Desonate (desonide gel) / LEO Pharma - LARVOL DELTA

Letters: The Paradox of Desonide: Treating Inflammation, Triggering Allergy. (PubMed, Dermatitis) - No abstract available

Journal • Allergy • Immunology • Inflammation

Multifunctional Hydrogel for the Treatment of Atopic Dermatitis: Current Advances and Translational Challenges. (PubMed, Eur J Pharm Sci) - "Multiple clinical trials have demonstrated that Desonide hydrogel provides substantial benefits to patients, making the design of multifunctional hydrogel dressings a research hotspot in recent years. This review first summarizes the feasible options for drug loading in hydrogels, then focuses on the advantages and disadvantages of different hydrogel types and drug delivery methods, and finally addresses the challenges and solutions for translating innovative hydrogels into clinical practice. Aimed at integrating perspectives from materials science, dermatology, and translational medicine, this review establishes a theoretical framework for the rational design of innovative hydrogels in local AD therapy."

Journal • Review • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation • Pruritus

Topical Glucocorticoid-Induced Cushing's Syndrome in a Patient with Erythrodermic Psoriasis: A Case Report. (PubMed, Clin Cosmet Investig Dermatol) - "Management included gradual withdrawal of topical steroids, initiation of oral methylprednisolone (8 mg daily) for HPA axis support, and transition to low-potency desonide. This case highlights the systemic risks of unsupervised, escalating use of high-potency topical corticosteroids in adults with impaired skin barrier. It underscores the need for adherence to dosing guidelines, patient education, and routine endocrine monitoring."

Journal • Cushing’s Disease • Dermatology • Dermatopathology • Endocrine Disorders • Immunology • Pediatrics • Psoriasis

Axillary Hyperpigmentation Treatment: A Systematic Review of the Literature. (PubMed, J Cosmet Dermatol) - "The most frequently used laser in treating AH was QS Nd-YAG without having any severe adverse effect. Various topical treatments including Niacinamide, desonide, HQ, AHA, and a few herbal extracts were shown to be effective for AH."

Journal • Review • Pain

A Randomized Controlled Study of Oxysophocarpine Cream in the Treatment of Mild to Moderate Atopic Dermatitis (ChiCTR) - P=N/A | N=78 | Not yet recruiting | Sponsor: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine; Yueyang Hospital of Inte

New trial • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Not all Herbal Extracts are Equal! Only a few have therapeutic potential (AAD 2025) - "Eight of 47 commercially available extracts were found to have significant anti-inflammatory effect superior to or comparable to prescription mometasone, desonide and dexamethasone. Five of these also produced significant inhibition of cutaneous pathogenic bacteria and yeast. Caution is needed in selection of extracts from the species within an herbal family due to large variation of therapeutic activity."

CXCL8 • IL6 • TNFA

New Eye Drop Formulation Based on Desonide and Xanthan Gum in Dry Eye Disease: Nonclinical Studies. (PubMed, Pharmaceutics) - "This study aimed to evaluate its pharmacodynamic properties and to characterize its rheological behavior and mucoadhesive characteristics, compared to another formulation containing 0.2% hyaluronic acid and 0.001% hydrocortisone (HYD). The ancillary anti-inflammatory effects of a low dose of DES combined with the biophysical properties of xanthan gum are supportive of a favorable therapeutic profile, promoting the maintenance or restoration of ocular surface homeostasis while minimizing the risk of adverse effects typically associated with standard-dose corticosteroids. The comparison with another low-dose corticosteroid highlights the superiority of XanterDES in pharmacodynamic and biophysical performance."

Journal • Corneal Abrasion • Dry Eye Disease • Inflammation • Ocular Inflammation • Ophthalmology • Uveitis

A Comparative, Multicenter, Prospective, Randomized Study to Evaluate the Efficacy, Safety, and Delay of Relapse of Ceramide-Based Post-biotic Moisturizer Versus Paraffin-Based Moisturizer in Mild to Moderate Atopic Dermatitis. (PubMed, Cureus) - "Although both moisturizers were effective in resolving symptoms in the treatment phase, the ceramide-based post-biotic moisturizer was more effective and statistically significant in extending the remission period against the paraffin-based moisturizer in patients with mild to moderate AD."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Inflammation

Study on the clinical efficacy of soothing moisturizing repairing cream combined with desonide in the treatment of atopic dermatitis in children. (PubMed, Medicine (Baltimore)) - "The combination of moisturizing cream and desonide in the treatment of AD in children is highly effective and safe. It is worth promoting for clinical application due to its significant therapeutic effects and high safety profile."

Clinical • Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

ALLERGIC CONTACT DERMATITIS TO TOPICAL CORTICOSTEROIDS: WHAT IS THE NEXT STEP IN MANAGEMENT? (ACAAI 2024) - "Although initial treatment adhered to established guidelines, including topical triamcinolone acetonide, emollients, and cetirizine, eczema did not improve and worsened. Adjustments to treatment, including introduction of pimecrolimus and topical mupirocin ointment, also failed to produce any improvement...However, the patient showed improvement with the administration of oral prednisolone...Patch tests for triamcinolone acetonide, desonide, and fluocinolone acetonide were positive, showing localized inflammation and worsening of eczema at application sites...Early consideration and use of dupilumab can result in notable clinical benefits for such patients. Consent granted from patient's parents to present case."

Atopic Dermatitis • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Different variants of Lichen Planus Pigmentosus in Filipino patients: A case series (EADV 2024) - "He began taking Delamanid and Linezolid for multidrug- resistant tuberculosis (MDR-TB) clinical trial in the same month, which then led to extensive hair loss...Patients received treatment with low-dose isotretinoin, topical tacrolimus 0.1%, desonide cream, and photoprotection... The cases show a wide range of etiologies and presentations of lichen planus pigmentosus in Filipino patients. While LPP can occur without a clear cause, potential etiologic agents such as hypopigmenting agents should be considered. Pediatric cases present additional challenges due to rarity and unidentified causes."

Clinical • Alopecia • Dermatitis • Dermatology • Dermatopathology • Human Immunodeficiency Virus • Immunology • Infectious Disease • Lichen Planus • Pediatrics • Pruritus • Respiratory Diseases • Tuberculosis

axillary hyperpigmentation treatment: a review of the literature (EADV 2024) - "Various topical agents such as hydroquinone (HQ) , tretinoin, and vitamin C as well as light and laser-based treatments namely QS Nd-YAG laser are being used in clinical practice. In this study, we found that both topical in addition to light and laser-based therapies are effective. The studied topical agents for axillary hyperpigmentation were Niacinamide, Desonide, CREO, AHA, HQ, and PFLE. Light and laser therapies applied for axillary hyperpigmentation were QS-Nd YAG and IPL."

Review • Dermatology

Decyl-Glucoside; this eco-friendly but skin-unfriendly surfactant:a case report (EADV 2024) - "Materials & Case report A 25-year-old female patient with personal and family history of atopy had been presenting with a pruritic facial rash lasting for two months as intermitent episodes, resistant to the usual treatment of her atopic dermatitis (local corticosteroids of moderate class: desonide)... The use of decyl glucoside is becoming increasingly common with the emergence of the “ Green ” label. The cosmetics industry is rediscovering this eco-friendly alkyl glucoside, synthesized from natural, renewable sources and considered a mild surfactant, but it shouldn ’ t escape suspicion during an allergological investigation into contact dermatitis."

Case report • Clinical • Surfactant • Atopic Dermatitis • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Oral ketoconazole induced cheilitis: A rare adverse effect (EADV 2024) - "It was developed as a first line agent for dermatophytosis, but was soon found to have various side effects, such as hepatotoxicity, leading to it being replaced by safer and effective drugs like terbinafine and itraconazole... Oral ketoconazole was stopped and treatment in the form of desonide 0.05% and petroleum jelly was given to be applied...Her dermatophytosis condition was managed with oral terbinafine and topical ciclopirox cream with significant improvement... Oral ketoconazole can be added to the list of causes of drug-induced cheilitis is, a hitherto unreported cause. Oral ketoconazole, though has varied other side-effects, such as hepatotoxicity and anti-androgenic side effects like gynaecomastia, cheilitis has never been reported with the use of this drug. Hence, it begins imperative to screen for cheilitis, along with other side effects, while using this drug."

Adverse events • Dermatology • Hepatology • Infectious Disease • Pruritus

Randomized controlled study on the treatment of mild to moderate atopic dermatitis with licorice extract cream (ChiCTR) - P=N/A | N=72 | Recruiting | Sponsor: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai; Yueyang Hospital of Integrated Traditional Chinese and Western Medi

New trial • Atopic Dermatitis • Dermatitis • Dermatology • Immunology

Efficacy and safety of LED-LLLT for treatment of patients with seborrheic dermatitis: a multicenter, single-blind, randomized, clinical Trial (ChiCTR) - P=N/A | N=80 | Not yet recruiting | Sponsor: Xiangya Hospital of Central South University; Xiangya Hospital Central South University

New trial • Dermatitis • Dermatology • Immunology • Seborrheic Dermatitis

Evaluation of bioequivalence and pharmacokinetic profiles for topical desonide cream using Chinese skin. (PubMed, Skin Pharmacol Physiol) - "This study demonstrated the applicability of skin blanching assay in Chinese skins and established the bioequivalence of test and reference desonide creams."

Journal • PK/PD data

Observational Clinical Investigation Evaluating an Ophthalmic Solution Containing Xanthan Gum and Low Concentration Desonide Phosphate in Dry Eye Disease Treatment. (PubMed, Ophthalmol Ther) - "the study formulation produced a significant improvement in the signs, symptoms, and QoL of patients with mild to moderate DED with a good safety profile after 1 month of treatment."

Journal • Dry Eye Disease • Ophthalmology

A pediatric case of dupilumab-induced pustular psoriasis. (PubMed, J Dermatolog Treat) - "After stopping dupilumab administration, topical corticosteroids (desonide and mometasone furoate creams) and oral desloratadine without relief. After 2 weeks of treatment, the lesions nearly resolved without recurrence in 1-year follow-up. Dupilumab-induced pustular psoriasis is rare in children."

Journal • Atopic Dermatitis • Dermatitis • Dermatology • Immunology • Pediatrics • Psoriasis • Pustular Psoriasis

Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation. (PubMed, Traffic) - "A screening in HEK-293 cells overexpressing NLGN3 of 2662 compounds (FDA-approved small molecule drug library), led to the identification of several glucocorticoids such as alclometasone dipropionate, desonide, prednisolone sodium phosphate, and dexamethasone (DEX), with the ability to favor the exit of full-length R451C NLGN3 from the ER. The effect of DEX was validated on a novel model system represented by neural stem progenitor cells and differentiated neurons derived from the R451C NLGN3 knock-in mouse, expressing the endogenous protein. This work shows a potential rescue strategy for an autism-linked mutation affecting cell surface trafficking of a synaptic protein."

Journal • Autism Spectrum Disorder • CNS Disorders • Developmental Disorders • Genetic Disorders • Psychiatry

Filament coating system assists recovery of ablative fCO laser treatment: A split-face clinical observation. (PubMed, J Cosmet Dermatol) - "Filament coating system was effective, safe, convenient, and economic in assisting recovery of ablative fCO laser, which might be a new option for additional nursing procedure."

Journal • Acne Vulgaris • Dermatology • Pain • HER-2

Simultaneous determination of 83 glucocorticoids in cosmetics by ultra performance liquid chromatography-tandem mass spectrometry (PubMed, Se Pu) - "Fluocinolone acetonide, beclomethasone dipropionate, desonide 21-acetate, and desonide were detected in four samples. In conclusion, the proposed method is simple, sensitive, reliable, and suitable for the high-throughput analysis of the 83 glucocorticoids in cosmetics with different matrices. This method could provide reliable technical support for the daily supervision of cosmetics and serve as a supplement to current glucocorticoid standards."

Journal • Cardiovascular • Dermatitis • Dermatology • Hypertension • Immunology

Raccoon eyes under the dermoscope: think of localized lichen planus (EADV 2023) - "She was prescribed a topical desonide 0,1% for three months with good improvement. Lichen planus of the eyelid is a condition that is often overlooked and should be considered in the list of possible diagnoses for eyelid dermatosis. Although topical steroids have shown efficacy in treating eyelid LP, further research is needed to determine the most optimal therapeutic approach for this condition."

Conjunctivitis • Contact Dermatitis • Dermatitis • Dermatology • Dermatopathology • Hepatitis C • Hepatology • Immunology • Infectious Disease • Inflammation • Inflammatory Arthritis • Keratitis • Lichen Planus • Lupus • Ocular Infections • Ocular Inflammation • Ophthalmology • Psoriasis

Raccoon eyes under the dermoscope: think of localized lichen planus (EADV 2023) - "She was prescribed a topical desonide 0,1% for three months with good improvement... Lichen planus of the eyelid is a condition that is often overlooked and should be considered in the list of possible diagnoses for eyelid dermatosis. Although topical steroids have shown efficacy in treating eyelid LP, further research is needed to determine the most optimal therapeutic approach for this condition."

Atopic Dermatitis • Conjunctivitis • Contact Dermatitis • Dermatitis • Dermatology • Dermatopathology • Dry Eye Disease • Immunology • Keratitis • Lichen Planus • Ocular Infections • Ocular Inflammation • Ophthalmology • Seborrheic Dermatitis

Cutaneous malakoplakia of the thigh (ASDP 2023) - "The patient was started on desonide 0.05% topical ointment and clobetasol 0.05% for itch relief. His clinical course is actively being followed, with future treatments based on clinical progression and symptomatology. Poster type: Poster Defense"

Cardiovascular • Dermatology • Heart Failure • Immunology • Infectious Disease • Psoriasis