chlorpheniramine / Generic mfg. - LARVOL DELTA

Comparison of chiral separation performance of （2-hydroxyethyl-β）-cyclodextrin bonded superficially porous and fully porous particle chiral stationary phases in supercritical fluid chromatography and reversed-phase liquid chromatography (PubMed, Se Pu) - "The evaluation was performed using ten chiral molecular probes： zopiclone， equol， 2-phenylpropionic acid， dobutamine， flutriafol， miconazole， folic acid， catechin， valacyclovir， and chlorphenamine. Polar organic solvent mode was not investigated either. Additionally， peak symmetry and theoretical plate numbers on the SPP-CSP were generally inferior to those observed on the commercial Hp-β-CD chiral column across both chromatographic modes."

Journal • Addiction (Opioid and Alcohol)

Suspected Biphasic Anaphylaxis Following the First Known Dose of Tirzepatide: A Case Report and Brief Review of Reported Hypersensitivity Reactions. (PubMed, Cureus) - "She was treated with intravenous fluids, nebulized bronchodilators, and two doses of intramuscular epinephrine, resulting in complete clinical resolution...Her symptoms resolved following treatment with intravenous hydrocortisone and chlorphenamine. Acute and baseline serum tryptase levels were unavailable, and validated allergy testing for tirzepatide was not performed; therefore, the underlying immunological mechanism could not be established. This case highlights the importance of early recognition and prompt treatment of tirzepatide-associated anaphylaxis, as well as continued pharmacovigilance and detailed reporting of severe hypersensitivity reactions."

Journal • Allergy • Cardiovascular • Dermatology • Diabetes • Hypotension • Immunology • Metabolic Disorders • Type 2 Diabetes Mellitus • Urticaria

A hERG blocker facilitates K+ channel current by promoting pore opening while blocking. (PubMed, J Gen Physiol) - "A process that may counteract arrhythmogenic hERG block, termed facilitation, is common to many clinically approved hERG blockers, including nifekalant, amiodarone, promethazine, imipramine, nortriptyline, haloperidol, verapamil, carvedilol, metoprolol, propranolol, quinidine, fluoxetine, and chlorpheniramine. Voltage-clamp measurements revealed that agonism-while-blocking can result in nifekalant block and facilitation. We speculate that this agonism-while-blocking mechanism contributes to the relative safety of hERG blockers that induce facilitation."

Journal • Cardiovascular

Severe bradycardia after amivantamab administration in a patient with epidermal growth factor receptor-positive non-small cell lung cancer: A case report. (PubMed, Fujita Med J) - "We report the case of a 53-year-old Japanese man with advanced EGFR exon 19-deleted lung adenocarcinoma who was treated with amivantamab plus lazertinib as eighth-line therapy...The infusion was interrupted and intravenous methylprednisolone, chlorpheniramine, and atropine were administered...On rechallenge with amivantamab 10 days later, bradycardia did not recur, suggesting that bradycardia is an IRR. Clinicians should be aware of this potential reaction and closely monitor cardiac rhythm during and after amivantamab infusion."

Journal • Cardiovascular • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Pain • Pulmonary Disease • Solid Tumor • EGFR

Probable pregabalin and amantadine-containing cold medication intoxication in an adolescent with rhabdomyolysis: Case report. (PubMed, J Taibah Univ Med Sci) - "A limited qualitative urine toxicology screen was negative, but the panel did not include pregabalin, amantadine, acetaminophen, caffeine, or chlorpheniramine. Creatine kinase decreased to 495 U/L by day 15. This case highlights the need for collateral medication histories and expanded toxicological testing when routine screening is negative."

Journal • Anesthesia • Cardiovascular • CNS Disorders • Myocardial Infarction • Psychiatry • Respiratory Diseases • MB

Acute and Chronic Toxicity Tests and Assessment of In Vitro and In Vivo Anti-Allergic Effects of Prabchompoothaweep Remedy. (PubMed, Int J Mol Sci) - "Several plant ingredients and the PCT extract inhibited β-hexosaminidase release more effectively than chlorpheniramine. In OVA-induced mice, PCT (75, 150, and 300 mg/kg) did not significantly lower OVA-specific serum IgE or IgG2a (OVA-specific IgG1 was likewise not reduced); however, it reduced inflammatory cell infiltration, goblet cell hyperplasia and mast cell numbers in the nasal mucosa and downregulated the T helper 2 (Th2) cytokines IL-5 and IL-13. These findings support the traditional anti-allergic use of the PCT remedy."

Journal • Preclinical • Allergic Rhinitis • Allergy • Immunology • Inflammation • Respiratory Diseases • IL13 • IL5

LC-MS/MS Quantification of Five Antihistamines in Antemortem Blood: Method Validation and Application. (PubMed, J Anal Toxicol) - "A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for five first-generation H1 antihistamines: chlorpheniramine, diphenhydramine, doxylamine, hydroxyzine, and promethazine. Selected case reports are presented to demonstrate the applicability of the method. The high percentage of polysubstance cases, range of concentrations, and delayed sample collection in DFC cases underscore the importance of a sensitive and reproducible method for these first-generation antihistamines, especially in human-performance casework."

Journal • Alzheimer's Disease • Anesthesia • CNS Disorders • Cognitive Disorders

Anaphylactic reaction to the second dose of dacarbazine following initial exposure in patient with hodgkin lymphoma. (PubMed, J Oncol Pharm Pract) - "The reaction was manifested by hypoxia, shivering, itching, and laryngeal edema.Management & OutcomePatient required immediate interruption of dacarbazine infusion and received 10 mg of intravenous chlorphenamine and 200 mg of intravenous hydrocortisone initially with no improvement. Hypoxia and laryngeal edema improved following the administration of 0.3 mg intramuscular epinephrine...Patient continued nivolumab, doxorubicin, and vinblastine (N + AV) for five cycles, and achieved complete metabolic response.DiscussionThis case highlights that anaphylactic reaction to dacarbazine may occur despite prior tolerance to the first dose. Physicians should suspect reaction during subsequent infusions of dacarbazine, even when initial cycle is tolerated."

Journal • Classical Hodgkin Lymphoma • Critical care • Hematological Disorders • Hematological Malignancies • Hodgkin Lymphoma • Lymphoma • Oncology

Analysis of eight OTC drug components in postmortem dried blood spot samples by liquid chromatography-tandem mass spectrometry. (PubMed, Leg Med (Tokyo)) - "We combined the DBS method with liquid chromatography coupled with electrospray ionization-tandem mass spectrometry to quantify eight OTC drug components (apronal, caffeine, chlorpheniramine, dextromethorphan, diphenhydramine, diprophylline, noscapine, and promethazine). Comparison with our general practice method showed good positive correlations at the quantifiable concentrations of all drugs. Furthermore, when applied to an actual case, it was possible to diagnose death by drug poisoning, confirming the usefulness of this method."

Journal

Stability-Indicating RP-HPLC Determination of Acetylsalicylic Acid, Dextromethorphan Hydrobromide, Phenylephrine Bitartrate, and Chlorpheniramine Maleate in an Effervescent Tablet Formulation. (PubMed, J AOAC Int) - "This method employs ion-pairing at pH 2.0 optimized for the effervescent matrix and dual-wavelength detection for the quantification of actives and selected impurities. Fully validated per ICH Q2(R2), it demonstrates a clear stability-indicating capability and suitability for QC and stability studies of the evaluated effervescent tablet formulation."

Journal

A synergy strategy of deep eutectic solvents and boric acid modified β-CD polymer for enhancing enantioseparation in HPLC. (PubMed, Anal Chim Acta) - "The resolutions of chlorpheniramine, propranolol, metoprolol, and bisoprolol increased by 17.16, 14.61, 12.63, and 8.86, respectively. In this paper, deep eutectic solvents (DESs) by modulating the hydrogen-bonding network and solvation microenvironment were introduced as auxiliary modifiers into the chiral mobile-phase additive (CMPA) mode of HPLC for the first time which could synergistically enhance chiral recognition. This strategy offers a green, versatile, and cost-effective solution for advancing chiral separation on conventional C18 columns in HPLC."

Journal

Intentional Dexketoprofen Overdose During Pregnancy: Maternal and Fetal Outcomes in Three Cases. (PubMed, Birth Defects Res) - "The three cases demonstrated heterogeneous pregnancy outcomes. No congenital anomalies were identified in the single evaluable live-born infant. Multiple co-ingested agents substantially complicate causal attribution, most notably ergotamine tartrate in Case 2. The limited case number and outcome heterogeneity preclude identification of a consistent pattern of fetal adverse effects or definitive conclusions regarding fetal risk. All overdoses were intentional, underscoring the importance of integrating psychiatric assessment into toxicological management during pregnancy. These cases represent the first available observational data on maternal and fetal outcomes following intentional dexketoprofen overdose in pregnancy, highlighting the need for a multidisciplinary approach in this clinical setting."

Journal • Gynecology • Psychiatry

Analysis of adverse event reports associated with complementary health products in Singapore from 2017 to 2023. (PubMed, Front Med (Lausanne)) - "Products found to contain undeclared illegal substances were most frequently indicated for pain relief, with dexamethasone, chlorpheniramine, and prednisolone being the most common adulterants found. These findings highlight the need for continued vigilance in the monitoring of CHPs to safeguard public health."

Adverse events • Journal • Pain

Over-the-counter drug poisoning among pediatric and adolescent patients presenting to emergency departments: a nationwide analysis of the COVID-19 impact. (PubMed, Clin Toxicol (Phila)) - "Among pediatric and adolescent patients, OTC drug poisoning declined while prescription drug poisoning rose significantly across the three periods. The pandemic-related increase in drug poisoning reflected prescription rather than OTC drugs."

Journal • Infectious Disease • Novel Coronavirus Disease • Pediatrics

Bioinspired core-shell photonic crystal microneedle patch for real-time optical monitoring of drug release in jellyfish envenomation therapy. (PubMed, Biosens Bioelectron) - "This device is fabricated by coating hyaluronic acid (HA) shells onto non-close-packed PCMN cores, which are functionalized with chlorpheniramine, while the HA shells incorporate lidocaine as a pain management payload...In a murine model of jellyfish sting envenomation, the PCMN@HA platform demonstrated partially attenuated systemic envenomation within 7 h. This work establishes a theranostic platform that integrates a biomimetic device design with optical signal readout, with potential applications extending to other dermatological conditions requiring temporally controlled pharmacotherapy."

Journal • Pain

Design Space Exploration and Multi-Color Analytical Profiling of a BBD Assisted RP-HPLC Method for Simultaneous Estimation of Butamirate Citrate and Chlorpheniramine Maleate. (PubMed, Ann Pharm Fr) - "Analytical performance was evaluated using the Red Analytical Performance Index (70) and Multi-Color Assessment Tool (72.6%), collectively reflecting strong scope, sensitivity, accuracy, and precision. Reliable quantification of both compounds in pharmaceutical dosage forms is offered by a validated, environmentally friendly approach, supporting routine quality control and research applications."

Journal

Anticholinergic toxidrome in a toddler with unwitnessed ingestion: Diagnostic clues pointing to over-the-counter medication overdose. (PubMed, J Anal Toxicol) - "Serum analysis by liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF/MS) identified chlorpheniramine and scopolamine, while excluding other agents. Scopolamine is highly toxic even at low concentrations, and pediatric cases with measured blood levels are exceedingly rare. Our findings highlight the need to consider additive or synergistic toxicity in OTC formulations containing multiple anticholinergic agents and emphasize the importance of caregiver education regarding the potential risks of OTC medications often perceived as safe."

Journal • Pediatrics

Dual temperature-sensitive liposome-in-liposome structure for advanced drug delivery systems. (PubMed, Colloids Surf B Biointerfaces) - "This was further validated by the independent release of commercial drugs, chlorpheniramine maleate and riboflavin sodium phosphate, as confirmed via HPLC analysis. These results validate the TSH-based LIL platform as a versatile and scalable strategy for developing smart, multi-stage delivery vehicles with environment-responsive release profiles."

Journal

Electroacupuncture as an eosinophil-targeting treatment in ovalbumin-induced allergic rhinitis involving β2-adrenergic receptor in a mouse model. (PubMed, Front Immunol) - "Using an ovalbumin (OVA)-induced AR mouse model, we compared EA with the antihistamine chlorpheniramine (CLP)...Mechanistic exploration involved administering β2-adrenergic (butoxamine) or dopamine D1 (butaclamol) antagonists before EA, followed by plasma catecholamine measurements and intranasal epinephrine rescue...Our findings demonstrate that EA reduces eosinophilic inflammation and AR behaviors associated with the activation of β2-adrenergic receptors. Unlike standard antihistamines that target mast cells, EA engages a sympathetic neuroimmune axis, representing a promising complementary intervention for eosinophil-driven AR."

IO biomarker • Journal • Preclinical • Allergic Rhinitis • Asthma • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases • CCR4 • IL13 • IL5 • RNASE2

Not so innocent after all: H1-antihistamine-induced Fixed Drug Eruption confirmed by lesional Patch Testing (BAD 2026) - "H1-antihistamines can be grouped by chemical structure into alkylamines (chlorphenamine), piperazines (hydroxyzine and cetirizine) and piperidines (loratadine and fexofenadine)...Symptoms persisted despite oral prednisolone but improved rapidly after stopping antihistamines...Repeat patch testing with fexofenadine and diphenhydramine is planned to assess cross-sensitivity. This case describes a rare antihistamine-associated fixed drug eruption with postulated class-related crossreactivity in a presumed safe drug class and highlights in situ patch testing as a safe diagnostic tool."

Immunology • Inflammation • Urticaria

Not so innocent after all: H1-antihistamine-induced Fixed Drug Eruption confirmed by lesional Patch Testing (BAD 2026) - "H1-antihistamines can be grouped by chemical structure into alkylamines (chlorphenamine), piperazines (hydroxyzine and cetirizine) and piperidines (loratadine and fexofenadine)...Symptoms persisted despite oral prednisolone but improved rapidly after stopping antihistamines...Repeat patch testing with fexofenadine and diphenhydramine is planned to assess cross-sensitivity. This case describes a rare antihistamine-associated fixed drug eruption with postulated class-related crossreactivity in a presumed safe drug class and highlights in situ patch testing as a safe diagnostic tool."

Immunology • Inflammation • Urticaria

Blood–brain barrier permeability of antihistamines and risk of depression in children and adolescents: a real-world cohort study (CINP 2026) - "Exposure groups were defined by antihistamine BBB permeability: the low-BBB cohort (fexofenadine, bilastine, ebastine, olopatadine, acrivastine) and the high-BBB cohort (diphenhydramine, chlorpheniramine, hydroxyzine, promethazine, doxylamine, triprolidine, pheniramine). This large-scale, real-world analysis suggests that high-BBB-penetrant antihistamines may confer an elevated risk of depression in children and adolescents with allergic rhinitis. The absence of associations for negative-control outcomes supports the internal validity of this finding and implicates BBB permeability as a plausible factor influencing psychiatric vulnerability. Clinically, these results highlight the importance of considering BBB penetrability when selecting antihistamines for pediatric patients, particularly those with emotional or behavioral risk factors."

Clinical • Real-world • Real-world evidence • Acne Vulgaris • Allergic Rhinitis • CNS Disorders • Depression • Immunology • Inflammation • Mental Retardation • Mood Disorders • Psychiatry

Clinical observations from a study comparing two different treatments for bluetongue in sheep. (PubMed, Ir Vet J) - "From a group of 83 sheep with acute and clear clinical signs of bluetongue, one group of 41 sheep received a single injection of meloxicam (1 mg/kg) followed by oral paracetamol tablets (10-20 mg/kg, 3dd for 3d). Another group with 42 sheep received the same treatment with the addition of an antihistamine injection (chlorphenamine maleate, 1 mg/kg, 1dd for 3d)...Based on our findings, however, we cannot recommend the use of antihistamines for treating bluetongue-affected sheep, as they did not improve survival. We would like to emphasize the importance of timely decision-making regarding the continuation or cessation of treatment, given the typically low survival rates in clinically affected sheep."

Journal • CNS Disorders • Depression • Infectious Disease • Psychiatry • Pulmonary Disease

Linarin Inhibits Mast Cell Degranulation and Ameliorates Allergic Rhinitis in Rats by Suppressing ERK/p38 MAPK Signaling Pathway. (PubMed, Recent Adv Inflamm Allergy Drug Discov) - "These findings support linarin as a promising safe, natural anti-allergic agent."

Journal • Preclinical • Allergic Rhinitis • Immunology • Inflammation • IL4 • TNFA

A hERG Blocker Facilitates K + Channel Current by Agonizing Pore Opening while Blocking. (PubMed, bioRxiv) - "A process that may counteract arrhythmogenic hERG block, termed facilitation, is common to many clinically-approved hERG blockers including nifekalant, amiodarone, promethazine, imipramine, nortriptyline, haloperidol, verapamil, carvedilol, metoprolol, propranolol, quinidine, fluoxetine, and chlorpheniramine. Voltage-clamp measurements reveal that agonism-while-blocking undergirds nifekalant block and facilitation. We speculate that this agonism-while-blocking mechanism contributes to the relative safety of hERG blockers that induce facilitation."

Journal • Cardiovascular