citalopram / Generic mfg. - LARVOL DELTA

Factors associated with drug-drug interactions involving citalopram in the UK Biobank. (PubMed, BJPsych Open) - "The high frequency of DDIs with citalopram in fragile groups confirms the need for careful consideration before prescribing and periodic re-evaluation."

Journal • Cardiovascular • CNS Disorders • Depression • Mood Disorders • Psychiatry

Clinical Study to Evaluate Cannabidiol Liver Enzyme Elevations and Drug Interactions (clinicaltrials.gov) - P1 | N=241 | Completed | Sponsor: Food and Drug Administration (FDA) | Recruiting ➔ Completed

Trial completion • Hepatology • Liver Failure

Urinary metabolic ratio of pain management and substance abuse treatment drugs: Drug-drug interactions. (PubMed, J Opioid Manag) - "The 18 drugs include dextromethorphan, oxycodone, hydrocodone, tramadol, morphine, buprenorphine, fentanyl, clonazepam, alprazolam, quetiapine, carisoprodol, tapentadol, ketamine, methadone, impramine, and amitriptyline. The 14 interfering drugs include fluoxetine, paroxetine, bupropion, citalopram, sertraline, venlafaxine, duloxetine, risperidone, trazodone, aripiprazole, cyclobenzaprine, amphetamine, and tetrahydrocannabinol...Using the MR reference intervals of the 18 drug pairs established in an earlier study, and the current DDI system, we can alert providers of unusual metabolism caused by DDIs. This will help providers do better prescribing or review more closely all medications and supplements patients are taking, thus avoiding underdosing or potential medication adverse reactions."

Journal • Pain • Substance Abuse • CYP2C19 • CYP3A4

Possible Association Between Concomitant Use of SSRIs with NSAIDs and an Increased Risk of Adverse Events Among People with Depressive Disorders: Data Mining of FDA Adverse Event Reporting System. (PubMed, Pharmaceuticals (Basel)) - "Objectives: This study analyzed FDA Adverse Event Reporting System (FAERS) data (2004-2024) to assess gastrointestinal bleeding, thrombocytopenia, and acute kidney injury (AKI) potential risks linked to SSRIs (citalopram, escitalopram, fluoxetine, paroxetine, fluvoxamine, and sertraline) and NSAIDs (propionic/acetic/enolic acid derivatives, COX-2 inhibitors) in depression patients, alone and combined. Certain combinations of SSRIs and NSAIDs might further elevate these risks of gastrointestinal bleeding, thrombocytopenia, and acute kidney injury in patients with depression. Given the potential drug-drug interactions, heightened clinical vigilance is advised when prescribing SSRIs and NSAIDs in combination to patients with depression."

Adverse events • Journal • Acute Kidney Injury • CNS Disorders • Depression • Gastroenterology • Hematological Disorders • Inflammation • Nephrology • Pain • Psychiatry • Renal Disease • Thrombocytopenia

Investigation into the Effects of Tramadol, Citalopram, Tianeptine, and Their Combinations on Rat Brain Tissue. (PubMed, Biomedicines) - " The tramadol + citalopram combination caused severe oxidative stress in brain tissue. Tramadol alone caused mild damage in brain tissue, whereas tianeptine prevented the brain damage caused by tramadol."

Journal • Preclinical • CNS Disorders • Solid Tumor • Vascular Neurology • CAT

Selective Serotonin Reuptake Inhibitor-Associated Intracranial Hemorrhage: Drug-Specific Risk Patterns and Patient-Level Modifiers. (PubMed, Neurol Int) - "This study highlights significant differences in ICH reporting patterns across SSRIs, modified by patient age, gender, and co-medication. These findings underscore the need for individualized SSRI prescribing, particularly in patients receiving anticoagulant therapy particularly in elderly patients and those receiving anticoagulant therapy, where sertraline and fluoxetine may pose increased risk."

Journal • Cerebral Hemorrhage • CNS Disorders • Hematological Disorders • Subarachnoid Hemorrhage

The Effect of the Antidepressant Citalopram on the Bioconcentration and Biomarker Response of Daphnia magna at Environmentally Relevant Concentrations. (PubMed, Toxics) - "Comprehensively, the responses of the phenotypic traits and energy metabolism of D. magna at various environmental concentrations were sensitive for CIT. This study provided basic data for the risk estimation of CIT in the real freshwater environment."

Biomarker • Journal • CAT

Decoding pharmaceutical removability in full-scale wastewater treatment plants via machine learning model integrating modified electrophilicity index. (PubMed, Water Res) - "Specifically, pharmaceuticals such as carbamazepine, diazepam, and citalopram exhibited higher predicted amenability to chemical treatment, whereas mifepristone, erythromycin, and sulfacetamide were more likely to be effectively removed under biological processes. Extended sludge and hydraulic retention time, along with optimized influent loading, were expected to further enhance the removal of persistent pharmaceuticals. This study offers predictive insights into pharmaceutical removal potential through the developed ML model and provides scientific support for pharmaceutical management in WWTPs."

Journal

Efficacy and Tolerability of Vortioxetine Versus Selective Serotonin Reuptake Inhibitors for Late-Life Depression: A Post-hoc Analysis of the VESPA Study. (PubMed, Drugs Aging) - P4 | "Vortioxetine was not superior to SSRIs in terms of efficacy and tolerability in older adults with moderate-to-severe depression. Additional trials, possibly based on fixed doses of vortioxetine, are needed."

Journal • Retrospective data • CNS Disorders • Depression • Mood Disorders • Psychiatry

Sedative co-medication patterns across frailty states in people with HIV: a network-based study. (PubMed, Int J Clin Pharm) - "Sedative co-medication patterns vary meaningfully across frailty states in people with HIV. Frailty is associated with more complex networks and a greater likelihood of high-risk drug interactions. Medications influencing these patterns can help identify opportunities for safer prescribing. The prefrail stage may offer a timely window for interventions aimed at minimizing polypharmacy and improving safety in middle-aged and older adults with HIV."

Journal • Human Immunodeficiency Virus • Infectious Disease

Separation and enrichment of fingolimod and citalopram active drug ingredients by fabric phase sorptive extraction followed by high performance liquid chromatographic analysis with diode array detection. (PubMed, J Chromatogr B Analyt Technol Biomed Life Sci) - "The method demonstrated good precision, with relative standard deviation (RSD) values below 6.0 % for spiked samples. Recovery rates from synthetic urine and saliva matrices ranged between 93.1 % and 105.0 % for both analytes, confirming the method's accuracy and applicability to biological samples."

Journal • CNS Disorders • Multiple Sclerosis

Antidepressant Prescription to Children/Adolescents and Its Effects on the Cardiovascular System, Comprising the Actual Questions of Periodicity of the Checkups, Cooperation among Pediatricians, Family Doctors, Cardiologists and Children-Adolescent Psychiatrists. (PubMed, Acta Med Litu) - "SSRIs, like citalopram and escitalopram, can disturb the heart rhythm by prolonging the QT interval, or increasing the risk of serious arrhythmias...Atypical antidepressants like bupropion can cause cardiovascular disturbances, especially when overdosed...Given these risks, careful prescribing, close monitoring, creating guidelines and collaboration among healthcare providers are essential to ensure safe and effective treatment. Additionally, more research is needed to fully understand the long-term cardiovascular impacts of these medications in the pediatric population."

Journal • Cardiovascular • CNS Disorders • Depression • Mental Retardation • Metabolic Disorders • Mood Disorders • Pediatrics • Psychiatry

Effect of temperature on chromatographic separation driven by enantiomer self-disproportionation. (PubMed, J Chromatogr A) - "Three chiral components of distinctly different structures and chemical properties were selected for the study: citalopram (CT), methyl p-tolyl sulfoxide (MTSO), and methyl 2-(acetylamino)propanoate (MAAP)...This resulted in complex dependences of the separation yield on temperature, which were specific for the chemical structure and the individual concentrations of the enantiomers in their mixtures. It was shown that temperature can be optimized to improve the separation performance."

Journal

Environmental risk assessment of selective serotonin reuptake inhibitors (SSRIs) after COVID-19 pandemic: a systematic review. (PubMed, Chemosphere) - "One of the most commonly prescribed classes of antidepressants is selective serotonin reuptake inhibitors (SSRIs), such as citalopram, fluoxetine, fluvoxamine, paroxetine, and sertraline. Given the elevated risks, it is crucial to implement preventive measures to limit the environmental concentrations of SSRIs. These should include upgrades to wastewater treatment technologies and the introduction of systematic micropollutant monitoring programs."

Journal • Review • CNS Disorders • Depression • Infectious Disease • Novel Coronavirus Disease • Psychiatry

Chronic exposure to environmentally relevant levels of citalopram affects crawl-out behavior and morphological antipredator plasticity in a freshwater gastropod. (PubMed, Ecotoxicol Environ Saf) - "Mantle pigmentation increased under high risk but was unaffected by citalopram. Overall, these fitness-reducing consequences of environmentally relevant levels of citalopram on aquatic gastropods likely have far-reaching ecological consequences."

Journal

Effects of the selective serotonin reuptake inhibitors citalopram and escitalopram on glucolipid metabolism: a systematic review. (PubMed, Front Endocrinol (Lausanne)) - "Further high-quality investigations are warranted to validate these findings and guide individualized treatment strategies. https://www.crd.york.ac.uk/PROSPERO/view/CRD42024544963, identifier CRD42024544963."

Journal • Review • CNS Disorders • Depression • Diabetes • Dyslipidemia • Major Depressive Disorder • Metabolic Disorders • Mood Disorders • Psychiatry • Type 2 Diabetes Mellitus

Physicochemical and Microbiological Stability of Commonly Prescribed APIs in SyrSpend® SF PH4: A Comprehensive Compatibility Study. (PubMed, Int J Pharm Compd) - "The following formulations were tested: azithromycin (40.0 mg/mL), bismuth subsalicylate (17.5 mg/mL), budesonide (0.25 mg/mL), buspirone (2.5 mg/mL), cephalexin (50.0 mg/mL), chlorpromazine hydrochloride (100.0 mg/mL), citalopram hydrobromide (2.0 mg/mL), cyanocobalamin (0.2 mg/mL), famotidine (8.0 mg/mL), meloxicam (0.2 mg/mL), and orphenadrine citrate (5.0 mg/mL). Its excipient profile - free from harmful substances like alcohol, parabens, propylene glycol, and sorbitol - supports safe use in pediatric and geriatric patients. The study provides evidence-based guidance for pharmacists in assigning appropriate BUDs and optimizing personalized therapy through compounded oral suspensions."

Journal • Geriatric Disorders • Pediatrics

Assessing neurological and cardiovascular effects caused by pharmaceuticals in river water: Insights from Daphnia magna and Danio rerio embryos. (PubMed, Chemosphere) - "Neuroactive drugs such as topiramate, rasagiline, citalopram, and fluvoxamine showed strong correlations with altered neurotransmitter levels in zebrafish, consistent with their known mechanisms. These findings support the utility of D. magna and zebrafish (D. rerio) embryos as sensitive and complementary biosentinels for monitoring pharmaceutical pollution and highlight zebrafish as a relevant model for studying environmentally driven neurotoxicity with potential human health implications."

Journal • Cardiovascular • CNS Disorders • Metabolic Disorders

Heightened anxiety with distinct prefrontal substrates is differentially sensitive to the anxiolytics, citalopram and ketamine: Prefrontal substrates and anxiolytic sensitivity. (PubMed, Biol Psychiatry) - "These data provide evidence that different faces of anxiety generated by distinct forms of prefrontal dysregulation, are differentially responsive to differing classes of anxiolytics, providing novel insight into the relationship between the neuro-aetiology of anxiety and its treatment."

Journal • Mood Disorders • Psychiatry

Expression of Concern: Protective effects of antidepressant citalopram against abnormal APP processing and amyloid beta-induced mitochondrial dynamics, biogenesis, mitophagy and synaptic toxicities in Alzheimer's disease. (PubMed, Hum Mol Genet) - No abstract available

Journal • Alzheimer's Disease • CNS Disorders

Progress towards whole-body models to infer the arterial input function non-invasively from PET images (SNMMI 2025) - "Glucose challenge failed to alter [18F]FDG AIF as muscle uptake was not increased as expected, likely due to anesthesia. For [11C]DASB, changes in the AIF (parent fraction) were observed following citalopram (Fig. 2A)."

Non-invasive • Anesthesia

Progress towards whole-body models to infer the arterial input function non-invasively from PET images (SNMMI 2025) - "Glucose challenge failed to alter [18F]FDG AIF as muscle uptake was not increased as expected, likely due to anesthesia. For [11C]DASB, changes in the AIF (parent fraction) were observed following citalopram (Fig. 2A)."

Non-invasive • Anesthesia

Prophylactic administration of Xuesaitong soft capsule ameliorating depression-like behaviors in rats after ischemic stroke by modulating metabolic disturbance. (PubMed, Phytomedicine) - "This study systematically deciphers XST's polypharmacology in PSD prevention, characterized by multi-target synergy (monoamine-glutamate axis), temporal metabolic adaptation, and MAOA-dependent mechanisms. Our findings propose a novel therapeutic strategy for PSD management, emphasizing early intervention and pathophysiological conditioning. XST emerges as a promising candidate for this paradigm, offering a potential step forward in PSD treatment."

Journal • Preclinical • Cardiovascular • CNS Disorders • Depression • Ischemic stroke • Metabolic Disorders • Mood Disorders • Psychiatry

Further evidence of depressive symptomatology profile predicting treatment outcome. (PubMed, Int J Psychiatry Clin Pract) - "Treatment outcomes were assessed after treatment with citalopram...The sex-specific differences suggest a thorough assessment of depressive features at the very first approach with the depressed patient. Sadness, sleep disturbances and reduced energy are strong predictors of poor outcome in depressed individualsSomatic complaints may be stronger predictors among females compared to malesAnhedonic features relate to non-response."

Journal • CNS Disorders • Depression • Major Depressive Disorder • Mood Disorders • Pain • Psychiatry • Sleep Disorder • Suicidal Ideation

Comparative Toxicokinetics and Biomarker Responses of Typical Psychiatric Pharmaceuticals in Daphnia magna. (PubMed, Toxics) - "In this study, eight typical PDs [carbamazepine (CBZ), citalopram (CIT), sertraline (SER), venlafaxine (VLF), amitriptyline (AMT), chlorpromazine (CPM), quetiapine (QTP) and clozapine (CLZ)] were selected to study the uptake, depuration and biological effects of PDs in Daphnia magna. The Ku of PDs, oxidative stress and metabolic level of D. magna combine to affect BCF levels together. In conclusion, this study contributes to a better understanding of the toxicokinetics and biochemical responses of PDs in D. magna and potential mechanisms of action, which may allow for a better assessment of their environmental health risks to aquatic ecosystems."

Biomarker • Journal • Pain • Psychiatry