VS-367 / Vasa Therapeutics - LARVOL DELTA

Rallying at the border: CD8+ T-cell density at the invasive margin in colon adenocarcinoma and its link to MMR protein expression (ECP 2026) - " With a median CD8+ T-cell density of 458.9 cell/mm2 (with a range between 87.7-1540.2) in the cohort, the MMR-deficient tumors exhibited a more than two-fold elevation in CD8+ T-cell density compared to the MMR-proficient group (755.7 vs 367.8 cells/mm2; p value=0.015)... MMR status is the strongest determinant of CD8+ T-cell density at the invasive margin in colon adenocarcinoma, consistent with the high neoantigen burden of MMR-deficient tumors. The inverse association with pT stage suggests progressive immune evasion with deeper invasion. Trends observed for Crohn-like reaction, perineural invasion, and nodal stage subgroups are biologically plausible and warrant confirmation in larger cohorts."

Colon Adenocarcinoma • Colon Cancer • Colorectal Adenocarcinoma • Colorectal Cancer • Crohn's disease • Gastroenterology • Immunology • Oncology • CD8

Spatial remodeling of the tumor-immune microenvironment (TIME) on neoadjuvant chemo-immunotherapy (NCIT) in patients (pts) with hormone receptor positive (HR+) early breast cancer (eBC) by multiplex immunofluorescence (mIF). (ASCO 2026) - P1 | " This is an exploratory analysis from trial NCT02999477 randomizing pts to a monotherapy run-in (A: nab-paclitaxel; B: pembrolizumab) followed by both in combination (NCIT)...At BL, RCB-0/I pts had numerically higher density of helper T cells (Th) (CD4+; median 2154.1 vs 890.0; p = .06), cytotoxic T cells (Tc) (CD8+; 728.1 vs 367.9; p = .08), activated Tc (6.1 vs 1.3; p = .06), APCs (HLA-ABC+, HLA-DR+: 124.6 vs 51.3; p = .36), and macrophages (CD68+CD206+; 63.4 vs 26.7; p = .25) vs RCB-II/III... TIME remodeling was heterogeneous, trending toward greater Tc and APC density and proximity to the tumor area in RCB 0/I."

Clinical • Breast Cancer • Hormone Receptor Breast Cancer • Hormone Receptor Positive Breast Cancer • Oncology • Solid Tumor • CD4 • CD68 • CD8 • FOXP3 • GZMB • HLA-C • MRC1

Right Ventricular Arterial Coupling in Pulmonary Arterial Hypertension: Idiopathic versus Systemic Sclerosis-Associated PAH (ISHLT 2026) - "Considering patients with PVR≥5, SSc-PAH patients had more advanced WHO functional class, more impaired exercise capacity, higher NT-proBNP levels and right atrial pressure, and lower cardiac index (respectively, WHO III/IV: 129 patients, 84% vs 126 patients, 72%, p=0.01; 6MWD: 335±106 m vs 367 ± 114 m, p=0.01; NT-proBNP: 535±696 pg/ml vs 212±407 pg/ml, p=ns, RAP: 9.3±4.6 mmHg vs 7.5±3.9 mmHg, p<0.001; CI: 2.2±0.5 l/min/m2 vs 2.4±0.6 l/min/m2,p=0.01).Conclusion SSc-PAH patients with PVR≥5 had less favorable RV adaptation to increased afterload compared to patients with IPAH. Intrinsic RV involvement seems to play a key role in the pathophysiology of SSc-PAH and may explain the poor outcome of these patients."

Cardiovascular • Immunology • Pulmonary Arterial Hypertension • Respiratory Diseases • Scleroderma • Systemic Sclerosis

Parallel trajectory of cannulated screws is biomechanically advantageous to diverging trajectory in moderate Pauwels angle femoral neck fractures. (PubMed, Injury) - "Parallel trajectory of cannulated screws in moderate Pauwels angle femoral neck fractures is biomechanically superior to diverging trajectory of cannulated screws. With widely available guides for consistent placement and reproducibility of parallel screws, this clinically feasible and efficient screw trajectory can most likely be relied upon for robust femoral neck fracture fixation."

Journal • Musculoskeletal Diseases • Orthopedics

Impact of pulmonary rehabilitation on functional status in ILD patients – experience of a tertiary hospital (ERS 2025) - "After PR, 6MWT showed improvement in walking distance (380±129,5m vs 367±131,2m)...The combined benefits of pharmacological treatments and PR were evident, as walking distances increased and post-exertion symptoms improved. Still, larger multicentric studies are needed to explore long-term PR benefits for ILD patients."

Clinical • Idiopathic Pulmonary Fibrosis • Immunology • Interstitial Lung Disease

Right ventricular arterial coupling in PAH: idiopatic versus systemic sclerosis-associated pulmonary arterial hypertension (ESC-WCC 2025) - "SSc-PAH had more advanced WHO functional class, more impaired exercise capacity, higher NT-proBNP, higher right atrial pressure, and lower cardiac index (respectively, WHO III/IV:129 patients, 84% vs 126 patients, 72%, p=0.01; 6MWD: 335 ± 106m vs 367 ± 114m, p=0.01; NT-proBNP: 535 ± 696 pg/ml vs 212 ± 407 pg/ml, p=ns, RAP: 9.3 ± 4.6mmHg vs 7.5 ± 3.9mmHg, p<0.001; CI values: 2.2 ± 0.5 l/min/m2 vs 2.4 ± 0.6 l/min/m2,p=0.01). SSc-PAH patients with PVR≥5 had less favorable RV adaptation to increased afterload, resulting in increased filling pressures, higher BNP plasma level, more impaired TAPSE/PASP and finally lower cardiac index compared with IPAH."

Cardiovascular

The role of multipoint left ventricular pacing compared to optimized cardiac resynchronization therapy on long-term follow-up in chronic heart failure patients (ESC-WCC 2025) - "Those long-term follow-up results probably reflect the differences observed between OPTCRT and OPTMPP at the first year of follow-up; where OPT MPP showed better 6-minute walking distance (405±129m vs 367±94m vs. p<0.001), NYHA class (2.36 vs. .45, p<0.001), VTIlvot (17.5±3.4 vs 14.25±3.2cm, p<0.001), stroke volume (59±15ml vs 48±13.5ml, p<0.001), LVEF (37%±7.7% vs. 29%±7.1% p<0.001), LA volume (67.7±32 vs. 77.2±34.2ml, p=0.02), RV strain (-11.8%±6.1% vs. 8.3%±6.9%, p=0.022). In chronic heart failure patients under CRT implantation, optimization of MPP showed beneficial effect on survival especially compared to optimization of CRT only, through favorable changes in various clinical, functional, and echocardiographic parameters, as well as quality of life. Combining MPP with optimization, both electrical and hemodynamic, was found to be able to reverse the long-term progression of HF and to..."

Clinical • Cardiomyopathy • Cardiovascular • Congestive Heart Failure • Heart Failure

Tryptophan metabolites clearance by hemodialysis and hemodiafiltration: an influence of comorbidities (ERA 2025) - "Hypertension was associated with improved KYN clearance (2.4 M vs 0.8 M, p = 0.0005) and KYN/Trp ratio (0.4 vs 0.1, p = 0.0007), but not KYNA, although in patients without hypertension higher predialysis KYNA concentration was observed (584.6 nM vs 367.4 nM, p = 0.0044)... Our study found incomplete removal of Trp metabolites in ESKD patients treated by HD and HDF procedures. Targeted strategies to lower selected KYN pathway metabolites concentration may be beneficial in patients with ESKD."

Atherosclerosis • Cardiovascular • Congestive Heart Failure • Heart Failure • Hypertension • Nephrology • Renal Disease

Improved Pharmacokinetic Performance and Pharmacodynamic Efficacy of IL-1Ra Complexed with Dual Polymeric Carrier in Type 1 Diabetes Mellitus. (PubMed, Adv Healthc Mater) - "Mice treated with IL-1Ra NCs exhibit a significant reduction in fasting blood glucose levels (232.25 ± 23.64 mg dL-1 vs 367.88 ± 21.83 mg dL-1 in the diabetic control). Furthermore, IL-1Ra NCs preserve β-cell integrity and exhibit an improved anti-inflammatory response as assessed by H&E and IHC analysis."

Journal • PK/PD data • Diabetes • Endocrine Disorders • Inflammation • Metabolic Disorders • Type 1 Diabetes Mellitus • IL1B • IL1R1