niclosamide / Generic mfg. - LARVOL DELTA

Canonical and noncanonical NF-κB signaling in uveal melanoma: mechanisms, microenvironment, and therapeutic modulation. (PubMed, Med Hypothesis Discov Innov Ophthalmol) - "Canonical NF-κB signaling is mechanistically related to UM cell survival, proliferation, and migration, as shown by pharmacologic inhibition like BAY11-7082, and niclosamide and genetic modulation like microRNA-9. NF-κB signaling, particularly the canonical branch, is required for UM malignancy, while noncanonical signaling is linked with high-risk features. Branch-specific genetic manipulations and clinically relevant models should be employed in future research to maximize therapeutic strategies."

Journal • Review • Eye Cancer • Melanoma • Ocular Melanoma • Oncology • Solid Tumor • Targeted Protein Degradation • Uveal Melanoma • BAP1 • TNFA

BAM 15 Exerts Molluscicidal Effects on Pomacea canaliculata Through the Induction of Oxidative Stress, Impaired Energy Metabolism, and Tissue Damage. (PubMed, Molecules) - "Our findings reveal that BAM 15 operates via a three-stage mechanism: (1) it disrupts membrane potential (ΔΨm) and impairs ATP production, severely disturbing energy metabolism; (2) energy deficits stimulate excessive electron transport chain activity, generating reactive oxygen species (ROS) and initiating oxidative stress; (3) persistent metabolic imbalance and oxidative damage culminate in extensive tissue injury. These results identify BAM 15 as a promising candidate for molluscicide development."

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Highly sensitive niclosamide detection using the multifunctional carbon nanoflowers@halloysite nanotubes@graphene nanoplates nanocomposite modified electrochemical sensor. (PubMed, Food Chem) - "The CNF@Hal@Gr/GCE sensor exhibited ultrasensitive NA detection performance, including wide linear range (0.01-20 μM) and low limit of detection (5.83 nM). Moreover, the CNF@Hal@Gr/GCE sensor presented superior practical applicability with relative standard deviations of 0.87-4.71% and recoveries of 95.18-103.1%."

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Niclosamide Encapsulated pH-Responsive Polyzwitterionic Block Copolymers for Cancer Therapy. (PubMed, Macromol Biosci) - "ZIP-NIC exhibited similar anti-cancer efficacy to free NIC in the HCT116 cell line. Our results suggest that polyzwitterionic nanoparticles constitute a promising class of materials to deliver antitumor drugs and warrant further investigation."

Journal • Oncology

Strategic Preparedness of Broad-Spectrum Antivirals for Rapid Response Towards Next Pandemics. (PubMed, Small Sci) - "Several repurposed drugs, such as niclosamide, favipiravir, remdesivir, nitazoxanide, and zinc-ionophores, have demonstrated potential broad-spectrum activity when formulated at the nanoscale. Such nanotechnological strategies not only improve antiviral efficacy across multiple viral families, including Coronaviridae, Flaviviridae, Orthomyxoviridae, and Poxviridae, but also support scalable, cost-effective production suitable for global deployment. By integrating drug repurposing with nanoengineering, BSAs can form the cornerstone of future pandemic preparedness, bridging the gap between laboratory innovation and rapid clinical response to emerging infectious diseases."

Journal • Infectious Disease • Novel Coronavirus Disease

Novel niclosamide-derived Schiff bases as a dual-targeted anticancer agents. (PubMed, Sci Rep) - No abstract available

Journal • Oncology

Chronic Exposure to Niclosamide Disrupts Structure and Metabolism of Digestive Glands and Foot in Cipangopaludina cathayensis. (PubMed, Biology (Basel)) - "At the population level, persistent niclosamide exposure may destabilize mollusk trophic-level populations, ultimately leading to ecological consequences. Our findings demonstrate the toxicological risks of niclosamide to freshwater mollusks."

Journal • Infectious Disease • Muscular Atrophy

EXPERIMENTAL STUDIES ON THE NEUROPROTECTIVE EFFECTS OF NICLOSAMIDE AND MOMORDICA CHARANTIA ON AUTOPHAGIC AND NF-ΚB SIGNALING PATHWAY IN MPTP-INDUCED PARKINSON'S DISEASE MODELS (ADPD 2026) - "Niclosamide and MC extract demonstrated synergistic neuroprotective effects in PD models. Their ability to reduce oxidative stress, inflammation, and dopaminergic neuron loss suggests therapeutic potential. This study supports further exploration of combined natural and pharmacological interventions for PD management."

CNS Disorders • Inflammation • Movement Disorders • Neuroblastoma • Parkinson's Disease • Solid Tumor • CAT • IL1B • TNFA

Electro-Stimulated Graphene-Polymer Nanocomposites Enable Wearable Patches With Feedback-Controlled Drug Release. (PubMed, Adv Healthc Mater) - "Stimuli-responsive nanomaterials capable of spatiotemporal control over drug release are of nanocomposite patch ("e-Medi-Patch") engineered from biodegradable polycaprolactone (PCL), graphene nanoplatelets, and a redox-active therapeutic, niclosamide...Beyond melanoma, the platform accommodates other redox-active therapeutics and offers scalable melt-blending fabrication. This work establishes an integrated materials-electronics strategy for wearable, feedback-controlled drug delivery, bridging multifunctional nanocomposites and precision medicine."

Journal • Melanoma • Oncology • Solid Tumor

Spray Drying for Pharmaceutical Raw Materials: A Systematic Review on Enhancing Bioavailability and Stability. (PubMed, Drug Des Devel Ther) - "S-SNEDDS produced AUC enhancements of 4-9.9-fold (sorafenib approximately 4.6-fold, enzalutamide approximately 7-fold, niclosamide approximately 9.9-fold). Ongoing deficiencies encompass inadequate carrier comparisons, insufficient mechanistic comprehension of drying kinetics, and issues related to scale-up and regulation. This review offers mechanistic insights and a standardized approach to facilitate future formulation development."

Journal • Review

TMEM16F-CLIC1 interaction mediates recipient DC cross-decoration after transplantation. (PubMed, Am J Transplant) - "Likewise, niclosamide therapy limits recipient cDC cross-decoration and suppresses alloresponses after transplantation. Collectively, these results suggest TMEM16F-CLIC1 interaction mediates recipient DC cross-decoration after transplantation and niclosamide can be repurposed for prevention of acute rejection."

Journal • Immunology • Transplant Rejection • Transplantation • ANO6 • RAB27A

Assessing the lethal effects of granular Bayluscide® on the early life stages of the freshwater mussel Lampsilis siliquoidea. (PubMed, Environ Toxicol Chem) - "The active ingredient of gB, niclosamide, was derived specifically as a molluscicide, therefore it is crucial to understand its impacts on a group of mollusks that have been imperiled due to many factors including the input of contaminants in the aquatic environment...Both early life stages of L. siliquoidea showed a marked sensitivity to gB. Although environmental conditions may have an influence on gB fate, the marked sensitivity of early life stages demonstrated in this study is crucial to understanding the effects of sustained gB application on the population dynamics of freshwater mussels."

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D-band center modulation-enabled enhancement of adsorption and electrochemical detection for niclosamide by α-MnO2-supported dry gel-derived Fe3O4@N-doped porous carbon. (PubMed, J Hazard Mater) - "It was further revealed that the efficient synergistic catalytic effect between the two makes the α-MnO2/Fe3O4@NPC/GCE electrochemical sensor have good adsorption and outstanding detection performance for NA. This study provides a new solution for NA concentration detection in complex environments."

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Translational potential of safe-by-design nanoengineered niclosamide in viral and cancer therapy. (PubMed, Mater Today Bio) - "This study presents a comprehensive evaluation of the long-term biocompatibility of CP-COV03 (NIC-MgO-HPMC), a nanohybrid formulation of niclosamide designed to overcome its limitations in solubility, stability, and bioavailability. The absence of systemic toxicities validates CP-COV03 as a scalable and biocompatible therapeutic platform suitable for extended dosing regimens. By combining durable safety with enhanced drug performance, CP-COV03 offers strong translational potential for persistent viral infections, including long COVID, future pandemic threats, and oncology applications."

Journal • Hematological Disorders • Infectious Disease • Novel Coronavirus Disease • Oncology

Basic Science and Pathogenesis. (PubMed, Alzheimers Dement) - "By integrating multiple layers of biological data from established reference atlases, our analysis of mitochondria-nuclear crosstalk revealed distinct transcriptional signatures associated with AD risk in glial and neural cells, with these associations exhibiting sex-biased patterns."

Journal • Alzheimer's Disease • CNS Disorders • Movement Disorders • Parkinson's Disease • Solid Tumor • Targeted Protein Degradation

Lactoferrin-modified niclosamide lipid nanocarriers reprogram ferroptosis and antioxidant networks for breast cancer suppression. (PubMed, Int J Pharm) - "Concurrently, VEGF downregulation and p53 upregulation reflected additional anti-angiogenic and pro-apoptotic effects. Collectively, the lactoferrin-functionalized Nic-NLC produced the most robust antitumor response, with superior ferroptosis induction, redox modulation, and anti-angiogenic activity."

Journal • Breast Cancer • Oncology • Solid Tumor • ALOX15

Dose-Response Relationship of Niclosamide and Metformin Combination in ApcMin/+ Mice: An Integrated In Vivo and Pharmacokinetic Modeling Study. (PubMed, Gut Liver) - "Notably, the predicted metformin plasma Cmax remained within a safe therapeutic window at the 100 mg/kg combination dose but exceeded a safety threshold at 200 mg/kg. By integrating in vivo efficacy testing with quantitative modeling, our study identified the 100 mg/kg combination of niclosamide and metformin as the optimal dose for chemoprevention in a murine FAP model, providing a strong rationale for future clinical translation in FAP management."

Journal • PK/PD data • Preclinical • Colonic Polyps • Colorectal Cancer • Genetic Disorders • Oncology • Solid Tumor • APC

Niclosamide suppresses gastric cancer progression through YTHDF2 inhibition-affected lactate metabolic reprogramming. (PubMed, iScience) - "Our research revealed comprehensive metabolic alterations in gastric cancer, including upregulated lactate metabolism that promotes tumorigenesis via the lactate shuttle. Niclosamide targets the m6A methylation regulatory protein YTHDF2, which influences genes related to metabolism, indicating its potential as a prospective treatment for GC."

Journal • Gastric Cancer • Metabolic Disorders • Oncology • Solid Tumor • YTHDF2

Niclosamide and Palbociclib Act Synergistically to Reduce Cholangiocarcinoma Cell Viability In Vitro and Inhibit Tumour Growth in a Mouse Model. (PubMed, Cancers (Basel)) - "Interestingly, the CDK4/6 kinase inhibitor Palbociclib selectively reduces the viability of cholangiocarcinoma cell lines compared to normal biliary epithelial cells and, importantly, Palbociclib synergises with Niclosamide to reduce cholangiocarcinoma cell viability in vitro as well as to reduce tumour growth in a mouse xenograft model. These preclinical results suggest that the combination of Niclosamide and an inhibitor of CDK4/6 is worthy of clinical evaluation as a potential treatment for this disease."

Journal • Preclinical • Biliary Cancer • Cholangiocarcinoma • Liver Cancer • Oncology • Solid Tumor

A novel graphene oxide-niclosamide hybrid as a potent antiviral agent against dengue virus serotype 3. (PubMed, Colloids Surf B Biointerfaces) - "The synergistic effect between GO and niclosamide contributed to the inhibition of viral replication. These findings highlight GO-Nic potential as a novel antiviral candidate for dengue infection."

Journal • Dengue Fever • Infectious Disease

Novel Therapeutic Strategy for Renal Cell Carcinoma: Niclosamide Enhances Sunitinib Efficacy via DNA Repair and Cell Cycle Pathways. (PubMed, Int J Mol Sci) - "Tyrosine kinase inhibitors (TKIs), such as sunitinib and sorafenib, are standard treatments for renal cell carcinoma (RCC). RNA sequencing (RNA-seq) and bioinformatic analyses showed that niclosamide modulated critical pathways, including BRIP1- and FANCA-mediated DNA repair and E2F2-regulated cell cycle progression. These findings provide proof-of-concept that niclosamide enhances TKI efficacy through modulation of DNA repair and cell cycle pathways, supporting the rationale for DNA damage response (DDR)-targeted combination strategies in RCC."

Journal • Genito-urinary Cancer • Oncology • Renal Cell Carcinoma • Solid Tumor • BRIP1 • E2F2 • FANCA

Succinate Dehydrogenase-Deficient Cancer Cells Have Increased Susceptibility to Ym155 Induced DNA Damage. (PubMed, bioRxiv) - "Given the reduced ATP-generating capacity of SDHB -KO cells, we hypothesized they would be uniquely sensitive to futile cycle induction with mitochondrial ionophores (2,4-Dinitrophenol (2-DNP), BAM15, Niclosamide, Nitazoxanide). Thus, the accumulation of succinate in SDH-deficient tumors inhibits KDM4 activity, impairs DNA repair and yields enhanced susceptibility to Ym155-induced reactive oxygen species (ROS) generation. The identified intrinsic susceptibilities of SDHB -deficient cancers has the potential to be therapeutically leveraged."

Journal • Gastrointestinal Cancer • Gastrointestinal Stromal Tumor • Genito-urinary Cancer • Oncology • Renal Cell Carcinoma • Sarcoma • Solid Tumor • SDHB

Dissecting macrophage heterogeneity in ulcerative colitis: Single-cell analysis and functional validation of S100A4 as a therapeutic target. (PubMed, Int Immunopharmacol) - "This study provides a comprehensive single-cell landscape of macrophage heterogeneity in UC, identifying S100A8+ and IL1B+ macrophages as key mediators of mucosal inflammation. Integrative analysis pinpointed S100A4 as a robust diagnostic and therapeutic candidate, with experimental validation underscoring its translational potential. These findings offer new insights into macrophage-driven pathogenesis and open avenues for targeted UC therapies."

Heterogeneity • Journal • Gastroenterology • Gastrointestinal Disorder • Immunology • Inflammation • Inflammatory Bowel Disease • Mucositis • Ulcerative Colitis • APOE • IL1B • S100A4 • S100A6 • S100A8

Targeting Mitochondrial Metabolism to Promote Viral Mimicry and Type I Interferon Response in Acute Myeloid Leukemia (ASH 2024) - "Transcriptomic analysis of persisting AML cells post-induction therapy (cytarabine and doxorubicin) in an MLL-AF9 immune-competent C57BL/6 mouse model revealed that the persisting AML cells were negatively enriched for type-I IFN response and positively enriched for myc, oxidative phosphorylation, unfolded protein response and fatty acid metabolism...We discovered that Artesunate (ART; an anti-parasitic drug used to treat malaria), and Niclosamide (NA; an anti-helminthic drug used to manage tapeworm infections), elicited ISRE activity in a dose-dependent manner...Treatment of AML cells with ART, NA, or the BH3 mimetic Venetoclax (mitochondrial inhibitor used in the management of AML) promoted the leakage of mitochondrial DNA in the cytosol; however, only NA and ART increased the activation of IFN-stimulated genes, highlighting that not all mitochondria-targeting agents act in the same way...We propose that ART can be repurposed as a potential STING agonist. Further..."

Acute Lymphocytic Leukemia • Acute Myelogenous Leukemia • Bone Marrow Transplantation • Hematological Malignancies • Infectious Disease • Leukemia • Malaria • Oncology • CD4 • CD8 • IFNA1 • STAT1 • STAT2

Dietary Sarcodia suieae Hydrocolloid Supplementation Elevates Quercetin Levels and Modulates Metabolic and Immune Pathways in the Hepatopancreas of Macrobrachium rosenbergii: Insights from Integrated Omics Analyses. (PubMed, Dev Comp Immunol) - "Conversely, certain amino acids like L-Allothreonine and L-Proline, and compounds such as 5-Aminopentanoic acid and Niclosamide, were significantly downregulated...The enrichment of autophagy and apoptosis pathways at higher concentrations suggests a significant impact on cellular turnover and stress responses, potentially contributing to adaptation or maintaining cellular homeostasis under the influence of the hydrocolloid. These integrated omics findings elucidate the complex molecular mechanisms by which S. suieae hydrocolloid influences the hepatopancreatic health and metabolic regulation in M. rosenbergii, providing valuable insights for the development of novel functional feeds in sustainable aquaculture."

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