MBP87-99 / Burnet Institute - LARVOL DELTA

Gut Infiltration of Lcn-2+Neutrophil Is Associated with Gut Dysbiosis and Intestinal Inflammation In A Spontaneous EAE Model Of Multiple Sclerosis (ACTRIMS Forum 2023) - "However, mechanism is not understood clearly and there are no bioindicator available to monitor these conditions.Objectives: To determine the cellular mechanism of Intestinal inflammation and gut dysbiosis and its biological indicator during MS using animal model. We investigated gut infiltration of immune cells in a spontaneous experimental autoimmune encephalomyelitis (EAE) model (transgenic (Tg) mice expressing HLA-DR2a and human T cell receptor (TCR) specific for myelin basic protein peptide (MBP87-99)/HLA-DR2a complexes)... This study suggests that gut infiltration of Th17 cells and recruitment of neutrophils are associated with the development of gut dysbiosis and intestinal inflammation, and that fecal Lcn-2 level is a sensitive biological indicator for gut dysbiosis and intestinal inflammation in MS."

IO biomarker • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Multiple Sclerosis • ELANE • LCN2 • MBP

Fecal Lcn-2 level is a sensitive biological indicator for gut dysbiosis and intestinal inflammation in multiple sclerosis. (PubMed, Front Immunol) - "To elucidate the underlying biology of MS-linked gut inflammation, we investigated gut infiltration of immune cells during the development of spontaneous experimental autoimmune encephalomyelitis (EAE) in humanized transgenic (Tg) mice expressing HLA-DR2a and human T cell receptor (TCR) specific for myelin basic protein peptide (MBP87-99)/HLA-DR2a complexes...Furthermore, a decrease in the relative abundance of Blautia massiliensis was significantly associated with a reduction of acetate in the serum of MS patients. This study suggests that gut infiltration of Th17 cells and recruitment of neutrophils are associated with the development of gut dysbiosis and intestinal inflammation, and that fecal Lcn-2 level is a sensitive biological indicator for gut dysbiosis in multiple sclerosis."

Biomarker • IO biomarker • Journal • CNS Disorders • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Multiple Sclerosis • ELANE • LCN2 • MBP

Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood. (PubMed, Proc Natl Acad Sci U S A) - "...In this study, we investigated the effects of age and gut dysbiosis on the development of CNS autoimmunity in humanized transgenic mice expressing the MS-associated MHC class II (MHC-II) gene, HLA-DR2a, and T-cell receptor (TCR) genes specific for MBP87-99/DR2a that were derived from an MS patient...Furthermore, gut dysbiosis induces the expression of complement C3 and production of the anaphylatoxin C3a, and down-regulates the expression of the Foxp3 gene and anergy-related E3 ubiquitin ligase genes. Consequently, gut dysbiosis was able to trigger the development of encephalitogenic T cells and promote the induction of EAE during the age window of young adulthood."

Clinical • IO Biomarker • Journal • Biosimilar • CNS Disorders • Immunology • Multiple Sclerosis

Altered peptide ligands of myelin basic protein produce antidepressant-like effects via inflammatory factors and p11 (Neuroscience 2017) - "Immunization with MBP87-99[A91, A96] produced prolonged antidepressant effects in rats, and the behavioral response is mediated by inflammatory factors and p11 signaling in the mPFC."

CNS Disorders