Emla-cream / Akorn, AstraZeneca - LARVOL DELTA

The Effects of EMLA Cream and Cold Application on Pain, Fear and Vital Signs Before Chest Tube Removal in Children (clinicaltrials.gov) - P=N/A | N=66 | Completed | Sponsor: Istanbul Medeniyet University | Recruiting ➔ Completed

Trial completion • Pain

Effect of CoolSense and EMLA Cream on Pain During Intravenous Cannulation in Pediatric Population: A Randomized, Controlled Trial - Correspondence. (PubMed, Indian J Pediatr) - No abstract available

Journal • Pain • Pediatrics

Management of Paediatric Difficult Airway in a case of Infantile Fibromatosis with Complete Trismus (ASA 2025) - "Awake IV access done using EMLA cream. Induction with sevoflurane while maintaining spontaneous ventilation, and titrated boluses of propofol were given as required to maintain adequate depth...The vocal cords were visualized, and ETT was inserted over the bronchoscope. Emergency surgical access was kept ready at all times."

Clinical • Anesthesia • Fibrosis • Pediatrics • Solid Tumor

Comparative analysis of the effectiveness of pharmacological and non-pharmacological interventions on arteriovenous fistula cannulation-related pain in patients receiving hemodialysis: A systematic review and network meta-analysis. (PubMed, Int J Nurs Stud) - "Non-pharmacological interventions, particularly cryotherapy combined with visual distraction, visual distraction alone, and lavender inhalation aromatherapy, were determined to be effective in reducing arteriovenous fistula cannulation-related pain in hemodialysis patients. Integrating these interventions into clinical practice can enhance patient comfort during hemodialysis procedures. Further research is needed to explore individualized approaches and assess the long-term efficacy of these interventions."

Journal • Retrospective data • Review • Anesthesia • Cardiovascular • CNS Disorders • Pain • Renal Disease

The effect of rubber dam on objective and subjective parameters of stress during dental treatment in children: a randomized clinical trial. (PubMed, BMC Oral Health) - P=N/A | "The results of this study indicate that rubber dam isolation is not stressful for child patients and dentist compared to the cotton roll technique. EMLA cream is suitable but less comfortable in reducing the pain and discomfort caused by rubber dam placement."

Clinical • Journal • Anesthesia • Mood Disorders • Pain • Pediatrics • Psychiatry

Evaluation of Different Forms of Topical Anesthesia Agents in Dental Practice. (PubMed, Children (Basel)) - "Therefore, atomized lidocaine topical anesthesia could be used as a substitute for EMLA cream prior to buccal anesthetic administration. On the other hand, further comprehensive studies are required to explore the effects of several doses of atomized lidocaine in various areas of the oral cavity."

Journal • Anesthesia • Mood Disorders • Pain • Pediatrics • Psychiatry

LAB: Local Anesthesia Before Bulkamid Injection (clinicaltrials.gov) - P=N/A | N=23 | Terminated | Sponsor: Medstar Health Research Institute | N=52 ➔ 23 | Trial completion date: Apr 2024 ➔ Dec 2024 | Recruiting ➔ Terminated | Trial primary completion date: Apr 2024 ➔ Aug 2024; Study was terminated prematurely due to meeting safety endpoint defined as 3 participants in the experimental arm requiring termination of in-office procedure due to pain.

Enrollment change • Trial completion date • Trial primary completion date • Trial termination • Anesthesia • Pain • Urinary Incontinence • Urology

Improving pain score and restraint duration during circumcision. (PubMed, J Family Med Prim Care) - "Ring block is the most effective method of analgesia, while topical crème (EMLA: lidocaine and prilocaine topical) alone is ineffective. We demonstrated the sustainability of reduced restraint time among attendings but to a lesser extent among residents and the sustainability of mean pain score among both. We conclude that improving effective analgesia during circumcision can be achieved and sustained using the QI project."

Journal • Pain • Pediatrics

REAL-TIME ULTRASOUND-GUIDED THORACIC EPIDURAL BLOCKADE VIA THE CAUDAL APPROACH FOR POSTOPERATIVE ANALGESIA IN AN AWAKE INFANT (ASRA-SPRING 2025) - "After topicalization with EMLA cream at the sacral hiatus and IV morphine (1.86 mg) for sedation, the infant was positioned in left lateral decubitus...Epidural space expansion was confirmed with a saline bolus before administering 2 mL of 0.2% ropivacaine with epinephrine (1:400,000)...Epidural placement in awake infants is generally not performed given concerns over movement or limited tolerability. However in this case where general anesthesia was deemed risky, ultrasound-guided thoracic epidural analgesia via the caudal approach effectively managed pain in this high-risk infant, highlighting its potential as a safe alternative in complex pediatric cases."

Anesthesia • Cardiovascular • Gastrointestinal Disorder • Hypertension • Pain • Pediatrics

The Effects of EMLA Cream and Cold Application on Pain, Fear and Vital Signs Before Chest Tube Removal in Children (clinicaltrials.gov) - P=N/A | N=72 | Recruiting | Sponsor: Istanbul Medeniyet University | Not yet recruiting ➔ Recruiting

Enrollment open • Pain

Adult circumcision using needle-free, topical EMLA cream (AUA 2025) - "The use of topical eutectic mixture of local anaesthetic (EMLA) cream (5% - 2.5% lidocaine and 2.5% prilocaine) in neonatal and paediatric circumcision is well described but very little in adult circumcision (1). Our study shows that adult men willing to undergo a circumcision under local anaesthesia, solely, using topical EMLA cream was safe and 100% effective when the cream was applied for at least 40 min. Our results are in contrast to those reported by Gyftopoulos (2), his study showed 20.5% effectiveness but topical EMLA was applied for only 20-30 min and furthermore, following EMLA cream application, an occlusive dressing was applied, the later may have contributed to uneven skin absorption, compounded by reduced application time of the EMLA cream. Dorsal penile block may be an effective alternative, when performing a circumcision but require a needle, blind administration and is operator-dependent and thus, not always effective (3)."

Clinical • Anesthesia • Infectious Disease • Pain • Pediatrics

Anaphylactic shock secondary to topical EMLA. (PubMed, J Cutan Aesthet Surg) - "Although side effects of EMLA are usually mild local skin reactions, rare complications such as methemoglobinemia, central nervous system toxicity, and cardiotoxicity can occur. Herein, we are reporting a case of anaphylactic shock to topical application of EMLA."

Journal • Aesthetic Medicine • Anesthesia • Cardiovascular • Dermatology • Hematological Disorders • Immunology • Urticaria

The Effects of EMLA Cream and Cold Application on Pain, Fear and Vital Signs Before Chest Tube Removal in Children (clinicaltrials.gov) - P=N/A | N=72 | Not yet recruiting | Sponsor: Istanbul Medeniyet University

New trial • Pain

Determining the duration of topical anesthetic drugs’ use for effective analgesia before various needle puncture procedures (ChiCTR) - P=N/A | N=288 | Not yet recruiting | Sponsor: Shanghai Changzheng Hospital; Shanghai Changzheng Hospital

New trial • Anesthesia • Pain

Pharmacological and Nonpharmacological Methods for Children in Venipuncture Pain (clinicaltrials.gov) - P=N/A | N=192 | Completed | Sponsor: Aynur Aytekin Ozdemir

New trial • Pain

Use of Cervical Cap and Menstrual Disc for Application of Topical Anesthetic Prior to IUD Insertion (clinicaltrials.gov) - P=N/A | N=24 | Not yet recruiting | Sponsor: Oregon Health and Science University

New trial • Anesthesia • Long-acting Reversible Contraceptives

Practical Recommendations for Minimizing Pain and Anxiety with IUD Insertion. (PubMed, J Am Board Fam Med) - "Moderately effective pharmacologic and non-pharmacologic methods exist for reducing pain and anxiety with IUD insertion. These treatment methods should be offered to create a more comfortable experience for patients. Additional research is needed to determine the comparative efficacy of these methods."

Journal • Review • Long-acting Reversible Contraceptives • Mood Disorders • Pain • Psychiatry • Women's Health

Myofascial Pain Syndrome: An Update on Clinical Characteristics, Etiopathogenesis, Diagnosis, and Treatment. (PubMed, Muscle Nerve) - "However, non-steroidal anti-inflammatory drugs, diclofenac, botulinum toxin, and transcutaneous electrical nerve stimulation show insufficient evidence, while the effectiveness of muscle relaxants, antidepressants, gabapentin, opioids, topical lidocaine, capsaicin, EMLA cream, and kinesio taping remains inconclusive. Effective management of MPS requires a patient-centered approach that integrates empirically supported and evidence-based treatments tailored to individual needs. This review synthesizes the current understanding of MPS and highlights the need for high-quality research to improve clinical decision-making in managing this complex condition."

Journal • Review • Anesthesia • Fibromyalgia • Musculoskeletal Pain • Neuralgia • Pain • Rheumatology

Local analgesia for the relief of pain in children undergoing venipuncture and intravenous cannulation: a systematic review and network meta-analysis. (PubMed, BMC Anesthesiol) - "Most local analgesia methods were effective in relieving pain in children undergoing venipuncture and intravenous cannulation except vapocoolant spray which did not show greater pain reduction than placebo or routine care. Amethocaine, Buzzy and lidocaine iontophoresis are the top 3 local analgesia methods to relieve pain in children undergoing venipuncture and intravenous cannulation. However, due to the limited number of direct comparisons, interpretation of some results should be made with caution."

Clinical • Journal • Retrospective data • Review • Pain

Clinicopathologic correlation in a case of irritant contact dermatitis caused by topical application of EMLA® cream (AAD 2025) - No abstract available

Clinical • Contact Dermatitis • Dermatitis • Dermatology • Immunology

Topical analgesia during needle-related procedures in children: a clinical practice guideline. (PubMed, Arch Dis Child) - "There is, however, uncertainty about the type of local anaesthetic (ie, eutectic mixture of topical analgesia (EMLA) or tetracaine-containing creams (eg, Rapydan) that should be used.Therefore, a clinical practice guideline (CPG) was developed to establish a comprehensive, evidence-based overview and provide recommendations for clinical practice.A comprehensive multidisciplinary panel was assembled, comprising 16 professionals and patient representatives in the Netherlands. We suggest the use of tetracaine-containing creams only when rapid cannulation/puncture (ie, within 30-60 min) is required (weak recommendation, very low-quality evidence).In this CPG, we provide recommendations regarding the choice of local anaesthetic for needle-induced pain during minor procedures in children. With these recommendations, we aim to reduce procedural pain and thereby contribute to improving care for children."

Clinical guideline • Journal • Anesthesia • Pain • Pediatrics

Ice Versus EMLA for Pain in Laser Hair Removal (clinicaltrials.gov) - P4 | N=30 | Active, not recruiting | Sponsor: Northwestern University | Phase classification: P=N/A ➔ P4 | Trial completion date: Dec 2024 ➔ Dec 2025 | Trial primary completion date: Dec 2024 ➔ Dec 2025

Phase classification • Trial completion date • Trial primary completion date • Aesthetic Medicine • Pain

Topical anesthetics methods used to reduce needle pain/discomfort prior to local anesthesia in children and adolescents: a scoping review. (PubMed, Evid Based Dent) - "Cooling is a technique with numerous clinical advantages from the clinical point of view, for reduction of pain/discomfort prior to needle puncture of dental local anesthesia in children and adolescents. It is an accessible, inexpensive and pleasant method that does not resemble needles or unpleasant tastes, nor involves systemic toxicity and complications that may be associated with others anesthetics agents. Future randomized controlled studies in accordance with the Consort Statement are needed to further investigate the topic."

Journal • Anesthesia • Pain

The safety study of EMLA cream for non-coring needle insertion in patients with TIAP (ChiCTR) - P4 | N=368 | Completed | Sponsor: Sun Yat-sen University Cancer Center; Sun Yat-sen University Cancer Center

New P4 trial • Oncology

EML4-ALK: Update on ALK Inhibitors. (PubMed, Int J Mol Sci) - "Since the discovery of the first-generation ALK inhibitor, many other tyrosine kinase inhibitors have been demonstrated to be effective in the first line or further lines of treatment in patients with advanced non-small cell lung cancer with EMLA4-ALK translocation...It presents the two options available for first-line treatment at the present time: sequencing different ALK inhibitors versus using the most potent inhibitor in front-line treatment. The efficacy outcomes of different ALK inhibitors in the first-line setting; the molecular profile of the disease, including mutation resistances and ALK variants and co-mutations; and patients' co-morbidities and inhibitor toxicities should be taken into account to address the choice of the first-line treatment, as suggested in this review."

Journal • Review • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • EML4