Remofuscin (soraprazan) / Katairo - LARVOL DELTA

Neuromuscular Electrostimulation of the Common Peroneal Nerve Increases Microvascular Flux in the Wound bed of Diabetic Foot Ulcers. (PubMed, Int J Low Extrem Wounds) - "Pulsatility in the wound bed increased by 183% (95%CI 61%-517%, P = .005), while pulsatility in the peri-wound increases by 359% (95%CI 264%-455%, P = .001). Additionally, an increase in flux and pulsatility was observed in the neuroischemic ulcers.ConclusionsNeuromuscular stimulation of the common peroneal nerve presents a mode of activating the leg muscle pump without additional pressure insult to the foot and has potential to support the microcirculation during wound-healing, effectively emulating exercise without any of the attendant risks of exercise to the neuropathic or neuroischemic foot."

Journal • Diabetic Neuropathy

Interrupted time series analysis of the impact of COVID-19 on emergency and elective surgeries in Iranian hospitals. (PubMed, East Mediterr Health J) - "Due to the pandemic there was a significant decrease by 359.6; however, we observed a gradual recovery in surgical activity with an average increase of 15.8 surgeries above the pre-pandemic levels...The COVID-19 pandemic significantly impacted surgical services in Iranian hospitals, causing a reallocation of resources to COVID-19 care and postponement of non-urgent surgeries. There is a need for strategic planning and policy interventions to ensure continuity of surgical care during health emergencies."

Journal • Infectious Disease • Novel Coronavirus Disease

AMF and biochar reshape the bacterial network in rhizosphere soil of Ricinus communis under chromium (Cr) stress and improve soil quality. (PubMed, J Hazard Mater) - "Results indicated that under 150 mg/kg Cr stress, the AMF-biochar combination significantly increased castor plant fresh weight and soil quality index by 359.70 % and 121.25 %, respectively, compared to treatments without biochar or AMF (P < 0.05)...Network analysis and community assembly results revealed that AMF and biochar together significantly enhanced soil bacterial network complexity and average niche width. In conclusion, the AMF-biochar combination effectively promoted Ricinus communis growth under Cr stress and regulated rhizosphere soil bacterial community stability and assembly processes, providing valuable insights into plant-microbe interactions under Cr(VI) stress."

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Efficacy of Potassium Competitive Acid Blockers (PCABs) vs Proton Pump Inhibitors (PPIs) for Healing of Duodenal Ulcers: A Systematic Review and Meta Analysis (APASL 2025) - "PCABs such as Vonoprazan, Tegoprazan, Soraprazan, Revaprazan, Keverprazan and Linaprazan are reversible, competitive antagonists of the H+/K+ ATPase that is seen to have more sustained acid suppression. PCABs such as Vonoprazan 20mg and Keverprazan 20mg are non inferior to PPIs in the healing of duodenal ulcers. Both classes of drugs had similar tolerability profiles. Table and Figure:Figure 1.Forest plot of PCAB vs PPI on healing of duodenal ulcers at Week 6 Figure 2.Forest plot of PCAB vs PPI on healing of duodenal ulcers at Week 4"

Retrospective data • Review • Chronic Kidney Disease • Musculoskeletal Diseases • Nephrology • Orthopedics • Peptic Ulcer • Renal Disease

Molecular dynamics method to predict the effects of temperature and strain rate on mechanical properties of Aluminum/Copper superalloy. (PubMed, J Mol Model) - "The results show a significant enhancement in both UTS and elastic modulus with increasing copper content, with the UTS increasing by 359% and the elastic modulus by 281% when copper content rises from 1 to 20%...Additionally, higher strain rates were found to improve both UTS and elastic modulus, with an 11.95% increase in UTS and an 8.34% increase in elastic modulus at the highest strain rate (0.01 ps-1). These findings demonstrate the critical role of alloy composition, temperature, and strain rate in tailoring the mechanical properties of Al-Cu alloys, providing insights for optimizing the material for high-performance applications."

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Predicting land use and land cover changes for sustainable land management using CA-Markov modelling and GIS techniques. (PubMed, Sci Rep) - "The build-up area expanded by 359.8 km², indicating rapid urbanization, while vegetation cover decreased by 198.7 km² and barren lands by 158.5 km²...This research is a significant framework for urban planners, providing insights that combine development with ecological conservation. The results highlight the necessity of incorporating predictive models into urban policy to promote sustainable development and environmental preservation in quickly changing areas such as Lahore."

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Development of a work systems stress questionnaire to predict job burnout: A mixed methods study based on a macroergonomics approach. (PubMed, Heliyon) - "To test the developed Work System Stress Questionnaire (WSSQ) in terms of its ability to predict burnout, a survey which included demographic items, the WSSQ, and the Maslach Burnout Inventory was completed by 359 employees...In turn, the WSSQ will enable remedial actions to be put into place. It may also be useful for understanding the consequences associated with other organizational ergonomic variables that are related to job stress."

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Wearable devices for out-of-hospital cardiac arrest: A population survey on the willingness to adhere. (PubMed, J Am Coll Emerg Physicians Open) - "The survey was completed by 359 participants...Individuals were willing to continuously wear wearable devices for OHCA detection, especially at increased hypothetical risk of OHCA. Optimizing willingness is not just a matter of adjusting for user preferences, but also increasing perception of urgency through awareness and education about OHCA."

Journal • Cardiovascular

TREATMENT OF HELICOBACTER PYLORI WITH POTASSIUM COMPETITIVE ACID BLOCKERS: A SYSTEMATIC REVIEW AND META-ANALYSIS (DDW 2024) - "Methods : This study following PRISMA 0 0 guidelines conducted a systematic review and meta-analysis by searching MEDLINE and SCOPUS libraries for randomized clinical trials (RCTs) or observational studies with the following command: [("Helicobacter pylori" OR "H pylori") AND ("Treatment" OR "Therapy" OR "Eradication") AND ("Vonaprazan" OR "Potassium-Competitive Acid Blocker" OR "P-CAB" OR "PCAB" OR "Revaprazan" OR "Linaprazan" OR "Soraprazan" OR "Tegoprazan")]. Vonoprazan-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori positioning it as a highly effective first-line regimen. Additionally Tegoprazan-based triple therapy wass non-inferior to classical PPI triple therapy."

Retrospective data • Review • Dyspepsia • Gastric Adenocarcinoma • Gastric Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Hematological Malignancies • Infectious Disease • Lymphoma • Marginal Zone Lymphoma • Oncology • Peptic Ulcer • Solid Tumor

Treatment of Helicobacter pylori with potassium competitive acid blockers: A systematic review and meta-analysis. (PubMed, World J Gastroenterol) - "VPZ-based triple therapy outperformed conventional PPI-based triple therapy in eradicating H. pylori, positioning it as a highly effective first-line regimen. Additionally, TPZ-based triple therapy was non-inferior to classical PPI triple therapy."

Clinical • Journal • Retrospective data • Review • Dyspepsia • Gastric Adenocarcinoma • Gastric Cancer • Gastroenterology • Gastrointestinal Cancer • Gastrointestinal Disorder • Hematological Malignancies • Infectious Disease • Lymphoma • Marginal Zone Lymphoma • Oncology • Peptic Ulcer • Solid Tumor

Remofuscin slows retinal thinning in Stargardt Disease (STGD1) – results from the Stargardt Remofuscin Treatment Trial (STARTT) a 2-year placebo-controlled study. (ARVO 2024) - "Remofuscin treated subjects showed less retinal thinning on SD-OCT compared to placebo. This effect appears to increase over time and was observed in both study and fellow eyes. Layman Abstract (optional): Provide a 50-200 word description of your work that non-scientists can understand."

Clinical • Inherited Retinal Dystrophy • Ophthalmology • Retinal Disorders

Enzymatic Synthesis of Indole-Based Imidazopyridine using α-Amylase. (PubMed, Chembiochem) - "The imidazo[1,2-a]pyridine scaffold has gained significant attention due to its presence as a lead structure in several commercially available pharmaceuticals like zolimidine, zolpidem, olprinone, soraprazan, etc. Further, indole-based imidazo[1,2-a]pyridine derivatives have been found interesting due to their anticancer and antibacterial activities...The generality and robustness of this protocol were shown by synthesizing differently substituted indole-based imidazo[1,2-a]pyridines in good isolated yields. Furthermore, to make α-amylase a reusable catalyst for GBB multicomponent reaction, it was immobilized onto magnetic metal-organic framework (MOF) materials [Fe3O4@MIL-100(Fe)] and found reusable up to four consecutive catalytic cycles without the significant loss in catalytic activity."

Journal • Oncology

Microplastic in mangroves: A worldwide review of contamination in biotic and abiotic matrices. (PubMed, Mar Pollut Bull) - "We analyzed 53 articles on MPs in Asia, America, and Africa and produced by 359 authors, although very localized, lacking wide-scale coverage of mangrove coasts around the world...Therefore, for future research, it is relevant to enhance spatial and temporal sampling of MP contamination and to establish standardized protocols to enable effective comparisons between mangrove areas, rivers, beaches, and coastal seas. In addition, it is crucial to investigate the role of MPs as carriers or vectors of other pollutants."

Journal • Review

The STArgardt Remofuscin Treatment Trial (STARTT): design and baseline characteristics of enrolled Stargardt patients. (PubMed, Open Res Eur) - P2 | "The baseline data represent the largest, multi-national, STGD1 cohort to date that underwent standardized qAF imaging, reading speed assessment and vision-related quality of life measures which all contribute to the characterization of STGD1. EudraCT registration: 2018-001496-20 (09/05/2019)."

Journal • Inherited Retinal Dystrophy • Ophthalmology • Retinal Disorders

Factors associated with implemented teacher-led movement and physical activity in early childhood education and care. (PubMed, Front Psychol) - "Data were obtained from questionnaires completed by 359 ECEC educators...The children are expected to develop their motor skills to a sufficient extent during the short moments of offered outdoor play. Teachers who are physically active in their leisure-time seem to offer gross motor training for the children to a higher extent than less active or inactive colleagues."

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What factors contribute towards ambulance on-scene times for suspected stroke patients? An observational study. (PubMed, Eur Stroke J) - "About 2037 suspected stroke patients were conveyed between July and December 2021, resulting in 581 fully completed surveys by 359 different clinicians...This type of data can be used to target interventions at behaviours that extend pre-hospital OST but which have questionable patient benefit. This approach will be evaluated in a follow up study in the North East of England."

Journal • Observational data • Cardiovascular

Comparing the Etiology of Viral Acute Respiratory Illnesses Between Children Who Do and Do Not Attend Childcare. (PubMed, Pediatr Infect Dis J) - "Children attending childcare experience a higher risk of adenovirus and human metapneumovirus infection and are regularly exposed to a rich and diverse pool of respiratory viruses in childcare environments. Our results underscore the necessity of thorough and multifaceted viral prevention strategies in childcare settings."

Journal • Infectious Disease • Respiratory Diseases

Repeatability of Quantitative Autofluorescence Imaging in a Multicenter Study Involving Patients With Recessive Stargardt Disease 1. (PubMed, Transl Vis Sci Technol) - P2 | "A total of 102 patients with STGD1 underwent qAF imaging as part of the Stargardt Remofuscin Treatment Trial (STARTT; EudraCT No...With improved operator training and by selecting the better of two recordings for evaluation, qAF serves as a useful method for assessing changes in autofluorescence signal. The qAF can be adopted as a clinical trial end point, but steps to counterbalance variability should be considered."

Clinical • Journal • Inherited Retinal Dystrophy • Ophthalmology • Retinal Disorders

The company Christmas party and employee happiness. (PubMed, Sci Rep) - "Data were provided by 359 employees from various organizations in Germany, who completed an online survey at the beginning of January 2019...Furthermore, employee age, organizational identification, involvement in planning, a human relations and an internal process culture, a speech, providing both alcoholic and non-alcoholic beverages, heavy drinking, supervisor and coworker inappropriate behavior, formality, and symbolism were differentially associated with high- and low-arousal positive and negative affect. These findings suggest several directions for future research on company parties and have practical implications for organizations and party planning committees."

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Terror-related injuries in Somalia: a retrospective cohort of 2426 hospitalized cases along 7 years. (PubMed, Sci Rep) - "A total of 2426 patients were injured by 359 explosions and firearm attacks during the study period...The inpatient mortality rate was 11.6%. The findings of the study revealed that suicide bombings explosions are associated with multiple body site injuries, a greater rate of severe and critical internal injuries, and a higher mortality rate."

Journal • Retrospective data • Critical care

Evaluation of the Brief COPE scale and exploration of coping among primary healthcare nurses' during COVID-19. (PubMed, J Nurs Manag) - "Nurse managers need to consider the workforce demographics when designing and implementing support strategies. The Brief COPE can identify current coping strategies and inform interventions to build coping capacity."

Journal • Infectious Disease • Novel Coronavirus Disease

Intraoperative adverse event reporting in urology: Global ICARUS survey results (EAU 2022) - "Regularly reporting iAEs is considered important or extremely important by 359 (93.7%) and neutral by 22 (5.7%) of those surveyed... While the majority believe regularly reporting iAEs is important, only about a third always report these events. Availability of classification systems and society guidelines are endorsed as the most likely to improve iAE reporting. Infrequent and inconsistent iAE reporting may be attributed to lack of awareness of current resources."

Adverse events • Clinical • Urology

Structural Basis for Binding of Potassium-Competitive Acid Blockers to the Gastric Proton Pump. (PubMed, J Med Chem) - "We show crystal and cryo-EM structures of the gastric proton pump in complex with four different P-CABs, tegoprazan, soraprazan, PF-03716556 and revaprazan, at resolutions reaching 2.8 Å. We reveal that revaprazan has a novel binding mode in which its tetrahydroisoquinoline moiety binds deep in the cation transport conduit. The mechanism of action of these P-CABs can now be evaluated at the molecular level, which will facilitate the rational development and improvement of currently available P-CABs to provide better treatment of acid-related gastrointestinal diseases."

Journal • Gastroenterology • Gastrointestinal Disorder

Treatment guideline concordance, initiation, and abandonment in patients with non-metastatic breast cancer from the African Breast Cancer-Disparities in Outcomes (ABC-DO) cohort in sub-Saharan Africa: a prospective cohort study. (PubMed, Lancet Oncol) - "A high proportion of patients with non-metastatic breast cancer did not initiate, did not fully complete, or abandoned treatment with surgery, systemic therapy, radiotherapy, or an appropriate combination of these, highlighting the need for improved treatment access and completion in sub-Saharan Africa to potentially prevent premature breast cancer deaths."

Journal • Breast Cancer • Oncology • Solid Tumor

Remofuscin induces xenobiotic detoxification via a lysosome-to-nucleus signaling pathway to extend the Caenorhabditis elegans lifespan. (PubMed, Sci Rep) - "Moreover, remofuscin failed to extend the lives of C. elegans with loss-of-function mutations (lipl-1, lbp-8, nhr-234, nhr-49, nhr-8, cyp-35A1, cyp-35A2, cyp-35A3, cyp-35A5, and gst-5), suggesting that these genes are associated with lifespan extension in remofuscin-treated C. elegans. In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan."

Journal • Ophthalmology • CYP3A4 • CYP3A5