GLK-33
/ Glykos
- LARVOL DELTA
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April 02, 2024
Targeting CD33+ acute myeloid leukemia with GLK-33, a lintuzumab-auristatin conjugate with a wide therapeutic window.
(PubMed, Mol Cancer Ther)
- "While previous CD33-targeting antibody-drug conjugates (ADCs) like gemtuzumab ozogamicin (GO, Mylotarg) have shown efficacy in AML treatment, they have suffered from toxicity and narrow therapeutic window...The development of GLK-33 addresses the limitations of previous ADCs, offering a wider therapeutic window, improved tolerability, and activity against drug-resistant leukemia cells. These findings encourage further exploration of GLK-33 in AML through clinical trials."
Journal • Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • Oncology • CD33
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