Remofuscin (soraprazan) / Katairo - LARVOL DELTA

Mesopic microperimetry in Stargardt disease: Application and reliability. (PubMed, Acta Ophthalmol) - "Given its high variability, PWS should be used cautiously. MS offers lower variability but may mask localised functional changes. A parafoveal ring strategy may improve reliability but requires validation. Limiting test duration to ≤450 seconds and comprehensive operator training are recommended to minimise potential bias."

Journal • Inherited Retinal Dystrophy • Ophthalmology • Retinal Disorders

Virtual screening of marine coumarins and xanthenes identifies novel acid-suppressive leads targeting histamine H₂ receptor and gastric proton pump. (PubMed, Biomol Biomed) - "Docking simulations were performed using curated structures of both targets, followed by an evaluation of the compounds for drug-likeness and predicted absorption, distribution, metabolism, and excretion (ADME) properties. Thirty-four compounds demonstrated a stronger predicted affinity for the H₂ receptor than famotidine; however, only three compounds (1, 5, and 150) met all drug-likeness criteria, achieving quantitative estimates of drug-likeness (QED) values exceeding 0.67. Screening against the proton pump yielded 98 hits with higher affinity than soraprazan, with compound 150 being the only candidate to fulfill all medicinal chemistry filters...ADME predictions suggested favorable permeability and a low risk for human ether-à-go-go-related gene (hERG) inhibition, although high plasma protein binding and the potential for cytochrome P450 (CYP) inhibition may require further optimization. These findings underscore the potential of pyranocoumarin compound..."

Journal • Metabolic Disorders

Retrospective Analysis of Injuries Related to Terrorism Among Hospitalized Patients in Somalia: A Focus on Medical Management and Outcomes [WITHDRAWN] (EUSEM 2025) - " A total of 2426 patients were injured by 359 explosions and firearm attacks during the study period... The findings of the study revealed that suicide bombing explosions are associated with multiple body site injuries, a greater rate of severe and critical internal injuries, and a higher mortality rate."

Retrospective data • Mood Disorders

Stargardt's Disease: Molecular Pathogenesis and Current Therapeutic Landscape. (PubMed, Int J Mol Sci) - "Small-molecule therapies target vitamin A dimerization (e.g., ALK-001), inhibit lipofuscin accumulation (e.g., soraprazan), or modulate the visual cycle (e.g., emixustat hydrochloride). Gene therapy trials explore ABCA4 supplementation including strategies like RNA exon editing (ACDN-01) and bioengineered ambient light-activated OPSIN...Trials like DRAGON (Phase 3, tinlarebant), STARLIGHT (phase 2, bioengineered OPSIN) show promise, but optimizing efficacy remains challenging. With the key problem of establishing genotype-phenotype correlations, the future of STGD1 therapy may rely on approaches targeting oxidative stress, lipid metabolism, inflammation, complement regulation, and genetic repair."

Journal • Review • Age-related Macular Degeneration • Gene Therapies • Inflammation • Inherited Retinal Dystrophy • Macular Degeneration • Metabolic Disorders • Ophthalmology • Retinal Disorders • ALK

Resilient HIV response in Peru: advancing person-centered care through national ART decentralization post-COVID-19 (IAS-HIV 2025) - "ART decentralization strengthened Peru's HIV response by improving access, equity, and continuity of care. Between 2019 and 2024, the number of ART-providing PHC centers increased by 359% (from 49 to 225), with nearly one-third of PLHIV now receiving treatment at PHC facilities. This approach enhanced health system resilience, ensuring that PLHIV remained at the center of the response during and after the COVID-19 pandemic."

Late-breaking abstract • Human Immunodeficiency Virus • Infectious Disease • Novel Coronavirus Disease

Assessing the Functional and Structural Properties of Peanut Meals Modified by Transglutaminase-Coupled Glycation. (PubMed, Foods) - "Additionally, superior emulsification, foaming, and oil-absorbing properties were achieved for the modified PM, which were named EPM, FPM, and OPM, respectively (specimens under different modification conditions). Notably, the emulsification activity of the EPM sample was enhanced by 69.8% (i.e., from 18.48 to 31.38 m2/g); the foaming capacity of the FPM specimen was increased by 84.00% (i.e., from 21.00 to 46.00%); and the oil-absorbing capacity of the OPM sample was enhanced by 359.57% (i.e., from 1.41 to 6.48 g/g protein)."

Journal

Understanding Risk Factors for Physical Assault in a Large Inpatient Behavioral Health System. (PubMed, Psychiatr Serv) - "A total of 15,186 unique inpatients were evaluated, and 556 physical assaults committed by 359 (2.4%) patients during the study period were identified...This study represents one of the largest investigations into rates of assault by patients in U.S. inpatient psychiatric hospitals. By attaining a greater understanding of risk factors for inpatient assault, this study may contribute to the development of risk assessment and management methodologies."

Journal • CNS Disorders • Psychiatry

Neuromuscular Electrostimulation of the Common Peroneal Nerve Increases Microvascular Flux in the Wound bed of Diabetic Foot Ulcers. (PubMed, Int J Low Extrem Wounds) - "Pulsatility in the wound bed increased by 183% (95%CI 61%-517%, P = .005), while pulsatility in the peri-wound increases by 359% (95%CI 264%-455%, P = .001). Additionally, an increase in flux and pulsatility was observed in the neuroischemic ulcers.ConclusionsNeuromuscular stimulation of the common peroneal nerve presents a mode of activating the leg muscle pump without additional pressure insult to the foot and has potential to support the microcirculation during wound-healing, effectively emulating exercise without any of the attendant risks of exercise to the neuropathic or neuroischemic foot."

Journal • Diabetic Neuropathy

Interrupted time series analysis of the impact of COVID-19 on emergency and elective surgeries in Iranian hospitals. (PubMed, East Mediterr Health J) - "Due to the pandemic there was a significant decrease by 359.6; however, we observed a gradual recovery in surgical activity with an average increase of 15.8 surgeries above the pre-pandemic levels...The COVID-19 pandemic significantly impacted surgical services in Iranian hospitals, causing a reallocation of resources to COVID-19 care and postponement of non-urgent surgeries. There is a need for strategic planning and policy interventions to ensure continuity of surgical care during health emergencies."

Journal • Infectious Disease • Novel Coronavirus Disease

AMF and biochar reshape the bacterial network in rhizosphere soil of Ricinus communis under chromium (Cr) stress and improve soil quality. (PubMed, J Hazard Mater) - "Results indicated that under 150 mg/kg Cr stress, the AMF-biochar combination significantly increased castor plant fresh weight and soil quality index by 359.70 % and 121.25 %, respectively, compared to treatments without biochar or AMF (P < 0.05)...Network analysis and community assembly results revealed that AMF and biochar together significantly enhanced soil bacterial network complexity and average niche width. In conclusion, the AMF-biochar combination effectively promoted Ricinus communis growth under Cr stress and regulated rhizosphere soil bacterial community stability and assembly processes, providing valuable insights into plant-microbe interactions under Cr(VI) stress."

Journal

Efficacy of Potassium Competitive Acid Blockers (PCABs) vs Proton Pump Inhibitors (PPIs) for Healing of Duodenal Ulcers: A Systematic Review and Meta Analysis (APASL 2025) - "PCABs such as Vonoprazan, Tegoprazan, Soraprazan, Revaprazan, Keverprazan and Linaprazan are reversible, competitive antagonists of the H+/K+ ATPase that is seen to have more sustained acid suppression. PCABs such as Vonoprazan 20mg and Keverprazan 20mg are non inferior to PPIs in the healing of duodenal ulcers. Both classes of drugs had similar tolerability profiles. Table and Figure:Figure 1.Forest plot of PCAB vs PPI on healing of duodenal ulcers at Week 6 Figure 2.Forest plot of PCAB vs PPI on healing of duodenal ulcers at Week 4"

Retrospective data • Review • Chronic Kidney Disease • Musculoskeletal Diseases • Nephrology • Orthopedics • Peptic Ulcer • Renal Disease

Molecular dynamics method to predict the effects of temperature and strain rate on mechanical properties of Aluminum/Copper superalloy. (PubMed, J Mol Model) - "The results show a significant enhancement in both UTS and elastic modulus with increasing copper content, with the UTS increasing by 359% and the elastic modulus by 281% when copper content rises from 1 to 20%...Additionally, higher strain rates were found to improve both UTS and elastic modulus, with an 11.95% increase in UTS and an 8.34% increase in elastic modulus at the highest strain rate (0.01 ps-1). These findings demonstrate the critical role of alloy composition, temperature, and strain rate in tailoring the mechanical properties of Al-Cu alloys, providing insights for optimizing the material for high-performance applications."

Journal

Predicting land use and land cover changes for sustainable land management using CA-Markov modelling and GIS techniques. (PubMed, Sci Rep) - "The build-up area expanded by 359.8 km², indicating rapid urbanization, while vegetation cover decreased by 198.7 km² and barren lands by 158.5 km²...This research is a significant framework for urban planners, providing insights that combine development with ecological conservation. The results highlight the necessity of incorporating predictive models into urban policy to promote sustainable development and environmental preservation in quickly changing areas such as Lahore."

Journal

Development of a work systems stress questionnaire to predict job burnout: A mixed methods study based on a macroergonomics approach. (PubMed, Heliyon) - "To test the developed Work System Stress Questionnaire (WSSQ) in terms of its ability to predict burnout, a survey which included demographic items, the WSSQ, and the Maslach Burnout Inventory was completed by 359 employees...In turn, the WSSQ will enable remedial actions to be put into place. It may also be useful for understanding the consequences associated with other organizational ergonomic variables that are related to job stress."

Journal

Wearable devices for out-of-hospital cardiac arrest: A population survey on the willingness to adhere. (PubMed, J Am Coll Emerg Physicians Open) - "The survey was completed by 359 participants...Individuals were willing to continuously wear wearable devices for OHCA detection, especially at increased hypothetical risk of OHCA. Optimizing willingness is not just a matter of adjusting for user preferences, but also increasing perception of urgency through awareness and education about OHCA."

Journal • Cardiovascular

TREATMENT OF HELICOBACTER PYLORI WITH POTASSIUM COMPETITIVE ACID BLOCKERS: A SYSTEMATIC REVIEW AND META-ANALYSIS (DDW 2024) - "Methods : This study following PRISMA 0 0 guidelines conducted a systematic review and meta-analysis by searching MEDLINE and SCOPUS libraries for randomized clinical trials (RCTs) or observational studies with the following command: [("Helicobacter pylori" OR "H pylori") AND ("Treatment" OR "Therapy" OR "Eradication") AND ("Vonaprazan" OR "Potassium-Competitive Acid Blocker" OR "P-CAB" OR "PCAB" OR "Revaprazan" OR "Linaprazan" OR "Soraprazan" OR "Tegoprazan")]. Vonoprazan-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori positioning it as a highly effective first-line regimen. Additionally Tegoprazan-based triple therapy wass non-inferior to classical PPI triple therapy."

Retrospective data • Review • Dyspepsia • Gastric Adenocarcinoma • Gastric Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Hematological Malignancies • Infectious Disease • Lymphoma • Marginal Zone Lymphoma • Oncology • Peptic Ulcer • Solid Tumor

Treatment of Helicobacter pylori with potassium competitive acid blockers: A systematic review and meta-analysis. (PubMed, World J Gastroenterol) - "VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori, positioning it as a highly effective first-line regimen. Additionally, TPZ-based triple therapy was non-inferior to classical PPI triple therapy."

Clinical • Journal • Retrospective data • Review • Dyspepsia • Gastric Adenocarcinoma • Gastric Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Hematological Malignancies • Infectious Disease • Lymphoma • Marginal Zone Lymphoma • Oncology • Peptic Ulcer • Solid Tumor

Remofuscin slows retinal thinning in Stargardt Disease (STGD1) – results from the Stargardt Remofuscin Treatment Trial (STARTT) a 2-year placebo-controlled study. (ARVO 2024) - "Remofuscin treated subjects showed less retinal thinning on SD-OCT compared to placebo. This effect appears to increase over time and was observed in both study and fellow eyes. Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand."

Clinical • Inherited Retinal Dystrophy • Ophthalmology • Retinal Disorders

Enzymatic Synthesis of Indole-Based Imidazopyridine using α-Amylase. (PubMed, Chembiochem) - "The imidazo[1,2-a]pyridine scaffold has gained significant attention due to its presence as a lead structure in several commercially available pharmaceuticals like zolimidine, zolpidem, olprinone, soraprazan, etc. Further, indole-based imidazo[1,2-a]pyridine derivatives have been found interesting due to their anticancer and antibacterial activities...The generality and robustness of this protocol were shown by synthesizing differently substituted indole-based imidazo[1,2-a]pyridines in good isolated yields. Furthermore, to make α-amylase a reusable catalyst for GBB multicomponent reaction, it was immobilized onto magnetic metal-organic framework (MOF) materials [Fe3O4@MIL-100(Fe)] and found reusable up to four consecutive catalytic cycles without the significant loss in catalytic activity."

Journal • Oncology

Microplastic in mangroves: A worldwide review of contamination in biotic and abiotic matrices. (PubMed, Mar Pollut Bull) - "We analyzed 53 articles on MPs in Asia, America, and Africa and produced by 359 authors, although very localized, lacking wide-scale coverage of mangrove coasts around the world...Therefore, for future research, it is relevant to enhance spatial and temporal sampling of MP contamination and to establish standardized protocols to enable effective comparisons between mangrove areas, rivers, beaches, and coastal seas. In addition, it is crucial to investigate the role of MPs as carriers or vectors of other pollutants."

Journal • Review

The STArgardt Remofuscin Treatment Trial (STARTT): design and baseline characteristics of enrolled Stargardt patients. (PubMed, Open Res Eur) - P2 | "The baseline data represent the largest, multi-national, STGD1 cohort to date that underwent standardized qAF imaging, reading speed assessment and vision-related quality of life measures which all contribute to the characterization of STGD1. EudraCT registration: 2018-001496-20 (09/05/2019)."

Journal • Inherited Retinal Dystrophy • Ophthalmology • Retinal Disorders

Factors associated with implemented teacher-led movement and physical activity in early childhood education and care. (PubMed, Front Psychol) - "Data were obtained from questionnaires completed by 359 ECEC educators...The children are expected to develop their motor skills to a sufficient extent during the short moments of offered outdoor play. Teachers who are physically active in their leisure-time seem to offer gross motor training for the children to a higher extent than less active or inactive colleagues."

Journal

What factors contribute towards ambulance on-scene times for suspected stroke patients? An observational study. (PubMed, Eur Stroke J) - "About 2037 suspected stroke patients were conveyed between July and December 2021, resulting in 581 fully completed surveys by 359 different clinicians...This type of data can be used to target interventions at behaviours that extend pre-hospital OST but which have questionable patient benefit. This approach will be evaluated in a follow up study in the North East of England."

Journal • Observational data • Cardiovascular

Comparing the Etiology of Viral Acute Respiratory Illnesses Between Children Who Do and Do Not Attend Childcare. (PubMed, Pediatr Infect Dis J) - "Children attending childcare experience a higher risk of adenovirus and human metapneumovirus infection and are regularly exposed to a rich and diverse pool of respiratory viruses in childcare environments. Our results underscore the necessity of thorough and multifaceted viral prevention strategies in childcare settings."

Journal • Infectious Disease • Respiratory Diseases

Repeatability of Quantitative Autofluorescence Imaging in a Multicenter Study Involving Patients With Recessive Stargardt Disease 1. (PubMed, Transl Vis Sci Technol) - P2 | "A total of 102 patients with STGD1 underwent qAF imaging as part of the Stargardt Remofuscin Treatment Trial (STARTT; EudraCT No...With improved operator training and by selecting the better of two recordings for evaluation, qAF serves as a useful method for assessing changes in autofluorescence signal. The qAF can be adopted as a clinical trial end point, but steps to counterbalance variability should be considered."

Clinical • Journal • Inherited Retinal Dystrophy • Ophthalmology • Retinal Disorders