omzotirome (TRC 150094) / Torrent Pharma - LARVOL DELTA

3,5-T2-an Endogenous Thyroid Hormone Metabolite as Promising Lead Substance in Anti-Steatotic Drug Development? (PubMed, Metabolites) - "Various high fat diet animal models with distinct thyroid hormone status indicate species- and dose-dependent efficiency of 3,5-T2 and its synthetic analogue TRC150094. No convincing evidence has been presented for their clinical use in the prevention or treatment of obesity and related metabolic conditions."

Journal • Review • Addiction (Opioid and Alcohol) • Endocrine Disorders • Genetic Disorders • Hepatology • Metabolic Disorders • Non-alcoholic Fatty Liver Disease • Obesity

TRC150094, a Novel Mitochondrial Modulator, Reduces Cardio-Metabolic Risk as an Add-On Treatment: a Phase-2, 24-Week, Multi-Center, Randomized, Double-Blind, Clinical Trial. (PubMed, Diabetes Metab Syndr Obes) - "Trial registration number: CTRI/2013/03/003444. Date of registration: 4th March 2013."

Clinical • P2 data • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders • Type 2 Diabetes Mellitus • APOB

Safety, Tolerability, and Pharmacokinetics of a Novel Mitochondrial Modulator, TRC150094, in Overweight and Obese Subjects: A Randomized Phase-I Clinical Trial. (PubMed, Front Pharmacol) - "Overall, TRC150094 ensured safety and exhibited suitability for all subjects. Clinical Trial Registration: EUDRA CT: 2009-014941-10 (SAD) and CTR-India registration: CTRI/2009/091/000601 (MAD)."

Clinical • Journal • P1 data • PK/PD data • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders • Obesity • Type 2 Diabetes Mellitus • APOB

Safety and Efficacy Study of TRC150094 to Improve the CV Risk in Subjects With Diabetes, Dyslipidemia and Hypertension (clinicaltrials.gov) - P3; N=1250; Recruiting; Sponsor: Torrent Pharmaceuticals Limited; Trial completion date: Aug 2020 ➔ Aug 2022; Trial primary completion date: Apr 2020 ➔ Apr 2022

Clinical • Trial completion date • Trial primary completion date • Cardiovascular • Diabetes • Dyslipidemia • Hypertension • Metabolic Disorders