diabetes Mellitus

Identification of the Potential Pharmacotherapeutic Risk in Hospitalized Geriatric Patients. (PubMed, Cureus) - "Our results underscore the urgent need for medication reviews by hospital pharmacists and the active promotion of drug deprescription among clinicians."

Journal • Geriatric Disorders

Role of Proton Pump Inhibitor as Stress Ulcer Prophylaxis in Sick Children: A Randomized Controlled Trial. (PubMed, Indian Pediatr) - "Among critically ill children, pantoprazole prophylaxis did not reduce the incidence of gastrointestinal bleeding, although, a notable decrease in gastrointestinal bleeding was observed in children with coagulopathy."

Journal • Critical care • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Infectious Disease • Pneumonia • Respiratory Diseases • Stress Ulcer

Gastric Perforation and Peritonitis Following Barium Swallow in a Patient With Prior Mechanical Ventilation and Stress Ulcer Prophylaxis: A Rare but Critical Complication. (PubMed, Clin Case Rep) - "A 65-year-old male with COPD and tobacco use disorder was treated with Oseltamivir for Influenza A infection, intubated for acute respiratory failure, and received IV pantoprazole for GI prophylaxis. He was successfully treated with a washout and antibiotics and was discharged in stable condition. This case underscores the necessity of vigilance for abdominal symptoms and the potential for gastric perforation in critically ill patients despite GI prophylaxis, highlighting the importance of recognizing early signs of pneumoperitoneum."

Journal • Cardiovascular • Chronic Obstructive Pulmonary Disease • Gastrointestinal Disorder • Immunology • Infectious Disease • Influenza • Nicotine Addiction • Pain • Peptic Ulcer • Pulmonary Disease • Respiratory Diseases • Stress Ulcer • Tobacco Addiction

In vitro-in vivo scaling of cytochrome P450-mediated metabolic clearance using a relative activity factor approach. (PubMed, Drug Metab Dispos) - "We selected multiple probe substrates for CYP1A2 (caffeine, tizanidine, phenacetin), CYP2C9 ((S)-acenocoumarol, glimepiride, lornoxicam, tolbutamide, (S)-warfarin), CYP2C19 ((S)-lansoprazole, omeprazole, pantoprazole), CYP2D6 (desipramine, metoprolol, nebivolol, tolterodine), and CYP3A4 (alprazolam, felodipine, midazolam, nisoldipine, sildenafil, triazolam) to calculate the representative RAF value for each P450 isoform based on the in vivo-to-in vitro clearance ratio of the multiple probe substrates...The fm values of the responsible P450 isoform(s) could be well predicted for mexiletine, tamsulosin, risperidone, celecoxib, and glibenclamide...By applying relative activity factor values obtained from multiple probe substrates, this study was able to quantitatively predict the in vivo clearances mediated by CYP1A2, CYP2C9, CYP2C19, CYP2D6, and CYP3A4. This simple, practical method will help optimize metabolic clearances via the major cytochrome P450..."

Journal • Preclinical • CYP1A2 • CYP2C19 • CYP2C9 • CYP3A4

Tacrolimus Associated Peptic Ulcer Disease Following Lung Transplant (ISHLT 2025) - "We report a case of tacrolimus associated peptic ulceration following lung transplant.Case Report A 68-year-old male with end-stage COPD underwent bilateral lung transplant and was placed on standard triple immunosuppression with tacrolimus, mycophenolate mofetil (MMF) and prednisone...He was switched from MMF to enteric coated mycophenolate sodium (EC-MPS) as well as decrease in the steroid dose to minimize GI symptoms, and treated medically with sucralfate, pantoprazole, and famotidine...Tacrolimus was then transitioned to cyclosporine...A follow up EGD showed a significant reduction of his largest ulcers, and the six month follow up EGD showed complete resolution of the ulcerations. This case reports a rare adverse effect of a commonly used immunosuppressant medication."

Anemia • Chronic Obstructive Pulmonary Disease • Gastroenterology • Gastrointestinal Disorder • Hematological Disorders • Immunology • Neutropenia • Pain • Peptic Ulcer • Respiratory Diseases • Transplantation

A large-scale population study on the eradication effect of Helicobacter pylori (ChiCTR) - P=N/A | N=5000 | Not yet recruiting | Sponsor: Fujian Medical University; Fujian Medical University

New trial • Infectious Disease

HSC-MS-24-1034: Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial) (clinicaltrials.gov) - P4 | N=400 | Recruiting | Sponsor: The University of Texas Health Science Center, Houston | Not yet recruiting ➔ Recruiting

Enrollment open • Acute Kidney Injury • Cardiovascular • Nephrology • Renal Disease

Prevention of Post-Cardiac Surgery Acute Kidney Injury by Proton Pump Inhibitor (clinicaltrials.gov) - P4 | N=100 | Completed | Sponsor: The University of Texas Health Science Center, Houston | Recruiting ➔ Completed | Trial completion date: Feb 2025 ➔ Oct 2024

Trial completion • Trial completion date • Acute Kidney Injury • Cardiovascular • Nephrology • Renal Disease

The Association Between Statin Drugs and Rhabdomyolysis: An Analysis of FDA Adverse Event Reporting System (FAERS) Data and Transcriptomic Profiles. (PubMed, Genes (Basel)) - "Simvastatin was associated with the highest risk of rhabdomyolysis. The risk of rhabdomyolysis was more pronounced in men than women. Several possible DDIs were identified including furosemide/Lasix, allopurinol clopidogrel/Plavix, and pantoprazole."

Adverse events • Journal • Dyslipidemia • Metabolic Disorders • Myositis • Renal Disease • MYH7 • SDHA • TNNT1

Pantoprazole prevents the occurrence and progression of liver fibrosis through inhibiting the activation of hepatic stellate cells partly via a glycolysis decrease (APASL 2025) - "PPZ showed preventive and therapeutic effects in murine liver fibrosis induced by CCl4, CDAHFD, and BDL through inhibiting HSCs activation, which may partly be attributed to a decrease of glycolysis via curbing phosphofructokinase. Our study adds to the growing body of evidence, that PPZ could be a potential effective drug for liver fibrosis."

Fibrosis • Hepatology • Immunology • Liver Cirrhosis • CCL2 • CCL20 • CXCL1 • HK1 • IL1B • TGFB1

Rebamipide in gastric mucosal protection and healing: An Asian perspective. (PubMed, World J Gastrointest Pharmacol Ther) - "The efficacy of this drug in treating ulcers often surpasses that of routinely used agents such as pantoprazole, sucralfate, misoprostol, famotidine, lansoprazole, and esomeprazole. Notably, it has been successfully employed in the treatment of ophthalmological, oncological, and bone regeneration-related issues. Rebamipide's exemplary safety and efficacy in treating gastric ulcers and other mucosa-related disorders support its potential for inclusion in treatment guidelines, not only in India but also globally."

Journal • Review • Gastroenterology • Gastroesophageal Reflux Disease • Gastrointestinal Disorder • Ophthalmology • Peptic Ulcer

IgG4-related retroperitoneal fibrosis presenting as a peripancreatic mass: a case series. (PubMed, Ann Med Surg (Lond)) - "Both patients were started on a regimen of prednisolone, pantoprazole, and vitamin D, which they tolerated well without adverse effects...Serum IgG4 levels can be normal in certain cases, histopathological and radiological investigations are necessary for the correct diagnosis. Early initiation of immunosuppressive drugs are necessary for the disease control."

Journal • Fibrosis • Gastroenterology • Immunology • Inflammation • Pain

Management of A Patient with Complicated Bleeding Duodenal Ulcer in Non-Operating Room Anesthesia Environment: A Medically Challenging Case (IARS-SOCCA 2025) - "Norepinephrine, propofol, octreotide and pantoprazole infusions were continued throughout the case...Challenges highlighted in this case are management of hemodynamically unstable and medically complex patients with ventilatory compromise and ongoing hemorrhagic shock requiring MTP in the NORA setting. The increased risk of complications when caring for critically ill patients in the NORA environment should be further studied and considered during procedural planning. Perioperative multidisciplinary discussions between the proceduralists, anesthesia, intensive care, and relevant consulting teams are essential."

Clinical • Anesthesia • Chronic Obstructive Pulmonary Disease • CNS Disorders • Hematological Disorders • Hypotension • Immunology • Orthopedics • Peptic Ulcer • Pulmonary Disease • Respiratory Diseases

Anesthetic Considerations for Chemosaturation Percutaneous Hepatic Perfusion (CS-PHP) for the Cardiac Patient (IARS-SOCCA 2025) - "Introduction: Metastatic liver lesions are more common than primary, are often inoperable and have a five-year survival rate of only eleven percent.1 Treatment options include chemosaturation percutaneous hepatic perfusion (CS-PHP) which delivers a high dose of the chemotherapeutic agent melphalan to the liver while limiting whole body exposure...Prior to the procedure, the patient received aspirin, Plavix, methylprednisolone, and pantoprazole... Protocols for the anesthetic management of cardiac patients undergoing CS-PHP are needed as previous studies excluded patients with an ejection fraction less than fifty percent.2 Norepinephrine is the preferred vasopressor given its alpha agonism and inotropic support. The latter being more important in patients with cardiac pathologies. As of yet, there have been no recommendations on the regular use of additional invasive cardiac monitoring, such as a pulmonary artery catheter, for cardiac patients approved for CS-PHP."

Clinical • Anemia • Anesthesia • Cardiovascular • Eye Cancer • Hematological Disorders • Hepatology • Melanoma • Ocular Melanoma • Oncology • Solid Tumor • Thrombocytopenia • Thrombosis • Uveal Melanoma

Efficacy of Potassium-Competitive Acid Blockers Versus Proton Pump Inhibitors for Gastric Ulcers: Bayesian and Frequentist Network Meta-Analysis With Cross-Inference Through a Quality management System. (PubMed, Curr Ther Res Clin Exp) - "The odds ratios (ORs) for the 4-week cure rate in Bayesian + frequentist NMA, tegoprazan 100 mg (OR = 4.14, 95% credible interval [CI] 0.56-26.3) and pantoprazole 40 mg (OR = 4.12, 95% CI 1.90-8.88) were the largest, respectively. The ORs for the 8-week cure rate in Bayesian + frequentist NMA, lansoprazole 30 mg (OR = 8.77, 95% credible interval [CI] 0.95-78.9) and lansoprazole 30 mg (OR = 7.91, 95% CI 2.60-24.03) was the largest, respectively. The results of the NMA reveal that the cure rates of P-CABs in cases of GU were not inferior to those of PPIs. As the inference by grouping PPIs and P-CABs, the results showed similar trends in terms of effectiveness between the two therapeutic classes."

Journal • Retrospective data • Peptic Ulcer

Can the Use of a Proton Pump Inhibitor be the Cause of an Elevated Phosphorus Level? (NKF-SCM 2025) - "Further analysis indicated when comparing omeprazole to pantoprazole, there were less patients on omeprazole meeting the 5 or 6 months (12) versus pantoprazole (18) despite taking higher doses. This study refutes that the incidence of PPI usage is directly correlated to hyperphosphatemia however future research is warranted to confirm results."

Chronic Kidney Disease • Metabolic Disorders • Nephrology • Renal Disease