dexamphetamine IR (PFR08026) / Ensysce Biosciences - LARVOL DELTA

Comparative pharmacology and abuse potential of oral dexamphetamine and lisdexamfetamine-A literature review. (PubMed, Hum Psychopharmacol) - "The available evidence from pharmacodynamic, pharmacokinetic and abuse liability studies suggests a comparable potential for oral abuse of dexamphetamine and LDX."

Journal • Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

Pharmacokinetics of a Modified-Release Dexamphetamine Sulfate Formulation Following Single and Multiple Dosing in Healthy Adults: Comparative Bioavailability with Immediate-Release Dexamphetamine Sulfate, between Strengths, Assessment of Food and Meal Composition Effects. (PubMed, Scand J Child Adolesc Psychiatr Psychol) - "DEX-MR should be administered with/after a meal to achieve the targeted pharmacokinetic profile (delayed t). Bioavailability of DEX-MR is not affected by meal composition (i.e., fat and caloric content)."

Journal • PK/PD data • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • CNS Disorders • Psychiatry

What is the potential for abuse of lisdexamfetamine in adults? A preclinical and clinical literature review and expert opinion. (PubMed, Expert Rev Clin Pharmacol) - ": Most of the studies highlighted a longer T than dexamphetamine leading to a delayed onset of effects and a decreased C. These PK parameters were often associated with a diminished feeling of euphoria, in comparison to immediate-release dexamphetamine. Overall, although LDX abuse seems possible, we did not find evidence concerning current safety signal. However, more long-term pharmaco-epidemiological studies are still needed to confirm this finding."

Journal • Preclinical • Review • ADHD (Impulsive Aggression) • Attention Deficit Hyperactivity Disorder • Binge Eating Disorder • CNS Disorders • Psychiatry