chlorpheniramine / Generic mfg. - LARVOL DELTA

Feasibility and safety of bispecific antibodies outpatient model in triple-refractory multiple myeloma patients in two Italian centers (ASH 2025) - "All patients underwent premedication with acetaminophen, chlorphenamine and dexamethasone during SUD and first full dose whereas three patients received post-medication with dexamethasone 16 mg the day after SUD1, SUD2 and first full dose...Seven patients were treated with teclistamab and one with talquetamab, approved after teclistamab in Italy...For both these two patients, tocilizumab was administered with rapid resolution of CRS and no need of hospitilization...A solid collaboration with emergency room doctors and nurses, the education of the patient and the outline of a path to rapidly and safely manage complications has been documented to be crucial. These encourage the feasibility of managing BSAbs therapy for MM patients in an outpatient setting in hub centres where multidisciplinary collaboration can be easily achieved."

Clinical • CNS Disorders • Hematological Disorders • Hematological Malignancies • Hypotension • Multiple Myeloma

Development of a predictive model for eosinophilia in patients treated with ampicillin/sulbactam or piperacillin/tazobactam. (PubMed, Br J Clin Pharmacol) - "This study proposes a clinically applicable risk-scoring model for predicting eosinophilia in patients treated with penicillin/beta-lactamase inhibitors. Incorporating machine learning improved model accuracy, enabling more precise identification of high-risk patients. The model supports proactive risk assessment and may inform tailored monitoring and intervention strategies in clinical settings."

Journal • Cardiovascular • Eosinophilia • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Psoroptes cuniculi infestation in an Angora rabbit from Kashmir and its therapeutic management. (PubMed, J Parasit Dis) - "Additionally, chlorpheniramine maleate at 0.4 mg/kg body weight was administered intramuscularly for 3 days as an adjunct therapy to alleviate pruritus. Significant clinical improvement was observed within 1 week, and the lesions were completely resolved after 1 month of treatment. This case highlights the successful management of P. cuniculi infestation in an Angora rabbit, with ivermectin proving effective in treating ear canker in this breed."

Journal • Preclinical • Dermatology • Pruritus

The first Mpox case in Zambia: a case report. (PubMed, J Med Case Rep) - "Our report emphasizes the transmission risk for Mpox in traditionally nonendemic areas resulting from cross-border movement. This highlights the need for countries to strengthen surveillance systems resulting in increased sensitivity, specificity, and timeliness required for early detection and response to Mpox. A multifaceted collaborative approach is required between countries to ensure formalized cross-border collaboration, strengthening health-seeking behavior through deployment of mobile clinics, and utilization of digital platforms risk communication and community engagement. Improved supply chain management for laboratory reagents, sample collection, and personal protective equipment coupled with training of health workers is crucial for adequate preparedness and successful containment of outbreaks. These initiatives, collectively undertaken, will result in a robust response system safeguarding public health and preventing emerging threats such as Mpox from..."

Journal • Fatigue • Hepatitis B • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Otorhinolaryngology • Pain

Treatment Patterns, Cough Formulations, and Antibiotics Usage for Pediatric Acute Cough in India: A Real-World Study. (PubMed, J Pharm Bioallied Sci) - "Among the antitussive combinations, chlorpheniramine + dextromethorphan + phenylephrine was widely prescribed for productive as well as nonproductive cough, respectively (9.2%, 20.22%). Azithromycin (nonproductive cough: 19.92% and productive cough: 19.55%) and cefpodoxime were frequently prescribed antibiotics...Overprescription of antibiotics and diverse management approaches, using mono- and combination therapies, across different types of pediatric acute cough highlight potential gaps in clinical practice and perhaps understanding. The results underscore the need for improved prescription monitoring, education across the specialties on cough categorization and effective management of pediatric acute cough and adherence to clinical guidelines."

Journal • Real-world evidence • Cough • Infectious Disease • Pediatrics • Respiratory Diseases

A combination strategy of HPLC and boric acid modified β-CD polymer for super-efficiently separating chiral substances with O/N atoms in chiral and/or adjacent carbons. (PubMed, Anal Chim Acta) - "Typical cases included bisoprolol (Rs = 48.19), propranolol (Rs = 45.50), chlorpheniramine (Rs = 38.36), and metoprolol (Rs = 20.26). The synergistic mechanism offers strong and specific recognition toward chiral substances with O/N atoms in chiral and/or adjacent carbons. This approach represents a novel strategy for efficient and economical HPLC-based enantioseparation using widely accessible materials and methods."

Journal

Infusion-Related Reactions (IRR) and Management in Patients With Red Blood Cell (RBC) Transfusion-Dependent (TD) Relapsed or Refractory Lower-Risk Myelodysplastic Syndromes (LR-MDS) Treated With Imetelstat From the IMerge Phase 3 Trial (JADPRO 2025) - P2/3 | "Background/Significance • Myelodysplastic syndromes (MDS) are hematologic malignancies marked by ineffective hematopoiesis, cytopenias, and an elevated risk of progression to acute myeloid leukemia1 •Imetelstat is a first-in-class, direct, and competitive inhibitor of telomerase enzymatic activity, approved in the United States (US) for the treatment of adult patients with low- to intermediate-1-risk MDS with transfusion- dependent (TD) anemia requiring ≥4 red blood cell (RBC) units over 8 weeks who have not responded to or have lost response to or are ineligible for erythropoiesis-stimulating agents (ESA)2 -Imetelstat is administered as an intravenous (IV) infusion over 2 hours every 4 weeks • Approval was based on the pivotal Phase 3 IMerge trial (NCT02598661), a multinational, randomized, double-blind, Phase 2/3 trial of imetelstat versus placebo in patients with RBC-TD, ESA-relapsed, refractory, or ineligible, and non-del(5q) lower-risk MDS Results showed..."

Clinical • P3 data • Acute Myelogenous Leukemia • Anemia • Dermatology • Hematological Malignancies • Immunology • Leukemia • Musculoskeletal Pain • Myelodysplastic Syndrome • Neutropenia • Pruritus • Thrombocytopenia • Urticaria

Comparison of Chlorpheniramine Mesotherapy and Oral Gabapentin on Pruritus Caused by Hypertrophic Scars in Burn Patients: A Single-Blind Randomized Controlled Trial. (PubMed, J Pain Palliat Care Pharmacother) - "Chlorpheniramine mesotherapy showed statistically significant short-term efficacy in reducing pruritus intensity and improving quality of life compared with oral gabapentin in burn patients with hypertrophic scars. However, given the study's limited follow-up period and lack of objective measures, further research is needed to assess long-term efficacy and broader clinical applications."

Journal • Dermatology • Pruritus

Toxic Epidermal Necrolysis and Recurrent Implantation Failure: Unveiling a Rare Phenomenon During Pregnancy. (PubMed, Clin Case Rep) - "Hydroxychloroquine (HCQ) is a common treatment for recurrent implantation failure (RIF), which may be associated with diverse side effects...With suspicion of Stevens-Johnson syndrome/Toxic epidermal necrolysis (TEN), HCQ was discontinued, and intravenous immunoglobulins (IVIg), triamcinolone, chlorpheniramine, and body lotion were administered...With the rising popularity of HCQ in immune-related conditions, it is essential to highlight the significance of continuous monitoring for uncommon adverse reactions. The need for vigilance becomes particularly critical in patients requiring immediate intervention to prevent irreversible consequences."

Journal • Gynecology • Infertility • Obstetrics • Pain • Sexual Disorders • Steven-Johnson Syndrome

From simulation to application: enhancing preclinical evaluation of dissolvable microarray patches through PBPK modelling. (PubMed, Drug Deliv Transl Res) - "In this study, an existing dermal PBPK model in MoBi® was optimised for dissolvable MAP by incorporating microneedle geometry and in vitro release profiles of MAP formulations containing the antihistamines loratadine (LOR) and chlorpheniramine maleate (CPM), as well as the antifungal drug itraconazole (ITZ). Validation was performed using in vitro permeation testing with porcine skin for CPM and LOR MAP, alongside in vivo preclinical studies in pigs for ITZ MAP. The optimised model demonstrated robust predictive performance across the diverse drug molecules and experimental conditions investigated, highlighting its value as a powerful tool to accelerate preclinical MAP development."

Journal • Preclinical

Chlorpheniramine Maleate Displaying Multiple Modes of Antiviral Action Against SARS-CoV-2: An Initial Mechanistic Study. (PubMed, Cureus) - "Conclusions These results suggest that CPM has the potential to serve as a multitarget antiviral agent against SARS-CoV-2 and potentially other respiratory viruses. Further investigations are warranted to explore its clinical implications and assess its efficacy in vivo."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Histamine regulates the activity and the expression of the Na+/H+ exchanger (NHE)3 in human epithelial HK-2 cells. (PubMed, Inflamm Res) - "Histamine shows early (within 60 min) and late (48 h) effects on NHE3 expression. The histamine H1 and H4 receptors are shown to contribute to these effects differentially. The findings of this study extends the evidence for a direct contribution of histamine on the renal reabsorptive machinery."

Journal

The efficacy of premedication with 10 mg versus 20 mg of intravenous dexamethasone for prevention of paclitaxel hypersensitivity reaction in low-risk gynecologic cancer patients: a non-inferiority, randomized controlled mono-institutional trial. (PubMed, BMC Cancer) - "Dexamethasone 10 mg was non-inferior to dexamethasone 20 mg in terms of prevention of paclitaxel hypersensitivity reactions."

Head-to-Head • Journal • Gynecologic Cancers • Immunology • Oncology

Simultaneous separation on a bisphenylureido β-cyclodextrin column and determination of eight antihistamine enantiomers in human plasma by HPLC. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "It had strong chiral separation abilities for antihistamines (Rs = 1.61-2.58) in isocratic elution, including chlorpheniramine maleate, bromopheniramine maleate, promethazine hydrochloride and trimeprazine tartrate. However, the new CUCDP exhibited high chiral selectivity for antihistamines, which was mainly related to the introduction of bisphenylureido group into the rim of cyclodextrin, and the strengthening of hydrogen bonding, π-π stacking and inclusion between CUCDP and analytes. This method could save analysis time, reduce solvent consumption, and improve efficiency at low cost."

Journal

Efficacy of Placebo Versus Chlorpheniramine for the Prevention of Allergic Transfusion Reactions. (clinicaltrials.gov) - P2 | N=6642 | Recruiting | Sponsor: Institute of Hematology & Blood Diseases Hospital, China | Trial completion date: Jun 2026 ➔ Jun 2027 | Trial primary completion date: Dec 2025 ➔ Dec 2026

Trial completion date • Trial primary completion date

Subcutaneous chlorphenamine for pruritus. (PubMed, BMJ Support Palliat Care) - "There is little literature about the use of subcutaneous chlorphenamine and this case report highlights its use can be effective for treatment of pruritus in palliative care and broaden therapeutic options. Further research is needed to support its use when administered subcutaneously."

Journal • Dermatology • Palliative care • Pruritus

The relaxant effect of the extract of Crocus sativus petal on Wistar rats airway smooth muscle and its possible mechanisms. (PubMed, Avicenna J Phytomed) - "In non-incubated TSM and in TSM groups incubated with diltiazem, chlorpheniramine, propranolol, glibenclamide, atropine and indomethacin, the relaxant effects of the extract were evaluated. The relaxant effects of C. sativus petal extract in TSM incubated with chlorpheniramine and indomethacin, were significantly reduced compared to non-incubated tissues (p<0.05 to p<0.001). The results showed an obvious relaxation effect of the petal of C. sativus extract on TSM and suggest that inhibition of cyclooxygenase pathway and histamine receptors contribute to the extract relaxant effect of the extract."

Journal • Preclinical • Pulmonary Disease • Respiratory Diseases

Rapid Detection of Chlorpheniramine Maleate in Human Blood and Urine Samples Based on NiCoP/PVP/PAN/CNFs Electrochemiluminescence Sensor. (PubMed, Molecules) - "The linear detection range of the sensor was 1 × 10-8-7 × 10-5 mol/L, and the detection limit was 7.8 × 10-10 mol/L. When human urine and serum samples were examined, the sensor was found to have a high recovery rate (94.35-103.36%), which is promising for practical applications."

Journal • Allergy

Antiallergic drugs drive the alteration of microbial community and antibiotic resistome in surface waters: A metagenomic perspective. (PubMed, J Hazard Mater) - "This study investigated the effects of seven AADs (chlorpheniramine, diphenhydramine, cetirizine, loratadine, desloratadine, sodium cromoglicate and calcium gluconate) at environmentally relevant concentrations on antibiotic resistome and bacterial community structures in water using microcosm experiments and metagenomic sequencing. Furthermore, AADs facilitated the horizontal transfer of ARGs (e.g., evgS) within microbial communities, contributing to antibiotic resistance dissemination. This study highlights the ecological risks of AADs in promoting antibiotic resistance spread and provides new insights into their impact on microbial communities and resistome dynamics in aquatic environments."

Journal

Treatment Patterns, Use of Cough Formulations, and Antibiotics in the Management of Acute Cough in Indian Adults and Elderly: A Real-world Study. (PubMed, J Assoc Physicians India) - "The study gives an overview of current cough management practices in India. The findings highlight the need for educating primary care physicians on the use of standardized guidelines and evidence-based management for common ailments like cough."

Journal • Real-world evidence • Cough • Respiratory Diseases

An allergic reaction in a patient with von Willebrand disease using plasma-derived Factor VIII (FVIII) concentrate is really due to concentration or excipient? (ISTH 2025) - "Initially, she was treated with hydrocortisone (50 mg) and chlorpheniramine (10 mg)...Diphenhydramine (15 mg) was prescribed every hourDuring the second desensitization, plasma samples were analyzed at 1 hour, 2 hours, 20 hours, and 26 hours (Table 1).A 5-year-old female, diagnosed with Von Willebrand disease type 3...Clinically, there was improvement with no hemorrhagic findings. Table or Figure Upload"

Clinical • Allergy • Anemia • Dermatology • Hematological Disorders • Hemophilia • Immunology

A case of prawn induced FDEIA (EAACI 2025) - "Intravenous methylprednisolone and chlorphenamine were administered, the patient was sent home where he made a full recovery. The patient was diagnosed with prawn-induced FDEIA. He was advised not to eat prawn in the presence of co-factors. He was permitted to eat cooked prawn in the absence of co-factors."

Clinical • Late-breaking abstract • Immunology • Inflammation

Anaphylaxis to Beta-Lactams: The Importance of the Oral Challenge Test in Diagnosis (EAACI 2025) - "Additionally, the patient reported a sensation of chest tightness and nausea.She was treated with 0.5 cc IM adrenaline, 4 mg IM betamethasone, and 10 mg/ml IM chlorphenamine, with a complete resolution of the clinical symptoms within 30 minutes...In this case, the patient reacted to a cephalosporin with a side chain completely different from that of amoxicillin; thus, it cannot be excluded that there was sensitization to common structural components or primary sensitization to both molecules, despite negative skin test results. This case highlights the importance of the oral drug challenge test in diagnosing beta-lactam allergies, as emphasized in the article by Romano (Allergy 2020), since a negative skin test result has limited value in determining the risk of future reactions."

Allergy • Immunology

Haemodynamic instability in haemodialysis patients with hypereosinophilia – more than just the circuit? (UKKW 2025) - "9 (70%) of the patients required treatment with Hydrocortisone and Chlorphenamine. In this cohort of patients with hypereosinophilia and haemodynamic instability, the predominant dialysis access was a tunnelled line. Recovery of haemodynamic stability was not dependent on resolution of the hypereosinophilia, and was seen in patients whether or not the dialyser was changed to a different type. The reasons for the haemodynamic instability are likely to be multi- factorial and a search for the cause should not stop at looking only at the components of the dialysis circuit."

Clinical • Eosinophilia

Laryngeal edema after ingestion of an ornamental plant (Alocasia odora): serial clinical images in an elderly patient. (PubMed, Clin Toxicol (Phila)) - "She received intramuscular adrenaline epinephrine, intravenous chlorphenamine maleate, famotidine, and methylprednisolone. Serial laryngoscopic images demonstrated the resolution of localized airway edema over 10 days. This case visually documents the time course of laryngeal edema due to calcium oxalate exposure and highlights the importance of early airway assessment following toxic plant ingestion."

Journal • Pain