citalopram / Generic mfg. - LARVOL DELTA

Disproportionality analysis of serotonin syndrome associated with selective serotonin reuptake inhibitors: a pharmacovigilance analysis. (PubMed, Eur J Clin Pharmacol) - "The findings underscore the potential signal detection between SSRIs and serotonin syndrome. Results also highlight the need to strengthen prevention and management to mitigate associated risks, while long-term studies on serotonin syndrome are essential for improving patient safety and optimizing treatment."

Adverse events • Journal

Tyrosine: A Key Neurotransmitter in Selective Serotonin Reuptake Inhibitor Treatment for Chronic Restraint Stress-Induced Reduction of Intestinal Innate Lymphoid Cell Type 3 Cells. (PubMed, ACS Chem Neurosci) - "Mice subjected to CRS were administered citalopram (CITA) during the modeling period, followed by behavioral assessments...Hence, CITA effectively ameliorates CRS-induced depressive-like behaviors and immune dysfunctions in the spleen and intestine. Tyrosine is a crucial neurotransmitter in CITA treatment for regulating depression-related intestinal immune disorders."

Journal • CNS Disorders • Depression • Immunology • Psychiatry • IL3 • IL7

Exploring the Impact of Citalopram on Human Colon Cells: Insights into Antidepressant Action Beyond the Brain. (PubMed, Spectrochim Acta A Mol Biomol Spectrosc) - "An increase in the Raman band intensity ratio I1444/I1660, I1055/I1444, I1584/I1004, I1660/I1256, I2854/I2930, and reduced I1243/I1263, was observed, indicating enlarged lipid accumulation, protein promotion, deactivation and inhibition of autophagy or apoptotic pathways, improvements in free cholesterol levels, minor changes in nucleic acid composition, increased content of polyunsaturated fatty acids and diminished lipid peroxidation under the influence of citalopram. Obtained results indicate that citalopram affects cellular homeostasis in a way that may weaken cancer cell proliferation."

Journal • CNS Disorders • Colon Cancer • Colorectal Cancer • Depression • Oncology • Psychiatry • Solid Tumor

Effect of antidepressants use on Cancer morbidity and mortality: A propensity score matched longitudinal cohort study. (PubMed, J Affect Disord) - "The use of antidepressants, particularly SSRIs, was associated with a lower risk of cancer morbidity and mortality, whereas the use of TCAs, such as amitriptyline, was linked to an increased risk of cancer-related mortality. Although causal relationships cannot be established, these findings should be interpreted with caution and warrant further investigation."

Journal • Cardiovascular • Oncology

Human Health and Ecological Impacts of Pharmaceuticals and Metals Released by Municipal Wastewater in Tehran: A Life Cycle Impact Assessment. (PubMed, Environ Toxicol Chem) - "Acetaminophen (7.7 µg/L) and zinc (88.4 µg/L) had the highest concentrations in untreated wastewater, while citalopram (0.4 µg/L) and zinc (55.1 µg/L) dominated in treated wastewater. The lowest concentrations were for alprazolam, vanadium, and beryllium, ranging from 2 to 100 ng/L...Sertraline and cadmium posed the greatest risks to human health, while thioridazine and cadmium was found to be most detrimental to ecosystems. These findings underscore the urgent need for improved wastewater management and further research into high-risk micropollutants."

Journal

Depression is associated with treatment response trajectories in adults with Prolonged Grief Disorder: A machine learning analysis. (PubMed, J Affect Disord) - "Differential PGDT courses and the role of depression severity and grief-related functional impairment in treatment non-response were identified. These findings underscore the importance of determining clinical factors relevant to optimizing individual treatment strategies."

Clinical • Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Combination therapy with citalopram, bupropion, and lithium for the amelioration of the depressive-related effects induced by dexamethasone in male mice. (PubMed, Eur J Pharmacol) - "Combination therapy with citalopram, bupropion, and lithium might be a novel therapeutic approach for depression treatment. However, additional investigations are needed to clarify the exact interactions between components."

Journal • Preclinical • CNS Disorders • Depression • Psychiatry

Visualization and quantification of citalopram hydrobromide within highly porous drug products by near-infrared chemical imaging. (PubMed, Eur J Pharm Sci) - "The obtained prediction models were accurate, having the root mean square error of prediction of the quantitative SVR models as low as 0.21. Additionally, NIR-CI could detect the printed drug in the samples along the cross-section and on the surface, thus making it a potent tool for the troubleshooting and quality control of TMD samples."

Journal

Polydrug fatal intoxication involving MDPHP: Detection and in silico investigation of multiple 3,4-methylenedioxy-derived designer drugs and their metabolites. (PubMed, J Anal Toxicol) - "Finally, to better understand the binding properties of the abovementioned MDDs to several documented transporters and receptors, an in-silico evaluation was performed. The medical examiner reported that the cause of death was an acute multidrug intoxication by MDPHP and clonazepam in presence of MDPPP, MDPV, MDPBP and citalopram."

Journal • CNS Disorders • Epilepsy • Mood Disorders • Psychiatry

An Overview of the Systematic Reviews About the Efficacy of Fluvoxamine on Depression. (PubMed, Pharmaceuticals (Basel)) - "Comparisons with imipramine, clomipramine, amitriptyline, dothiepin, paroxetine, fluoxetine, citalopram, mianserin, nortriptyline, and moclobemide generally revealed no significant differences in efficacy. However, some reviews indicated that venlafaxine and mirtazapine were superior to fluvoxamine in certain outcomes, while fluvoxamine demonstrated greater efficacy than desipramine in one review. Sertraline and milnacipran showed mixed or review-quality-dependent results, with one low-quality review favoring milnacipran...While no single antidepressant was universally superior, fluvoxamine's unique pharmacological profile and favourable safety characteristics support its clinical utility. Further research is needed to explore its role in personalized treatment strategies and emerging therapeutic contexts, such as comorbid anxiety and post-traumatic stress disorder."

Journal • Review • CNS Disorders • Depression • Mental Retardation • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry

Five-Year Trends in SSRI Consumption: A Precision Medicine Approach to Comparative Analysis Between Serbia and European Countries. (PubMed, Healthcare (Basel)) - "In the Republic of Serbia, commonly prescribed SSRIs include fluoxetine, citalopram, paroxetine, sertraline, and escitalopram. Sertraline was the most commonly prescribed SSRI drug in Serbia from 2018 to 2021. However, in 2022, escitalopram became the most commonly used drug in this group both in Serbia and worldwide, with a consistent increase in consumption."

Journal • CNS Disorders • Depression • Mental Retardation • Mood Disorders • Psychiatry

Removal of psychopharmaceuticals from WWTP effluent by an algae-mussel trophic cascade: a potential nature-based solution? (PubMed, Environ Sci (Camb)) - "The compounds fell into 3 categories: positive removal (citalopram, lamotrigine, and venlafaxine), negative removal (carbamazepine, gabapentin, and pregabalin), and no significant changes in concentration (amitriptyline, quetiapine, tramadol, fluvoxamine, lidocaine, and ibuprofen). Pregabalin and gabapentin also increased in risk, but did, however, not significantly change the overall risk from the analysed compounds due to their low concentrations. Since the presently designed nature-based treatment could not negate risk, it is not suitable for the removal of psychopharmaceuticals."

Journal

Automatised online SPE-LC-MS/MS method for the enantioselective determination of chiral β-blockers and antidepressants in wastewater. (PubMed, Anal Chim Acta) - "In this work, an automatised method based on online solid phase extraction (SPE) coupled to liquid chromatography-tandem mass spectrometry (LC-MS/MS) was optimised and validated for the enantiomeric determination of highly prescribed (β-blockers (atenolol, metoprolol and propranolol), antidepressants (citalopram, fluoxetine, sertraline, duloxetine and venlafaxine) and two of their metabolites in influent and effluent wastewater. The method allows their automatised enantiomeric determination, including sample treatment, SPE column wash and conditioning, and LC-MS/MS determination, in 40 min with enantioresolution from 0.51 to 1.24. The online SPE method developed provides a fast way to obtain information about chiral compounds in wastewater reducing labour intensity, exposure to organic solvents, analyte loss and plastic waste."

Journal

Investigating drug-induced optic nerve hypoplasia and septo-optic dysplasia from the FDA adverse events database. (PubMed, Can J Ophthalmol) - "A possible association was found between prenatal diazepam exposure and ONH/SOD. Further investigation is required to confirm this relationship and drug safety profiles."

Adverse events • Journal

Citalopram as a Potential Treatment Option for Cataplectic Episodes in the Absence of Narcolepsy (APA 2025) - "Venlafaxine and fluoxetine are the current first-line antidepressants for cataplexy without narcolepsy. We also highlight some key future directions for this research topic such as with a focus on controlling for the severity and type of cataplexy to mitigate confounds. As SSRIs are the gold standard for a variety of psychiatric and neuropsychiatric conditions, the use of citalopram as treatment for cataplexy can potentially lead to more personalized treatment regimens and help alleviate polypharmacy."

Cataplexy • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Narcolepsy • Psychiatry • Sleep Disorder

Opioids and Antidepressant Use in Fibromyalgia Sleep Apnea and Psychiatric Co-Morbidities (APA 2025) - "SSRIs included escitalopram (n=95), sertraline (n=84), fluoxetine (n=53), citalopram (n=50), and paroxetine (n=37). Antidepressants currently prescribed are duloxetine (n=75, 22%, 58% decrease), bupropion (n=38, 11%, 67% decrease), and SSRIs (n=53, 16%, 71% decrease)... The study found a high comorbidity of depression in FM patients, who more often used SSRIs. Pain management often involved duloxetine, pregabalin, and tramadol. Opioid use was higher in patients with arthritis and pain syndromes."

CNS Disorders • Depression • Fibromyalgia • Genetic Disorders • Immunology • Major Depressive Disorder • Mood Disorders • Musculoskeletal Pain • Obesity • Obstructive Sleep Apnea • Pain • Psychiatry • Respiratory Diseases • Rheumatology • Sleep Apnea • Sleep Disorder

Guiding Antidepressant Choice and Clinical Drug Development Strategies for Novel and Marketed Drugs (APA 2025) - "1. Derived neurons can be used to predict citalopram response and serve as a tool for profiling neuroplasticity. 2."

Clinical • CNS Disorders • Depression • Psychiatry

Burning Up - How Heat Stroke Can Spark GBS (ATS 2025) - "Case Presentation: A 50-year-old female with diabetes mellitus and bipolar disorder (managed with citalopram, high-dose quetiapine, alprazolam, and oxcarbazepine) presented with acute confusion and lethargy...A central line was placed, and sedation was maintained with midazolam... Guillain-Barré Syndrome secondary to heat stroke presents a unique diagnostic challenge. This case highlights the critical role of early diagnosis and intervention, as timely initiation of IVIG may improve prognosis. Further research into the pathophysiological link between heat stroke and GBS could better inform clinical management and enhance awareness of this rare association."

Anesthesia • Bipolar Disorder • Cardiovascular • CNS Disorders • Diabetes • Epilepsy • Infectious Disease • Metabolic Disorders • Mood Disorders • Myositis • Pain • Psychiatry • Respiratory Diseases

Delayed Bupropion Cardiotoxicity Treated With Intravenous Lipid Emulsion: A Case Report (ATS 2025) - "Case Presentation: A 51-year-old man with a history of prior suicide attempt presented after an intentional multi-substance overdose with a reported ingestion of 19.5 grams of bupropion sustained release, 1200 milligrams of citalopram, an unknown quantity of trazodone, and 750 milliliters (mL) of wine. This case demonstrates successful use of ILE to treat later-developing cardiotoxicity from an intentional multidrug overdose with a high toxic dose of bupropion prior to hemodynamic collapse. The exact clinical indication for ILE in lipid-soluble drug overdoses outside of LAST remains unclear, but this case suggests that administration in lipid-soluble medication overdose at first signs of cardiovascular complications may outweigh the risks."

Case report • Clinical • Anesthesia • Cardiovascular • CNS Disorders • Epilepsy • Psychiatry

Role of endogenous serotonin in psychedelic-like effects of psilocybin in mice. (PubMed, Int J Neuropsychopharmacol) - "The present findings reveal an inverse correlation between cortical 5-HT levels and the acute psychedelic-like effects of psilocybin. Consequently, the enhancement of serotonergic activity induced by prior antidepressant treatment may underlie interindividual variability in the acute response to psychedelics. Investigating these mechanisms in relation to the sustained therapeutic outcomes of psilocybin could contribute to optimizing the efficacy of psychedelic-based therapies."

Journal • Preclinical • CNS Disorders • Depression • Psychiatry

Galactooligosaccharides Attenuate Behavioural, Haematological and Immunological Abnormalities and Influence Gut Microbiota in Rats with Amygdala Hyperactivation Induced by Electrical Stimulation. (PubMed, Int J Mol Sci) - "The effect of GOS was comparable to citalopram and even more effective in WBC and PLT normalisation and IL-10 induction. The obtained results indicate the high therapeutic potential of GOS in anxiety and stress-related disorders. GOS supplementation may support conventional therapy or the prevention of PTSD, depression and anxiety disorders."

Journal • Preclinical • CNS Disorders • Depression • Hematological Disorders • Inflammation • Mental Retardation • Mood Disorders • Post-traumatic Stress Disorder • Psychiatry • IL10 • TNFA

Impact of additives on the long-term physical stability of antidepressant citalopram hydrobromide in personalized drug delivery systems. (PubMed, Int J Pharm) - "The difference in the release profiles of CHB from these foams became insignificant on storage. These findings indicate that CHB-loaded solid foams should be stored in a cold and dry environment, or the formulation without additives should be used to ensure the long-term physical stability of ingredients in the foam."

Journal

Did Serendipity Contribute to the Discovery of New Antidepressant Drugs? Historical Analysis Using Operational Criteria. (PubMed, Alpha Psychiatry) - "Selective serotonin reuptake inhibitors (fluoxetine, fluvoxamine, citalopram, paroxetine, sertraline, and escitalopram), selective dopamine and noradrenaline reuptake inhibitors (bupropion), noradrenaline and serotonin reuptake inhibitors (venlafaxine, milnacipram, duloxetine, and desvenlafaxine), selective noradrenaline reuptake inhibitors (reboxetine), noradrenergic and specific serotonergic antidepressants (mirtazapine), melatonergic agonists (agomelatine), and serotonin modulators and stimulators (vortioxetine, vilazodone, tianeptine) correspond to the type IV pattern. Ketamine, a glutamatergic modulator, corresponds to the type III pattern, characterized by a non-serendipitous origin (initial development as an anesthetic agent) leading to a serendipitous observation (the discovery of antidepressant efficacy in individuals illicitly using). The majority of new antidepressants adhere to a type IV pattern, characterized by a rational and targeted design process where..."

Journal • Anesthesia

Single-Substance SSRI Intoxication: A Clinical and Outcome Profile Presentation in a Poisoning Referal Center. (PubMed, Emerg Med Int) - "Sertraline was the most frequently ingested SSRI (43.6%), followed by fluoxetine (18.8%)...One patient developed a first-degree AV block after taking 600 mg of citalopram... This study indicates that overdosing on a single SSRI typically results in mild to moderate clinical manifestations. Cardiac issues, such as QT prolongation, were relatively common among our patients."

Journal • CNS Disorders • Epilepsy

Progress towards whole-body models to infer the arterial input function non-invasively from PET images (SNMMI 2025) - "Glucose challenge failed to alter [18F]FDG AIF as muscle uptake was not increased as expected, likely due to anesthesia. For [11C]DASB, changes in the AIF (parent fraction) were observed following citalopram (Fig. 2A)."

Non-invasive • Anesthesia