citalopram / Generic mfg. - LARVOL DELTA

Clinical outcomes in patients with multiple myeloma and antidepressant use: A retrospective cohort study (ASH 2025) - "Adult patients with multiple myeloma since 2010 and prescribed antidepressants (sertraline, escitalopram, citalopram, paroxetine, fluoxetine, fluvoxamine, venlafaxine, duloxetine, trazodone, mirtazapine, or bupropion) were identified using ICD-10 diagnostic and RxNorm codes. While some associations were modest in magnitude, the consistent pattern of increased risk suggests that pre-existing depression and its treatment may identify a more vulnerable subgroup of multiple myeloma patients. Further prospective studies are needed to clarify underlying mechanisms and to evaluate the potential impact of early psychiatric intervention."

Clinical data • Retrospective data • Chronic Kidney Disease • CNS Disorders • Depression • Hematological Malignancies • Infectious Disease • Major Depressive Disorder • Multiple Myeloma • Musculoskeletal Diseases • Nephrology • Renal Disease

FLT3-F691L confers kinase-independent resistance via Grb2-dependent MAPK signaling in AML (ASH 2025) - "Unlike gilteritinib or a negative controlPROTAC, CRBN(FLT3)-8 robustly suppressed viability, clonogenicity, and RAF/MEK signaling in FLT3-F691LAML, indicating that FLT3-F691L retains essential non-kinase functions.To uncover pathways mediating the FLT3-F691L kinase-independent function, we performed a genome-wide CRISPR-Cas9 dropout screen in isogenic FLT3-ITD and FLT3-F691L AML cells treated with gilteritinib.Grb2, an adaptor protein that links receptor tyrosine kinases to Ras activation via SOS, emerged as a topdependency unique to gilteritinib-treated FLT3-F691L cells. Our findings support thedevelopment of FLT3 degraders or combined targeting of FLT3 and Ras/MAPK pathways to overcomeFLT3-F691L-driven resistance in relapsed/refractory AML. Importantly, this work suggests that otherrecurrent hot-spot mutations in oncogenic kinases may similarly confer kinase-independent functions incancer and should be systematically investigated as potential drivers of therapeutic..."

Acute Myelogenous Leukemia • Hematological Malignancies • Leukemia • CRBN • FLT3 • STAT5

Equilibrium theory-based framework for descripting separation of enantiomers by frontal achiral chromatography. (PubMed, J Chromatogr A) - "Two model components were selected for the study, i.e., citalopram and methyl N-acetyl-phenylalaninate, which exhibited the phenomenon of self-disproportionation when eluted from a silica gel column...The equilibrium-dispersive model was used to assess the effect of band broadening on the accuracy of the ET solution. It was demonstrated that ET is an effective mathematical tool for rapid prediction of the SDE-driven chromatographic process."

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Persistent and Dose-Dependent Neural and Metabolic Gene Expression Changes Induced by Transient Citalopram Exposure in Zebrafish Embryos. (PubMed, Int J Mol Sci) - "All four citalopram doses suggested synaptic and neurotransmitter alterations, implying that persistent neurodevelopmental impacts resulted from a limited early window of exposure. These data highlight that transient, low-level SSRI exposures shape long-term embryonic gene expression."

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The Comparative Efficacy of Antidepressant and Psychological Therapies on Cognition in Depression: A Systematic Review and Network Meta-Analysis. (PubMed, Neuropsychol Rev) - "Common antidepressants, including escitalopram, citalopram, paroxetine and fluoxetine were not significantly different from placebo in improving cognition. The findings suggest that, among antidepressants, vortioxetine is the sole treatment improving cognition in depression. The effects were however small, highlighting the need for the development of MDD interventions targeting cognition."

Journal • Retrospective data • Review • CNS Disorders • Cognitive Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Bioaccumulation of Psychoactive Contaminants and Their Effects on Brain-Gonad-Sperm Neurotransmitter Networks in Fish. (PubMed, Environ Sci Technol) - "Here, we investigated the effects of environmentally relevant concentrations of a mixture of seven PSYCs (citalopram, donepezil, gabapentin, methamphetamine, sertraline, tramadol, and venlafaxine) on European perch (Perca fluviatilis) during a 23 day exposure. No significant changes were observed in gonadal histopathology or sperm-quality parameters; however, the observed molecular alterations suggest potential consequences under longer or chronic exposures. These findings identify sperm as a previously overlooked target for psychoactive pollutants and reveal neurochemical disruption along the brain-gonad-sperm axis as a previously unrecognized mechanism through which PSYCs may affect fish physiology."

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Adjustment for dispensed doses does not explain higher antidepressant concentrations in post-mortem toxicology. (PubMed, Br J Clin Pharmacol) - "Dose adjustment generally did not improve the separation of poisoning vs non-poisoning suicides, indicating that post-mortem concentrations may not have clear dose-concentration relationships."

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The impact of antidepressant use on antibiotic treatment outcomes in urinary tract infections and pneumonia: A population-based cohort study. (PubMed, Psychiatry Clin Neurosci) - "Antidepressants are associated with a modest rise in UTI treatment failure risk, possibly due to antibiotic resistance or other mechanisms. Despite this, their essential role in mental health management outweighs the small risk, emphasizing the need for judicious use, particularly in females and older adults. Further research is warranted to clarify underlying mechanisms."

Journal • Infectious Disease • Nephrology • Pneumonia • Respiratory Diseases

Hyperfiltration and Metabolism Before and After a Low-Calorie, Pre-Gastric Bypass Surgery Diet: Significance for Concentrations of Hydrophilic and Lipophilic Drugs. (PubMed, Basic Clin Pharmacol Toxicol) - "The greater the individual weight loss, the greater the concentration increase in hydrophilic drugs that undergo glomerular filtration, for example, pregabalin and gabapentin, suggesting that this reflects decreased glomerular hyperfiltration. By contrast, for highly lipophilic drugs, for example, mirtazapine and sertraline, the greater the individual creatinine and cystatin C loss, the greater the decrease in drug concentration, interpreted as increased drug metabolism based on decreased liver inflammation and steatosis. Venlafaxine/O-desmethylvenlafaxine displayed a complicated pattern suggesting the involvement of both glomerular filtration and metabolism. Serum concentrations of modestly lipophilic drugs, for example, duloxetine and (es)citalopram, were not significantly affected by the diet. In conclusion, hydrophilicity- and lipophilicity-related changes in drug concentrations over the diet period covary with markers of changes in hyperfiltration and metabolism,..."

Journal • Genetic Disorders • Inflammation • CST3

Perinatal citalopram exposure alters the gut composition and microbial metabolic profiles of Sprague-Dawley rat dams and female offspring but not male offspring. (PubMed, Biol Sex Differ) - "These findings demonstrate that maternal citalopram exposure during pregnancy and lactation has lasting, sex-specific impacts on the offspring's gut microbiome and microbial metabolic pathways. The pronounced alterations in female, but not male offspring, suggest that host sex may be a critical determinant in the developmental response to citalopram exposure. This work underscores the value of metagenomic approaches in uncovering complex host-microbiome interactions and highlights the need to consider offspring sex in evaluating the safety and long-term effects of antidepressant use during pregnancy."

Journal • Preclinical

Comparative evaluation of safety and efficacy of dapoxetine, silodosin, and citalopram in the management of premature ejaculation: a randomized clinical trial. (PubMed, BMC Urol) - P4 | "In this direct head-to-head comparison of active treatments for lifelong PE, daily citalopram (20 mg) demonstrated superior efficacy in prolonging IELT and improving psychosocial outcomes compared to daily or on-demand dapoxetine and silodosin. The findings suggest that citalopram is a highly effective first-line option, while the dose-dependent efficacy of dapoxetine and the distinct side-effect profile of silodosin provide alternative considerations for personalized treatment strategies."

Clinical • Journal • Sexual Disorders

Opioid overdose associated with concomitant use of hydrocodone and selective serotonin reuptake inhibitors. (PubMed, BMC Med) - "In this cohort study, based on data from US healthcare claims databases, initiating citalopram, escitalopram, fluoxetine, or paroxetine while on hydrocodone was associated with an increased risk of opioid overdose compared with sertraline. No substantial risk differences were observed across SSRIs other than sertraline."

Journal • Retrospective data • Addiction (Opioid and Alcohol) • CNS Disorders • CYP3A4

The role of empathy in antidepressant withdrawal. (PubMed, Ther Adv Psychopharmacol) - "Part of a larger prospective cohort study in major depressive disorder patients using sertraline or citalopram recruited through university medical centres and connected general practitioners, pharmacies and mental health institutions. Perceived empathy was positively associated with subjective success and negatively associated with the negative effects of discontinuation. Although we could not demonstrate an association of perceived empathy and objective discontinuation, we consider the finding of a relation between subjective success as relevant because a successful experience regarding antidepressant discontinuation may positively influence the initiation of future attempts."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Analysis of the Prevalence of Alcohol and Psychoactive Substances Among Drivers in the Material from the Department of Forensic Medicine at the Medical University of Bialystok in Poland. (PubMed, Toxics) - "Among the total positive cases, psychoactive substances used alone or in combination included THC-46.3% (range 0.2-20 ng/mL), alcohol-26.8% (range 0.1-4.1‱), amphetamines-20.7% (range 15-2997 ng/mL), opiates-4.3% (morphine 66.0 ng/mL; methadone 174.0 ng/mL; ranges: tramadol 15.0-600.0 ng/mL; fentanyl 45.0-100.0 ng/mL), benzodiazepines-9.8% (ranges: diazepam 55.0-480.0 ng/mL; midazolam 17.0-1200.0 ng/mL; clonazepam 21.0-36.0 ng/mL), stimulants-6.10% (ranges: amphetamine 15.0-2997.0 ng/mL; cocaine 4.0-30.0 ng/mL; benzoylecgonine 38.0-602.0 ng/mL; PMMA 45.0-360.0 ng/mL; MDMA 20.0-75.0 ng/mL; mephedrone 37.5 ng/mL; alfa-PVP 120 ng/mL), psychotropic drugs-3.1% (carbamazepine 8.0-2100.0 ng/mL; zolpidem 233.0 ng/mL; citalopram 320.0 ng/mL; opipramol 220 ng/mL). Among the psychoactive substances most frequently used alone or in combination with others, THC was predominant. Roadside testing, based on effects similar to alcohol intoxication, was mainly conducted on male drivers."

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Targeted Biocatalyst Design for Asymmetric Citalopram Conversion in a Membrane Reactor. (PubMed, Pharmaceutics) - "In the resolution of citalopram, the system achieved 96% conversion of S-citalopram within 24 h, with the enantiomeric excess of 93% in favor of the S-ester over the R-ester. These findings demonstrate the system's potential for efficient and stereoselective biocatalytic applications."

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Utilizing Pharmacogenetic Results to Optimize Medication Management in Hospice Care: A Pilot Study. (PubMed, J Pers Med) - "Three patients underwent medication changes based on PGx guidance, including switching from citalopram to bupropion and adding morphine to tramadol therapy, which improved symptom control. While not yet routinely implemented in hospice settings, this pilot study suggests PGx-guided prescribing can support personalized medication decisions and enhance emotional and physical comfort in end-of-life care when test results are available."

Biomarker • Journal • Pain • Palliative care

Dual one-step LC-MS/MS methods for hair analysis in drug-facilitated crime: application to an alleged Fraud-Related case. (PubMed, Forensic Sci Med Pathol) - "This study aimed to develop and validate two simplified, one-step extraction methods coupled with liquid chromatography-tandem mass spectrometry (LC-MS/MS) for the simultaneous segmental analysis of psychoactive substances, specifically doxylamine (DOX), haloperidol (HAL), citalopram (CTP), sildenafil (SDF), and common illicit drugs in hair samples. Segmental hair analysis provided critical retrospective evidence, reinforcing its value in complex DFC investigations. The interpretation remained confined to analytical evidence, without inferring intent."

Journal • CNS Disorders • Psychiatry

Restoring STAR*D: A RIAT Reanalysis of Medication Augmentation Therapy After Failed SSRI Treatment Using Patient-Level Data with Fidelity to the Original Research Protocol. (PubMed, medRxiv) - "A similar reanalysis is warranted for STAR*D's augmentation study in which citalopram was augmented with sustained-release bupropion or buspirone. Compared with the original STAR*D publication, our reanalysis identified inflated remission rates, low sustained remission, and marked differences in TESI risk between augmentation strategies. These findings suggest that both treatments offer lower acute and sustained benefit than is widely understood, with buspirone associated with more TESI."

Journal • Psychiatry • Suicidal Ideation

Effect of prescribing and deprescribing oxycodone on pain and function in a mouse model of osteoarthritis: impact of polypharmacy and sex on response. (PubMed, bioRxiv) - "Here we aimed to assess the effects of chronic oxycodone, as monotherapy and in polypharmacy (oxycodone, citalopram, simvastatin, oxybutynin, and metoprolol), and of deprescribing oxycodone, on allodynia, physical and cognitive function, and daily activities in middle-aged, osteoarthritic male and female C57BL/6J mice (n=11-15/ group). Deprescribing oxycodone was well tolerated and did not alter physical or cognitive function but did reverse some of the daily activity changes and mechanical allodynia in polypharmacy treated animals only. This clinically relevant preclinical model provides an opportunity to understand the effects of prescribing and deprescribing opioids in older adults with osteoarthritis, including the impact of comedications and sex."

Journal • Preclinical • Addiction (Opioid and Alcohol) • CNS Disorders • Immunology • Mood Disorders • Oncology • Osteoarthritis • Pain • Psychiatry • Rheumatology

Agitation in Alzheimer's disease: From assessment to therapeutics. (PubMed, World J Psychiatry) - "For chronic agitation, serotonin-selective reuptake inhibitors, especially citalopram and escitalopram, are often preferred due to safety concerns associated with the long-term use of antipsychotics. Promising novel strategies, such as new compounds and neuromodulation, are likely to be incorporated into agitation therapeutics in the next few years."

Journal • Review • Alzheimer's Disease • CNS Disorders • Dementia • Depression • Mood Disorders • Psychiatry

Comparative BMI-z Changes With Initiation and Adherence to Antidepressant Medications Among Youth. (PubMed, J Am Acad Child Adolesc Psychiatry) - "Among youth, initiation and adherence to bupropion was not associated with 12-month BMI-z change, though four other most-common antidepressants were associated with small increases in BMI-z over this time. Clinicians should consider these differences when prescribing antidepressants to youth, alongside FDA approvals, clinical guidelines, and evidence of safety and efficacy."

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Negative affective bias in depression following treatment with psilocybin or escitalopram - a secondary analysis from a randomized trial. (PubMed, Transl Psychiatry) - "Recent clinical trial data suggests that ratings on depression scales are lowered after psilocybin therapy compared to placebo, though it is unclear what neuropsychological mechanisms underpin these effects. Therefore, a more positive behavioural bias in emotional processing was seen following psilocybin and citalopram compared to baseline. This highlights the potential for at least some overlap in cognitive mechanisms across two distinct treatments, which is noteworthy given the short dosing regimen with psilocybin."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Dementia medications and the use of psychotropic drugs: A cross-sectional study in Saudi healthcare. (PubMed, J Alzheimers Dis) - "The analysis revealed memantine (62.4%) and rivastigmine (37.6%) as the most commonly prescribed medications, with a notable increase in prescriptions among older adults and a higher prevalence in married patients. Among psychotropic medications, quetiapine, lorazepam, and citalopram were the most frequently used, with quetiapine leading in prescription numbers (27%).ConclusionsThis study provides insights into current prescribing patterns for dementia in Saudi Arabia. Future research should address limitations in coding information and long-term outcomes to improve the management of dementia."

Journal • Observational data • Alzheimer's Disease • CNS Disorders • Dementia

Distinct genetic responses to fluoxetine sertraline and citalopram in mouse cortical neurons. (PubMed, iScience) - "These findings highlight distinct molecular actions among SSRIs despite their common target. These insights underscore the importance of exploring SSRI actions beyond serotonin pathway and may facilitate the development of more effective and personalized treatment strategies for MDD."

Journal • Preclinical • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Trends in antipsychotic and antidepressant prescriptions among German adolescents: Data from the largest statutory health insurance in Germany. (PubMed, Psychiatry Res) - "Our results indicate an increase in pharmacotherapy for mental disorders in adolescents, especially among girls. The quantity and quality of changes in the prescription of psychotropic drugs are greater than would be expected based solely on the increase in diagnoses. This could indicate a change in prescribing behavior, in the sense of earlier drug intervention for mental disorders and/or more off-label prescriptions. This gives rise to concerns about the appropriateness of psychotropic prescriptions to this group of patients."

Journal • Reimbursement • US reimbursement • CNS Disorders • Mental Retardation • Psychiatry