citalopram / Generic mfg. - LARVOL DELTA

Evaluating the accuracy of ChatGPT in delivering patient instructions for medications: an exploratory case study. (PubMed, Front Artif Intell) - "This study aims to assess the accuracy of output of ChatGPT compared with those of CareNotes® in providing patient instructions for three medications: tirzepatide, citalopram, and apixaban. Additionally, ChatGPT reports have the potential to cause harm and may negatively affect medication adherence. Although ChatGPT demonstrated promising results, particularly in terms of correctness, it cannot yet be considered a reliable standalone source of patient drug information."

Journal

Mood reactivity to daily social conflict in hostile adults: An experimental intervention. (PubMed, Health Psychol) - "Citalopram reduces hostile mood responses to social conflict during daily life in dispositionally hostile adults."

Journal • Cardiovascular

The Potential Influence of Associated Antidepressants on the Pharmacokinetic Profile of Esketamine in Patients Affected by Treatment-resistant Depression. (PubMed, Curr Neuropharmacol) - "The CYP450-related status of co-administered antidepressants may affect esketamine levels. However, the small sample sizes of the co-administered drug subgroups and multiple prescriptions do not allow for drawing strong conclusions."

Journal • PK/PD data • Cardiovascular • CNS Disorders • Depression • Mood Disorders • Psychiatry

Efficacy and tolerability of antidepressants in individuals suffering from physical conditions and depressive disorders: network meta-analysis. (PubMed, Br J Psychiatry) - "Antidepressants are effective in individuals with comorbid physical conditions, although tolerability is a relevant concern. Selective serotonin reuptake inhibitors (SSRIs) have the best benefit-risk profile, making them suitable as first-line treatments, while tricyclics are highly effective but less tolerated than SSRIs and placebo."

Journal • Retrospective data • Review • CNS Disorders • Depression • Mood Disorders • Psychiatry

Minimizing STOPP and Beers Criteria Risks in PIM Treatments Using PM-TOM and ChatGPT: A Case Study. (PubMed, Stud Health Technol Inform) - "She was initially prescribed acetaminophen, alendronate, omeprazole, lisinopril, metoprolol, aspirin, citalopram, and vitamin D, which were assessed as inadequate...In the optimized treatment, omeprazole (PPI) was replaced with famotidine (H2-blocker), citalopram (SSRI) with agomelatine (atypical antidepressant), zoledronic acid (bisphosphonate) with denosumab (RANK ligand inhibitor), aspirin (NSAID) with ticagrelor (antiplatelet), and lisinopril with benazepril (ACE inhibitor)...Finally, ChatGPT validated the proposed adjustments, confirming their alignment with the guidelines and highlighting the potential for longer-term benefits. This case study illustrates how a combined use of PM-TOM and AI tools can effectively support the clinical decision-making process by optimizing polypharmacy treatments and minimizing their PIMs, major contributors to morbidity in older adults and high healthcare costs."

Journal • Cardiovascular • CNS Disorders • Coronary Artery Disease • Depression • Gastroesophageal Reflux Disease • Heart Failure • Hypertension • Immunology • Osteoarthritis • Osteoporosis • Pain • Psychiatry • Rheumatology

Global burden of antidepressant-associated seizures from 1967 to 2023: A comparative analysis of the international pharmacovigilance database. (PubMed, J Affect Disord) - "Our findings align with earlier studies indicating that SNRIs and SSRIs carry a lower risk of seizures, whereas bupropion and clomipramine are linked to a higher risk. Agomelatine, vortioxetine, and SNRIs like desvenlafaxine and duloxetine may potentially be safe alternatives."

Adverse events • Journal • CNS Disorders • Epilepsy

Simplified methods for SERT occupancy estimation measured with [11C]DASB PET bolus plus infusion. (PubMed, Neuroimage) - "Method 3 integrated aspects of both Methods 1 and 2, utilizing BPND and the pre-dose citalopram equilibrium phase. The results showed equivalent occupancy values (p<0.05) for the majority of VOIs and high agreement (max R2 = 0.89) between the reference (utilizing arterial blood sampling, along with the placebo and citalopram scan) and the proposed methods, indicating that they are a promising solution for simplifying occupancy estimation."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry

Repurposing serotonergic drugs for gastric cancer: induction of apoptosis in vitro. (PubMed, Mol Biol Rep) - "This study highlights the potential of Tropisetron, Imipramine, Ketanserin, and Cyproheptadine as repurposed drugs for gastric cancer therapy, with Tropisetron and Imipramine showing particularly promising apoptotic effects. These findings pave the way for further preclinical and clinical investigations, offering a foundation for personalized therapeutic strategies in gastric cancer management."

IO biomarker • Journal • Preclinical • Gastric Cancer • Oncology • Solid Tumor • ANXA5 • BCL2 • HTR2A • HTR2B • PCNA • SLC6A4

Esketamine Combined With SSRI or SNRI for Treatment-Resistant Depression. (PubMed, JAMA Psychiatry) - "Treatment with esketamine combined with an SSRI (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline, or vilazodone) or an SNRI (desvenlafaxine, duloxetine, levomilnacipran, milnacipran, or venlafaxine). In this retrospective comparative effectiveness study, among the study sample, incidence of mortality, hospitalizations, depressive relapses, and suicide attempts was low. The esketamine + SNRI group showed lower incidence of mortality, hospitalizations, and depressive relapses, while the esketamine + SSRI group showed a slightly lower incidence of suicidal attempts."

Journal • CNS Disorders • Depression • Mood Disorders • Psychiatry

Beyond Depression: The Role of Antidepressants in Managing Chronic Temporomandibular Disorders. A Systematic Review. (PubMed, J Oral Rehabil) - "Antidepressants, particularly when combined with non-pharmacological treatments, may enhance pain relief and functional outcomes for chronic TMD pain. However, high-quality, long-term studies are needed."

Journal • Review • CNS Disorders • Depression • Mood Disorders • Musculoskeletal Diseases • Pain • Psychiatry

Circadian antidepressant treatments in depression: A systematic review and meta-analysis. (PubMed, Chronobiol Int) - "The optimal time of maximum efficacies in 5 out of 15 drugs in the 10 studies was at zeitgeber time (ZT) 2, including fluoxetine, sertraline, citalopram, doxepin, and agomelatine. The best therapeutic effects of mirtazapine, trazodone, and agomelatine were at ZT10, while maximum efficacies of venlafaxine and fluvoxamine were at ZT6 and ZT13, respectively...More prospective randomized trials or randomized experiments are demanded to establish recommendations for optimal circadian timing of depression based on zeitgeber time. It would be of interest to further evaluate this time-selection as a potential viable novel therapeutic in future research."

Journal • Retrospective data • Review • CNS Disorders • Depression • Mood Disorders • Psychiatry

Citalopram-Associated Hyponatremia Presenting as Distal Extremity Numbness: A Case Report. (PubMed, J Clin Psychopharmacol) - No abstract available

Journal • Cardiovascular • Heart Failure

Decreased citalopram concentration caused by enzyme induction effect of rifampin: a case report. (PubMed, Ther Adv Psychopharmacol) - "Based on the therapeutic drug monitoring results of citalopram, the dosage of citalopram was adjusted to 40 mg daily, resulting in a significant improvement in depressive symptoms. This case provides further evidence of a clinically significant interaction that may occur between rifampin and citalopram."

Journal • CNS Disorders • Depression • Infectious Disease • Insomnia • Mood Disorders • Psychiatry • Pulmonary Disease • Respiratory Diseases • Sleep Disorder • Tuberculosis

Network based approach for drug target identification in early onset Parkinson's disease. (PubMed, Sci Rep) - "Notably, shared pathway analysis shows that prioritized drugs such as Amantadine, Apomorphine, Atropine, Benztropine, Biperiden, Bromocriptine, Cabergoline, Carbidopa, and Citalopram, currently used for other conditions, interact with key EOPD-associated diagnostic markers, suggesting their potential for drug repurposing. The constructed functional network's validity is reinforced by statistically significant drug-target pairs. The findings provide new insights into EOPD drug mechanisms and identify promising therapeutic candidates, potentially leading to more effective, personalized treatment approaches for EOPD patients."

Biomarker • Journal • CNS Disorders • Movement Disorders • Parkinson's Disease • APOA1 • BDNF • PTK2B

Commonly prescribed multi-medication therapies exert sex-specific effects on Alzheimer's disease pathology and metabolomic profiles in AppNL-G-F mice: Implications for personalized therapeutics in aging. (PubMed, Alzheimers Dement) - "Two polypharmacy combinations show sex-specific effects on AD pathology and serum metabolomic profiles. Metoprolol+simvastatin+aspirin+paracetamol+citalopram improves memory and amyloid pathology in male mice. Replacing metoprolol and simvastatin with enalapril and atorvastatin eliminates benefits in male mice and impairs memory in female mice. Selected monotherapies produce sex-specific effects but only partially explain the outcomes of the combinations. Metabolomic pathways in serum indicate possible mechanisms and biomarkers for evaluating the effectiveness and safety of personalized therapies in aging and dementia."

Journal • Preclinical • Alzheimer's Disease • Cardiovascular • CNS Disorders • Dementia • Inflammation

Escitalopram for agitation in Alzheimer's dementia: a randomized controlled phase 3 trial. (PubMed, Nat Med) - P3 | "Clinicians need to be cautious in recommending escitalopram as an alternative to citalopram for this condition. ClincialTrials.gov identifier: NCT03108846 ."

Journal • P3 data • Alzheimer's Disease • CNS Disorders • Dementia

AI One-Click Processing-Assisted Nanozyme-Based Fluorescence Capillary Imprinted Sensor Array for Microvolume Rapid Discrimination Antidepressants. (PubMed, Anal Chem) - "In this study, a nanozyme fluorescence capillary imprinted sensor array combined with fluorescence mode and artificial intelligence (AI) one-click processing fluorescence image mode was developed for the rapid visual discrimination and quantification of five ADs (imipramine, citalopram, clomipramine, amitriptyline, and sertraline). With the lower detection limit for identification of five ADs, the nanozyme fluorescence capillary imprinted sensor array was successfully employed for the discrimination of unknown samples in lake water and hospital sewage and freeze-dried with an accuracy of 90.5%. With the advantage of high sensitivity and low reagent consumption, the nanozyme fluorescence capillary imprinted sensor array provides a new strategy for the rapid detection of ADs in trace multipollutant environmental samples."

Journal

Detection of Clinically Significant Drug-Drug Interactions in Fatal Torsades de Pointes: Disproportionality Analysis of the Food and Drug Administration Adverse Event Reporting System. (PubMed, J Med Internet Res) - "Clinical evidence on DDIs is limited, and not all combinations of heart rate-corrected QT interval (QTc)-prolonging drugs result in TdP, even when involving high-risk drugs or those with known risk of TdP. This study provides a comprehensive real-world overview of drug-induced TdP, delimiting both clinically significant DDIs and negative DDIs, providing valuable insights into the safety profiles of various drugs, and informing the optimization of clinical practice."

Adverse events • Journal • Cardiovascular

Effectiveness of treatment of sexual dysfunction in men with premature ejaculation, injured as a result of hostilities. (PubMed, Wiad Lek) - " The study demonstrates that the neurotransmitter serotonin plays a key role in the modulation of ejaculation, as the use of reuptake inhibitors increases the intravaginal latency to ejaculation. Among the selective serotonin reuptake inhibitors, venlafaxine was found to be the most effective."

Journal • CNS Disorders • Mood Disorders • Psychiatry • Sexual Disorders

Patterns in (es)citalopram prescriptions to Medicaid and Medicare patients in the United States: the potential effects of evergreening. (PubMed, Front Psychiatry) - "Moreover, among these general pharmacoepidemiologic trends exists significant geographic variability. There was disproportionate spending (relative to their use) on the brand versions of these medicines relative to their generic forms."

Journal • Medicare • Reimbursement • US reimbursement • CNS Disorders • Depression • Mental Retardation • Mood Disorders • Psychiatry

An Ultrasensitive and Environmentally Benign Synchronous Spectrofluorimetric Strategy for Determining the Anti-Inflammatory (Celecoxib) and the Antidepressant (Citalopram) in Different Matrices. (PubMed, Luminescence) - "The Green Analytical Procedure Index, Analytical GREEnness Metric approach, and the Green Solvents Selecting tool found that these procedures have a high level of environmental friendliness. In addition, the Blue Applicability Grade Index evaluation tool determined that the suggested technique was workable."

Journal • CNS Disorders • Depression • Immunology • Inflammatory Arthritis • Psychiatry • Rheumatoid Arthritis • Rheumatology

Effect of Selective Serotonin Reuptake Inhibitors on Coagulation: Fact or Fiction? (PubMed, Clin Transl Sci) - "TGA parameters were not significantly changed compared to the control condition regardless of the citalopram concentration. All in all, our findings failed to demonstrate any compromised coagulation function associated with SSRI therapy."

Journal • Review • CNS Disorders • Depression • Mood Disorders • Psychiatry

Changes in S-Citalopram Plasma Concentrations Across Pregnancy and Postpartum. (PubMed, Clin Pharmacol Ther) - "However, at the 36-week reference point, the mean concentration to dose ratio in pregnant CYP2C19 intermediate metabolizers was 35.7% lower than the distant postpartum ratio, while the ratios in extensive and rapid/ultrarapid metabolizers were 15.4% and 18.5% lower, respectively. Without dose adjustment, people with intermediate or poor CYP2C19 activity may be at risk for subtherapeutic S-citalopram concentrations during pregnancy."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Psychiatry • CYP2C19

Fluorescent PyrAte-(S)-citalopram conjugates enable imaging of the serotonin transporter in living tissue. (PubMed, Chem Sci) - "The large Stokes shift of the PyrAte fluorophore enables simultaneous detection of its own fluorescence signal at 500 nm along with that of a yellow fluorescent protein-based serotonergic marker. Our findings provide novel tools for unprecedented SERT visualization and establish the utility of PyrAtes for the selective staining of membrane proteins in live cells and tissue."

Journal

Sociodemographic, clinical, and genetic factors associated with self-reported antidepressant response outcomes in the UK Biobank. (PubMed, Psychol Med) - "Self-reported antidepressant response in the UK Biobank is influenced by sociodemographic, clinical, and genetic factors, mirroring clinical response measures. While positive outcomes are more frequent than remission reported in clinical trials, these self-reports replicate known treatment associations, suggesting they capture meaningful aspects of antidepressant effectiveness from the patient's perspective."

Journal • Retrospective data • CNS Disorders • Depression • Major Depressive Disorder • Mental Retardation • Mood Disorders • Psychiatry • CYP2C19