chlorpheniramine / Generic mfg. - LARVOL DELTA

Rhabdomyolysis secondary to chlorpheniramine maleate toxicity: a case report. (PubMed, Front Pharmacol) - "Chlorpheniramine maleate poisoning can cause hallucinations, hypertension, tachycardia, organ dysfunction, and central nervous system depression. Additionally, it may be a potential etiological factor for rhabdomyolysis."

Journal • Acute Kidney Injury • Cardiovascular • CNS Disorders • Depression • Hypertension • Nephrology • Psychiatry • Renal Disease • MB

Microwave plasma torch mass spectrometry for rapid prediction of photo-thermal stability and degradation pathways of pharmaceuticals. (PubMed, Talanta) - "Using direct desorption/ionization of intact tablets, six pharmaceuticals: chlorpheniramine, ornidazole, metronidazole, tinidazole, acetaminophen, and theophylline, were analyzed on average in 2 min with milligram-level sample consumption...The technique also resolved stability differences among isomers such as xylenes and nitrobenzenes. These results highlight MPT-MS as a powerful high-throughput tool for rapid screening of drug candidates, providing both stability ranking and mechanistic insight."

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Microwave-Assisted Wet Granulation for Engineering Rice Starch-Mannitol Co-Processed Excipients for Direct Compression of Orally Disintegrating Tablets. (PubMed, Pharmaceutics) - "The optimized excipient was further evaluated in ODT formulations containing chlorpheniramine maleate and piroxicam and benchmarked against a commercial co-processed excipient (Starlac®). Microwave-assisted wet granulation provides an efficient, scalable, and environmentally friendly strategy for engineering starch-based co-processed excipients with enhanced functionality for direct compression ODT applications. The developed excipient demonstrates strong potential for solid dosage form manufacturing."

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HMGB-1 Mediates The Exacerbation of Anaphylactic Shock Under Hyperlipidemic Conditions. (PubMed, J Cell Physiol) - "Pretreatment with an H1R inhibitor (chlorpheniramine) or an HMGB-1 neutralizing antibody improved survival and attenuated hypothermia in mice. In summary, ox-LDL exacerbates endothelial cell damage, resulting in increased HMGB-1 release and vascular permeability, which may worsen anaphylaxis to anaphylactic shock. The mechanisms are not fully understood, but HMGB-1 could be a potential target for future alleviation of anaphylactic shock."

Journal • Atherosclerosis • Cardiovascular • Coronary Artery Disease • Dyslipidemia • Heart Failure • Respiratory Diseases • CD31 • PECAM1

The interplay between serotonin syndrome and syndrome of inappropriate antidiuresis: a fatal case of acute hyponatremia during treatment with duloxetine, chlorphenamine, amitriptyline, and L-tryptophan. (PubMed, Ther Adv Psychopharmacol) - "Clinicians should maintain high vigilance for SS and hyponatremia in patients receiving serotonergic agents, especially when multiple such drugs are co-administered. Comprehensive medication anamnesis, prompt electrolyte monitoring, and avoidance of pharmacodynamic duplication are essential to prevent similar outcomes."

Journal • Allergy • Cardiovascular • CNS Disorders • Heart Failure

Risk assessment of a mixture of pharmaceuticals and personal care products (PPCPs) in thermal waters of Kütahya, Türkiye. (PubMed, Environ Geochem Health) - "A total of five PPCPs (caffeine, DEET, ephedrine, carbamazepine, and chlorphenamine) were quantified using a validated LC-MS/MS method. Geological and hydrogeological factors, such as fault-controlled mixing between shallow and deep aquifers, were identified as pathways for contamination. These findings highlight the need for regulatory oversight of PPCPs in thermal waters and recommend safeguards, such as isolating well intakes from shallow aquifers, to reduce ecological and health risks."

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Structure-reactivity relationships in UV/chlorine degradation, NDMA formation, and cytotoxicity of chlorpheniramine and doxylamine. (PubMed, J Hazard Mater) - "Cytotoxicity assays using ML-1 murine hepatoma cells showed a significant decrease in viability only for CPM-treated samples, consistent with the formation of chlorinated aromatic byproducts, whereas DOX and its oxidation products exhibited negligible toxicity. Overall, this study demonstrates that substituent-driven electronic effects can fundamentally redirect degradation pathways, NDMA formation, and biological responses of structurally similar pharmaceuticals under UV/chlorine treatment, providing risk-relevant insights into contaminant behavior in complex water matrices."

Journal • Hepatocellular Cancer • Liver Cancer • Solid Tumor

A Case of Rare Facial Infection Caused by Mycobacterium scrofulaceum. (PubMed, Clin Lab) - "This article reports a rare case of facial infection caused by Mycobacterium scrofulaceum. Mycobacterium scrofulaceum was quickly and accurately identified through mycobacterial strain identification (DNA microarray chip method) and mNGS. Reasonable treatment measures were adopted clinically, and the patient improved and was discharged. We hope that in the future, this study can provide assistance for the clinical diagnosis and treatment of Mycobacterium scrofulaceum infection."

Journal • Infectious Disease • Musculoskeletal Diseases • Orthopedics • Pain • Pulmonary Disease • Respiratory Diseases • Tuberculosis • CRP • IL6

Evaluation of six eco-analytical tools for the sustainable HPLC analysis of a quinary anti-cold drug mixture. (PubMed, Sci Rep) - "We present a novel, eco-friendly RP-HPLC method for determining five key components commonly found in anti-cold pharmaceutical formulations simultaneously: Paracetamol (PAR), an analgesic and antipyretic; pseudoephedrine (PSE), an antihistamine; chlorpheniramine (CHL) and preservatives methylparaben (MET) and propylparaben (PRO)...Using sustainable metrics for routine pharmaceutical analysis is an important step toward eco-friendly chromatographic practices, which is pioneered in this study. Furthermore, it fosters responsible innovation in pharmaceutical quality control by ensuring regulatory compliance and analytical reliability."

Journal • Allergic Rhinitis • Immunology • Inflammation • Pain

Capillary Electrophoretic Chiral Separation of Antihistamines: Enantiomers Recognition Mechanism by Isothermal Titration Calorimetry and Simulation Studies. (PubMed, Chirality) - "The chiral separation of chlorpheniramine, brompheniramine, and dimetindene antihistamines was achieved by capillary electrophoresis using β-CD, DM-β-CD, and TM-β-CD in 50 mM phosphate buffer (pH 3.0), with an applied voltage of 20 kV, a temperature of 20°C, and UV detection at 220 nm...The isothermal titration calorimetry and molecular docking revealed that hydrogen bondings and π-alkyl interactions played key roles in chiral recognition. The developed method is suitable for assessing enantiomeric purity in antihistamine formulations."

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Lipase-based HKUST-1 (Cu) biocomposites as chiral stationary phase for enantiomer separation in capillary electrochromatography. (PubMed, Anal Chim Acta) - "The effective combination of cost-effective lipase (from porcine pancreatic) and MOF materials enriches the library of chiral materials for enantioseparation. The understanding of the chiral recognition mechanism inspires the design of ideal performance materials. The highly stable MOF separation platform for biological functions has introduced a pioneering research paradigm for the CSP development of OT-CEC."

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Validated RP-HPLC-UV Method for Simultaneous Quantification of Aminophenazone, Dipyrine, and Chlorpheniramine Maleate in Pharmaceutical Formulations Considering Dipyrine Decomposition. (PubMed, Int J Anal Chem) - "This method was successfully employed for the analysis of aminopyrine, metamizole, and chlorpheniramine maleate in marketed products, and the results were satisfactory. The confirmed RP-HPLC-UV method may be a workable analytical approach on a routine analysis."

Journal • Pain

Rebound Pruritus and Urticaria Post-discontinuation of Chronic Cetirizine Use: A Case Report. (PubMed, Cureus) - "Through shared decision-making, he was switched to loratadine and chlorpheniramine for three days before transitioning to an "as-needed" regimen without recurrence of pruritus or urticaria. While the pathophysiology of rebound pruritus and urticaria post-discontinuation of chronic cetirizine use remains poorly understood, this case report suggests that the phenomenon may be drug-specific rather than a class-specific adverse effect. Larger studies are necessary to confirm if a temporary switch and short-term bridging with alternative antihistamines offer a safer discontinuation strategy for patients on chronic cetirizine."

Journal • Allergic Rhinitis • Atopic Dermatitis • Cardiovascular • Dermatology • Dyslipidemia • Hypertension • Immunology • Inflammation • Pruritus • Urticaria

Retrospective Determination of the Incidence of Apparent Type I Hypersensitivity Reaction to Intravenous Amoxicillin-Clavulanate in Dogs and Cats. (PubMed, J Vet Emerg Crit Care (San Antonio)) - "The incidence of a type I HS reaction to the new formulation of IV AC in dogs was low, and the outcome was excellent. No reactions in cats were identified. A cause for clustering of cases within a 6-month period was not elucidated."

Journal • Retrospective data • Allergy • Cardiovascular • Immunology

Behavioral abnormalities in older patients with chronic renal function decline following administration of compound paracetamol and amantadine hydrochloride capsules. (PubMed, J Med Case Rep) - "The central toxicity of amantadine is significantly enhanced in older patients with renal insufficiency, and chlorphenamine may increase the risk of delirium. The risks associated with using this medication in older patients suffering from the common cold far outweigh the benefits, warranting cautious use in clinical practice; adverse reactions should be managed with prompt discontinuation of the medication and hydration to facilitate drug clearance. This study provides crucial warnings about medication safety in the older population."

Journal • CNS Disorders • Nephrology • Renal Disease • Respiratory Diseases

Successful Management of Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema With Tranexamic Acid: A Case Report. (PubMed, Cureus) - "His history included hypertension treated with a recently up-titrated dose of ramipril, type 2 diabetes, gout, and prior deep vein thrombosis. Initial management following anaphylaxis protocol with intramuscular adrenaline, intravenous hydrocortisone, chlorphenamine, and adrenaline nebulisers produced no improvement. Given the strong suspicion of bradykinin-mediated angioedema, 1 g of intravenous tranexamic acid (TXA) was administered...This case highlights TXA as a safe, effective, and accessible therapeutic option for ACEI-induced angioedema, particularly in settings where targeted therapies are unavailable. It underscores the importance of recognizing this distinct clinical entity and the need for further prospective studies to define TXA's role in treatment algorithms."

Journal • Cardiovascular • Diabetes • Gout • Hematological Disorders • Hypertension • Inflammatory Arthritis • Metabolic Disorders • Otorhinolaryngology • Pulmonary Disease • Rheumatology • Thrombosis • Type 2 Diabetes Mellitus

Pharmacist-Led Prevention of Recurrent Cetuximab Infusion Reactions. (PubMed, Cureus) - "A 69-year-old woman with metastatic colorectal cancer (RAS wild-type, microsatellite instability-high, BRAF V600E mutation) receiving encorafenib/binimetinib plus cetuximab developed Grade 2 IR during her first cetuximab infusion (approximately 98 min after initiation)...After discontinuing the infusion, she was treated with oxygen, d-chlorpheniramine, and famotidine, allowing completion at a reduced rate...The generalizability of the findings is limited due to the single-patient design. Prospective validation comparing H1 alone versus combined H1 + H2 premedication, using predefined infusion-rate algorithms, is warranted."

Journal • Colorectal Cancer • Microsatellite Instability • Oncology • Solid Tumor • BRAF • MSI

Relevant pharmacokinetics, bioavailability, and bioequivalence studies on Chlorpheniramine maleate (various species): a review. (PubMed, Front Pharmacol) - "CPM remains a pharmacologically valuable molecule with underexplored delivery routes and applications. Standardization of formulations, population-specific pharmacokinetics, and further trials are warranted to unlock the full therapeutic potential of this approach beyond classical allergy treatment."

Journal • PK/PD data • Review • Allergy • Immunology

Successful re-administration after nano-liposomal irinotecan-induced severe hypersensitivity reaction: a case report. (PubMed, J Pharm Health Care Sci) - "The novelty of this report lies in presenting, for the first time, the detailed course and process by which treatment was successfully continued in a patient experiencing severe HSR upon initial nal-IRI administration, through enhanced supportive care tailored to the characteristics of the drug and stepwise dose adjustment."

Journal • Allergy • CNS Disorders • Epilepsy • Immunology • Oncology • Pancreatic Cancer • Solid Tumor

Feasibility and safety of bispecific antibodies outpatient model in triple-refractory multiple myeloma patients in two Italian centers (ASH 2025) - "All patients underwent premedication with acetaminophen, chlorphenamine and dexamethasone during SUD and first full dose whereas three patients received post-medication with dexamethasone 16 mg the day after SUD1, SUD2 and first full dose...Seven patients were treated with teclistamab and one with talquetamab, approved after teclistamab in Italy...For both these two patients, tocilizumab was administered with rapid resolution of CRS and no need of hospitilization...A solid collaboration with emergency room doctors and nurses, the education of the patient and the outline of a path to rapidly and safely manage complications has been documented to be crucial. These encourage the feasibility of managing BSAbs therapy for MM patients in an outpatient setting in hub centres where multidisciplinary collaboration can be easily achieved."

Clinical • CNS Disorders • Hematological Disorders • Hematological Malignancies • Hypotension • Multiple Myeloma

Development of a predictive model for eosinophilia in patients treated with ampicillin/sulbactam or piperacillin/tazobactam. (PubMed, Br J Clin Pharmacol) - "This study proposes a clinically applicable risk-scoring model for predicting eosinophilia in patients treated with penicillin/beta-lactamase inhibitors. Incorporating machine learning improved model accuracy, enabling more precise identification of high-risk patients. The model supports proactive risk assessment and may inform tailored monitoring and intervention strategies in clinical settings."

Journal • Cardiovascular • Eosinophilia • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Psoroptes cuniculi infestation in an Angora rabbit from Kashmir and its therapeutic management. (PubMed, J Parasit Dis) - "Additionally, chlorpheniramine maleate at 0.4 mg/kg body weight was administered intramuscularly for 3 days as an adjunct therapy to alleviate pruritus. Significant clinical improvement was observed within 1 week, and the lesions were completely resolved after 1 month of treatment. This case highlights the successful management of P. cuniculi infestation in an Angora rabbit, with ivermectin proving effective in treating ear canker in this breed."

Journal • Preclinical • Dermatology • Pruritus

The first Mpox case in Zambia: a case report. (PubMed, J Med Case Rep) - "Our report emphasizes the transmission risk for Mpox in traditionally nonendemic areas resulting from cross-border movement. This highlights the need for countries to strengthen surveillance systems resulting in increased sensitivity, specificity, and timeliness required for early detection and response to Mpox. A multifaceted collaborative approach is required between countries to ensure formalized cross-border collaboration, strengthening health-seeking behavior through deployment of mobile clinics, and utilization of digital platforms risk communication and community engagement. Improved supply chain management for laboratory reagents, sample collection, and personal protective equipment coupled with training of health workers is crucial for adequate preparedness and successful containment of outbreaks. These initiatives, collectively undertaken, will result in a robust response system safeguarding public health and preventing emerging threats such as Mpox from..."

Journal • Fatigue • Hepatitis B • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Otorhinolaryngology • Pain

Treatment Patterns, Cough Formulations, and Antibiotics Usage for Pediatric Acute Cough in India: A Real-World Study. (PubMed, J Pharm Bioallied Sci) - "Among the antitussive combinations, chlorpheniramine + dextromethorphan + phenylephrine was widely prescribed for productive as well as nonproductive cough, respectively (9.2%, 20.22%). Azithromycin (nonproductive cough: 19.92% and productive cough: 19.55%) and cefpodoxime were frequently prescribed antibiotics...Overprescription of antibiotics and diverse management approaches, using mono- and combination therapies, across different types of pediatric acute cough highlight potential gaps in clinical practice and perhaps understanding. The results underscore the need for improved prescription monitoring, education across the specialties on cough categorization and effective management of pediatric acute cough and adherence to clinical guidelines."

Journal • Real-world evidence • Cough • Infectious Disease • Pediatrics • Respiratory Diseases

A combination strategy of HPLC and boric acid modified β-CD polymer for super-efficiently separating chiral substances with O/N atoms in chiral and/or adjacent carbons. (PubMed, Anal Chim Acta) - "Typical cases included bisoprolol (Rs = 48.19), propranolol (Rs = 45.50), chlorpheniramine (Rs = 38.36), and metoprolol (Rs = 20.26). The synergistic mechanism offers strong and specific recognition toward chiral substances with O/N atoms in chiral and/or adjacent carbons. This approach represents a novel strategy for efficient and economical HPLC-based enantioseparation using widely accessible materials and methods."

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