chlorpheniramine / Generic mfg. - LARVOL DELTA

Evaluation of six eco-analytical tools for the sustainable HPLC analysis of a quinary anti-cold drug mixture. (PubMed, Sci Rep) - "We present a novel, eco-friendly RP-HPLC method for determining five key components commonly found in anti-cold pharmaceutical formulations simultaneously: Paracetamol (PAR), an analgesic and antipyretic; pseudoephedrine (PSE), an antihistamine; chlorpheniramine (CHL) and preservatives methylparaben (MET) and propylparaben (PRO)...Using sustainable metrics for routine pharmaceutical analysis is an important step toward eco-friendly chromatographic practices, which is pioneered in this study. Furthermore, it fosters responsible innovation in pharmaceutical quality control by ensuring regulatory compliance and analytical reliability."

Journal • Allergic Rhinitis • Immunology • Inflammation • Pain

Capillary Electrophoretic Chiral Separation of Antihistamines: Enantiomers Recognition Mechanism by Isothermal Titration Calorimetry and Simulation Studies. (PubMed, Chirality) - "The chiral separation of chlorpheniramine, brompheniramine, and dimetindene antihistamines was achieved by capillary electrophoresis using β-CD, DM-β-CD, and TM-β-CD in 50 mM phosphate buffer (pH 3.0), with an applied voltage of 20 kV, a temperature of 20°C, and UV detection at 220 nm...The isothermal titration calorimetry and molecular docking revealed that hydrogen bondings and π-alkyl interactions played key roles in chiral recognition. The developed method is suitable for assessing enantiomeric purity in antihistamine formulations."

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Lipase-based HKUST-1 (Cu) biocomposites as chiral stationary phase for enantiomer separation in capillary electrochromatography. (PubMed, Anal Chim Acta) - "The effective combination of cost-effective lipase (from porcine pancreatic) and MOF materials enriches the library of chiral materials for enantioseparation. The understanding of the chiral recognition mechanism inspires the design of ideal performance materials. The highly stable MOF separation platform for biological functions has introduced a pioneering research paradigm for the CSP development of OT-CEC."

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Validated RP-HPLC-UV Method for Simultaneous Quantification of Aminophenazone, Dipyrine, and Chlorpheniramine Maleate in Pharmaceutical Formulations Considering Dipyrine Decomposition. (PubMed, Int J Anal Chem) - "This method was successfully employed for the analysis of aminopyrine, metamizole, and chlorpheniramine maleate in marketed products, and the results were satisfactory. The confirmed RP-HPLC-UV method may be a workable analytical approach on a routine analysis."

Journal • Pain

Rebound Pruritus and Urticaria Post-discontinuation of Chronic Cetirizine Use: A Case Report. (PubMed, Cureus) - "Through shared decision-making, he was switched to loratadine and chlorpheniramine for three days before transitioning to an "as-needed" regimen without recurrence of pruritus or urticaria. While the pathophysiology of rebound pruritus and urticaria post-discontinuation of chronic cetirizine use remains poorly understood, this case report suggests that the phenomenon may be drug-specific rather than a class-specific adverse effect. Larger studies are necessary to confirm if a temporary switch and short-term bridging with alternative antihistamines offer a safer discontinuation strategy for patients on chronic cetirizine."

Journal • Allergic Rhinitis • Atopic Dermatitis • Cardiovascular • Dermatology • Dyslipidemia • Hypertension • Immunology • Inflammation • Pruritus • Urticaria

Retrospective Determination of the Incidence of Apparent Type I Hypersensitivity Reaction to Intravenous Amoxicillin-Clavulanate in Dogs and Cats. (PubMed, J Vet Emerg Crit Care (San Antonio)) - "The incidence of a type I HS reaction to the new formulation of IV AC in dogs was low, and the outcome was excellent. No reactions in cats were identified. A cause for clustering of cases within a 6-month period was not elucidated."

Journal • Retrospective data • Allergy • Cardiovascular • Immunology

Behavioral abnormalities in older patients with chronic renal function decline following administration of compound paracetamol and amantadine hydrochloride capsules. (PubMed, J Med Case Rep) - "The central toxicity of amantadine is significantly enhanced in older patients with renal insufficiency, and chlorphenamine may increase the risk of delirium. The risks associated with using this medication in older patients suffering from the common cold far outweigh the benefits, warranting cautious use in clinical practice; adverse reactions should be managed with prompt discontinuation of the medication and hydration to facilitate drug clearance. This study provides crucial warnings about medication safety in the older population."

Journal • CNS Disorders • Nephrology • Renal Disease • Respiratory Diseases

Successful Management of Angiotensin-Converting Enzyme Inhibitor-Induced Angioedema With Tranexamic Acid: A Case Report. (PubMed, Cureus) - "His history included hypertension treated with a recently up-titrated dose of ramipril, type 2 diabetes, gout, and prior deep vein thrombosis. Initial management following anaphylaxis protocol with intramuscular adrenaline, intravenous hydrocortisone, chlorphenamine, and adrenaline nebulisers produced no improvement. Given the strong suspicion of bradykinin-mediated angioedema, 1 g of intravenous tranexamic acid (TXA) was administered...This case highlights TXA as a safe, effective, and accessible therapeutic option for ACEI-induced angioedema, particularly in settings where targeted therapies are unavailable. It underscores the importance of recognizing this distinct clinical entity and the need for further prospective studies to define TXA's role in treatment algorithms."

Journal • Cardiovascular • Diabetes • Gout • Hematological Disorders • Hypertension • Inflammatory Arthritis • Metabolic Disorders • Otorhinolaryngology • Pulmonary Disease • Rheumatology • Thrombosis • Type 2 Diabetes Mellitus

Pharmacist-Led Prevention of Recurrent Cetuximab Infusion Reactions. (PubMed, Cureus) - "A 69-year-old woman with metastatic colorectal cancer (RAS wild-type, microsatellite instability-high, BRAF V600E mutation) receiving encorafenib/binimetinib plus cetuximab developed Grade 2 IR during her first cetuximab infusion (approximately 98 min after initiation)...After discontinuing the infusion, she was treated with oxygen, d-chlorpheniramine, and famotidine, allowing completion at a reduced rate...The generalizability of the findings is limited due to the single-patient design. Prospective validation comparing H1 alone versus combined H1 + H2 premedication, using predefined infusion-rate algorithms, is warranted."

Journal • Colorectal Cancer • Microsatellite Instability • Oncology • Solid Tumor • BRAF • MSI

Relevant pharmacokinetics, bioavailability, and bioequivalence studies on Chlorpheniramine maleate (various species): a review. (PubMed, Front Pharmacol) - "CPM remains a pharmacologically valuable molecule with underexplored delivery routes and applications. Standardization of formulations, population-specific pharmacokinetics, and further trials are warranted to unlock the full therapeutic potential of this approach beyond classical allergy treatment."

Journal • PK/PD data • Review • Allergy • Immunology

Successful re-administration after nano-liposomal irinotecan-induced severe hypersensitivity reaction: a case report. (PubMed, J Pharm Health Care Sci) - "The novelty of this report lies in presenting, for the first time, the detailed course and process by which treatment was successfully continued in a patient experiencing severe HSR upon initial nal-IRI administration, through enhanced supportive care tailored to the characteristics of the drug and stepwise dose adjustment."

Journal • Allergy • CNS Disorders • Epilepsy • Immunology • Oncology • Pancreatic Cancer • Solid Tumor

Feasibility and safety of bispecific antibodies outpatient model in triple-refractory multiple myeloma patients in two Italian centers (ASH 2025) - "All patients underwent premedication with acetaminophen, chlorphenamine and dexamethasone during SUD and first full dose whereas three patients received post-medication with dexamethasone 16 mg the day after SUD1, SUD2 and first full dose...Seven patients were treated with teclistamab and one with talquetamab, approved after teclistamab in Italy...For both these two patients, tocilizumab was administered with rapid resolution of CRS and no need of hospitilization...A solid collaboration with emergency room doctors and nurses, the education of the patient and the outline of a path to rapidly and safely manage complications has been documented to be crucial. These encourage the feasibility of managing BSAbs therapy for MM patients in an outpatient setting in hub centres where multidisciplinary collaboration can be easily achieved."

Clinical • CNS Disorders • Hematological Disorders • Hematological Malignancies • Hypotension • Multiple Myeloma

Development of a predictive model for eosinophilia in patients treated with ampicillin/sulbactam or piperacillin/tazobactam. (PubMed, Br J Clin Pharmacol) - "This study proposes a clinically applicable risk-scoring model for predicting eosinophilia in patients treated with penicillin/beta-lactamase inhibitors. Incorporating machine learning improved model accuracy, enabling more precise identification of high-risk patients. The model supports proactive risk assessment and may inform tailored monitoring and intervention strategies in clinical settings."

Journal • Cardiovascular • Eosinophilia • Immunology • Inflammatory Arthritis • Rheumatoid Arthritis • Rheumatology

Psoroptes cuniculi infestation in an Angora rabbit from Kashmir and its therapeutic management. (PubMed, J Parasit Dis) - "Additionally, chlorpheniramine maleate at 0.4 mg/kg body weight was administered intramuscularly for 3 days as an adjunct therapy to alleviate pruritus. Significant clinical improvement was observed within 1 week, and the lesions were completely resolved after 1 month of treatment. This case highlights the successful management of P. cuniculi infestation in an Angora rabbit, with ivermectin proving effective in treating ear canker in this breed."

Journal • Preclinical • Dermatology • Pruritus

The first Mpox case in Zambia: a case report. (PubMed, J Med Case Rep) - "Our report emphasizes the transmission risk for Mpox in traditionally nonendemic areas resulting from cross-border movement. This highlights the need for countries to strengthen surveillance systems resulting in increased sensitivity, specificity, and timeliness required for early detection and response to Mpox. A multifaceted collaborative approach is required between countries to ensure formalized cross-border collaboration, strengthening health-seeking behavior through deployment of mobile clinics, and utilization of digital platforms risk communication and community engagement. Improved supply chain management for laboratory reagents, sample collection, and personal protective equipment coupled with training of health workers is crucial for adequate preparedness and successful containment of outbreaks. These initiatives, collectively undertaken, will result in a robust response system safeguarding public health and preventing emerging threats such as Mpox from..."

Journal • Fatigue • Hepatitis B • Human Immunodeficiency Virus • Infectious Disease • Inflammation • Musculoskeletal Diseases • Musculoskeletal Pain • Orthopedics • Otorhinolaryngology • Pain

Treatment Patterns, Cough Formulations, and Antibiotics Usage for Pediatric Acute Cough in India: A Real-World Study. (PubMed, J Pharm Bioallied Sci) - "Among the antitussive combinations, chlorpheniramine + dextromethorphan + phenylephrine was widely prescribed for productive as well as nonproductive cough, respectively (9.2%, 20.22%). Azithromycin (nonproductive cough: 19.92% and productive cough: 19.55%) and cefpodoxime were frequently prescribed antibiotics...Overprescription of antibiotics and diverse management approaches, using mono- and combination therapies, across different types of pediatric acute cough highlight potential gaps in clinical practice and perhaps understanding. The results underscore the need for improved prescription monitoring, education across the specialties on cough categorization and effective management of pediatric acute cough and adherence to clinical guidelines."

Journal • Real-world evidence • Cough • Infectious Disease • Pediatrics • Respiratory Diseases

A combination strategy of HPLC and boric acid modified β-CD polymer for super-efficiently separating chiral substances with O/N atoms in chiral and/or adjacent carbons. (PubMed, Anal Chim Acta) - "Typical cases included bisoprolol (Rs = 48.19), propranolol (Rs = 45.50), chlorpheniramine (Rs = 38.36), and metoprolol (Rs = 20.26). The synergistic mechanism offers strong and specific recognition toward chiral substances with O/N atoms in chiral and/or adjacent carbons. This approach represents a novel strategy for efficient and economical HPLC-based enantioseparation using widely accessible materials and methods."

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Infusion-Related Reactions (IRR) and Management in Patients With Red Blood Cell (RBC) Transfusion-Dependent (TD) Relapsed or Refractory Lower-Risk Myelodysplastic Syndromes (LR-MDS) Treated With Imetelstat From the IMerge Phase 3 Trial (JADPRO 2025) - P2/3 | "Background/Significance • Myelodysplastic syndromes (MDS) are hematologic malignancies marked by ineffective hematopoiesis, cytopenias, and an elevated risk of progression to acute myeloid leukemia1 •Imetelstat is a first-in-class, direct, and competitive inhibitor of telomerase enzymatic activity, approved in the United States (US) for the treatment of adult patients with low- to intermediate-1-risk MDS with transfusion- dependent (TD) anemia requiring ≥4 red blood cell (RBC) units over 8 weeks who have not responded to or have lost response to or are ineligible for erythropoiesis-stimulating agents (ESA)2 -Imetelstat is administered as an intravenous (IV) infusion over 2 hours every 4 weeks • Approval was based on the pivotal Phase 3 IMerge trial (NCT02598661), a multinational, randomized, double-blind, Phase 2/3 trial of imetelstat versus placebo in patients with RBC-TD, ESA-relapsed, refractory, or ineligible, and non-del(5q) lower-risk MDS Results showed..."

Clinical • P3 data • Acute Myelogenous Leukemia • Anemia • Dermatology • Hematological Malignancies • Immunology • Leukemia • Musculoskeletal Pain • Myelodysplastic Syndrome • Neutropenia • Pruritus • Thrombocytopenia • Urticaria

Comparison of Chlorpheniramine Mesotherapy and Oral Gabapentin on Pruritus Caused by Hypertrophic Scars in Burn Patients: A Single-Blind Randomized Controlled Trial. (PubMed, J Pain Palliat Care Pharmacother) - "Chlorpheniramine mesotherapy showed statistically significant short-term efficacy in reducing pruritus intensity and improving quality of life compared with oral gabapentin in burn patients with hypertrophic scars. However, given the study's limited follow-up period and lack of objective measures, further research is needed to assess long-term efficacy and broader clinical applications."

Journal • Dermatology • Pruritus

Toxic Epidermal Necrolysis and Recurrent Implantation Failure: Unveiling a Rare Phenomenon During Pregnancy. (PubMed, Clin Case Rep) - "Hydroxychloroquine (HCQ) is a common treatment for recurrent implantation failure (RIF), which may be associated with diverse side effects...With suspicion of Stevens-Johnson syndrome/Toxic epidermal necrolysis (TEN), HCQ was discontinued, and intravenous immunoglobulins (IVIg), triamcinolone, chlorpheniramine, and body lotion were administered...With the rising popularity of HCQ in immune-related conditions, it is essential to highlight the significance of continuous monitoring for uncommon adverse reactions. The need for vigilance becomes particularly critical in patients requiring immediate intervention to prevent irreversible consequences."

Journal • Gynecology • Infertility • Obstetrics • Pain • Sexual Disorders • Steven-Johnson Syndrome

From simulation to application: enhancing preclinical evaluation of dissolvable microarray patches through PBPK modelling. (PubMed, Drug Deliv Transl Res) - "In this study, an existing dermal PBPK model in MoBi® was optimised for dissolvable MAP by incorporating microneedle geometry and in vitro release profiles of MAP formulations containing the antihistamines loratadine (LOR) and chlorpheniramine maleate (CPM), as well as the antifungal drug itraconazole (ITZ). Validation was performed using in vitro permeation testing with porcine skin for CPM and LOR MAP, alongside in vivo preclinical studies in pigs for ITZ MAP. The optimised model demonstrated robust predictive performance across the diverse drug molecules and experimental conditions investigated, highlighting its value as a powerful tool to accelerate preclinical MAP development."

Journal • Preclinical

Chlorpheniramine Maleate Displaying Multiple Modes of Antiviral Action Against SARS-CoV-2: An Initial Mechanistic Study. (PubMed, Cureus) - "Conclusions These results suggest that CPM has the potential to serve as a multitarget antiviral agent against SARS-CoV-2 and potentially other respiratory viruses. Further investigations are warranted to explore its clinical implications and assess its efficacy in vivo."

Journal • Infectious Disease • Novel Coronavirus Disease • Respiratory Diseases

Histamine regulates the activity and the expression of the Na+/H+ exchanger (NHE)3 in human epithelial HK-2 cells. (PubMed, Inflamm Res) - "Histamine shows early (within 60 min) and late (48 h) effects on NHE3 expression. The histamine H1 and H4 receptors are shown to contribute to these effects differentially. The findings of this study extends the evidence for a direct contribution of histamine on the renal reabsorptive machinery."

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The efficacy of premedication with 10 mg versus 20 mg of intravenous dexamethasone for prevention of paclitaxel hypersensitivity reaction in low-risk gynecologic cancer patients: a non-inferiority, randomized controlled mono-institutional trial. (PubMed, BMC Cancer) - "Dexamethasone 10 mg was non-inferior to dexamethasone 20 mg in terms of prevention of paclitaxel hypersensitivity reactions."

Head-to-Head • Journal • Gynecologic Cancers • Immunology • Oncology

Simultaneous separation on a bisphenylureido β-cyclodextrin column and determination of eight antihistamine enantiomers in human plasma by HPLC. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "It had strong chiral separation abilities for antihistamines (Rs = 1.61-2.58) in isocratic elution, including chlorpheniramine maleate, bromopheniramine maleate, promethazine hydrochloride and trimeprazine tartrate. However, the new CUCDP exhibited high chiral selectivity for antihistamines, which was mainly related to the introduction of bisphenylureido group into the rim of cyclodextrin, and the strengthening of hydrogen bonding, π-π stacking and inclusion between CUCDP and analytes. This method could save analysis time, reduce solvent consumption, and improve efficiency at low cost."

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