lacosamide / Generic mfg. - LARVOL DELTA

Genes Do Not Read DSM: Tuberous Sclerosis Complex May Dominate with Multi-Neuropsychiatric Symptoms. (PubMed, Harv Rev Psychiatry) - "Treatment with lacosamide eliminated detectable epileptiform activity and substantially reduced the frequency and severity of her panic-like episodes; depressive and anxiety symptoms also improved with combined lacosamide and duloxetine treatment. Stereotyped, brief, recurrent, and treatment-refractory psychiatric episodes-particularly when accompanied by neurocutaneous findings-should prompt electroencephalography and brain imaging. The case also emphasizes that an uninformative or uncertain genetic result does not exclude clinically established TSC or alter recommended surveillance and multidisciplinary management."

Journal • CNS Disorders • Depression • Epilepsy • Genetic Disorders • Mental Retardation • Mood Disorders • Psychiatry • Pulmonary Disease • TSC1

Unmasking the Masquerader: Paroxysmal Kinesigenic Dyskinesia (PKD) Misdiagnosed as Epilepsy for Nearly a decade: Time to Act (Consecutive Cohort of 25 patients) (MDS Congress 2026) - "Median diagnostic delay was staggering- 8 years (range 0.25 to 22) with 5 patients ( 20%) receiving levetiracetam, valproate or lacosamide under an epilepsy label before correct diagnosis...Carbamazepine (CBZ)(76%) and oxcarbazepine (OXC) (20%) at a mean dose od 238 168mg/day achieved symptom freedom in 84% at one year... In this Northern India cohort, PKD masqueraded as epilepsy or was undiagnosed for nearly a decade before correct diagnosis, a delay that is avoidable, harmful and must end. Sodium channel blockers achieve near-universal symptoms control to zero pharmacological failures. Recognising PKD is not an academic exercise, it is the difference between eight years of wrong treatment or no treatment to one tablet that works."

Clinical • Ataxia • CNS Disorders • Epilepsy • Movement Disorders

Morvan Syndrome Associated with Malignant Thymoma and Double-Positive CASPR2/LGI1 Antibodies (MDS Congress 2026) - "Treatment with methylprednisolone pulse therapy and lacosamide resulted in partial improvement... This case highlights an unusual presentation of Morvan syndrome associated with malignant thymoma and double-positive CASPR2/LGI1 antibodies. The coexistence of SIADH and exophthalmos expands the clinical spectrum. Our analysis suggests a less pronounced male predominance than previously reported and indicates that double-positive cases may present with more severe autonomic dysfunction, higher rates of hallucinations and confusion, and a rapidly progressive course."

Alzheimer's Disease • CNS Disorders • Epilepsy • Insomnia • Movement Disorders • Musculoskeletal Pain • Sleep Disorder

Use of Slow Low-Efficiency Dialysis in a Patient With Status Epilepticus Secondary to Herpes Simplex Encephalitis With Severe Acute Kidney Injury. (PubMed, Case Rep Nephrol) - "Seizures were controlled with midazolam drip, valproic acid, and lacosamide. SLED can be used as a treatment modality in a neurocritically ill patient with status epilepticus for solute clearance. Good clinical judgment, early recognition, and ability to individualize care with management of AKI in the critical care unit can help improve clinical outcomes."

Journal • Acute Kidney Injury • Chronic Kidney Disease • CNS Disorders • Critical care • Epilepsy • Herpes Simplex • Infectious Disease • Nephrology • Renal Disease

Silent Channels, Lethal Rhythms: Perioperative Management of Infantile SCN5A Brugada Syndrome requiring Defibrillator Placement (ASA 2026) - "We report the case of a male infant with SCN5A Brugada Syndrome and prior ventricular fibrillation cardiac arrest, following administration of Lacosamide, scheduled for ICD implantation...Anesthetic challenges included line placement, avoidance of certain anesthetic drugs, as well as strict temperature and electrolyte regulation. This case underscores the importance of comprehensive multidisciplinary anesthetic planning, detailed family and perinatal history gathering, and strict avoidance of arrhythmogenic medications in infants with SCN5A-related Brugada syndrome undergoing high-risk cardiac procedures."

Cardiovascular • Genetic Disorders

Role of 18 F-FDG-PET/CT in a case of suspected Rasmussen encephalitis (EANM 2026) - "The patient remains on antiepileptic treatment (lacosamide) with preserved functional status and temporary seizure control. Brain FDGPET/CT demonstrated a characteristic pattern of unilateral hemispheric hypometabolism, correlated closely with structural MRI findings, supporting the diagnosis of RE. Although 18F-FDG-PET/CT is not a mandatory diagnostic test for RE diagnosis, it can provide important complementary information in suspected RE, particularly in atypical presentations, delineating the extent of cortical dysfunction and contributing to clinical decision-making."

Clinical • FDG PET • CNS Disorders • Epilepsy • Immunology • Ventriculomegaly

Itraconazole and Lacosamide Combination Therapy Rescues CGG Repeat Expansion Induced Neurotoxicity in Fragile X-Associated Tremor/Ataxia Syndrome. (PubMed, ACS Chem Neurosci) - "Biophysical studies revealed the selective interaction of the drug combination with CGG-expanded RNA. These findings identify the ITZ+LCM combination as a promising, clinically translatable therapeutic strategy against FXTAS to counter RNA-mediated neurotoxicity."

Journal • Ataxia • CNS Disorders • Movement Disorders • FMR1

Case Report: Seizure freedom after resection of a temporal choroidal fissure cyst in drug-resistant epilepsy. (PubMed, Front Neurosci) - "Postoperatively, she continued lacosamide 150 mg twice daily and lamotrigine 100 mg twice daily. The available histopathological specimens showed no definite evidence of hippocampal sclerosis or ILAE-classifiable focal cortical dysplasia (FCD). These findings suggest that, in certain cases, choroidal fissure cysts may act as independent epileptogenic triggers, with implications for epilepsy diagnosis and management."

Journal • CNS Disorders • Epilepsy

Volumetric Microsampling for Patient-Centric Therapeutic Drug Monitoring in Clinical Pharmacology: A Scoping Review. (PubMed, J Clin Pharmacol) - "Fixed conversion factors performed well for lacosamide and levetiracetam but were less reliable for lamotrigine at high concentrations. Several analyte-matrix combinations, including cefepime, vancomycin, meropenem, paclitaxel, abiraterone, and mitotane, did not consistently meet agreement criteria. Volumetric microsampling can support patient-centered drug monitoring when validated for the specific analyte, matrix, device, and clinical application. Future research should prioritize drug-specific optimization, multicenter validation, standardized conversion reporting, and integration with MIPD platforms."

Journal • Review

Bilateral lingual epilepsy following traumatic brain injury. (PubMed, Pract Neurol) - "These events were refractory to carbamazepine, lacosamide and valproate. Electroencephalography showed irregular and sharpened left-sided slow waves but no epileptiform activity, even during episodes of lingual twitching. Bilateral lingual seizures in this patient implied that the left operculum cortex innervated both hypoglossal nuclei."

Journal • CNS Disorders • Epilepsy • Oncology • Vascular Neurology

Management Guidelines for the Treatment of Pediatric Brain Tumor-Associated Seizure: A Modified Delphi Consensus Report. (PubMed, Ann Child Neurol Soc) - "Respondents universally agreed to start a patient on anti-seizure medication (ASM) only after their first seizure, with levetiracetam as the first-line and lacosamide or oxcarbazepine as the second-line. Finally, the presence of cortical dysplasia or mesial temporal sclerosis should prompt an upfront epilepsy surgery evaluation. This study yielded guidelines for pediatric brain tumor-related epilepsy established from the opinions of child neurologists specializing in the care of these patients."

Journal • Brain Cancer • CNS Disorders • Epilepsy • Oncology • Pediatrics • Solid Tumor

A Real‑World Comparative Study of Lacosamide Combined with Valproate in the Treatment of Epilepsy Based on Propensity Score Matching (ChiCTR) - P=N/A | N=200 | Not yet recruiting | Sponsor: Yancheng First People's Hospital; Yancheng First People's Hospital

New trial • Real-world evidence • CNS Disorders • Epilepsy

Intravenous Lacosamide for the Treatment of Acute Pain in Trigeminal Neuralgia (clinicaltrials.gov) - P=N/A | N=20 | Recruiting | Sponsor: Hospital Universitari de Bellvitge | Trial completion date: May 2027 ➔ Dec 2027 | Trial primary completion date: Dec 2026 ➔ Dec 2027

Trial completion date • Trial primary completion date • Neuralgia • Pain

Continuous-Flow Synthesis of Antiepileptic Drugs: Process Intensification, Sustainability Metrics, and Scalable Manufacturing. (PubMed, ACS Omega) - "The review will examine examples of recent advances in continuous-flow processing of major molecules, including pregabalin, levetiracetam, lacosamide, and brivaracetam. In addition, the review will discuss the obstacles preventing a complete transition to an automated, environmentally friendly, and continuous-flow process for producing AEDs."

Journal • Review

Time-dependent retention and discontinuation of eslicarbazepine acetate treatment in real-world focal epilepsy: The first three months as a key period. (PubMed, Clin Neurol Neurosurg) - "The first 3 months are a key period for optimizing treatment retention and minimizing adverse events. Careful consideration of concomitant ASM is required, as concomitant ASM may be associated with lower retention and more adverse events, particularly sodium channel blockers."

Journal • Real-world evidence • CNS Disorders • Epilepsy

Cognitive Side Effects of Antiseizure Medications in Adults with Epilepsy: An Update with a Focus on New Therapeutic Agents. (PubMed, CNS Drugs) - "Overall, newer-generation ASMs, including rufinamide, lacosamide, brivaracetam, cannabidiol, fenfluramine, and ganaxolone, demonstrate generally favourable cognitive profiles when used at recommended doses, particularly in monotherapy or rational polytherapy. Eslicarbazepine and cenobamate may be associated with mild, dose-dependent cognitive effects, occurring only at the upper end of the recommended dose range. In contrast, old ASMs and certain second-generation agents, notably topiramate and zonisamide, remain consistently associated with higher cognitive risks...Cognitive dysfunction in epilepsy is multifactorial, reflecting the interaction between disease-related neurobiological mechanisms and treatment effects. Optimal management requires balancing seizure control with cognitive preservation through individualised drug selection, cautious titration, and minimisation of polytherapy to achieve the best functional and quality-of-life outcomes."

Adverse events • Journal • Review • CNS Disorders • Cognitive Disorders • Developmental Disorders • Epilepsy • Mental Retardation

Reversible Heart Failure, Right Bundle Branch Block And Sinus Bradycardia In A Patient Treated With Lacosamide [Poster no. 516] (HFSA 2026) - No abstract available

Clinical • Cardiovascular • Congestive Heart Failure • Heart Failure

Exploratory definition of a clinically meaningful change in intracranial EEG features: Analysis of data from a long-term treatment study of the RNS® System. (PubMed, Epilepsy Behav) - "If LE reductions may serve as a potential biomarker, a threshold associated with meaningful improvement in CSs is paramount. Results from this hypothesis-generating analysis support the use of a ≥ 30% LE reduction as a biomarker associated with clinically meaningful improvement in focal epilepsy."

Journal • CNS Disorders • Epilepsy

Membrane-Dependent Adsorption of Lacosamide in CRRT: Implications for Drug Dosing in Critically Ill Renal Patients. (PubMed, Med Sci Monit) - "Adsorption was more pronounced in plasma than in saline for PAN-PEI and PAN membranes. These findings indicate that lacosamide concentrations may decrease during extracorporeal circulation and should be considered in settings involving hemodialysis or continuous renal replacement therapy."

Journal • CNS Disorders • Epilepsy

Gestational Changes in Antiseizure Medication Concentrations and the Impact of Polytherapy: A Prospective Multicenter Cohort Study in China. (PubMed, Neurology) - P=N/A | "Pregnancy was the primary driver of declining C/D ratios, and concomitant ASMs and body weight acted as secondary modifiers. These findings support individual therapeutic drug monitoring."

Journal • Observational data • CNS Disorders • Epilepsy

Concentration-to-dose ratio as a predictor of lacosamide efficacy in Chinese children with epilepsy: a single-center retrospective cohort study. (PubMed, Front Pharmacol) - "These findings support the use of CDR for guiding individualized LCM therapy. Further multicenter studies with larger samples are warranted to validate these results and establish an optimal CDR range."

Journal • Retrospective data • CNS Disorders • Epilepsy • Pediatrics

Real-world evaluation of capillary microsampling for drug monitoring of anti-seizure medications. (PubMed, Epilepsia) - "VAMS-based self-collection is feasible and reliable for at-home TDM, provided that high-quality sampling is ensured. qDBS represents a reliable alternative for ambulatory monitoring. Future work should focus on optimizing sampling procedures for older adults and improving logistics for home-based microsampling."

Journal • CNS Disorders • Epilepsy • Pain

Narrative Review: Efficacy, Safety, and Tolerability of Newer Third-Generation Antiseizure Medications for Focal Epilepsy: A New Benchmark in Treatment Outcomes? (PubMed, Neurol Ther) - "All third-generation ASMs were effective adjunctive therapies. Cenobamate was associated with higher responder and seizure freedom rates and higher long-term retention rates. Brivaracetam and lacosamide had favorable tolerability profiles. The notable seizure freedom rates with cenobamate suggest a potential new benchmark in focal seizure treatment. Comparator trials are needed to confirm possible efficacy and tolerability differences among third-generation ASMs."

Journal • Review • CNS Disorders • Eosinophilia • Epilepsy • Fatigue • Pain • Psychiatry

Transient Acute-onset Holmes-like Tremor After Cortical Stroke. (PubMed, Neurol Sci) - "This case is unusual because of the acute onset, isolated precentral cortical lesions, distal predominance of tremor, and spontaneous remission. The absence of prior tremor, the close temporal relationship with the new infarct, and complete recovery suggest that the acute cortical lesion was the most likely trigger. The cortical localization is consistent with network-based models suggesting that Holmes tremor may arise from disruption of a distributed motor circuit rather than a single anatomical structure. The rapid resolution supports the hypothesis of a transient functional network disturbance rather than a stable oscillatory circuit dysfunction."

Journal • Cardiovascular • Epilepsy • Ischemic stroke • Movement Disorders

Advances in Sodium Channel Modulation in Epilepsy Therapy: Focus on Eslicarbazepine, Lacosamide and Cenobamate. (PubMed, Biomedicines) - " Recent advances in sodium channel modulation have expanded therapeutic options for focal epilepsy and support the development of more selective, mechanism-based ASM therapies. Eslicarbazepine acetate, lacosamide, and cenobamate demonstrate favorable efficacy and tolerability profiles and may improve seizure control in patients with drug-resistant epilepsy."

Journal • Review • Cardiovascular • CNS Disorders • Epilepsy • Fatigue • Heart Failure