JMKX003142 / Shanghai Jeyou Pharmaceutical - LARVOL DELTA

A Dose-finding Study of JMKX003142 in Treatment of Renal Edema (clinicaltrials.gov) - P2 | N=133 | Completed | Sponsor: Jemincare | Recruiting ➔ Completed | N=216 ➔ 133

Enrollment change • Trial completion

A Dose-finding Study of JMKX003142 in Treatment of Cardiac Edema (clinicaltrials.gov) - P2 | N=160 | Completed | Sponsor: Jemincare | Trial completion date: May 2027 ➔ Apr 2026 | Trial primary completion date: Jan 2027 ➔ Mar 2026 | Not yet recruiting ➔ Completed

Trial completion • Trial completion date • Trial primary completion date • Cardiovascular • Congestive Heart Failure • Heart Failure

Drug-Drug Interactions of JMKX003142 in Healthy Participants (clinicaltrials.gov) - P1 | N=112 | Not yet recruiting | Sponsor: Jemincare

New P1 trial • Autosomal Dominant Polycystic Kidney Disease • Genetic Disorders • Nephrology • Polycystic Kidney Disease • Renal Disease

A Study to Investigate the Effects of JMKX003142 on QTc Interval in Healthy Adults (clinicaltrials.gov) - P1 | N=24 | Not yet recruiting | Sponsor: Jemincare

New P1 trial • Autosomal Dominant Polycystic Kidney Disease • Genetic Disorders • Nephrology • Polycystic Kidney Disease • Renal Disease

Mass Balance and Absolute Bioavailability Study of JMKX003142 In Healthy Volunteers (clinicaltrials.gov) - P1 | N=8 | Not yet recruiting | Sponsor: Jemincare

New P1 trial • Autosomal Dominant Polycystic Kidney Disease • Genetic Disorders • Nephrology • Polycystic Kidney Disease • Renal Disease

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Intravenous Administration JMKX003142 in Chinese Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Single, and Multiple Ascending Dose Phase I Clinical Trial. (PubMed, Drug Des Devel Ther) - P1 | "Overall, both single and multiple intravenous injections of JMKX003142 have been demonstrated to be safe, well tolerated, and to possess excellent PK characteristics as well as significant diuretic activity. This study was registered with ClinicalTrials.gov (NCT06344533)."

Clinical • First-in-human • Journal • P1 data • PK/PD data

Drug-Drug Interaction of JMKX003142 With Amiodarone and Febuxostat in Healthy Subjects (clinicaltrials.gov) - P1 | N=48 | Not yet recruiting | Sponsor: Jemincare

New P1 trial • Autosomal Dominant Polycystic Kidney Disease • Genetic Disorders • Nephrology • Polycystic Kidney Disease • Renal Disease

A Dose-finding Study of JMKX003142 in Treatment of Renal Edema (clinicaltrials.gov) - P2 | N=216 | Recruiting | Sponsor: Jemincare | Not yet recruiting ➔ Recruiting

Enrollment open

Trial of JMKX003142 in Participants With Rapidly Progressive Autosomal Dominant Polycystic Kidney Disease (ADPKD) (clinicaltrials.gov) - P2 | N=135 | Recruiting | Sponsor: Jemincare | Not yet recruiting ➔ Recruiting

Enrollment open • Autosomal Dominant Polycystic Kidney Disease • Genetic Disorders • Nephrology • Polycystic Kidney Disease • Renal Disease

A Dose-finding Study of JMKX003142 in Treatment of Cardiac Edema (clinicaltrials.gov) - P2 | N=160 | Not yet recruiting | Sponsor: Jemincare

New P2 trial • Cardiovascular • Congestive Heart Failure • Heart Failure

Trial of JMKX003142 in Participants with Rapidly Progressive Autosomal Dominant Polycystic Kidney Disease (ADPKD) (clinicaltrials.gov) - P2 | N=135 | Not yet recruiting | Sponsor: Jemincare

New P2 trial • Autosomal Dominant Polycystic Kidney Disease • Genetic Disorders • Nephrology • Polycystic Kidney Disease • Renal Disease

A Dose-finding Study of JMKX003142 in Treatment of Renal Edema (clinicaltrials.gov) - P2 | N=216 | Not yet recruiting | Sponsor: Jemincare

New P2 trial

Study to Evaluate the Drug-drug Interaction of JMKX003142 in Healthy Subjects (clinicaltrials.gov) - P1 | N=48 | Not yet recruiting | Sponsor: Jemincare

New P1 trial • Autosomal Dominant Polycystic Kidney Disease • Genetic Disorders • Nephrology • Polycystic Kidney Disease • Renal Disease

Study of JMKX003142 Injection in Chinese Healthy Subjects (clinicaltrials.gov) - P1 | N=78 | Not yet recruiting | Sponsor: Jemincare

New P1 trial

Phase 1 Clinical Study of JMKX003142 Tablets (clinicaltrials.gov) - P1 | N=106 | Recruiting | Sponsor: Jemincare

New P1 trial